共查询到20条相似文献,搜索用时 15 毫秒
1.
D. Zhou E. Semones R. Gaza S. Johnson N. Zapp M. Weyland 《Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment》2007,580(3):1283-1289
Radiation in low Earth orbit (LEO) is mainly from Galactic Cosmic Rays (GCR), solar energetic particles and particles in South Atlantic Anomaly (SAA). These particles’ radiation impact to astronauts depends strongly on the particles’ linear energy transfer (LET) and is dominated by high LET radiation. It is important to investigate the LET spectrum for the radiation field and the influence of radiation on astronauts. At present, the best active dosimeters used for all LET are the tissue equivalent proportional counter (TEPC) and silicon detectors; the best passive dosimeters are thermoluminescence dosimeters (TLDs) or optically stimulated luminescence dosimeters (OSLDs) for low LET and CR-39 plastic nuclear track detectors (PNTDs) for high LET. TEPC, CR-39 PNTDs, TLDs and OSLDs were used to investigate the radiation for space mission Expedition 12 (ISS-11S) in LEO. LET spectra and radiation quantities (fluence, absorbed dose, dose equivalent and quality factor) were measured for the mission with these different dosimeters. This paper introduces the operation principles for these dosimeters, describes the method to combine the results measured by CR-39 PNTDs and TLDs/OSLDs, presents the experimental LET spectra and the radiation quantities. 相似文献
2.
The LET dependences of thermoluminescence dosimeters of Mg2SiO4:Tb (TLMS) and radiophotoluminescent glass dosemeters (RPLG) were examined using high energy, heavy ion beams. TLMS kept its efficiency below 10 keV micrometer-1 and decreased almost linearly with the logarithm of LET for higher LET particles. The efficiency of RPLG decreased more gradually than TLMS although its reduction was observed at a lower LET region around 0.5 keV micrometer-1. Accordingly, the ratio of TLMS to RPLG valued showed a maximum peak around 20 keV micrometer-1 of LET. The results obtained with both dosemeters in the 40 day space mission in the Russian space station Mir showed that not only dose level but also radiation quality were varying considerable in the Mir Core Module. 相似文献
3.
Clinical application of light ion beams requires correct understanding of the complex processes of ion interaction with matter and the development of accurate transport methods. Knowledge of the fluence differential in energy of primary and secondary particles is important since it allows evaluation of different linear energy transfer (LET) dose components in the patient. The low LET and high LET particle distributions and the corresponding absorbed doses due to primary and secondary particles were evaluated for different depths in a water phantom using the Monte Carlo code SHIELD-HIT. SHIELD-HIT calculations are compared with the experimental LET distributions for a carbon beam of energy 278 MeV u(-1) from the HIMAC facility in Japan. The capability of the code for the evaluation of particle transport in thin layers of a few micrometres is demonstrated. 相似文献
4.
Benton ER Benton EV Frank AL Leonov A Gaskin J 《Radiation protection dosimetry》2002,100(1-4):489-494
The Mir Orbital Station provided a unique platform on which to carry out a variety of space radiation dosimetry measurements. A number of experiments were conducted using a combination of passive detectors on the interior of the Mir during 1996-97. Thermoluminescent detectors were used to measure absorbed dose. CR-39 plastic nuclear track detectors were used to measure the LET spectra > or =5 keV.microm(-1). Results from TLDs and CR-39 PNTDs were combined to determine total dose and dose equivalent. Mean dose rate was found to decrease while mean dose equivalent rate and average quality factor increased with increasing shielding. Secondary particles from proton-induced target fragmentation interactions, not primary HZE particles, were found to be the largest contributor to the LET spectrum above 100 keV.microm(-1). During the 1997 measurements, mean quality factor was found to vary from 1.7 to 2.1 as a function of location within the Mir. 相似文献
5.
Responses of TLD-BeO:Na (UD-170A) to high-LET particles were examined with selected heavy ion beams (He, C, Ne, Ar, and Kr) at NIRS-HIMAC, and compared with TLD-Mg2SiO4:Tb (TLMS) and radiophotoluminescent glass (RPLG). The relative TL efficiency of UD-170A as 137Cs gamma ray equivalent arose notably with increasing LET infinity.H2O for He and C, and decreased for the heavier charged particles. In contrast, the efficiencies of TLMS and RPLG did not increase over the range of LET from 0.5 to 410 keV.micron-1. The three detectors were used for space radiation measurement in the Mir space station for 40 days at 400 km altitude and 51.65 degrees inclination. The values from each detector as gamma ray absorbed dose equivalent showed a large spatial variation by a factor 2 in the same Core module. The detector values were in the order of UD-170A > TLMS > RPLG as expected from the results obtained on the ground, although ratios of these values changed depending on positions. These results indicate that both radiation quality and dose level in a spacecraft change significantly and a measurement at one location cannot accurately represent the individual dose to an astronaut. These small detectors should be useful as supplementary personal dosemeters for astronauts. 相似文献
6.
The generalised state-vector model of radiation carcinogenesis (SVM) simulates radiation induced biological effects by expressing the transition rates between the various initiation and promotion stages in terms of dose rate for low and high linear energy transfer (LET) particles. In the present work, the SVM has been reformulated to incorporate single track characteristics of particles with varying LET. Transition rates of the initiation phase were expressed as functions of LET by describing the complexity and clustering of DNA double strand breaks (DSBs) and its effect on repair kinetics, while the promotion phase was reformulated based on a multi-target single-hit hypothesis. Such an approach allows the consideration of hit frequencies and the variability of the specific energy and LET spectra of radon progeny alpha particles in bronchial target cells for different exposure conditions. 相似文献
7.
A linear energy transfer (LET) spectrometer based on the evaluation of particle track parameters in a chemically etched polyallyldiglycolcarbonate (PADC) track detector has been developed at our laboratory. It permits us to determine LET spectra between 10 and 700 keV microm(-1) in tissues. The LET spectra obtained permit us to calculate total dose and dose equivalent corresponding to particles with etchable tracks also. We have recently been able to verify the calibration curves used by using C, Mg, Ne, Si and Fe ion beams with different energies. The calibration curves obtained are presented and compared with those originally used, and a good correlation is found. The LET spectrometer with new calibration was used to analyse the radiation quality of the radiotherapy proton beam at the Joint Institute for Nuclear Research (JINR). The radiation quality was studied along the proton's range, particular attention being devoted to the region of the Bragg peak. It was found that the biologically weighted effective dose (BWE) reaches a value of about 1.25 at the Bragg peak region. At the beam entrance this value increases to about 1.02 due to secondary particles created through primary proton nuclear reactions in tissues. 相似文献
8.
In order to obtain a deeper insight into the molecular mechanism controlling the cellular response to high-linear energy transfer (LET) radiation, the number and size of pATM (S1981) and gamma-H2AX foci were compared in cultures of diploid human fibroblasts after exposure to charged particles of varying species, energy and LET at the NIRS-HIMAC-facility (Chiba, Japan). Particle LET ranged from 2.2 to 300 keV/mum, and a low fluence of 7.3 x 10(4) cm(-2) was chosen. Therefore, about 1 out of 7 nuclei was traversed by a particle. Doses and LET were verified with thermoluminescence detectors (LiF:Mg, Ti) evaluated according to the high temperature ratio method. Two hours after irradiation, fibroblasts were fixed and the subcellular distribution of pATM (S1981) and gamma-H2AX was visualised by immunofluorescence or histochemical staining using phosphorylation-specific antibodies. It was found that the number of pATM (S1981) foci per nucleus was higher after exposure to higher-LET particles. Irradiation with the two highest LET beams (Fe-ions, 197 and 300 keV/mum) gave a significant increase in the number of pATM foci, whereas ions with an LET lower than 30 keV/mum yielded similar numbers of pATM foci compared with unirradiated control samples. These data show that the early cellular response to high-LET radiation is modulated by the energy deposition of the particle. Therefore, the correlation between the microdosimetric aspect of energy deposition and biologic consequences at low radiation doses deserves further study. 相似文献
9.
One of the many risks of long-duration space flights is the excessive exposure to cosmic radiation, which has great importance particularly during solar flares and higher sun activity. Monitoring of the cosmic radiation on board space vehicles is carried out on the basis of wide international co-operation. Since space radiation consists mainly of charged heavy particles (protons, alpha and heavier particles), the equivalent dose differs significantly from the absorbed dose. A radiation weighting factor (w(R)) is used to convert absorbed dose (Gy) to equivalent dose (Sv). w(R) is a function of the linear energy transfer of the radiation. Recently used equipment is suitable for measuring certain radiation field parameters changing in space and over time, so a combination of different measurements and calculations is required to characterise the radiation field in terms of dose equivalent. The objectives of this project are to develop and manufacture a three-axis silicon detector telescope, called Tritel, and to develop software for data evaluation of the measured energy deposition spectra. The device will be able to determine absorbed dose and dose equivalent of the space radiation. 相似文献
10.
Vana N Schoner W Noll M Fugger M Akatov Y Shurshakov V 《Radiation protection dosimetry》1999,85(1-4 PT 2):291-294
The HTR method, developed for determination of absorbed dose and average LET of mixed radiation fields in space, was applied during several space missions on space station MIR, space shuttles and satellites. The method utilises the changes of peak height ratios in the glow curves in dependence on the linear energy transfer LET. Due to the small size of the dosemeters the evaluation of the variation of absorbed dose and average LET in dependence on the position of the dosemeters inside the space station is possible. The dose and LET distribution was determined during the experiment ADLET where dosemeters were exposed in two positions with different shielding conditions and during two following experiments (MIR-95, MIR-96) using six positions inside the space station. The results were compared with the shielding conditions of the positions. Calculations of the absorbed dose were carried out for comparison. Results have shown that the average LET increases with increasing absorbing thickness while the absorbed dose decreases. 相似文献
11.
Redpath JL 《Radiation protection dosimetry》2006,122(1-4):528-533
The major health risk associated with low photon energy imaging is thought to be the induction of cancer as a consequence of the radiation exposure and this is the focus of this paper. Low photon energy imaging typically involves exposure to a low dose (<50 mGy) of low linear energy transfer (LET) radiation delivered at high dose-rate. Since epidemiologic data cannot provide an accurate assessment of risk at the doses used in imaging, risk estimates are currently made by fitting a linear response to intermediate and high dose data for cancer induction in radiation-exposed human populations. This method assumes a linear no-threshold (LNT) response and implies that no dose of radiation is safe. This assumption is not borne out by many laboratory studies of cancer-related endpoints that would suggest that the risk at low doses is much less than would be estimated from linear extrapolation from intermediate to high doses. It is also well recognised that the dose-response from many epidemiologic studies could equally well be fit by threshold models.Through the study of radiation-induced neoplastic transformation in vitro J-shaped dose-response curves for a variety of low LET radiations, including those used in low photon energy imaging, have been demonstrated. The relative risks calculated from this data compare remarkably well with those for breast cancer and leukemia incidence in radiation-exposed populations. From this it is concluded that the LNT hypothesis is likely to overestimate the risk of cancer induction by low photon energy imaging, at least for certain tumors. 相似文献
12.
High-energy proton radiotherapy beams give rise to secondary heavy charged particles with elevated linear energy transfer (LET), which contribute to the dose in a patient. This contribution to the characteristics of radiotherapy proton beams was experimentally studied by means of a LET spectrometer based on a track detector. The spectrometer permits LET spectra to be established in the region above 10 keV.micron-1 in tissue. Sets of track detectors were exposed in the various depths of a phantom irradiated with protons of two energies, 150 and 205 MeV. It was observed that the contribution of particles with the values of LET mentioned increases with the depth, representing from about 2 (at the surface) up to few tens% close to Bragg peak region of the total dose. There, some of primary protons contribute also above 10 keV.micron-1. Using the 'biological weighted function' proposed, the clinical RBE was calculated, it could approach 1.3. This effect has to be taken into account during the clinical beam production and the radiotherapy. 相似文献
13.
The microdosimetric variance-covariance method has been used for cosmic radiation measurements on-board aircraft. Two independent methods of data analysis are presented; the first based on a high energy neutron calibration and the second on identification of single high LET events in the measured multiple event spectrum. Reduced dose levels at high geomagnetic latitudes are observed on one flight in a period of enhanced solar activity as indicated by a reduced ground-level neutron fluence rate. It is shown that with a reduced 137Cs-calibration factor, a Geiger-Mueller tube can be used as a low LET monitor, and that the wall thickness of a tissue-equivalent proportional counter is not crucial for flight measurements. No covariance is observed on any flight indicating it is sufficient to base dose determinations on variance measurements with only one detector. The uncertainties involved are also discussed in some detail. 相似文献
14.
The use of LiF:Mg,Ti thermoluminescence dosemeters (TLDs) in space radiation fields is reviewed. It is demonstrated in the context of modified track structure theory and microdosimetric track structure theory that there is no unique correlation between the relative thermoluminescence (TL) efficiency of heavy charged particles, neutrons of all energies and linear energy transfer (LET). Many experimental measurements dating back more than two decades also demonstrate the multivalued, non-universal, relationship between relative TL efficiency and LET. It is further demonstrated that the relative intensities of the dosimetric peaks and especially the high-temperature structure are dependent on a large number of variables, some controllable, some not. It is concluded that TL techniques employing the concept of LET (e.g. measurement of total dose, the high-temperature ratio (HTR) methods and other combinations of the relative TL efficiency of the various peaks used to estimate average Q or simulate Q-LET relationships) should be regarded as lacking a sound theoretical basis, highly prone to error and, as well, lack of reproducibility/universality due to the absence of a standardised experimental protocol essential to reliable experimental methodology. 相似文献
15.
Randers-Pehrson G 《Radiation protection dosimetry》2002,99(1-4):471-472
Dose and its usefulness as a single parameter to describe the amount of radiation absorbed are well established for most situations. The conditions where the concept of dose starts to break down are well known, mostly from the study of microdosimetry. For low doses of high LET radiation it is noted that the process of taking the limiting value of the energy absorbed within a test volume divided by the mass within that volume yields either zero or a relatively large value. The problem is further exacerbated with microbeam irradiations where the uniformity of the energy deposition is experimentally manipulated on the spatial scale of cells being irradiated. Booz introduced a quantity to deal with these problems: the unfortunately named 'mean specific energy in affected volumes'. This quantity multiplied by the probability that a test volume has received an energy deposit is equal to dose (in situations where dose can be defined). I propose that Booz's quantity be renamed 'specific dose', that is the mean energy deposited divided by the mass within a specified volume. If we believe for instance that the nucleus of a cell is the critical volume for biological effects, we can refer to the nuclear specific dose. A microbeam experiment wherein 10 per cent of the cell nuclei were targeted with 10 alpha particles would be described as delivering a nuclear specific dose of 1.6 Gy to 10 per cent of the population. 相似文献
16.
A spectrometer measuring energy lost (deltaE) was used to determine linear energy transfer (LET) spectra on board the Mir orbital station during the period from 8 October 1997 to 16 June 2000, i.e. during the 24th, 26th, 27th and 28th basic expeditions. It was found that the LET spectra of secondary particles between 10 and 700 keV.microm(-1) in tissue do not depend on the external radiator, with the average quality factors for the region mentioned being about 6.4 with ICRP 26 quality factors or about 7.4 with ICRP 60 quality factors. Both differential and integral LET spectra are presented for some typical cases. The spectra permitted us to calculate the total doses and dose equivalents due to particles with the LET values in the mentioned region. It was found that these doses are higher when the detector was placed in a less shielded area. It was also found that these doses vary from one expedition to another. The correlation of these variations with the solar activity level was studied. 相似文献
17.
Akopova AB Dudkin VE Kovalev EE Magradze NV Potapov YuV 《Radiation protection dosimetry》1987,18(3):153-156
The most important characteristic of the hazard due to cosmic radiation is the spectrum of linear energy transfer (LET), which enables one to estimate the dose equivalent. This has prompted us to study LET spectra of cosmic radiation aboard Cosmos-1129 using nuclear emulsions as a threshold detector. 相似文献
18.
For measurements of the equivalent dose of the mixed radiation fields in aircraft many different measuring devices are usually necessary for consideration of the different components of the radiation field. The possibility is discussed of using thermoluminescence dosemeters (TLDS) for determination of absorbed dose and average LET of this complex radiation field in aircraft. The HTR method, developed for determination of the equivalent dose in spacecraft, enables the measurement of the average LET in addition to the absorbed dose. Furthermore, a rem counter based on TLDs and a modified pair method (TLD-600, TLD-700) was used for determination of the absorbed dose due to the neutron component. Using small TLD crystals it is possible to obtain the depth distribution of absorbed dose and average LET by exposing TLDs in Bonner spheres with different diameters. The results indicate that the standards for determination of the effective dose may not be applicable in these mixed radiation fields in aircraft. 相似文献
19.
Recombination microdosimetric method (RMM), based on the phenomenon of initial recombination of ions is applied to determine the distribution of the absorbed dose versus linear energy transfer (LET). Usually, the recombination chambers used for RMM are filled with tissue-equivalent gas, but the response of the device can be adjusted to the actual needs by the use of different gases. Using a graphite chamber filled with nitrogen and 10BF3 it was shown that RMM can also be used with chambers containing these gases. This opens the possibility of designing a recombination chamber for the determination of the dose fractions due to gamma radiation, fast neutrons, neutron capture on nitrogen and high-LET particles from the (n,10B) reaction in simulated tissue with different contents of 10B. It was also necessary to improve the method for the determination of initial recombination at low polarising voltages, when volume-recombination and back-diffusion of ions are considerably high. 相似文献
20.
Domingo C Font J Baixeras C Font Ll Fernandez F 《Radiation protection dosimetry》1999,85(1-4 PT 2):295-299
Primary cosmic radiation arriving near the Earth may be classified into two general categories: the gamma component and the hadronic component. The hadronic component contains mainly protons, a small amount of alpha particles and a smaller amount of heavier charged nuclei (ions). Although the fluxes of these heavier ions are very small in comparison to those of protons, they are able to originate a huge linear energy transfer (LET). This work studies the contribution of heavy ions from cosmic rays to the radiation hazard to which the crew of a manned long duration space flight might be exposed. The geometry of the energy deposition by a heavy ion is studied, and it is found that energies of the order of up to 10(23) J kg-1 are deposited. 相似文献