When to start cholesterol-lowering therapy in patients with coronary heart disease. A statement for healthcare professionals from the American Heart Association Task Force on Risk Reduction

At present a large number of patients with atherosclerotic disease are not receiving aggressive cholesterol-lowering therapy. Consequently they are being deprived of a cost-effective, risk-reducing treatment. Every physician who treats patients with clinical atherosclerotic disease should become fully informed about the results of cholesterol-lowering trials in patients at high risk. All physicians who care for high-risk patients should take responsibility for cholesterol management, including primary care physicians and cardiovascular specialists. Highly effective and generally safe drugs for cholesterol lowering are available. The benefits of therapy for reducing recurrent CHD and prolonging life are considerable. There is no justification for unduly delaying institution of therapy for the majority of patients. The many advantages of nonpharmaceutical therapy call for its use in almost all patients, but drug treatment should not be postponed if the target for LDL cholesterol lowering (< or = 100 mg/dL) is unlikely to be achieved in the near term by a nonpharmaceutical approach alone. The view that patients with CHD or other forms of atherosclerotic disease do not receive substantial clinical benefits from aggressive cholesterol-lowering therapy is no longer warranted. Intensive cholesterol reduction, initiated immediately, has the potential to significantly reduce both morbidity and mortality. Cholesterol-lowering therapy thus should become a routine part of clinical management to reduce risk of future coronary events and to prolong life in patients with CHD or other forms of atherosclerotic disease.     

Evidence of a Time-Dependent Long-Term Stage of Memory for a Spatial Learning Task in the Chick (Callus gallus).

The generalizability of temporal parameters of memory formation previously observed for a passive avoidance task was investigated in a spatial task with day-old chicks (Callus gallus). The percentage improvement in completion time over 2 separate trials was measured, and chicks were found to complete the second trial faster at all times tested up to 2 hr, except at 55 min posttraining. In addition, retention at 120 min, but not at 30 min, posttraining was found to be impaired by protein synthesis inhibition. These findings are consistent with the timing of a long-term stage of memory formation following passive avoidance training, implying that there may be some hardwiring to the temporal characteristics of memory formation in this species. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Separating trait effects from trait-specific method effects in multitrait-multimethod models: A multiple-indicator CT-C(M-1) model.

An overview of several models of confirmatory factor analysis for analyzing multitrait-multimethod (MTMM) data and a discussion of their advantages and limitations are provided. A new class of multi-indicator MTMM models combines several strengths and avoids a number of serious shortcomings inherent in previously developed MTMM models. The new models enable researchers to specify and to test trait-specific-method effects. The trait and method concepts composing these models are explained in detail and are contrasted with those of previously developed MTMM models for multiple indicators. The definitions of the models are explained step by step, and a practical empirical application of the models to the measurement of 3 traits x 3 methods is used to demonstrate their advantages and limitations. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Taste potentiation of auditory aversions in rats (Rattus norvegicus): A case for spatial contiguity.

Examined whether an auditory stimulus, which is not likely to be associated with food in rats, could be potentiated by taste and whether spatial contiguity is a necessary requirement for this effect. Ss were 13 male and 42 female Sprague-Dawley rats. An aversion for an auditory stimulus was established in Ss when a tone was spatially and temporally contiguous with a novel taste in a food CS compound followed by toxicosis. The procedure involved varying the location of the tone relative to a novel-tasting food. During toxicosis conditioning, 1 group ate sweet food with a speaker located in the food, 2 groups ate sweet food with the speaker displaced (near or far) from the food, and a 4th group was presented with a tone without food available. It was found that the potentiation of auditory aversions required both the presence of a novel taste and spatial contiguity between the taste and the tone. (16 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Sensitivity to change of generic quality of life instruments in patients with rheumatoid arthritis: preliminary findings in the generic health OMERACT study. OMERACT/ILAR Task Force on Generic Quality of Life. Life Outcome Measures in Rheumatology. International League of Associations for Rheumatology

In order to investigate intraspecific differences in Loxosceles intermedia spider venom we compared some biological properties of male and female venoms. Females produced higher amounts of venom than males. Furthermore, female venom presented more potent dermonecrotic and complement-dependent activities than male venom. Interestingly, the F35 toxin, a dermonecrotic and complement-dependent haemolytic factor, was also present in greater amounts in female venom, as demonstrated by ELISA. Therefore, the higher production and increased toxicity of venom in female specimens as compared to males may contribute to the variability observed in the severity of envenoming caused by L. intermedia spiders.     

Interference from irrelevant features on visual discrimination by macaques (Macaca fuscata): A behavioral analogue of the human Stroop effect.

To study the operation of selective attention in a conflict situation with automatic processes, we trained 4 Japanese macaques; (Macaca fuscata) extensively on a manual go/no-go task. The monkey had to discriminate either the color, shape, motion direction, or location of a visual stimulus. In each trial, the behavioral meaning of the relevant feature (go or no-go) could either be congruent or incongruent with irrelevant features of the same stimulus. Reaction times were slowed, and error rates increased when irrelevant stimulus features were incongruent with the required response. The effects were obtained when the monkey attended to the color, shape, or motion direction, but not when it attended to the location of the stimulus. The effects were cumulative so that the interference from 1 incongruent feature was smaller than that from 2 incongruent features. We propose that the present paradigm provides a behavioral analogue of the human Stroop effect. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Auditory scene analysis in Estrildid finches (Taeniopygia guttata and striata domestica): A species advantage for detection of conspecific song.

Operant-conditioning techniques were used to investigate the ability of zebra finches (Taeniopygia guttata) and Bengalese finches (Lonchura striata domestica) to detect a zebra finch or a Bengalese finch target song intermixed with other birdsongs. Sixteen birds were trained to respond to the presence of a particular target song, either of their own species (n?=?8) or of another species (n?=?8). The birds were able to learn a discrimination between song mixtures that contained a target song and song mixtures that did not, and they were able to maintain their response to the target song when it was mixed with novel songs. Zebra finches, but not Bengalese finches, learned the discrimination with a conspecific target more quickly and were worse at detecting a Bengalese finch in the presence of a conspecific song. The results indicate that selective attention to birdsongs within an auditory scene is related to their biological relevance. (PsycINFO Database Record (c) 2010 APA, all rights reserved)