共查询到20条相似文献,搜索用时 156 毫秒
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静电纺丝技术能便捷地制备连续性纳米纤维,为高效过滤提供了新的过滤介质.介绍了静电纺纳米纤维用于过滤介质所需要的结构与性能的表征,详细总结了静电纺纳米纤维用于液体过滤和气体过滤的研究现状,并在此基础上展望了静电纺纳米纤维用于过滤介质的开发趋势. 相似文献
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新型纳米碳材料的应用新进展 总被引:2,自引:0,他引:2
近年来,富勒烯、纳米碳管和石墨烯的发现和报道使纳米碳材料受到各界广泛地重视。新型碳材料可以显著提高复合材料的机械性能和导热性能;制备出具有特殊形貌和微观结构的电极材料,应用在电化学器件中可以改善电化学性能,提高能量转化效率;在催化剂和储氢材料方面也有良好的应用前景。主要总结了这三种纳米碳材料的优异性能及其在储氢材料、超级电容器、催化材料等领域的最新研究进展,并对其未来发展趋势予以展望。 相似文献
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随着纳米技术与精准医学的不断发展,纳米药物与基因载体已被广泛应用于肿瘤等相关疾病的治疗。纳米技术不但能提高药物生物利用度,而且可以降低药物毒副作用,这对于开发新型药物制剂具有重要的意义。构筑纳米药物与基因载体的手段多种多样,自组装方法是目前最常用的手段之一。利用自组装可以构筑出具有新型结构与功能的超分子组装体,对探索和设计新型功能的纳米药物与基因载体具有重要的研究意义。通过环糊精自组装来构筑纳米药物与基因载体是目前的研究热点之一。自组装可以避免复杂的合成步骤与纯化工艺,具有方便、灵活与快捷的优势。通过两方面(共价偶联方案与聚轮烷方案)介绍了基于环糊精自组装的纳米药物与基因载体,并对其发展前景作了进一步的展望。 相似文献
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Cancer nanotheranostics aims to combine imaging and therapy of cancer through use of nanotechnology. The ability to engineer nanomaterials to interact with cancer cells at the molecular level can significantly improve the effectiveness and specificity of therapy to cancers that are currently difficult to treat. In particular, metastatic cancers, drug-resistant cancers, and cancer stem cells impose the greatest therapeutic challenge for targeted therapy. Targeted therapy can be achieved with appropriately designed drug delivery vehicles such as nanoparticles, adult stem cells, or T cells in immunotherapy. In this article, we first review the different types of nanotheranostic particles and their use in imaging, followed by the biological barriers they must bypass to reach the target cancer cells, including the blood, liver, kidneys, spleen, and particularly the blood-brain barrier. We then review how nanotheranostics can be used to improve targeted delivery and treatment of cancer cells. Finally, we discuss development of nanoparticles to overcome current limitations in cancer therapy. 相似文献
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Amanda L. Facklam Lisa R. Volpatti Daniel G. Anderson 《Advanced materials (Deerfield Beach, Fla.)》2020,32(13):1902005
Cell therapy has already had an important impact on healthcare and provided new treatments for previously intractable diseases. Notable examples include mesenchymal stem cells for tissue regeneration, islet transplantation for diabetes treatment, and T cell delivery for cancer immunotherapy. Biomaterials have the potential to extend the therapeutic impact of cell therapies by serving as carriers that provide 3D organization and support cell viability and function. With the growing emphasis on personalized medicine, cell therapies hold great potential for their ability to sense and respond to the biology of an individual patient. These therapies can be further personalized through the use of patient-specific cells or with precision biomaterials to guide cellular activity in response to the needs of each patient. Here, the role of biomaterials for applications in tissue regeneration, therapeutic protein delivery, and cancer immunotherapy is reviewed, with a focus on progress in engineering material properties and functionalities for personalized cell therapies. 相似文献
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《工程(英文)》2015,(1)
Magnetic helical micro- and nanorobots can perfo rm 3D navigation in various liquids with a sub-micrometer precision under low-strength rotating magnetic fields( 10 m T). Since magnetic fields with low strengths are harmless to cells and tissues, magnetic helical micro/nanorobots are promising tools for biomedical applications, such as minimally invasive surgery, cell manipulation and analysis, and targeted therapy. This review provides general information on magnetic helical micro/nanorobots, including their fabrication, motion control, and further functionalization for biomedical applications. 相似文献
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Haili Yan Jiangfeng Du Shuang Zhu Guangjun Nie Hui Zhang Zhanjun Gu Yuliang Zhao 《Small (Weinheim an der Bergstrasse, Germany)》2019,15(49)
Carbon monoxide (CO) therapy has emerged as a hot topic under exploration in the field of gas therapy as it shows the promise of treating various diseases. Due to the gaseous property and the high affinity for human hemoglobin, the main challenges of administrating medicinal CO are the lack of target selectivity as well as the toxic profile at relatively high concentrations. Although abundant CO releasing molecules (CORMs) with the capacity to deliver CO in biological systems have been developed, several disadvantages related to CORMs, including random diffusion, poor solubility, potential toxicity, and lack of on‐demand CO release in deep tissue, still confine their practical use. Recently, the advent of versatile nanomedicine has provided a promising chance for improving the properties of naked CORMs and simultaneously realizing the therapeutic applications of CO. This review presents a brief summarization of the emerging delivery strategies of CO based on nanomaterials for therapeutic application. First, an introduction covering the therapeutic roles of CO and several frequently used CORMs is provided. Then, recent advancements in the synthesis and application of versatile CO releasing nanomaterials are elaborated. Finally, the current challenges and future directions of these important delivery strategies are proposed. 相似文献
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《Current Opinion in Solid State & Materials Science》2012,16(6):269-275
Multifunctional nanocarriers for the delivery and targeting of therapeutic and diagnostic agents in cancer therapy have received significantly increased interest in recent years.Several multifunctional nanocarriers engineered from a wide range of materials with consolidation of various functionalities for long circulation, targetability, stimuli-sensitivity, intracellular delivery for therapy and imaging have been shown to be capable of killing the desired target diseased cells with minimal side effects to provide enhanced contrast during imaging for disease location and monitor both the fate of the nanocarrier and treatment in real time. This review highlights recent advances in the design and engineering of multifunctional nanocarriers, along with the importance of intracellular delivery. 相似文献
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Cancer is a leading cause of death worldwide. Despite the great advancement in understanding the pharmacology and biology of cancer, it still signifies one of the most serious human‐health related problems. The current treatments for cancer may include surgery, radiotherapy, and chemotherapy, but these procedures have several limitations. Current studies have shown that nanoparticles (NPs) can be used as a novel strategy for cancer treatment. Developing nanosystems that allow lower doses of therapeutic agents, as well as their selective release in tumour cells, may resolve the challenges of targeted cancer therapy. In this review, the authors discuss the role of the size, shape, and surface modifications of NPs in cancer treatment. They also address the challenges associated with cancer therapies based on NPs. The overall purpose of this review is to summarise the recent developments in designing different hybrid NPs with promising therapeutic properties for different types of cancer.Inspec keywords: tumours, reviews, patient treatment, nanomedicine, surgery, radiation therapy, cellular biophysics, nanobiotechnology, nanoparticles, cancerOther keywords: current treatments, cancer treatment, targeted cancer therapy, cancer therapies, surface‐functionalised hybrid nanoparticles, targeted treatment, serious human‐health related problems 相似文献
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Jian Wang Mingxu You Guizhi Zhu Mohammed Ibrahim Shukoor Zhuo Chen Zilong Zhao Meghan B. Altman Quan Yuan Zhi Zhu Yan Chen Cheng Zhi Huang Weihong Tan 《Small (Weinheim an der Bergstrasse, Germany)》2013,9(21):3678-3684
In this work, a DNA inter‐strand replacement strategy for therapeutic activity is successfully designed for multimodal therapy. In this multimodal therapy, chlorin e6 (Ce6) photosensitizer molecules are used for photodynamic therapy (PDT), while aptamer‐AuNRs, are used for selective binding to target cancer cells and for photothermal therapy (PTT) with near infrared laser irradiation. Aptamer Sgc8, which specifically targets leukemia T cells, is conjugated to an AuNR by a thiol‐Au covalent bond and then hybridized with a Ce6‐labeled photosensitizer/reporter to form a DNA double helix. When target cancer cells are absent, Ce6 is quenched and shows no PDT effect. However, when target cancer cells are present, the aptamer changes structure to release Ce6 to produce singlet oxygen for PDT upon light irradiation. Importantly, by combining photosensitizer and photothermal agents, PTT/PDT dual therapy supplies a more effective therapeutic outcome than either therapeutic modality alone. 相似文献
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Nanocarriers as an emerging platform for cancer therapy 总被引:6,自引:0,他引:6
Nanotechnology has the potential to revolutionize cancer diagnosis and therapy. Advances in protein engineering and materials science have contributed to novel nanoscale targeting approaches that may bring new hope to cancer patients. Several therapeutic nanocarriers have been approved for clinical use. However, to date, there are only a few clinically approved nanocarriers that incorporate molecules to selectively bind and target cancer cells. This review examines some of the approved formulations and discusses the challenges in translating basic research to the clinic. We detail the arsenal of nanocarriers and molecules available for selective tumour targeting, and emphasize the challenges in cancer treatment. 相似文献
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Cornel Iancu Ioana R. Ilie Carmen E. Georgescu Razvan Ilie Alexandru R. Biris Teodora Mocan 《Particulate Science and Technology》2013,31(6):562-574
Stem cells hold enormous potential in the treatment of diseases such as diabetes, arthritis, cirrhosis, spinal cord injury, and Alzheimer's disease, due to their unique ability to differentiate into various cell lines and tissues and integrate seamlessly into damaged or diseased tissue. The use of nanoparticles as bioactive molecules is still considered a nascent science, but their unique physical and chemical properties hold great hopes for drug delivery, cancer targeting, and bioimaging. There is active worldwide ongoing research to generate advanced therapeutic compounds for incurable diseases, combining the unique properties of nanomaterials and stem cells. The present review will cover emerging areas of nanotechnology applications in stem cell therapy, one of the next frontiers of medical science. 相似文献