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电子传输材料PDPDP—Bu—t的合成 总被引:3,自引:0,他引:3
电子传输材料在有机电致发光器件有重要的作用,通过7步反应合成了具有优良电子传输功能的1,3-双(5-(对-特丁基苯基)-1,3,4-恶二唑基-2)苯(PDPDP-Bu-t)试剂并讨论了其合成条件。 相似文献
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苯甲氧苯基环丙烷化合物作为杀菌杀虫剂EP889024(Rohm&Hass)1(3羟基苯基)2苯基环丙烷α[2(溴甲基)苯基]β甲氧基丙烯酸甲酯以及KOH在DMF中搅拌得到59%的3甲氧基2[2[3(2苯基环丙基)苯氧甲基]苯基]丙酸甲酯对黄瓜Sphaerothecafulginea有防效。OCH2CHCH3OCH2COOMe[(氨基苯氧苯基)乙酰胺基]异噻唑及吡啶化合物杀虫杀菌剂(BayerAG)DE197271622-5g4氯3甲基5[4(4硝基苯氧基… 相似文献
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2—乙基—3,5—二甲基吡啶的合成 总被引:1,自引:0,他引:1
2-乙基-3,5-二甲基吡啶的合成肖国民,吴平东(东南大学化学化工系,南京210096)(浙江大学二次资源化工国家专业实验室,杭州310027)2-乙基-3,5-二甲基吡啶〔EDP)是合成2,2.1反应温度的影响3,5-三甲基吡啶[1]、3,5-二梭... 相似文献
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新试剂3,5—二溴苯基乙炔的合成 总被引:4,自引:1,他引:3
报道了一种新的化学试剂-3,5-二溴苯基乙炔的合成,为制备用于苯乙炔树型物合物的重要单体-3’,5‘-二溴-2-苯基-1-(三甲基硅基)乙炔提供了一条新途径。 相似文献
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以4-(1,1,3,3-四甲基丁基)-苯酚2为原料,通过3步合成了2-丁氧基-5-(1,1,3,3-四甲基丁基)-苯硫酚1。4-(1,1,3,3-四甲丁基)-苯酚2是由苯酚与二聚异丁烯在硫酸存在下反应制得。3个化合物的结构以HNMR予以表和下。 相似文献
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诺氟沙星(氟哌酸)生产工艺中螯合反应方程式的改正和环合反应的改进诺氟沙星(氟哌酸)目前一般以3-氯-4氟苯胺为原料,经与乙氧基亚甲基丙二酸二乙酯(EMME)缩环合,环合物与乙基化试剂反应得前体酯(1-乙基-6-氟-7-氯-1,4-二氢-4-氧代喹啉-... 相似文献
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《Inorganic chemistry communications》2003,6(6):666-669
The zinc(II) complex, of the dimeric {Zn[3-(Ac-Phe)-5-methyl-pyrazole]2}2(ClO4)4 (5) was obtained by the reaction of the amino acid–pyrazole conjugate, 3-(Ac-Phe)-5-methyl-pyrazole (4) and Zn(ClO4)2. An acetone solvate of this complex was analyzed by single crystal X-ray crystallography, which establishes the dimeric nature of the complex with a large Zn–Zn separation of 5.551(6) Å and exbihiting coordination to the distorted trigonal bipyramidal zinc centers through the amino acid CO and the pyrazole N. 相似文献
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Dr. Palanisamy Ravichandiran Dr. Sivakumar Allur Subramaniyan Dr. Seon-Young Kim Prof. Jong-Soo Kim Prof. Byung-Hyun Park Prof. Kwan Seob Shim Prof. Dong Jin Yoo 《ChemMedChem》2019,14(5):532-544
1,4-Naphthoquinones are exceptional building blocks in organic synthesis and have been used to synthesize several well-known pharmaceutically active agents. Herein we report the synthesis, structural characterization, and biological evaluation of new phenylaminosulfanyl-1,4-naphthoquinone derivatives. We evaluated the cytotoxic activity of the synthesized compounds against three human cancer cell lines: A549, HeLa, and MCF-7. Most of the synthesized compounds displayed potent cytotoxic activity. Specifically, compounds 5 e [3,5-dichloro-N-(4-((4-((1,4-dioxo-3-(phenylthio)-1,4-dihydronaphthalen-2-yl)amino)phenyl)sulfonyl)phenyl)benzamide], 5 f [N-(4-((4-((1,4-dioxo-3-(phenylthio)-1,4-dihydronaphthalen-2-yl)amino)phenyl)sulfonyl)phenyl)-3,5-dinitrobenzamide], and 5 p [N-(4-((4-((1,4-dioxo-3-(phenylthio)-1,4-dihydronaphthalen-2-yl)amino)phenyl)sulfonyl)phenyl)thiophene-2-carboxamide] showed remarkable cytotoxic activity. The synthesized compounds showed low toxicity in normal human kidney HEK293 cells. The cytotoxic mechanism of compounds 5 e , 5 f , and 5 p was explored in MCF-7 cells. The results confirmed that these three compounds induce apoptosis and arrest the cell cycle at the G1 phase. In addition, compounds 5 e , 5 f , and 5 p were found to induce apoptosis via upregulation of caspase-3 and caspase-7 proteins as well as by upregulation of the gene expression levels of caspases-3 and -7. Our findings demonstrate that compounds 5 e , 5 f , and 5 p could be potent agents against a number of cancer types. 相似文献
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(1-Phenyl-5-methyl-pyrazolyl-4)-acetylene was prepared by treating 1-phenyl-4-acetyl-5-methyl-pyrazole with Vilsmeier complex. During the first stage of the reaction the β-(1-phenyl-5-methyl-pyrazolyl-4)-β-chloro-acroleine separated, and suffered in the presence of alkali a dechloroformylation to form the ethinylic compound. As the acroleine intermediate is an α,β-unsaturated aldehyde it can react with substituted hydrazines leading to substituted pyrazoline derivatives. The structures of the monomers were confirmed by means of IR and NMR spectral measurements. In the presence of PdCl2 as catalyst, oligomers were obtained which have then been transformed into charge transfer-complexes. Variation of the ESR signal intensity was followed as a function of A/D ratio. 相似文献
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以金刚烷乙酸为起始原料,经溴代、混酸氧化、氨解、氨基Boc保护以及(1R,2S)-2-氨基-1,2-二苯基乙醇拆分得到(S)-N-叔丁氧羰基-3-羟基-1-金刚烷甘氨酸,之后再与(1S,3S,5S)-2-氮杂二环[3.1.0]己烷-3-甲酰胺对甲苯磺酸盐在HATU条件下缩合得到N-[(1S)-2-[(1S,3S,5S)-3-氨甲酰基-2-氮杂双环[3.1.0]己烷-2-基]-1-(3-羟基-1-金刚烷)-2-氧代乙基]氨基甲酸叔丁酯,最后经酰胺脱水、氨基脱保护反应得到沙格列汀,总收率为16.1%,纯度为99.8%,e.e.99.9%。 相似文献
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本文研究了治疗骨髓增殖性肿瘤药物TG101209的合成工艺。以2,4-二羟基-5-甲基嘧啶为起始原料,与三氯氧磷、氨水发生氯化、取代反应生成2-氯-4-氨基-5-甲基嘧啶(B),B再与N-叔丁基-3-溴苯磺酰胺(C)发生Buchwald偶联反应得到3-[(2-氯-5-甲基-4-嘧啶基)胺基]-N-(叔丁基)苯磺酰胺(D)。以甲醇为溶剂,D与CH3OH-HCl反应得到3-[(2-氯-5-甲基-4-嘧啶基)胺基]-N-(叔丁基)苯磺酰胺盐酸盐(E),E与1-甲基-4-(4-氨基苯基)哌啶(G)发生亲核取代反应得到N-叔丁基-3-(5-甲基-2-[4-(4-甲基-1-哌嗪)苯胺基]-4-胺基嘧啶)-苯磺酰胺(TG101209)。总收率达到30.9%,HPLC测得纯度达到99.7%。 相似文献
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对氯苯基卟啉-氨基酸及其锌配合物的合成和表征 总被引:8,自引:0,他引:8
为了探索氯的空间位置及不同的氨基酸对卟啉 -氨基酸化合物性能的影响 ,合成了 5 - [4-(3 -酪氨酸丙氧基 )苯基 ]- 1 0 ,1 5 ,2 0 -三 (4-氯苯基 )卟啉 ,5 - [4- (3 -组氨酸丙氧基 )苯基 ]- 1 0 ,1 5 ,2 0 -三(4-氯苯基 )卟啉 ,两种新型的尾式卟啉 -氨基酸化合物及其锌配合物 ,用元素分析 ,紫外 -可见光谱 ,红外光谱 ,核磁共振氢谱 ,质谱确证了其结构 ,并测试了其荧光光谱 相似文献
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Damian Kuaga Anna Karolina Drabczyk Grzegorz Sataa Gniewomir Latacz Anna Boguszewska-Czubara Damian Plauk Jolanta Jakowska 《International journal of molecular sciences》2022,23(21)
Considering the key functions of the 5-HT7 receptor, especially in psychiatry, and the fact that effective and selective 5-HT7 receptor ligands are yet to be available, in this work, we designed and synthesized novel 1,3,5-triazine derivatives particularly based on the evaluation of the effect of substituents at aromatic rings on biological activity. The tested compounds showed high affinity to the 5-HT7 receptor, particularly ligands N2-(2-(5-fluoro-1H-indol-3-yl)ethyl)-N4-phenethyl-1,3,5-triazine-2,4,6-triamine 2 (Ki = 8 nM) and N2-(2-(1H-indol-3-yl)ethyl)-N4-(2-((4-fluorophenyl)amino)ethyl)-1,3,5-triazine-2,4,6-triamine 12 (Ki = 18 nM) which showed moderate metabolic stability, and affinity to the CYP3A4 isoenzyme. As for the hepatotoxicity evaluation, the tested compounds showed moderate cytotoxicity only at concentrations above 50 µM. Compound 12 exhibited less cardiotoxic effect than 2 on Danio rerio in vivo model. 相似文献
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以3-甲基-4-硝基苯甲酸为原料,经酯化、催化加氢、缩合、硝化和精制,合成了两个医药中间体:3-甲基-4-正丁酰胺基苯甲酸甲酯和3-甲基-4-正丁酰胺基-5-硝基苯甲酸甲酯,并通过1H NMR和IR验证了其结构。 相似文献
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N-1,3,4-噻二唑基取代水杨醛Schiff碱的合成与表征 总被引:2,自引:2,他引:0
以氨基硫脲和羧酸为原料,在浓硫酸或三氯氧磷作用下合成了2-氨基-5-烃基(芳基)-1,3,4-噻二唑类化合物1,并通过化合物1与水杨醛的缩合反应合成了相应的含1,3,4-噻二唑基席夫碱类化合物3。研究结果表明在合成芳基取代的1,3,4-噻二唑时,浓硫酸作脱水剂的反应收率较低,三氯氧磷作脱水剂时得到较高的收率。同时研究了不同反应条件对化合物3的收率的影响,发现当反应以对甲苯磺酸为催化剂,在乙醇溶液中加热回流时的收率较高。合成的目标化合物的结构用IR、1H NMR、13C NMR等进行了分析与表征。 相似文献