共查询到20条相似文献,搜索用时 15 毫秒
1.
Wilson Robert S.; Beckett Laurel A.; Barnes Lisa L.; Schneider Julie A.; Bach Julie; Evans Denis A.; Bennett David A. 《Canadian Metallurgical Quarterly》2002,17(2):179
The authors examined change in cognitive abilities in older Catholic clergy members. For up to 6 years, participants underwent annual clinical evaluations, which included a battery of tests from which summary measures of 7 abilities were derived. On average, decline occurred in each ability and was more rapid in older persons than in younger persons. However, wide individual differences were evident at all ages. Rate of change in a given domain was not strongly related to baseline level of function in that domain but was moderately associated with rates of change in other cognitive domains. The results suggest that change in cognitive function in old age primarily reflects person-specific factors rather than an inevitable developmental process. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
2.
A theory concerning the etiology of age-related cognitive decline, like Alzheimer's disease (AD), is presented. The view utilizes the idea that this form of dementia is a etiologically complex and heterogeneous brain disorder that is caused by various co-factors. A particular patient with AD would have some combination of these co-factors present but the exact type and combinations might be different from another patient. This theory could also be used to explain other forms of dementia and age-related cognitive decline and the differences in severity of memory impairments associated with each. The co-factors in the present model include genes, neurotransmitter changes, vascular abnormalities, stress hormones, circadian rhythms, head trauma, and seizures. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
3.
Gerstorf Denis; Ram Nilam; Hoppmann Christiane; Willis Sherry L.; Schaie K. Warner 《Canadian Metallurgical Quarterly》2011,47(4):1026
Life span researchers have long been interested in how and why fundamental aspects of human ontogeny differ between cohorts of people who have lived through different historical epochs. When examined at the same age, later born cohorts are often cognitively and physically fitter than earlier born cohorts. Less is known, however, about cohort differences in the rate of cognitive aging and if, at the very end of life, pervasive mortality-related processes overshadow and minimize cohort differences. We used data on 5 primary mental abilities from the Seattle Longitudinal Study (Schaie, 2005) to compare both age-related and mortality-related changes between earlier born cohorts (1886–1913) and later born cohorts (1914–1948). Our models covary for several individual and cohort differences in central indicators of life expectancy, education, health, and gender. Age-related growth models corroborate and extend earlier findings by documenting level differences at age 70 of up to 0.50 SD and less steep rates of cognitive aging on all abilities between 50 and 80 years of age favoring the later born cohort. In contrast, mortality-related models provide limited support for positive cohort differences. The later born cohort showed steeper mortality-related declines. We discuss possible reasons why often reported positive secular trends in age-related processes may not generalize to the vulnerable segment of the population that is close to death and suggest routes for further inquiry. (PsycINFO Database Record (c) 2011 APA, all rights reserved) 相似文献
4.
Hamilton Joanne M.; Salmon David P.; Galasko Douglas; Raman Rema; Emond Jenn; Hansen Lawrence A.; Masliah Eliezer; Thal Leon J. 《Canadian Metallurgical Quarterly》2008,22(6):729
Dementia with Lewy bodies (DLB) is often characterized by pronounced impairment in visuospatial skills, attention, and executive functions. However, the strength of the phenotypic expression of DLB varies and may be weaker in patients with extensive concomitant Alzheimer's disease (AD). To determine whether strength of the DLB clinical phenotype impacts cognitive decline, visuospatial and language tests were retrospectively used to predict 2-year rate of global cognitive decline in 22 autopsy-confirmed DLB patients (21 with concomitant AD) and 44 autopsy-confirmed "pure" AD patients. Generalized estimating equations (GEE) revealed a significant interaction such that poor baseline performances on tests of visuospatial skills were strongly associated with a rapid rate of cognitive decline in DLB but not AD (p 相似文献
5.
There are many reports of relations between age and cognitive variables and of relations between age and variables representing different aspects of brain structure and a few reports of relations between brain structure variables and cognitive variables. These findings have sometimes led to inferences that the age-related brain changes cause the age-related cognitive changes. Although this conclusion may well be true, it is widely recognized that simple correlations are not sufficient to warrant causal conclusions, and other types of correlational information, such as mediation and correlations between longitudinal brain changes and longitudinal cognitive changes, also have limitations with respect to causal inferences. These issues are discussed, and the existing results on relations of regional volume, white matter hyperintensities, and diffusion tensor imaging measures of white matter integrity to age and to measures of cognitive functioning are reviewed. It is concluded that at the current time the evidence that these aspects of brain structure are neuroanatomical substrates of age-related cognitive decline is weak. The final section contains several suggestions concerning measurement and methodology that may lead to stronger conclusions in the future. (PsycINFO Database Record (c) 2011 APA, all rights reserved) 相似文献
6.
Experience in a domain can sometimes offset cognitive declines that occur with aging. Using a series of neural network simulations of learning chess opening positions, the authors investigated how structured knowledge in a distributed representation may influence age-related declines. Aging manipulations implemented as modulations of neural noise showed increased knowledge as being protective of performance on a chess memory span task, whereas changes in neural plasticity and neural loss lead to main effects without interactions and steeper declines for the initially more able. The models could also simulate the increase in variability in older groups. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
7.
Finkel Deborah; Reynolds Chandra A.; McArdle John J.; Gatz Margaret; Pedersen Nancy L. 《Canadian Metallurgical Quarterly》2003,39(3):535
Latent growth models were applied to data from the Swedish Adoption/Twin Study of Aging to discover if the rate of change in cognitive performance increased from middle age to later adulthood. The sample included 590 participants aged 44 to 88 years at first measurement. Data were gathered at 2 follow-up occasions at intervals of 3 years. Cognitive ability was assessed through 11 tests that tapped crystallized, fluid, memory, and spatial abilities and perceptual speed. Results indicated stability for measures of crystallized ability, linear age changes for many cognitive abilities, and a significant acceleration in linear decline after age 65 for measures with a large speed component. Gender differences were found only in mean level, not in rate of decline. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
8.
Although age-related deficits in emotion recognition have been widely explored, the nature and scope of these deficits remain poorly understood. We conducted two experiments to examine whether these deficits are less pronounced when older adults evaluate dynamic compared with static images, and second, whether age-related cognitive decline exacerbates these deficits. Our results suggest that age-related cognitive decline exacerbates older adults' deficits in detecting anger, but only from static faces. Furthermore, older adults do not show emotion recognition deficits when evaluating global emotions from dynamic images of faces. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
9.
Performance on complex, cognitive tasks often is sensitive to low-level sensory and perceptual factors. These relations are particularly important for cognitive aging researchers because aging is associated with a variety of changes in sensory and perceptual function. In this article, the author first selectively outlines some relations between task performance and sensory function. Next, the author summarizes age-related changes in visual function and the implications of these changes for task performance, using the digit-symbol subtest of the Wechsler Adult Intelligence Test as an example. Then the author offers some reasons why age-related sensory decline may not be important to all cognitive tasks. Finally, several recommendations are offered for cognitive gerontologists who want to minimize the risk that the age differences they observe are sensory in nature. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
10.
De Santi Susan; Pirraglia Elizabeth; Barr William; Babb James; Williams Schantel; Rogers Kimberley; Glodzik Lidia; Brys Miroslaw; Mosconi Lisa; Reisberg Barry; Ferris Steven; de Leon Mony J. 《Canadian Metallurgical Quarterly》2008,22(4):469
The aim of the study was to compare the performance of Robust and Conventional neuropsychological norms in predicting clinical decline among healthy adults and in mild cognitive impairment (MCI). The authors developed Robust baseline cross sectional and longitudinal change norms from 113 healthy participants retaining a normal diagnosis for at least 4 years. Baseline Conventional norms were separately created for 256 similar healthy participants without follow-up. Conventional and Robust norms were tested in an independent cohort of longitudinally studied healthy (n=223), MCI (n=136), and Alzheimer's disease (AD, n=162) participants; 84 healthy participants declined to MCI or AD (NL→DEC), and 44 MCI declined to AD (MCI→AD). Compared to Conventional norms, baseline Robust norms correctly identified a higher proportion of NL→DEC with impairment in delayed memory and attention-language domains. Both norms predicted decline from MCI→AD. Change norms for delayed memory and attention-language significantly incremented baseline classification accuracies. These findings indicate that Robust norms improve identification of healthy individuals who will decline and may be useful for selecting at-risk participants for research studies and early interventions. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
11.
L?vdén Martin; Bergman Lars; Adolfsson Rolf; Lindenberger Ulman; Nilsson Lars-G?ran 《Canadian Metallurgical Quarterly》2005,20(2):303
This study has 2 objectives: (a) to explore typical paths of cognitive development associated with aging, terminal decline, and dementia and (b) to promote and illustrate an individual-oriented approach to the study of cognitive aging based on longitudinal panel data from a population-based sample (N = 500; age rangeT1= 60-80, where T refers to time) tested at 3 occasions 5 years apart. Results document interindividual differences in multivariate patterns of change. Although cognitive changes generally covary, the present study indicates that subgroups of individuals develop along different paths characterized by selective changes in subsets of cognitive functions. Typical progression of dementia followed a developmental cascade from low declarative memory, via low functioning across all observed cognitive measures, to dementia diagnosis, and finally, death. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
12.
Bielak Allison A. M.; Hultsch David F.; Strauss Esther; MacDonald Stuart W. S.; Hunter Michael A. 《Canadian Metallurgical Quarterly》2010,25(3):575
In this study, the authors addressed the longitudinal nature of intraindividual variability over 3 years. A sample of 304 community-dwelling older adults, initially between the ages of 64 and 92 years, completed 4 waves of annual testing on a battery of accuracy- and latency-based tests covering a wide range of cognitive complexity. Increases in response-time inconsistency on moderately and highly complex tasks were associated with increasing age, but there were significant individual differences in change across the entire sample. The time-varying covariation between cognition and inconsistency was significant across the 1-year intervals and remained stable across both time and age. On occasions when intraindividual variability was high, participants' cognitive performance was correspondingly low. The strength of the coupling relationship was greater for more fluid cognitive domains such as memory, reasoning, and processing speed than for more crystallized domains such as verbal ability. Variability based on moderately and highly complex tasks provided the strongest prediction. These results suggest that intraindividual variability is highly sensitive to even subtle changes in cognitive ability. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
13.
Tucker-Drob Elliot M.; Johnson Kathy E.; Jones Richard N. 《Canadian Metallurgical Quarterly》2009,45(2):431
The term cognitive reserve is frequently used to refer to the ubiquitous finding that, during later life, those higher in experiential resources (e.g., education, knowledge) exhibit higher levels of cognitive function. This observation may be the result of either experiential resources playing protective roles with respect to the cognitive declines associated with aging or the persistence of differences in functioning that have existed since earlier adulthood. These possibilities were examined by applying accelerated longitudinal structural equation (growth curve) models to 5-year reasoning and speed data from the no-contact control group (N = 690; age 65–89 years at baseline) of the Advanced Cognitive Training for Independent and Vital Elderly study. Vocabulary knowledge and years of education, as markers of cognitive reserve, were related to levels of cognitive functioning but unrelated to rates of cognitive change, both before and after the (negative) relations between levels and rates were controlled for. These results suggest that cognitive reserve reflects the persistence of earlier differences in cognitive functioning rather than differential rates of age-associated cognitive declines. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
14.
Kemper Susan; Greiner Lydia H.; Marquis Janet G.; Prenovost Katherine; Mitzner Tracy L. 《Canadian Metallurgical Quarterly》2001,16(2):227
The present study examines language samples from the Nun Study. Measures of grammatical complexity and idea density were obtained from autobiographies written over a 60-year span. Participants who had met criteria for dementia were contrasted with those who did not. Grammatical complexity initially averaged 4.78 ( on a 0-to-7-point scale) for participants who did not meet criteria for dementia and declined .04 units per year; grammatical complexity for participants who met criteria for dementia initially averaged 3.86 and declined .03 units per year. Idea density averaged 5.35 propositions per 10 words initially for participants who did not meet criteria for dementia and declined an average of .03 units per year, whereas idea density averaged 4.34 propositions per 10 words initially for participants who met criteria for dementia and declined .02 units per year. Adult experiences, in general, did not moderate these declines. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
15.
Objective: Although neurocognitive functions are known to decline normatively with adult age, there is a common belief that everyday functions (e.g., paying bills, following medication instructions, making change, looking up telephone numbers in a phone book) are unaffected by these changes. Method: This hypothesis was examined by applying longitudinal growth models to data from a community-based sample of 698 adults (ages 65 to 94 years and living independently at baseline) who were repeatedly measured over five years on neurocognitive tests of executive reasoning, episodic memory, and perceptual speed, and on a number of tasks that adults should be reasonably expected to be able to perform in their day-to-day lives. Results: Individual differences in changes in neurocognitive performance were strongly correlated with individual differences in changes in performance on the everyday tasks. Alternatively, changes in self-reports of everyday functions were only weakly correlated with changes in performance on the neurocognitive tests and the everyday tasks. Conclusions: These results together suggest that normative neurocognitive aging has substantial consequences for the daily lives of older adults and that both researchers and clinicians should be cautious when interpreting self-reports of everyday functioning. (PsycINFO Database Record (c) 2011 APA, all rights reserved) 相似文献
16.
Allen Philip A.; Hall Rosali J.; Druley Jennifer A.; Smith Albert F.; Sanders Raymond E.; Murphy Martin D. 《Canadian Metallurgical Quarterly》2001,16(3):532
Several theories have suggested that age-related declines in cognitive processing are due to a pervasive unitary mechanism, such as a decline in processing speed. Structural equation model tests have shown some support for such common factor explanations. These results, however, may not be as conclusive as previously claimed. A further analysis of 4 cross-sectional data sets described in T. Salthouse, D. Hambrick, and K. McGuthry (1998) and T. Salthouse and S. Czaja (2000) found that although the best fitting model included a common factor in 3 of the data sets, additional direct age paths were significant, indicating the presence of specific age effects. For the remaining data set, a factor-specific model fit at least as well as the best fitting common factor model. Three simulated data sets with known structure were then tested with a sequence of structural equation models. Common factor models could not always be falsified-even when they were false. In contrast, factor-specific models were more easily falsified when the true model included a unitary common factor. These results suggest that it is premature to conclude that all age-related cognitive declines are due to a single mechanism. Common factor models may be particularly difficult to falsify with current analytic procedures. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
17.
Mungas Dan; Beckett Laurel; Harvey Danielle; Tomaszewski Farias Sarah; Reed Bruce; Carmichael Owen; Olichney John; Miller Joshua; DeCarli Charles 《Canadian Metallurgical Quarterly》2010,25(3):606
This study examined trajectories of cognitive change in psychometrically matched measures of episodic memory, semantic memory, and executive function in an ethnically, demographically, and cognitively diverse sample of older persons. Individual rates of change showed considerable heterogeneity in each domain. Baseline clinical diagnosis predicted differential change in semantic memory and executive function, dementia > mild cognitive impairment (MCI) > normal, but average decline in verbal episodic memory was similar across all 3 diagnostic groups. There was substantial overlap of distributions of cognitive change across baseline diagnostic groups for all 3 measures. Cognitive change was strongly related to change in clinical diagnosis. Rapid and similar change was present for all 3 cognitive measures in patients with dementia and in those with normal cognition and those with MCI who progressed clinically. In cognitively normal patients, verbal episodic memory change was greater than change in the other two domains. Global status, measured by the Clinical Dementia Rating scale (Morris, 1993), predicted change in semantic memory and executive function, whereas APOE genotype predicted change in verbal episodic memory, and age had no effect on rates of change in any domain independent of global status and APOE. Results show important limitations in using cross-sectional diagnosis to predict prognosis and suggest that research to identify robust predictors of cognitive change across the full spectrum from normal to dementia is needed for better early identification of diseases that cause progressive decline. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
18.
Sharp Emily Schoenhofen; Reynolds Chandra A.; Pedersen Nancy L.; Gatz Margaret 《Canadian Metallurgical Quarterly》2010,25(1):60
The purpose of this study was to examine whether openness to experience is related to longitudinal change in cognitive performance across advancing age. Participants were 857 individuals from the Swedish Adoption/Twin Study of Aging (SATSA). Factors for 5 cognitive domains were created, including verbal ability, spatial ability, memory, processing speed, and a global score, g. Latent growth curve models were used to assess level and longitudinal trajectories of cognitive performance. It was hypothesized that individuals who endorsed higher levels of openness would have higher cognitive test scores and lesser rates of cognitive decline. As predicted, higher openness to experience was associated with significantly higher performance across all cognitive tests for both men and women even after adjusting for education, cardiovascular disease, and activities of daily living. Openness, however, was not predictive of differences in the trajectories of cognitive performance over age. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
19.
Burgmans Saartje; van Boxtel Martin P. J.; Vuurman Eric F. P. M.; Smeets Floortje; Gronenschild Ed H. B. M.; Uylings Harry B. M.; Jolles Jelle 《Canadian Metallurgical Quarterly》2010,24(2):264
Burgmans et al. (2009) stated that the prevalence of cortical gray matter atrophy may be overestimated in the healthy aging brain, because the inclusion of participants with preclinical cognitive pathology might have been responsible for the age effects found in previous studies. Fjell et al. (2010) and Raz and Lindenberger (2010) verified this statement by reanalyzing previously published data. They both argue that it is unlikely that preclinical cognitive pathology explains cortical gray matter atrophy in healthy aging. Burgmans et al. (2010) respond to these commentaries. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
20.
Bielak Allison A. M.; Gerstorf Denis; Kiely Kim M.; Anstey Kaarin J.; Luszcz Mary 《Canadian Metallurgical Quarterly》2011,26(3):576
Depressive symptoms and cognitive decline are associated in older age, but research is inconsistent about whether one condition influences the development of the other. We examined the directionality of relations between depressive symptoms and perceptual speed using bivariate dual change score models. Assessments of depressive symptoms and perceptual speed were completed by 1,206 nondemented older adults at baseline, and after 2, 8, 11, and 15 years. After controlling for age, education, baseline general cognitive ability, and self-reported health, allowing depressive symptoms to predict subsequent change in perceptual speed provided the best fit. More depressive symptoms predicted subsequently stronger declines in perceptual speed over time lags of 1 year. (PsycINFO Database Record (c) 2011 APA, all rights reserved) 相似文献