The structure of PTSD among two cohorts of returning soldiers: Before, during, and following deployment to Iraq.

Evidence suggests either a four-factor emotional numbing or dysphoria model likely reflects the underlying structure of posttraumatic stress disorder (PTSD). Questions remain as to which of these structures best represents PTSD, how the structure changes with time, the applicability of models to returning veterans, and the validity of the symptom clusters. The present study addresses these questions among two longitudinal samples of National Guard soldiers assessed prior to, during, and following a combat deployment to Iraq. Findings support a four-factor intercorrelated dysphoria model of PTSD that remains stable across samples and time points. Differential associations were observed among PTSD symptom clusters over time and between symptom clusters and both depression and combat exposure, supporting important distinctions between symptom clusters. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Attachment deficits, personality structure, and PTSD.

Comments on an article by P. Verhaeghe and S. Vanheule (see record 2006-00627-003). The question surrounding etiological factors informing the emergence of posttraumatic stress disorder (PTSD) due to preexisting personality deficits is explored in relation to recent advances in understanding the indissolubility between attachment pathology and developmental trauma. Universal generalizations regarding the causal relation between structural self-deficits and the emergence of PTSD remain suspended. The nature of traumatic representation continues to be a contested area of empirical and theoretical debate, the consequences of which may inevitably inform clinical technique. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

PTSD Arousal and Depression Symptoms Associated With Increased Right-Sided Parietal EEG Asymmetry.

Researchers have proposed that depression and particular types of anxiety are associated with unique patterns of regional brain activation. The authors examined the relationship among posttraumatic stress disorder (PTSD), anxiety, and depressive symptoms and frontal, temporal, and parietal EEG alpha asymmetry in female Vietnam War nurse veterans. The results indicate that PTSD arousal symptoms are associated with increased right-sided parietal activation. However, the combination of arousal, depression, and their interaction explain more than twice the variance in parietal asymmetry compared with arousal alone. The results support the contention that the association between anxiety and right-sided posterior activation is specific to the anxious arousal subtype. These findings underscore the importance of isolating, both theoretically and statistically, emotional subcomponents in studies of regional brain activation. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Posttraumatic stress disorder following assault: The role of cognitive processing, trauma memory, and appraisals.

Two studies of assault victims examined the roles of (a) disorganized trauma memories in the development of posttraumatic stress disorder (PTSD), (b) peritraumatic cognitive processing in the development of problematic memories and PTSD, and (c) ongoing dissociation and negative appraisals of memories in maintaining symptomatology. In the cross-sectional study (n=81), comparisons of current, past, and no-PTSD groups suggested that peritraumatic cognitive processing is related to the development of disorganized memories and PTSD. Ongoing dissociation and negative appraisals served to maintain PTSD symptoms. The prospective study (n=73) replicated these findings longitudinally. Cognitive and memory assessments completed within 12-weeks postassault predicted 6-month symptoms. Assault severity measures explained 22% of symptom variance; measures of cognitive processing, memory disorganization, and appraisals increased prediction accuracy to 71%. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Positive and negative life changes following sexual assault.

A longitudinal study was conducted to investigate (a) the timing and course of posttraumatic growth and (b) the relations between positive and negative life changes and posttraumatic distress among recent female sexual assault survivors (N=171). Most survivors reported positive change even at 2 weeks postassault. Positive changes generally increased over time and negative changes decreased, although change in different domains followed different courses and there was significant individual variability in change patterns. Both positive and negative changes were associated with distress in expected ways, although the relations with negative changes were stronger. The least distress at 12 months was reported by those who noted positive life changes at both 2 weeks and 12 months postassault. Implications for theory and research on posttraumatic growth are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Arousal, learning, and memory.

Reviews the literature relating arousal and human learning and memory. It is argued that it is important to distinguish between effects of arousal on storage and those on retrieval. The distinction between item arousal and S arousal is also of importance, and more work is needed to consider the conjoint influence of these sources of arousal on performance. Current hypotheses are seen as inadequate because they do not take into account task difficulty in discussing the effects of arousal. A hypothesis is proposed which assumes that high levels of arousal affect storage by focusing attention on physical characteristics of presented information, whereas they affect retrieval by biasing S's search process toward readily accessible sources of stored information. (85 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Posttraumatic stress disorder (PTSD), actual pathology, and the question of representability: A reply to Attachment deficits, personality structure, and PTSD (J. Mills).

Replies to commentary by J. Mills (see record 2008-03991-014) on the current authors' original article (see record 2006-00627-003) regarding posttraumatic stress disorder and the question of representability. In the first part of our answer, we will clarify certain of our ideas in the light of Mills's critical remarks. In the second part, we want to address what we consider to be the main problem in matters of posttraumatic stress disorder (PTSD), that is, the question of representability. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Evaluation of a brief cognitive-behavioral program for the prevention of chronic PTSD in recent assault victims.

The efficacy of a brief prevention program (BP) aimed at arresting the development of chronic posttraumatic stress disorder (PTSD) was examined with 10 recent female victims of sexual and nonsexual assault who received 4 sessions of a cognitive-behavioral program shortly after the assault. Their PTSD and depression severity was compared with that of 10 matched recent female assault victims who received repeated assessments of their trauma-related psychopathology (assessment control; AC). The BP program consisted of education about common reactions to assault and cognitive-behavioral procedures. Two months postassault, victims who received the BP program had significantly less severe PTSD symptoms than victims in the control condition; 10% of the former group met criteria for PTSD versus 70% of the latter group. Five and a half months postassault, victims in the BP group were significantly less depressed than victims in the AC group and had significantly less severe reexperiencing symptoms. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

All PTSD symptoms are highly associated with general distress: Ramifications for the dysphoria symptom cluster.

This study used longitudinal data collected from two trauma-exposed samples, survivors of community violence (N = 294) and wildfire evacuees (N = 234), to examine a key claim underlying a proposed reformulation of the symptom structure of posttraumatic stress disorder (PTSD). This theory, which we term the PTSD–dysphoria model, posits that 8 of 17 symptoms of PTSD reflect dysphoria or general psychological distress and might be deemphasized to improve the utility of the PTSD construct (Simms, Watson, & Doebbeling, 2002). For each sample, we analyzed PTSD symptoms and measures of general distress administered at 2 time points. A consistent pattern of findings was observed across assessments for each sample: All 17 PTSD symptoms were highly associated with measures of general distress. Moreover, we found no evidence that dysphoria symptoms were more highly correlated than PTSD-specific symptoms with general distress. Results call into question both the conceptual basis and the clinical utility of differentiating between symptoms that appear to be relatively specific to PTSD and those that seem more broadly characteristic of general psychological distress. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The two-factorial symptom structure of post-traumatic stress disorder: depression-avoidance and arousal-anxiety

BACKGROUND: Yeast pyruvate kinase (PK) catalyzes the final step in glycolysis. The enzyme therefore represents an important control point and is allosterically activated by fructose-1,6-bisphosphate (FBP). In mammals the enzyme is found as four different isozymes with different regulatory properties: two of these isozymes are produced by alternate splicing. The allosteric regulation of PK is directly related to proliferation of certain cell types, as demonstrated by the expression of an allosterically regulated isozyme in tumor cells. A model for the allosteric transition from the inactive (T) state to the active (R) state has been proposed previously, but until now the FBP-binding site had not been identified. RESULTS: We report here the structures of PK from yeast complexed with a substrate analog and catalytic metal ions in the presence and absence of bound FBP. The allosteric site is located 40 A from the active site and is entirely located in the enzyme regulatory (C) domain. A phosphate-binding site for the allosteric activator is created by residues encoded by a region of the gene corresponding to the alternately spliced exon of mammalian isozymes. FBP activation appears to induce several conformational changes among active-site sidechains through a mechanism that is most likely to involve significant domain motions, as previously hypothesized. CONCLUSIONS: The structure and location of the allosteric activator site agrees with the pattern of alternate genetic splicing of the PK gene in multicellular eukaryotes that distinguishes between a non-regulated isozyme and the regulated fetal isozymes. The conformational differences observed between the active sites of inactive and fully active PK enzymes is in agreement with the recently determined thermodynamic mechanism of allosteric activation through a 'metal relay' that increases the affinity of the enzyme for its natural phosphoenolpyruvate substrate.     

Anxiety sensitivity and PTSD symptom severity are reciprocally related: Evidence from a longitudinal study of physical trauma survivors.

Cross-lagged panel analysis of interview data collected from survivors of traumatic physical injury (N = 677) was used to examine the temporal relationship between anxiety sensitivity and posttraumatic stress disorder (PTSD) symptom severity. The 2 constructs were assessed at 3 time points: within days of physical injury, at 6-month follow-up, and at 12-month follow-up. Results indicated that anxiety sensitivity and PTSD symptom severity were reciprocally related such that anxiety sensitivity predicted subsequent PTSD symptom severity, and symptom severity predicted later anxiety sensitivity. Findings have both theoretical and clinical implications. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Perceived control and distress following sexual assault: A longitudinal test of a new model.

Longitudinal data were collected from female sexual assault survivors (N=171) at 4 points postassault. Consistent with the predictions of the temporal model (P. Frazier, M. Berman, & J. Steward, 2002), past, present, and future control were differentially related to posttrauma distress. Both personal past (behavioral self-blame) and vicarious past (rapist blame) control were associated with higher distress levels. In addition, the belief that future assaults are less likely was more strongly associated with lower distress levels than was future control. Present control (i.e., control over the recovery process) was most adaptive. Hierarchical linear modeling analyses revealed that changes in perceived control were associated with changes in distress after linear change in distress over time was accounted for. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Arousal of frustration following gradual reductions in reward magnitude in rats.

16 male Holtzman rats were assigned to each of 4 groups; Ss were given a 14-pellet reward for 60 runway acquisition trials. During a subsequent 18-trial shift phase, one group was shifted to a 1-pellet reward on Trial 1, a 2nd was shifted on Trial 13, and a 3rd was given 1 less pellet each trial and then 1 pellet for the last 6 trials. The speeds of all 3 groups decreased to a level below that of a control group given a 1-pellet reward throughout training. All Ss were then given hurdle-jump training to escape from the 1-pellet reward to a neutral box. All 3 shifted groups showed acquisition of the response, whereas the control group did not. Results indicate that both gradual and abrupt reward reductions arouse frustration. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Reappraising the link between peritraumatic dissociation and PTSD symptom severity: Evidence from a longitudinal study of community violence survivors.

Cross-lagged panel analysis of longitudinal data collected from young adult survivors of community violence was used to examine the relationship between recall of peritraumatic dissociation and posttraumatic stress disorder (PTSD) symptom severity. Recollections of peritraumatic dissociation assessed within days of exposure differed from recollections measured at 3- and 12-month follow-up interviews. Peritraumatic dissociation was highly correlated with PTSD symptoms within each wave of data collection. Baseline recollections of peritraumatic dissociation were not predictive of follow-up PTSD symptom severity after controlling for baseline PTSD symptom severity. This pattern of results replicates previous work demonstrating a correlation between peritraumatic dissociation and subsequent symptom severity. However, findings are not consistent with the prevailing view that peritraumatic dissociation leads to increased PTSD symptom severity. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Arousal, monotony, and accidents in line driving.

Lack of alertness in monotonous work situations may result from lowered arousal induced by restricted and repetitive stimulation. Line driving is held to be monotonous in this sense, hence laboratory evaluation of a driver's resistance to monotony should predict his accident record. A highly repetitive, 42-min paced task was performed under controlled conditions by 20 line drivers. Self-reports on monotony susceptibility, intelligence test scores, and peer ratings were obtained. Supervisory ratings, traffic convictions, and objective driving measures were criteria in addition to accident records. Accidents of 1 type were predicted by task errors (r = .63; p     

Arousal, affect, and attention as components of temperament.

Contemporary models of human temperament have been based on the general constructs of arousal, emotion, and self-regulation. In order to more precisely investigate these constructs, they were theoretically decomposed into 19 subconstructs, and homogeneous scales were developed to assess them. The scales were constructed through an item-selection technique that maximized internal consistency and minimized conceptual overlap. Correlational and factor analyses suggested that arousal can be usefully assessed in terms of its central, autonomic, and motor components. The emotions of sadness, relief, and low-intensity pleasure were most closely related to the measures of central arousal. Emotions of fear, frustration, discomfort, and high-intensity pleasure were more closely related to measures of attentional control. We discuss these findings in terms of the functional relations between arousal, emotion, and attention. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Cognitive predictors of symptom return following depression treatment.

This study tested whether poor cognitive change during depression treatment predicted time to return of depressive symptoms. Depressed participants (N=121) completed assessments of dysfunctional attitudes and extreme thinking (i.e., number of totally agree and totally disagree responses) during hospitalization and again after 6 months of outpatient treatment. Participants then completed monthly depression assessments for 1 year. Survival analyses for time to symptom recurrence during follow-up were conducted among participants who reported 50% improvement in their depressive symptoms and were at least partially asymptomatic at the end of treatment (n=53). Poor change in dysfunctional attitudes and poor change in extreme thinking both predicted shorter time to return of depressive symptoms. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Attentional Interference Effects of Emotional Pictures: Threat, Negativity, or Arousal?

Attentional interference arising from emotional pictures was examined. Participants had to ignore emotional pictures while solving math problems (Study 1, N = 126) or detecting the location of a line (Study 2, N = 60). Data analyses tested predictions of 3 theories. Evolutionary threat theory predicts interference by snake pictures. Categorical negativity theory predicts interference by negative pictures regardless of their intensity. According to arousal theory, arousal level predicts interference effects. The results supported arousal theory, with the most arousing pictures (strong unpleasant pictures, oppositesex models) producing the strongest interference. The findings are interpreted in the context of process models of emotions that postulate an initial relevance check before further processing of valence and other appraisal dimensions. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Arousal, extraversion, and individual differences in resource availability.

Three studies of the effects of extraversion and self-report arousal on attentional task performance were conducted, using sustained attention, visual/memory search, and letter transformation tasks. Differing predictions were derived from the Yerkes-Dodson Law (R. M. Yerkes and J. D. Dodson, 1908) and from M. S. Humphreys and W. Revelle's (see record 1984-16903-001) theory of individual differences in multiple attentional resources. Higher arousal was consistently associated with more efficient performance of demanding versions of the attentional tasks. This finding supports Humphreys and Revelle's hypothesis that arousal is positively associated with the resources required for sustained information transfer. No support for the Yerkes-Dodson Law was found in any study: Relationships between arousal and performance were largely linear. Interactive effects of extraversion and arousal on response criterion were found with self-paced tasks. Extraversion may affect more than 1 type of cognitive process, with the strategic demands of the task influencing the kind of extraversion effect found in any given experiment. (PsycINFO Database Record (c) 2010 APA, all rights reserved)