共查询到20条相似文献,搜索用时 40 毫秒
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Charnes-Cooper提出了一种线性分式规划的算法。本文在此基础上证明了线性分式规划与一种特定的线性规划等价。将Karmarkar算法用于该线性规划,我们得到了线性分式规划的多项式算法。 相似文献
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2009年对国内三大地区进口二次油片市场进行了专题调研,先后走访了二十多家相关企业,并征求国内部分变压器厂的专家对进口二次油片的看法和意见,经过整理和认真分析,提出了二次油片的来源、加工过程、可能产生的质量稳患、对我国取向电工钢市场环境的影响,提出几点建议。对正确认识二次油片,改善我国取向电工钢市场环境,使变压器行业减少质量、安全隐患,健康发展,为国家如何管理进口二次油片,提供了一定的信息支撑和参考建议。 相似文献
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Previous attempts at optimization of radiotherapy planning are described and criticized, and consideration of these attempts has resulted in the development of a new technique using quadratic programming. Uniformity of tumour dose is selected as the most important feature of any plan, and this is achieved by minimizing the variance of the dose to preselected points within the tumour. The dose to vulnerable regions can be constrained not to exceed a given percentage of the mean tumour dose. Optimization of field weight and field type is possible. The operation of the system is described and some typical results are given. 相似文献
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The kinetic behaviour of a naproxen human serum albumin conjugate (Nap23-HSA) was investigated in rats and in isolated perfused rat livers (IPRL), as compared to its active metabolite naproxen-lysine (Nap-lysine) and free naproxen. Through covalently linking the anti-inflammatory drug naproxen to HSA, this drug can be selectively delivered to non parenchymal cells of the liver. Liver endothelial and Kupffer cells play an important role in the pathogenesis of inflammatory liver diseases. Targeting naproxen to these cells might increase its efficacy and reduce the side effects. The altered kinetic properties of Nap23-HSA, after i.v. injection of 22 mg x kg(-1), as compared to an equimolar amount of the uncoupled drug, were demonstrated in vivo by a decrease in the steady state volume of distribution (41 +/- 5 vs. 134 +/- 19 ml x kg(-1)), a decrease in its clearance (0.48 +/- 0.05 vs. 0.63 +/- 0.1 ml x min(-1) x kg(-1)), a shorter plasma half life (60 +/- 11 vs. 152 +/- 44 min) and a sustained biliary excretion. Liver targeting of Nap23-HSA was clearly demonstrated: drug content of the liver 180 min after injection was about 30 times higher for Nap23-HSA as compared to naproxen itself. The IPRL experiments showed that the Vmax of hepatic removal of the conjugate was 40 microg x min(-1) x g liver(-1). With doses below receptor saturation a rapid removal of the conjugate (t1/2 = 6 min) from the perfusion medium was found. In conclusion, this study demonstrates the saturable uptake of Nap23-HSA and its lysosomal degradation in both in vivo and IPRL experiments. Covalently linked naproxen is released as Nap-lysine. This active metabolite accumulates in Kupffer and endothelial cells in which it reaches therapeutic concentrations. Release from these cells leads to rapid uptake by hepatocytes and carrier mediated excretion into bile. Levels of Nap-lysine in bile and plasma reflect the slowest step in its generation: the proteolytic release in endothelial and Kupffer cells. 相似文献
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简洪平 《有色冶金设计与研究》2002,23(4):77-79
采用序列二次规划法对空间网架结构优化设计时,起控制作用的约束条件是应力约束,在对应力约束函数进行序列二次归格化时必须进行应力灵敏度分析,同时设计变量运动极限的选取将直接影响到迭代过程的平稳度、迭代次数以及迭代计算结果的精确度,既此提出了应力灵敏度和设计变量运动极限的计算方法及理论依据。 相似文献
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针对求解一类二层多目标规划问题,首先将其转化为等价的单目标规划问题,然后利用遗传算法优化的反演性和混沌优化方法的遍历性,并结合精确罚函数求解非线性约束优化问题,提出了求解此类问题的混沌遗传算法.该方法能够有效改善遗传算法的局部搜索能力和搜索精度,求解精度和可靠性较高.实际算例表明,算法是有效可行的. 相似文献
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JJ Neglia RB Krol I Giorgberidze P Mathew C Lewis AN Munsif S Saksena 《Canadian Metallurgical Quarterly》1997,1(1):49-56
Lungs from eight goats of mixed sexes and breeds (Cashmere, Nubian and Toggenburg) aged between 10 and 48 months were used in this study. Tissues from lung parenchyma were minced and routinely prepared for transmission electron microscopy (TEM) after using different methods of fixation. Thick sections were examined with a light microscope and samples, to include terminal bronchioles, respiratory bronchioles, alveolar ducts and alveolar membrane, were selected for ultrathin sectioning. Six cell types, ciliated, non-ciliated bronchiolar epithelial, mucus-producing, alveolar Type I, alveolar Type II and capillary endothelial cell were identified and characterised cytologically. It was established that the cell population in the distal airways is similar to that observed in other domestic mammals. The mucus-producing cell, which appears to be a common cell type in the distal airways of man and Rhesus monkey, was encountered particularly in adult goats in the present study. This study has also established that the Clara cell of the goat shows some cytological differences from those of some other mammalian species by having a large amount of SER, particularly in the apical region. Lipid vacuoles were seen to be a feature of the alveolar Type II cells; these do not appear to have been reported in other mammalian species. The study has provided a basic understanding of the morphological features of the cell population of the epithelium lining the distal airways in the goat's respiratory tract. The difference in junctional complexes between the various alveolar epithelial cells perhaps signify a different pattern of intercellular transport, thus influencing the pathogenesis and resolution of alveolar pulmonary edema. 相似文献
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针对后方交会危险圆的问题,介绍了确定后方交会点是否落在危险圆域内的程序设计方法. 相似文献