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1.
以异香兰素为原料,经Wittig反应、常温常压催化氢化、二异丁基氢化铝还原制得中间体3-(3-羟基-4-甲氧基苯基)丙醛。S-叔丁基-L-半胱氨酸甲酯与N-叔丁氧羰基-L-天冬氨酸-4-叔丁酯经1-乙基-(3-二甲基氨基丙基)碳酰二亚胺盐酸盐以及1-羟基苯并三唑水合物缩合制得二肽化合物N-(N-叔丁氧羰基-4-叔丁酯-L-α-天冬氨酰)-S-叔丁基-L-半胱氨酸-1-甲酯,并在氯化氢-二氧六环溶液中脱保护制得二肽化合物N-(L-α-天冬氨酰)-S-叔丁基-L-半胱氨酸-1-甲酯;然后将中间体3-(3-羟基-4-甲氧基苯基)丙醛与N-(L-α-天冬氨酰)-S-叔丁基-L-半胱氨酸-1-甲酯通过亚胺化钯碳氢气常压催化氢化得到目标化合物N-[N-[3-(3-羟基-4-甲氧基苯基)丙基]-L-α-天冬氨酰基]-S-叔丁基-L-半胱氨酸-1-甲酯。经红外光谱、质谱以及核磁共振仪对产物进行结构鉴定,确定目标产物结构。 相似文献
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为合成新型二肽类甜味剂,以甲醇、3,3-二甲基丙烯酸为初始原料,经Fischer酯化反应得到3,3-二甲基丙烯酸甲酯,再与2,5-二甲酚、甲烷磺酸发生Friedel-Crafts烷基化反应得到4,4,5,8-四甲基-3,4-二氢香豆素,产物以LiAlH_4为还原剂还原得到3-(2-羟基-3,6-二甲基苯基)-3-甲基丁醇,经2步保护反应分别保护醇羟基和酚羟基之后,用CH_3COOH脱掉叔丁基二甲基硅基(TBS)得到乙酰基保护的醇,用Dess-Martin periodinane氧化醇得到纽甜类似物的中间体3-(2-乙酰基-3,6-二甲基苯基)-3-甲基丁醛,最后将中间体与阿斯巴甜在硼氢化钠(Na BH_4)的还原胺化作用下合成高倍甜味剂纽甜类似物N-[N-[3-(2-乙酰基-3,6-二甲基苯基)-3-甲基丁基]-L-α-天冬氨酰]-L-苯丙氨酸1-甲酯。采用红外光谱(IR)、质谱(MS)以及核磁共振(NMR)对终产物进行结构鉴定和表征,结果确定其为目标终产物,并测得其甜度约为蔗糖的70 000倍。 相似文献
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《中国食品卫生杂志》2018,(5)
正根据《食品安全法》规定,审评机构组织专家对(±)-1-环己基乙醇等5种食品添加剂新品种和食品添加剂N-[N-(3,3-二甲基丁基)]-L-α-天门冬氨-L-苯丙氨酸1-甲酯(又名纽甜)等7种扩大使用范围、用量的品种安全性评估材料审查并通过。特此公告。附件:1.食品用香料新品种(±)-1-环己基乙醇2.壳聚糖酶等2种食品工业用酶制剂新品种3.食品营养强化剂新品种柠檬酸亚铁钠4.食品添加剂新品种L-苹果酸钠5.食品添 相似文献
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1 蛋白糖简介“蛋白糖”这个名词刚刚诞生五年,对于很多人来说可能还比较陌生。顾名思义,蛋白糖(APM)即是由构成天然蛋白质的最小单位氨基酸所组成的,是一种二肽类新型甜味剂,其学名为天门冬氨酰苯丙氨酸甲酯,即由天门冬氨酸和苯丙氨酸构成。1966年,美国塞尔(G.D.Searle)公司的研究人员在合成促胃液分泌激素时,偶然发现其中间体天门冬氨酰苯丙氨酸甲酯 相似文献
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Since grapevine ( Vitis spp .) rootstock material is being traded increasingly as disbudded woody material a lack of distinctive morphological features on such material necessitates an alternative and reliable means of identification. Methods described here were developed for rapid and efficient extraction of DNA from woody samples rich in phenolic compounds and polysaccharides, and for subsequent identification of varieties by RAPD PCR. Using these methods, and with the application of only one selected RAPD primer, we were able to differentiate sixteen rootstock varieties, including the seven varieties most commonly used in Germany. Problems commonly encountered with reproducibility of RAPD patterns were avoided by choosing primers with a dinucleotide sequence and a high G/C content that allowed a rather high annealing temperature of 45°C. Methods described here should also be useful for other horticultural crops, especially those with woody tissues rich in phenolic compounds and polysaccharides. 相似文献
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John Gilbert Catherine Simoneau David Cote Achim Boenke 《Food Additives & Contaminants》2000,17(10):889-893
An internet website (http://cpf.jrc.it/smt/) has been produced as a means of dissemination of methods of analysis and supporting spectroscopic information on monomers and additives used for food contact materials (principally packaging). The site which is aimed primarily at assisting food control laboratories in the European Union contains analytical information on monomers, starting substances and additives used in the manufacture of plastics materials. A searchable index is provided giving PM and CAS numbers for each of 255 substances. For each substance a data sheet gives regulatory information, chemical structures, physico-chemical information and background information on the use of the substance in particular plastics, and the food packaging applications. For monomers and starting substances (155 compounds) the infra-red and mass spectra are provided, and for additives (100 compounds); additionally proton NMR are available for about 50% of the entries. Where analytical methods have been developed for determining these substances as residual amounts in plastics or as trace amounts in food simulants these methods are also on the website. All information is provided in portable document file (PDF) format which means that high quality copies can be readily printed, using freely available Adobe Acrobat Reader software. The website will in future be maintained and up-dated by the European Commission's Joint Research Centre (JRC) as new substances are authorized for use by the European Commission (DG-ENTR formerly DGIII). Where analytical laboratories (food control or other) require reference substances these can be obtained free-ofcharge from a reference collection housed at the JRC and maintained in conjunction with this website compendium. 相似文献
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Sophie Guillot Laurence Peytavi Sylvie Bureau Renaud Boulanger Jean-Paul Lepoutre Jean Crouzet Sabine Schorr-Galindo 《Food chemistry》2006
The characterization of the aromatic profile of several apricot cultivars with molecular tracers in order to obtain objective data concerning the aromatic quality of this fruit was undertaken using headspace–solid phase microextraction (HS–SPME). Six apricot cultivars were selected according to their organoleptic characteristics: Iranien, Orangered, Goldrich, Hargrand, Rouge du Roussillon and A4025. The aromatic intensity of these varieties measured by HS–SPME–Olfactometry were defined and classified according to the presence and the intensity of grassy, fruity and apricot like notes. In the six varieties, 23 common volatile compounds were identified by HS–SPME–GC–MS. Finally, 10 compounds, ethyl acetate, hexyl acetate, limonene, β-cyclocitral, γ-decalactone, 6-methyl-5-hepten-2-one, linalool, β-ionone, menthone and (E)-hexen-2-al were recognized by HS–SPME–GC–O as responsible of the aromatic notes involved in apricot aroma and considered as molecular tracers of apricot aromatic quality which could be utilized to discriminate apricot varieties. 相似文献
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Jesus Simal-Gandara Miguel Sarria-Vidal Arjen Koorevaar Rinus Rijk 《Food Additives & Contaminants》2000,17(8):703-711
The advent of the functional barrier concept in food packaging has brought with it a requirement for fast tests of permeation through potential barrier materials. In such tests it would be convenient for both foodstuffs and materials below the functional barrier (sub-barrier materials) to be represented by standard simulants. By means of inverse gas chromatography, liquid paraffin spiked with appropriate permeants was considered as a potential simulant of sub-barrier materials based on polypropylene (PP) or similar polyolefins. Experiments were performed to characterize the kinetics of the permeation of low molecular weight model permeants (octene, toluene and isopropanol) from liquid paraffin, through a surrogate potential functional barrier (25 μm-thick oriented PP) into the food simulants olive oil and 3% (w/v) acetic acid. These permeation results were interpreted in terms of three permeation kinetic models regarding the solubility of a particular model permeant in the post-barrier medium (i.e. the food simulant). The results obtained justify the development and evaluation of liquid sub-barrier simulants that would allow flexible yet rigorous testing of new laminated multilayer packaging materials. 相似文献
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Yoko Uematsu Keiko Hirata Kumi Suzuki Kenji Iida Kazuo Saito 《Food Additives & Contaminants》2001,18(2):177-185
BADGE.2HCl and BFDGE.2HCl were determined in 28 samples of ready-to-drink canned coffee and 18 samples of canned vegetables (10 corn, 5 tomatoes and 3 others), all from the Japanese market. HPLC was used as the principal analytical method and GCMS for confirmation of relevant LC fractions. BADGE.2HCl was found to be present in one canned coffee and five samples of corn, BFDGE.2HCl in four samples of canned tomatoes and in one canned corn. No sample was found which exceeded the 1mg/kg limit of the EU for the BADGE chlorohydrins. However the highest concentration was found for the sum of BFDGE.2HCl and BFDGE.HCl.H2O at a level of 1.5mg/kg. A Beilstein test confirmed that all cans containing foods contaminated with BADGE.2HCl or BFDGE.2HCl had at lest one part coated with a PVC organosol. 相似文献
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A strong science base is required to underpin the planning and decision-making process involved in determining future European community legislation on materials and articles in contact with food. Significant progress has been made in the past 5 years in European funded work in this area, with many developments contributing to a much better understanding of the migration process, and better and simpler approaches to food control. In this paper this progress is reviewed against previously identified work-areas (identified in 1994) and conclusions are reached about future requirements for R&D to support legislation on food contact materials and articles over the next 5 or so years. 相似文献
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M. S. Garcí a-Falc n J. Simal-G ndara S. T. Carril-Gonz lez-Barros 《Food Additives & Contaminants》2000,17(12):957-964
A simple, rapid and inexpensive method has been developed for the determination of benzo[a 相似文献
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H. J. Van Den Top A. Boenke P. A. Burdaspal J. Bustos H. P. Van Egmond T. Legarda A. Mesego A. Mourino W. E. Paulsch C. Salgado 《Food Additives & Contaminants》2001,18(9):810-824
This paper describes the second part of a project undertaken to develop certified mussel reference materials for paralytic shellfish poisoning toxins. In the first part two interlaboratory studies were undertaken to investigate the performance of the analytical methodology for several PSP toxins, in particular saxitoxin and decarbamoyl-saxitoxin in lyophilized mussels, and to set criteria for the acceptance of results to be applied during the certification exercise. Fifteen laboratories participated in this certification study and were asked to measure saxitoxin and decarbamoyl-saxitoxin in rehydrated lyophilized mussel material and in a saxitoxin-enriched mussel material. The participants were allowed to use a method of their choice but with an extraction procedure to be strictly followed. The study included extra experiments to verify the detection limits for both saxitoxin and decarbamoyl-saxitoxin. Most participants (13 of 15) were able to meet all the criteria set for the certification study. Results for saxitoxin.2HCl yielded a certified mass fraction of <0.07 mg/kg in the rehydrated lyophilized mussels. Results obtained for decarbamoyl-saxitoxin.2HCl yielded a certified mass fraction of 1.59+/-0.20 mg/kg. The results for saxitoxin.2HCl in enriched blank mussel yielded a certified mass fraction of 0.48 +/- 0.06 mg/kg. These certified reference materials for paralytic shellfish poisoning toxins in lyophilized mussel material are the first available for laboratories to test their method for accuracy and performance. 相似文献
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《肉类研究》2014,(2)
<正>We are pleased to announce the launch of a new international peer-reviewed journal-Food Science and Human Wellness,ISSN 2213-4530,which is an open access journal,produced and hosted by Elsevier B.V.on behalf of Beijing Academy of Food Sciences.Food Science and Human Wellness is an international peer-reviewed English journal that provides a forum for the dissemination of the 相似文献