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Xiaolei Gu Zhehong Zhu Qianyi Fan Yaohua Wei Guanglin Wang Fenghua Meng Zhiyuan Zhong Chao Deng 《Small (Weinheim an der Bergstrasse, Germany)》2019,15(45)
Future healthcare requires development of novel theranostic agents that are capable of not only enhancing diagnosis and monitoring therapeutic responses but also augmenting therapeutic outcomes. Here, a versatile and stable nanoagent is reported based on poly(ethylene glycol)‐b‐poly(l ‐thyroxine) (PEG‐PThy) block copolypeptide for enhanced single photon emission computed tomography/computed tomography (SPECT/CT) dual‐modality imaging and targeted tumor radiotherapy in vivo. PEG‐PThy acquired by polymerization of l ‐thyroxine‐N‐carboxyanhydride (Thy‐NCA) displays a controlled Mn, high iodine content of ≈49.2 wt%, and can spontaneously form 65 nm‐sized nanoparticles (PThyN). In contrast to clinically used contrast agents like iohexol and iodixanol, PThyN reveals iso‐osmolality, low viscosity, and long circulation time. While PThyN exhibits comparable in vitro CT attenuation efficacy to iohexol, it greatly enhances in vivo CT imaging of vascular systems and soft tissues. PThyN allows for surface decoration with the cRGD peptide achieving enhanced CT imaging of subcutaneous B16F10 melanoma and orthotopic A549 lung tumor. Taking advantages of a facile iodine exchange reaction, 125I‐labeled PThyN enables SPECT/CT imaging of tumors and monitoring of PThyN biodistribution in vivo. Besides, 131I‐labeled and cRGD‐functionalized PThyN displays remarkable growth inhibition of the B16F10 tumor in mice (tumor inhibition rate > 89%). These poly(l ‐thyroxine) nanoparticles provide a unique and versatile theranostic platform for varying diseases. 相似文献
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Sustainable Solid‐State Supercapacitors Made of 3D‐Poly(3,4‐ethylenedioxythiophene) and κ‐Carrageenan Biohydrogel
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Georgina Fabregat L'udmila Hodásová Luis J. del Valle Francesc Estrany Carlos Alemán 《Advanced Engineering Materials》2018,20(7)
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Chiara Tonda‐Turo Chiara Audisio Sara Gnavi Valeria Chiono Piergiorgio Gentile Stefania Raimondo Stefano Geuna Isabelle Perroteau Gianluca Ciardelli 《Advanced Engineering Materials》2011,13(5):B151-B164
The preparation and characterization of PCL guides filled with a porous matrix of a freeze‐dried, genipin‐crosslinked gelatin sponge (GL/GP) is described. Porous guides are obtained by dip coating a rotating mandrel with a PCL/PEO blend solution followed by PEO solvent extraction. PCL/PEO 60/40 is selected as the optimal composition to obtain model porous membranes with suitable morphological properties to ensure nutrient permeation and moderate stiffness. GL/GP sponges show increased mechanical strength and water stability, compared to uncrosslinked GL sponges. GL/GP in the form of films, sponges and internal fillers support the in vitro adhesion and proliferation of Schwann like cells. 相似文献
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L. Groenendaal G. Zotti P.‐H. Aubert S.M. Waybright J.R. Reynolds 《Advanced materials (Deerfield Beach, Fla.)》2003,15(11):855-879
An overview of the electrochemistry of poly(3,4‐alkylenedioxythiophene)s (PXDOTs) is presented. As a class of conducting and electroactive polymers that can exhibit high and quite stable conductivities, a high degree of optical transparency as a conductor, and the ability to be rapidly switched between conducting doped and insulating neutral states, PXDOTs have attracted attention across academia and industry. Numerous fundamental aspects are addressed here in detail, ranging from the electrochemical synthesis of PXDOTs, a variety of in‐situ characterization techniques, the broad array of properties accessible, and morphological aspects. Finally, two electrochemically‐driven applications, specifically electrochromism and chemical sensors of PXDOTs are discussed. 相似文献
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