Variations in plasma volume affect total and low-density lipoprotein cholesterol concentrations during the menstrual cycle

Serum lipids are known to vary during the menstrual cycle. To determine if changes in plasma volume contribute to this effect, we determined serum lipids, lipoproteins, and estimated changes in plasma volume in 18 premenopausal women at the start of and at 5-day intervals after menstruation. Eleven men served as a comparison group. Changes in plasma volume were estimated from changes in hemoglobin and hematocrit. Total and low-density lipoprotein (LDL) cholesterol (mean +/- SD) increased 15 +/- 14 mg/dL (9% +/- 10%) and 11 +/- 13 (11% +/- 14%) within 10 days after the start of menstruation (P < .05) and then decreased toward baseline during the rest of the cycle. High-density lipoprotein (HDL) cholesterol increased 3 mg/dL, or 5%, (P < .05) on days 10 and 15 after menstruation. Plasma volume decreased 4% +/- 9% (P < .06) 10 days after the start of menstruation, and this maximum decrease in plasma volume coincided with peak increases in total, LDL, and HDL cholesterol. Except for an 8-mg/dL increase in LDL cholesterol at day 5, lipid changes were no longer significant after adjusting for changes in plasma volume. We conclude that alterations in plasma volume account for approximately half of the increase in total and LDL cholesterol during the menstrual cycle.     

Sex and menstrual cycle differences in the subjective effects from smoked cocaine in humans.

To investigate sex and menstrual cycle effects in response to cocaine administration, data from existing studies were analyzed. First, responses to a single delivery of 0.4 mg/kg smoked cocaine were investigated. Women reported lower ratings for measures of paranoid/suspicious and heart racing/pounding than did men. In addition, women in the luteal phase reported diminished ratings for a measure of feel high than did both women in the follicular phase of the menstrual cycle and men. Second, responses to up to 6 deliveries of 0.4 mg/kg smoked cocaine were investigated. Women, compared with men, had lower ratings on feel high, heart racing/pounding, and feel stimulated. Results suggest that there are significant sex and menstrual phase differences in the subjective effects of cocaine. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Sleep and the menstrual cycle.

To evaluate changes in sleep across the phases of the menstrual cycle, sleep-wake diaries were completed by 32 healthy women twice daily for 2 menstrual cycles. There was a significant increase in sleep onset latency and a significant decrease in sleep efficiency and sleep quality during the luteal phase. This increase in sleep disturbance was observed in the entire sample and was not related to the severity of other premenstrual symptoms. However, women having increased severity of other premenstrual symptoms reported greater luteal increase in daytime sleepiness. Thus, although menstruating women are likely to show increased sleep disturbance during the luteal phase, those with other, more severe premenstrual symptoms are more likely to experience a luteal increase in daytime sleepiness. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Contribution of generalized negative affect to elevated menstrual cycle symptom reporting

We investigated women's belief that they suffered from premenstrual syndrome (PMS) by monitoring patterns of symptom reporting over a 5-week period in relation to the underlying trait of negative affect. We expected that women reporting high negative affect would be more likely to report menstrual cycle distress than those reporting low negative affect. One hundred twenty-one women rated the typical occurrence and severity of premenstrual changes on a retrospective questionnaire and then made daily ratings of their changes for the duration of one cycle. In addition, they completed a questionnaire measuring positive and negative affect. Data analysis revealed a clear subgroup whose retrospective reports of premenstrual change were not substantiated by the cycle of their daily ratings. Although this subgroup also reported more negative affect, the magnitude of the effect was relatively small. The possible contribution of both negative outlook and the meaning of the self-identified label of PMS are discussed.     

The timing of breast cancer surgery during the menstrual cycle

A number of recent studies have suggested that survival among premenopausal women after primary treatment of breast cancer may be affected by the estimated hormonal milieu at the time of surgery, especially in those with axillary lymph node metastases. The concept has created considerable controversy and has resulted in the publication of many negative reports. However, several biological mechanisms have been suggested for the observed survival advantage. These include cyclical patterns of immune function, as well as cell division and cell death, that correlate with hormonal fluctuations of the menstrual cycle. Comparisons among studies of timing have been complicated by differences in menstrual cycle divisions, variability in the sources of study populations, limited availability of menstrual history data, and changes over the past 2 decades in primary and adjuvant breast cancer therapy. Several recent publications have been enhanced by the availability of serum collected at the time of surgery that enables accurate measurement of the hormonal milieu. In these studies, the likelihood of misclassification by menstrual cycle phase is reduced, and dependence on recalled menstrual history is eliminated. High progesterone levels have been associated with improved survival. These findings have encouraged some to suggest that perioperative administration of progesterone or tamoxifen (Nolvadex) may provide a preventive avenue comparable to scheduling surgery during the luteal phase. Further multidisciplinary studies are needed, however, to clarify the influence of the naturally occurring or medically induced hormonal milieu at the time of breast cancer surgery on survival in premenopausal women.     

The menstrual cycle and punitiveness.

Studied the levels of punishment and reliability of punishments/judgments made by menstruating or premenstrual women by having Ss read vignettes of 7 different college disciplinary cases and select a level of punishment. 12 menstrual, 10 premenstrual, and 13 intermenstrual women participated, as did 10 males of comparable age and background. Two additional groups of 7 women each were led to believe they were (1) in the premenstrual phase or (2) still several days away from it. Findings show that punitiveness and reliability of judgments did not differ across menstrual phases or between males and females. The task was perceived as more difficult by males and by females led to believe they were premenstrual. A relationship was found between severity of menstrual symptoms and punitiveness. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The menstrual cycle and typing skill: An ecologically-valid test of the "raging hormones" hypothesis.

Tested the "raging hormones" hypothesis, which states that the performance of women is periodically impaired during the perimenstruum. The typing skill of 9 female professional typists (aged 24–40 yrs) was evaluated at work with the use of typing tests administered at intervals throughout the menstrual cycle. There was no variation in typing performance as a function of the menstrual cycle for errors or rate of typing. Moreover, no variation of self-reported mood with the menstrual cycle was observed. Findings refute the view that work performance, at least for a skilled perceptual-motor task, is impaired at any phase of the menstrual cycle. (French abstract) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Thermic effect of food during each phase of the menstrual cycle

The effect of the menstrual cycle on the thermic effect of food (TEF) was examined in eight healthy, normal-weight [mean +/- SD: 56.1 +/- 5.6 kg and body mass index (in kg/m2) 21.3 +/- 1.8] women aged 22-38 y. Their lean body mass and fat mass were 39.4 +/- 2.7 kg and 16.9 +/- 6.5 kg, respectively. TEF was measured on 4 separate days selected to match the four phases of a menstrual cycle: early follicular, follicular, luteal, and late luteal. The volunteers consumed a 3138-kJ liquid meal (54.5% carbohydrate, 14.0% protein, and 31.5% fat) on each test day. Resting metabolic rate was measured for 55 min before the meal and every 30 min after the start of the meal for 205 min. Although resting metabolic rate remained unchanged, there was a significant difference (P < 0.01 by ANOVA) in mean (+/- SEM) values for TEF among the four phases of the cycle: 0.94 +/- 0.05 kJ/min during the early follicular phase, 0.86 +/- 0.09 kJ/min during the follicular phase, 0.70 +/- 0.10 kJ/min during the luteal phase, and 0.76 +/- 0.07 kJ/min during the late luteal phase. TEF decreased significantly (P < 0.025 by paired t test) during postovulation (average of luteal and late luteal phases), when it was 0.73 +/- 0.07 kJ/min, compared with preovulation (average of early follicular and follicular phases), when it was 0.90 +/- 0.06 kJ/min. In conclusion, TEF decreased during the luteal phase of the menstrual cycle, possibly as a result of impairment of glucose uptake and slower transit of food through the upper gastrointestinal tract.     

On sex differences in spatial abilities.

The present author agrees with the suggestions by P. J. Caplan et al (see record 1986-10956-001) that sex differences in average performance on spatial tasks are often modest in magnitude and inconsistent from one task to another and that spatial ability is not a unitary construct; however, their contentions that sex differences in spatial abilities are nonexistent and that the concept of spatial abilities is not sufficiently valid as to allow meaningful investigation of sex differences are challenged. (5 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Serum levels of the pregnancy zone protein during the normal menstrual cycle

pregnancy zone protein (PZ), low polar estrogen, progesteorne, luteinizing hormone, and follicle stimulating hormone levels during normal menstrual cycles were studied. Serum samples were taken from 12 healthy women of different ages throughout their menstrual cycle. PZ levels showed no significant pattern and no statistically significant association was shown between PZ levels and any of the hormones. PZ levels were higher in older women and varied within each women's cycle. The study results indicate that peak estrogen levels during the menstrual cycle are not sufficient in duration or magnitude to cause increased serum levels of PZ.     

Endometrial cytology during menstrual cycle, menopause and progestinic treatment

The AA. examined 72 cytological smears of the human normal endometrium. Twenty-three were taken during the proliferative phase, 17 during the secretory phase, 21 during menopause and 11 during estro-progestinic treatment. The study pointed out that the endometrial smear, which has been employed up to now almost exclusively in the cyto-oncological field, is also quite suitable for a dynamic cyto-functional evaluation of ovarian function, because of the series of interpretative elements, easily and readily identifiable at the microscope, which it furnishes.     

Ethnic differences in the length of the menstrual cycle during the postmenarcheal period

In 1989, 125 African-American and 123 European-American girls aged 12-14 years were enrolled in a 2-year study in which they maintained a menstrual calendar, recording the date and amount of menstrual bleeding. Weight, exercise, and stress during the previous week were recorded at the start of each menstrual cycle. Although only minor ethnic differences were observed in expected cycle length (29.3 vs. 28.8 days for European-American and African-American girls, respectively), more prominent differences were observed in the between-subjects standard deviation of cycle length (2.9 vs. 2.2 days, respectively) and in the odds of having a cycle longer than 45 days (odds ratio=1.86, 95% confidence interval 1.17-2.97) for European-American compared with African-American girls. Low weight for height and high levels of exercise increased the probability of having a cycle longer than 45 days and decreased expected cycle length of 13- to 45-day cycles. Additional investigation of potential ethnic differences in menstrual cycle characteristics is warranted.     

Endometrial glandular proliferation and estrogen receptor content during the normal menstrual cycle

The 5' untranslated region of an RNA molecule is thought to play an important role in the regulation of translation. Following a recent report that a single nucleotide is sufficient to act in this role in the unicellular organism Giardia, we show that this is also the case for a mammalian in vitro system. These results also demonstrate that an RNA can initiate translation from a start codon where an ideal translational consensus sequence is impossible.     

Endocrine regulation of the menstrual cycle

Physiological data concerning the serum concentrations and the pituitary content of varian steroids and gonadotropins, respectively, are reviewed. On the basis of these physiological data results from experimental studies are critically evaluated as far as their significance for the understanding of the physiology of the cycle is concerned. Data from the literatur and results from own studies are incorporated in a concept of the endocrine regulation of the human menstrual cycle.     

Changes in cognitive task performance across the menstrual cycle.

Examined the effect on cognitive tests of menstrual-cycle-related changes in estrogen in 87 undergraduates. The estrogen peak was expected to facilitate performance of 4 "automatized" tasks and to impair performance of "perceptual-restructuring" tasks, compared with performance in the postovulatory phase when progesterone is thought to counteract the action of estrogen. Daily basal body temperature (BBT) records suggested that 21 Ss did not ovulate in the cycle(s) studied. No main effect of Day 10 of the cycle vs Day 20 occurred for any task in the 66 Ss who did appear to ovulate. However, the magnitude of predicted shifts in performance was significantly correlated with proximity of the "Day 10" testing day to the lowest BBT, the presumed preovulatory estrogen peak; and to the "Day 20" proximity to the highest BBT, the presumed progesterone peak. Ss tested 3 or fewer days before the thermal nadir and on or after the thermal peak had the predicted significant changes on 3 of the 4 tasks. Results support the hypotheses and indicate that precise timing is essential to demonstrate the phenomena. (31 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Endocrine, cardiovascular, and psychological correlates of olfactory sensitivity changes during the human menstrual cycle.

Established signal detection measures of olfactory sensitivity (d′) and measures of blood pressure, heart rate, body temperature, nasal airflow, and respiration rate in test sessions held across 17 menstrual cycles of 9 females not taking oral contraceptives, 6 menstrual cycles of 3 females taking oral contraceptives, and 6 equivalent time periods of 3 males. Ss were between the ages of 18 and 37. In addition, plasma levels of luteinizing hormone, follicle stimulating hormone, estrone, estradiol, progesterone, and testosterone and responses to the Moos Menstrual Distress Questionnaire (MDQ) were established. Peaks in olfactory sensitivity were noted during the 2nd half of menses, midcycle, and midluteally in females taking and not taking oral contraceptives. The lack of correlation between the fluctuations in d′ and the circulating hormone levels in Ss using oral contraceptives suggests that factors other than gonadal hormones were responsible for these changes. Significant fluctuations were also noted across the cycle phases of the normally cycling females for all the hormones examined, as well as for body temperature, nasal airflow, and the MDQ Water Retention and Pain scales. (74 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)