Prolonged speech and modification of stuttering: perceptual, acoustic, and electroglottographic data

Prolonged speech and its variants are a group of novel speech patterns that form the basis of a popular treatment for stuttering (Ingham, 1984). It is difficult to determine which features of prolonged speech are necessary for the elimination of stuttered speech because the speech pattern produces simultaneous changes in respiratory, laryngeal, and articulatory activity. Experimental studies have shown that the modification of phonation and of speech rate contributes to stuttering reduction, and increased duration of speech segments and reduced variability of vowel duration are known to occur as a result of prolonged-speech treatment programs. However, previous studies of prolonged speech have all instructed subjects to modify their customary speech patterns in a particular way. The aim of the present study was to investigate changes in the speech pattern of individual subjects when stuttering was modified with prolonged speech without specific instruction in how this should be done. In one experimental phase, 3 subjects showed clinically significant stuttering reductions when instructed to use whichever features of prolonged speech they needed to reduce their stuttering. The resulting perceptually stutter-free speech was judged to be natural sounding. Stuttering in a fourth subject reduced without experimental intervention. Recordings of acoustic and electroglottographic signals from the 4 subjects were analyzed. Changes in the variability of vowel duration occurred in all subjects. Theoretical and clinical implications of the results are discussed.     

Effect of biofeedback-based relaxation on stuttering during reading and spontaneous speech.

Conducted 3 studies to develop methodology for using biofeedback to reduce stuttering by teaching relaxation of speech-related muscles. A total of 19 stutterers (mean ages 22.1–24.6 yrs) participated in 8–25 1-hr sessions. In Study 1, 7 Ss learned voluntary relaxation of the masseter muscles, and stuttering was essentially eliminated while reading units of 1–4 syllables. Study 2 attempted to enhance the generalization of fluency by training 6 Ss to develop their own internal cues for relaxation. Fluency generalized well to periods of no feedback, but relaxation generalized much less well. In Study 3, which specifically attempted to enhance the generalization of relaxation, 6 Ss were successfully trained to generalize both relaxation and fluency skills to spontaneous speech periods of up to 4-word units involving no feedback. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Temporal dynamics of repetitions during the early stage of childhood stuttering: an acoustic study

The purpose of this study was to compare duration characteristics of single-syllable whole-word repetitions (with one and two repeated units) and part-word repetitions (with one repeated unit) in the speech of preschool children who stutter (N = 20) recorded near the onset of their stuttering to those of control nonstuttering children (N = 20). Disfluent episodes were identified in audiotape recordings of the subjects' conversational speech. The digitized signals were analyzed by means of the CSpeech computer software (Milenkovic, 1987). Using visual displays of sound spectrograms, the durations of the spoken repetition unit(s), the silent interval(s) between the units, and the total disfluency were measured. The stutters exhibited shorter silent intervals between spoken repetition units. The duration of the spoken repetition units was very similar for the two groups of children. The total duration of the stutterers' disfluencies was significantly shorter because of their shorter silent intervals when compared to disfluencies of equal repetition units produced by the control subjects. Statistical analysis revealed that silent interval duration was capable of differentiating stuttering from normally fluent children with 72-87% accuracy, dependent upon the disfluency type. To the degree that the groups of subjects represented random samples of the two specified populations from which they were drawn, there appears to be an overall tendency for repetitions during the early stage of stuttering to be produced at a faster rate than repetitions produced by nonstuttering children.     

Word frequency effects and eye movements during two readings of a text.

Examined the influence of word frequency on rereading performance. 28 students read short passages, each twice in succession, while their eye movements were monitored. Two classes of data were presented: global measures, which were based on an entire passage, and target word measures, based on the target words. Results show that fixation durations were shorter for high frequency words during both readings and the decrease in fixation duration was similar in magnitude for low and high frequency words. It was concluded that word frequency and repetition independently influenced reading time. Replacing a target with a synonym did not increase processing time for the replacement word. This suggests that rereading can be used to gain insight into cognitive processes. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The frequency of disfluencies during phonatory transitions in stuttered and nonstuttered speech

The AA. investigated the frequency of antibodies against Toxoplasma gondii in 426 women with repeated abortions, perinatal mortality and malformed newborns. They showed on the whole a low incidence even if they demonstrated a high incidence (77.7%) of antibodies in women with malformed newborns. The meaning of the observations are briefly discussed.     

Further evidence of acoustic invariance in speech production: the stop-glide contrast

We have conducted a detailed comparative acoustic analysis of the labial stop and glide, [b] and [w], and we have attempted to identify an invariant acoustic property which can accurately distinguish stops and glides. To this end, we conducted three experiments. In experiment I, we undertook computer analysis of the labial stop [b] and the labial glide [w] as produced in five vowel contexts by two speakers. Results indicated that transition durations and formant frequencies often differed considerably in these two classes of sounds--and to a much greater extent than suggested in previous perception experiments. In experiment II we examined a measure of amplitude--unit energy. We calculated the degree of relative amplitude change occurring in the vicinity of the stop and glide release and found reliably larger changes in energy associated with the stop release than the glide release across vowel contexts and speakers. These changes seemed to provide an invariant property characterizing the stop--glide contrast. In experiment III we tested the generality of our claims by examining a new set of data consisting of the stops [d] and [g] and the glide [y]. Results of this experiment further supported our hypothesis. We have related our findings to a general theory of acoustic invariance in speech.     

Lactation-induced reduction in rats' acoustic startle is associated with changes in noradrenergic neurotransmission.

The acoustic startle response (ASR) with or without fear conditioning was compared between cycling (CYC) and lactating (LACT) female rats. ASR sensitivity to changes in endogenous noradrenergic (NA) release was examined using the α-2 NA receptor drugs yohimbine and clonidine. Groups of CYC and LACT females were also tested in the open field. ASR was reduced in all LACT, compared with that in CYC females. Both groups exhibited a robust response to fear conditioning and unpotentiated ASR subsequent to conditioning was increased in LACT females. The lowest dose of yohimbine significantly increased ASR in LACT females, but not in CYC females. Clonidine reduced ASR in both groups of females, with a greater potency in CYC females. In the open field, LACT females displayed a shorter latency to emerge, less freezing behavior, and more entries into the field than did CYC females. The authors concluded that (a) LACT females are less anxious in a novel environment and that decreased anxiety can be efficiently counteracted by fear conditioning, and (b) changes in NA neurotransmission contribute to lactation-induced modifications in ASR. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Transient auditory storage of acoustic details is associated with release of speech from informational masking in reverberant conditions.

Perceptual integration of the sound directly emanating from the source with reflections needs both temporal storage and correlation computation of acoustic details. We examined whether the temporal storage is frequency dependent and associated with speech unmasking. In Experiment 1, a break in correlation (BIC) between interaurally correlated wideband or narrowband noises was detectable even when an interaural interval (IAI) was introduced. The longest IAI, which varied markedly across participants, could be up to about 20 ms for wideband noise and decreased as the center frequency was increased for narrowband noises. In Experiment 2, when the interval between target speech and its single-reflection simulation (intertarget interval [ITI]) was reduced from 64 to 0 ms, intelligibility of target speech was markedly improved under speech-masking but not noise-masking conditions. The longest effective ITI correlated with the longest IAI for detecting the BIC only in the low-frequency (≤400 Hz) narrowband noise. Thus the ability to temporally store fine details contributes to perceptual integration of correlated leading and lagging sounds, which in turn, contributes to releasing speech from informational masking in noisy, reverberant environments. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Changes in stuttering frequency as a function of various intervals of delayed auditory feedback.

5 different intervals of delayed auditory feedback (DAF) were presented to 6 severe stutterers while they read aloud. Results indicate that the continuous presentation of DAF significantly reduced stuttering frequency. Fluency enhancement was generally greatest during the shortest DAF intervals tested. No evidence was found for the carryover of fluency generated by DAF into the period immediately following Ss' experience on DAF. Results are consistent with a view that stuttering is based on a defect in the processing of auditory feedback. (15 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Membrane capacitance changes associated with particle uptake during phagocytosis in macrophages

We report the use of capacitance measurements to monitor particle uptake after cellular exposure to phagocytic stimuli. In these studies, human monocyte-derived macrophages (HMDMs) and cells from the murine macrophage-like cell line J774.1 were exposed to immune complexes or sized latex particles (0.8 or 3.2 micron in diameter). An average decrease in cell capacitance of 8 pF was seen after exposure of the cells to immune complexes. Cells in which particle uptake was inhibited by cytochalasin B treatment before exposure to immune complexes showed an average increase of 0.5 pF. The decrease in membrane capacitance after exposure of cells to particulate stimuli was absent with the soluble stimulus, platelet-activating factor, further confirming that decreases in membrane capacitance were due to particle uptake. Exposure of cells to sized latex particles resulted in a graded, stepwise decrease in membrane capacitance. The average step size for 0.8-micron particles was 250 fF, and the average step change for the larger 3.2-micron particles was 480 fF, as calculated from Gaussian fits to the step size amplitude histograms. The predicted step size for the individual particles based upon the minimum amount of membrane required to enclose a particle and a specific capacitance of 10 fF/micron2 was 20 and 320 fF, respectively. The step size for the smaller particles deviates significantly from the predicted size distribution, indicating either a possible lower limit to the size of the phagocytic vacuole or multiple particles taken up within a single phagosome. Dynamic interaction between phagocytosis and exocytosis was observed in a number of cells as a biphasic response consisting of an initial rapid increase in capacitance, consistent with cellular exocytosis, followed by stepwise decreases in capacitance.     

Adaptation to life changes in children and adults: Cross-sectional studies.

Five studies were conducted to test a general theory of adaptation or sequence of emotional stances to major life changes. Children entering school, middle-class students later in school, students in college, and women getting married and becoming mothers all seemed to renegotiate a similar sequence of concern with receptive issues, then with issues of autonomy and assertion, and finally with issues of integration. Exceptions to these results involved working-class students and new fathers. (21 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Lexical effects on the phonetic categorization of speech: The role of acoustic structure.

This study examines the extent to which acoustic parameters contribute to lexical effects on the phonetic categorization of speech. Experiment 1 was designed to replicate previous findings. Two test continua were created varying in voice onset time. Results of both identification and reaction time (RT) range data showed an effect of lexical status at the phonetic boundary, but only in the slowest RT ranges, suggesting that lexical effects on phonetic categorization are postperceptual. Experiment 2 explored whether the lexical effect would emerge when the stimulus continua more nearly approximated the parameter values of natural speech. Both identification and RT range data indicated that the lexical effect disappeared. These results suggest that without attention to the acoustic structure of the stimuli, the role of top–down processing in phonetic categorization may be overemphasized. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The specific-word frequency effect: Implications for the representation of homophones in speech production.

In a series of experiments, the authors investigated whether naming latencies for homophones (e.g., /nΛn/) are a function of specific-word frequency (i.e., the frequency of nun) or a function of cumulative homophone frequency (i.e., the sum of the frequencies of nun and none). Specific-word but not cumulative-homophone frequency affected picture-naming latencies. This result was obtained in 2 languages (English and Chinese). An analogous finding was obtained in a translation task, where bilingual speakers produced the English names of visually presented Spanish words. Control experiments ruled out that these results are an artifact of orthographic or articulatory factors, or of visual recognition. The results argue against the hypothesis that homophones share a common word-form representation, and support instead a model in which homophones have fully independent representations. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Chest X-ray changes in air space disease are associated with parameters of mechanical ventilation in ICU patients

To assess relationships between parameters of mechanical ventilation (MV) and portable chest X-ray (CXR) measurements of lung length (LL) and severity of air space disease, a prospective, randomized, blinded comparison of 102 adults in a university hospital was performed. Each patient received two portable, supine CXRs on different MV breaths within 5 min of one another. Ventilator parameters were recorded. All 204 CXRs were randomly assorted and read independently by three radiologists. Air space disease was considered more severe with pressure support ventilation (PSV) breaths than with intermittent mandatory ventilation (IMV) breaths (p = 0.0003), and its extent correlated inversely with static compliance (p = 0.0001, r = -0.40). Among patients having CXRs on both IMV and PSV breaths, 15 of 67 (22%) had their overall degree of air space disease read differently by one category (mild, moderate, or severe). Increases in LL between the two CXRs were associated with increasing peak (p = 0.0038) or mean (p = 0.0065) airway pressure, tidal volume (VT) (p = 0.022), and VT per kilogram (p = 0.006). We conclude that lung volume changes during MV, typically not noted nor controlled for during portable chest radiography, may substantially alter the interpretation of air space disease and LL. Physicians monitoring intensive care unit (ICU) patients with daily CXRs should be aware of the variables influencing interpretation of portable CXRs of ICU patients.     

Word frequency effects in speech production: Retrieval of syntactic information and of phonological form.

In 7 experiments the authors investigated the locus of word frequency effects in speech production. Exp 1 demonstrated a frequency effect in picture naming that was robust over repetitions. Exps 2, 3, and 7 excluded contributions from object identification and initiation of articulation. Exps 4 and 5 investigated whether the effect arises in accessing the syntactic word (lemma) by using a grammatical gender decision task. Although a frequency effect was found, it dissipated under repeated access to a word's gender. Exp 6 tested whether the robust frequency effect arises in accessing the phonological form (lexeme) by having Ss translate words that produced homophones. Low-frequent homophones behaved like high-frequent controls, inheriting the accessing speed of their high-frequent homophone twins. Because homophones share the lexeme, not the lemma, this suggests a lexeme-level origin of the robust effect. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Post-hypoxia frequency decline in rats: sensitivity to repeated hypoxia and alpha2-adrenoreceptor antagonism

Peroxynitrite, a potent cytotoxic oxidant formed by the reaction of NO with superoxide anion, has been proposed to have major pathogenetic role in inflammatory process. Here we have investigated the therapeutic efficacy of Mn(III)tetrakis (4-benzoic acid) porphyrin (MnTBAP), a novel superoxide dismutase mimetic that possesses peroxynitrite scavenging effect, in rats subjected to carrageenan-induced pleurisy. In vivo treatment with MnTBAP (3 and 10 mg/kg 5 min before carrageenan) prevented in a dose-dependent manner the carrageenan-induced the degree of pleural exudation, polymorphonuclear migration in rats subjected to carrageenan-induced pleurisy. Lung myeloperoxidase (MPO) activity and histological organ injury was significantly reduced by MnTBAP. However, MnTBAP did not inhibit the inducible NO synthase in lung samples. Immunohistochemical analysis for nitrotyrosine, a footprint of peroxynitrite, revealed a positive staining in lungs from carrageenan-treated rats. No positive nitrotyrosine staining was found in the lungs of the carrageenan-treated rats that received MnTBAP (10 mg/kg) treatment. In addition, in vivo MnTBAP treatment significantly reduced in a dose-dependent manner peroxynitrite formation as measured by the oxidation of the fluorescent dye dihydrorhodamine 123, prevented the appearance of DNA damage, the decrease in mitochondrial respiration and partially restored the cellular level of NAD+ in ex vivo macrophages harvested from the pleural cavity of rats subjected to carrageenan-induced pleurisy. Our study demonstrates that the MnTBAP exerts multiple protective effects in carrageenan-induced pleurisy. We suggest peroxynitrite produced during the inflammatory process trigger DNA strand breakage and subsequent cellular dysfunction. Part of these anti-inflammatory effects may be related to: (1) reduction of superoxide formation due to the superoxide dismutase-like activity of the compound and (2) scavenging of peroxynitrite.