Preparation and MRI performances of core-shell structural PEG salicylic acid-gadolinium composite nanoparticles

Gadolinium (III)-based T₁ contrast agents have been widely used in clinical MRI. In this study, salicylic acid-gadolinium chelate was prepared via directly coordination reaction of gadolinium ion and salicylic acid. Then, three polyethylene glycols with different molecular weight were modified on the surface of salicylic acid-gadolinium by simple chemical coupling to construct three core-shell structural Gd based composites. The scanning electron microscopy (SEM) and transmission electron microscopy (TEM) characterization results show that the composite is a spherical particle with a diameter of about 100–200 nm. The longitudinal relaxation rate r₁ of the Gal-PEG-2000 is 11.097 (mmol/L)^?1/s, and the ratio of r₂/r₁ is as low as 2.53. The composite shows good liver and intestines MRI performances after being used in in vivo imaging, showing a good prospect of biological application.     

Synthesis and Spectral Properties of Mixed-Ligand Complexes of Lanthanide Perchlorate with Bis-(phenylsulfinyl)ethane and Organic Lewis Bases

ＳｙｎｔｈｅｓｉｓａｎｄＳｐｅｃｔｒａｌＰｒｏｐｅｒｔｉｅｓｏｆＭｉｘｅｄＬｉｇａｎｄＣｏｍｐｌｅｘｅｓｏｆＬａｎｔｈａｎｉｄｅＰｅｒｃｈｌｏｒａｔｅｗｉｔｈＢｉｓ（ｐｈｅｎｙｌｓｕｌｆｉｎｙｌ）ｅｔｈａｎｅａｎｄＯｒｇａｎｉｃＬｅｗｉｓＢａｓｅ...     

Synthesis, Characterization and Properties of Lanthanide Nitrate Complexes with Isonicotinoyl Hydrazone

Ｔｈｅｄｅｓｉｇｎａｎｄｓｙｎｔｈｅｓｉｓｏｆｓｔａｂｌｅｌａｎ ｔｈａｎｉｄｅｃｏｍｐｌｅｘｅｓａｒｅｏｆｇｒｅａｔｉｍｐｏｒｔａｎｃｅｆｏｒｔｈｅｉｎｖｅｓｔｉｇａｔｉｏｎｏｆｔｈｅｐｒｏｐｅｒｔｉｅｓａｎｄａｐｐｌｉｃａ ｔｉｏｎｓｏｆｌａｎｔｈａｎｉｄｅｃｏｍｐｌｅｘｅｓ .Ｍａｃｒｏｃｙｃｌｉｃｏｒａｃｙｃｌｉｃｌｉｇａｎｄｓｗｉｔｈｍｕｌｔｉｄｅｎｔａｔｅｄｏｎｏｒａｔｏｍｓｕｓｕａｌｌｙｆｏｒｍｓｔａｂｌｅｃｏｍｐｌｅｘｅｓｗｉｔｈｌａｎｔｈａｎｉｄｅｃａｔｉｏｎｓ .Ｔｈｅｓｉｚｅｏｆ…     

Synthesis, EPR and Fluorescence Properties of Quaternary Lanthanide Complexes with Chloroacetate and Phenanthroline Ligands

A series of novel quaternary mixed anion complexes of lanthanide containing 1, 10-phenanthroline (phen) and chloroacetate ligands were synthesized from the water/ethanol solution with slightly acidic solution and characterized by elemental analysis, IR, UV and thermal analysis. The EPR and fluorescence properties also were studied.     

Synthesis, Characterization and Fluorescence of Phenylcarboxymethyl Sulfoxide Complexes with Lanthanide Nitrates

Ｒａｒｅｅａｒｔｈｃｏｍｐｌｅｘｅｓｗｉｔｈｓｕｌｆｏｘｉｄｅａｎｄａｒｏｍａｔｉｃｃａｒｂｏｘｙｌａｃｉｄｈａｖｅｂｅｅｎｗｉｄｅｌｙｓｔｕｄ ｉｅｄ[1～ 3 ] .Ｉｔｉｓｐｒｏｖｅｄｔｈａｔｔｈｅｙｂｏｔｈｈａｖｅｂｅｔ ｔｅｒｆｌｕｏｒｅｓｃｅｎｃｅｃｈａｒａｃｔｅｒ .Ｈｏｗｅｖｅｒｔｈｅａｒｏ ｍａｔｉｃｃａｒｂｏｘｙｌｏｆｒａｒｅｅａｒｔｈｃｏｍｐｌｅｘｅｓｈａｖｅｖｅｒｙｈｉｇｈｆｌｕｏｒｅｓｃｅｎｃｅｅｍｉｓｓｉｏｎｉｎｔｅｎｓｉｔｙａｎｄｓｔａｂｉｌｉｔｙ ,ｂｕｔｓｏｌｕｂｉｌｉｔｙｉ…     

Synthesis and Characterization of Lanthanide Complexes Involving Cyclopentadienyl and Benzohydroximic Acid Ligand

Ｉｎｇｅｎｅｒａｌ,ｈｙｄｒｏｘｉｍｉｃａｃｉｄｓ (ＲＣＯＮ ＨＯＨ)ａｒｅｗｅａｋｏｒｇａｎｉｃａｃｉｄｓ .ＴｈｉｓｃｌａｓｓｏｆｏｒｇａｎｉｃｃｏｍｐｏｕｎｄｓｃｏｎｔａｉｎｉｎｇｔｈｅｒｅａｃｔｉｖｅｇｒｏｕｐＣＯＮＨＯＨ ,ｋｎｏｗｎａｓｔｈｅｈｙｄｒｏｘｉｍｉｃａｃｉｄｓ,ｈａｖｅｂｅｅｎｗｉｄｅｌｙｓｔｕｄｉｅｄｂｙｏｒｇａｎｉｃｃｈｅｍｉｓｔｓ.Ｔｈｅｈｙｄｒｏｘｉｍｉｃａｃｉｄｓａｒｅｃｈｅｌａｔｅｌｉｇａｎｄｓｆｏｒｍａｎｙｍｅｔａｌｓ .Ｔｈｅｙａｒｅｗｉｄｅｌｙｕｓｅｄａｓｃｈｅｌ…     

Synthesis, Characterization and Crystal Structure of Neutral Homoleptic Lanthanide Amide Yb(NPh_2)_3(THF)

Ｌａｎｔｈａｎｉｄｅａｍｉｄｅｃｏｍｐｌｅｘｅｓａｒｅａｎｉｍ ｐｏｒｔａｎｔｃｌａｓｓｏｆｐｒｅｃｕｒｓｏｒｓｆｏｒｌａｎｔｈａｎｉｄｅｄｅｒｉｖａｔｉｖｅｓ .Ｉｔｃａｎｂｅｅａｓｉｌｙｔｒａｎｓｆｏｒｍｅｄｔｏｃｏｒ ｒｅｓｐｏｎｄｉｎｇｌａｎｔｈａｎｉｄｅｃｏｍｐｌｅｘｂｙｒｅａｃｔｉｎｇｗｉｔｈｉｎｖｏｌｖｉｎｇｐｒｏｔｉｃｒｅａｇｅｎｔｓ[1,2 ] .Ｔｈｅｌａｎｔｈａｎｉｄｅａｍｉｄｅｕｓｅｄａｓｓｙｎｔｈｅｔｉｃｐｒｅｃｕｒｓｏｒｉｓｎｅｕｔｒａｌｈｏｍｏｌｅｐｔｉｃｃｏｍｐｌｅｘ ,ｏｔｈ…     

Synthesis, Characterization and Crystal Structure of Neutral Homoleptic Lanthanide Amide Yb（NPh2）3（THF）2

A neutral homoleptic lanthanide amide Yb(NPh2)3(THF)2 was obtained by reaction of anhydrous YbCl3 with LiNPh2 in THF. The product was characterized by elemental analysis, infrared spectrum and X-ray crystallographic analysis. The crystal data are monoclinic, P21/n space group, a=1.2052(2) nm, b=1.9369(3) nm, c=1.6523(2) nm, β=92.79(1)°, V=3.8524(9) nm3, Z=4, Dc=1.417 g*cm-3, μ=24.67 cm-1 (Mo Kα), F(000)=1668, R=0.036, Rw=0.039. The central metal ytterbium is coordinated by three terminal NPh2 groups and two THF molecules to form a five-coordinate distorted trigonal bipyramid. The mean Yb-N bond length is 0.2219(6) nm.     

镧系元素磷钒杂多酸盐的合成与表征

首次合成了具有bicapped-Keggin型结构[PV14O42]9-阴离子的四种稀土盐:H1.5Ln2.5[PV14O42]·nH2O(Ln=La3 、Ce3 、Pr3 、Gd3 ),并用化学分析、IR、UV、TG、摩尔电导等方法对其进行了表征。结果表明,四种稀土盐处于杂多阴离子[PV14O42]9-的外界,并且[PV14O42]9-仍基本保持着bicapped-Keggin型结构。     

Synthesis, Characterization and Antioxidative Activity of Lanthanide Complexes with 3,5-Dibenzyloxybenzoyl-2,4-Dihydroxybenzaldehyde-Hydrazone

Scientistshavepaidmuchattentiontotherareearthelementswithpharmaceuticalactivity[1] .Hydra zonesandtheircomplexeswithtransitionmetalshavebeenstudiedwidelyfortheirpossessionofadiversespectrumofbiologicalandpharmaceuticalactivities ,suchasanticancer ,antitumourandantioxidativeactiv ities ,aswellastheinhibitionoflipidperoxidationandsoon[2 ] .Metalcomplexesofacylhydrazones ,particu larlythecopper(Ⅱ )complexesof 2 pyridinecarboxy laldehyde 2′ pyridylhydrazoneandsalicylaldehydebenzoylhydrazoneshow…     

铕、钆-苯甲酸-1,10-菲咯啉的合成及荧光性质

分别合成了稀土（铕、钆）与苯甲酸、1，1-菲咯啉配位的有机稀土羧酸配合物。通过元素分析和红外分析确定了配合物的组成与结构。通过荧光光谱与荧光寿命研究了它们的荧光性质。结果表明，当钆掺入配合物后，能极大地增强铕的特征荧光，当铕与钆的摩尔比为5：5时，荧光强度最强，且此时的荧光寿命最长。经拟合后发现，在（铕、钆）-苯甲酸-1，10-菲咯啉配合物中，钆离子对铕荧光的敏化程度随钆含量的降低以指数形式衰减。     

Synthesis of a Polyaminopolycarboxylic Acid and Fluorescence of Tb~(3 ) Complexes in Aqueous Solution

ＳｙｎｔｈｅｓｉｓｏｆａＰｏｌｙａｍｉｎｏｐｏｌｙｃａｒｂｏｘｙｌｉｃＡｃｉｄａｎｄＦｌｕｏｒｅｓｃｅｎｃｅｏｆＴｂ３＋ＣｏｍｐｌｅｘｅｓｉｎＡｑｕｅｏｕｓＳｏｌｕｔｉｏｎＧｏｎｇＭｅｎｇｌｉａｎ（龚孟濂），ＷｕＷｅｉｎｉｎｇ（吴炜宁），ＳｈｉＨｕ...     

Synthesis,Characterization and Luminescent Properties of Complexes of Rare Earth Nitrates with Tris{2-[N-(pyridine-methanoyl)amino]ethyl} amine

Duringthelastdecade ,thedesignandsynthesisoftripodalligandsandtheirmetalcomplexeshaveattractedconsiderableattentionduetotheirpotentialusesaslumi nescentprobesinmedicineandbiochemistry[1～ 7] ,ascatalysts[8] andelectrochemicalmaterials[9] .However ,thecomplexesofrareearthmetalwithtripodalligandshavefewreported[10 ] .Asanextensionofourstudiesoncomplexesofmetalwithtripodalligands ,anewtripodalligand (tris { 2 [N (pyridine methanoyl)amino]ethyl}amine ,L)anditscomplexeswithrareearthnitratesweresyn…     

Synthesis and Application of Lanthanide Complexes with Schiff Base of Pridoxylidence-Glycine

Ｔｈｅｈａｒｍｆｕｌｎｅｓｓｏｆｈｅａｖｙｍｅｔａｌｅｌｅｍｅｎｔｓｏｎｐｌａｎｔｓｉｓｏｎｅｏｆｔｈｅｓｅｒｉｏｕｓｅｎｖｉｒｏｎｍｅｎｔａｌｐｒｏｂｌｅｍｓｏｆｔｈｅｍｏｄｅｒｎｗｏｒｌｄ .Ｉｎｒｅｃｅｎｔｙｅａｒｓ ,ｔｈｅｓｔｕｄｙｏｎｔｈｅｍｉｓａｌｓｏｏｎｅｏｆｖｅｒｙａｃ ｔｉｖｅｒｅｓｅａｒｃｈｐｒｏｊｅｃｔｓｉｎｐｌａｎｔｐｏｌｌｕｔｉｏｎｅｃｏｌｏｇｙｆｉｅｌｄｓ[1～ 6 ] .ＬａｎｔｈａｎｉｄｅｃｏｍｐｌｅｘｅｓｗｉｔｈｔｈｅＳｃｈｉｆｆｂａｓｅａｒｅａｃｌａｓｓｏｆｃｏｍｐｏｕ…     

1,2,3,4-丁烷四羧酸镧系络合物的制备及热重和红外光谱研究

1,2,3,4-丁烷四羧酸镧系(Ln=La,Ce,Pr,Nd,Yb)络合物为结晶固体,其通式:Ln4(C8H6O8)3·nH2O,Ln=Ce、Pr、Nd,n=8;Ln=La,n=7;Ln=Yb,n=11。在加热过程中,它们首先失去络合物中所含的水,再进一步加热,开始分一步(Ce,Pr)或两步(La,Yb,Nd,中间产物为Ln2O2CO3)热分解,最终生成镧系金属氧化物。红外光谱研究表明Ln4(C8H6O8)3·nH2O中羧酸盐基团为双齿配位螯合体。     

Synthesis of N,O-rich active site porous polymers and their efficient recovery of Gd(Ⅲ) from solution

Our previous study found that the adsorption performance of porous carbon for Gd(Ⅲ) could be significantly improved by increasing the N,and O functional groups on its surface.Unfortunately,the adsorption capacity of porous carbon is low due to the limited number of N,and O functional groups that can be loaded on its surface.Due to the advantage of customizable functional groups of porous organic polymers(POPs),the triazine-based Tb-MEL and hydroxyl-modified triazine-based Tp-MEL were synthesized...     

Synthesis, Characterization and Catalytic Activity of Propionamide Complexes of Rare Earth Chlorides

ＴｈｅｒａｒｅｅａｒｔｈｓｙｓｔｅｍｏｆＺｉｅｇｌｅｒＮａｔａｃａｔａｌｙｓｔｃａｎｂｅａｐｐｒｏｘｉｍａｔｅｌｙｄｉｖｉｄｅｄｉｎｔｏｔｗｏｍａｉｎｃａｔａｌｏｇｕｅｓ，ｔｈａｔｉｓ，ｔｈｅｔｒｉｎａｒｙｓｙｓｔｅｍａｎｄｔｈｅｂｉｎａｒｙｓｙｓ...     

Synthesis and Fluorescence Properties of Europium,Terbium Doped Zn^2＋, Cd^2＋, and Cr^3＋ Complexes

Europium and terbium complexes with strong fluorescence intensity and long fluorescence lifetime were prepared. By replacing half of the europium or terbium ion with M （M = Zn^2＋, Cd^2＋, and Cr^3＋） using the doped method, and then incorporating it with 18-crown-6 ether and terephthalic acid, six heteronuclear samples EuZnLL＇Cl3·3H2O（1）, EuCdLL2＇Cl3·5H2O（2）, EuCrLL＇Cl4· 4H2O（3）, TbZnLL＇Cl3·4H2O（4）, TbCdLL＇2Cl3·4H2O（5）, and TbCrLL＇2Cl4 ·4H2O（6） （L = terephthalic acid, L＇= 18-Crown-6 ether） were obtained. The elemental analysis, molar conductivities, rare earth complexometry, Fourier Transform Infrared Spectroscopy （FT-IR）, ultraviolet （UV）, TGA, fluorescence intensity, and fluorescence lifetime of the samples were measured. The results showed that there were good luminescence properties for heteronuclear complexes （1）, （2）, （4）, and （5）, which were even stronger than those of the homonuclear complexes Eu2LL＇2Cl4·4H2O and Tb2LL＇2Cl4 ·4H2O, but the luminescence properties of EuCrLL＇Cl4·4H2O, TbCrLL＇Cl4·4H2O were very weak. A possible luminescence mechanism was suggested by the organic-inorganic doped mechanism and the law of intramolecular energy transfer.     

Preparation and properties of bifunctional Gd2O3/GQD composite nanoparticles

Nanocomposites of graphene quantum dots (GQDs) modified gadolinium oxide (Gd₂O₃) particles were successfully synthesized. In addition, the effects of the amount of GQDs and the particle size of Gd₂O₃ on the properties of nanocomposites were investigated. The structures and properties of nanoparticles were characterized by X-ray diffraction, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, photoluminescence spectrometry, and magnetic resonance imaging. The results show that the synthesized particles Gd₂O₃/GQD are spherical with a diameter of approximately 40 nm and have excellent fluorescence and magnetic property, and its relaxation rate (r₁ = 25.18 (mmol/L)^?1/s) is higher than that of the typical commercial contrast agents Gd-DTPA (r₁ = 4.5 (mmol/L)^?1/s). The fluorescence property of Gd₂O₃/GQD is optimized by varying the V_GQDs:V_Gd2O3 ratio, and 1:1 ratio of V_GQDs:V_Gd2O3 results in the best fluorescence property. The large particles of Gd₂O₃ improve the relaxation property of nanocomposites. Therefore, the nanocomposites Gd₂O₃/GQD with magnetic and fluorescence characteristics can be used in biological imaging, drug targeting, and in-vivo diagnostic analysis.