浅谈丁苯橡胶装置丁二烯脱阻聚剂系统夹带问题

浅谈丁苯橡胶装置丁二烯脱阻聚剂系统夹带问题任军（齐鲁石油化工公司橡胶厂,淄博,２５５４３８）１工艺流程在丁二烯脱阻聚剂叔丁基邻苯二酚（ＴＢＣ）滗析器（ＤＥ－１０１）中装有１０％ＮａＯＨ,混合丁二烯与ＮａＯＨ经限流孔板进入ＤＥ－１０１脱除混合丁二烯中Ｔ...     

乙腈法丁二烯装置新阻聚剂技术应用

金兴化工厂乙腈法丁二烯装置采用亚硝酸钠、TBC和E 331、B 590阻聚剂相结合的使用方法,阻聚效果较好,有效地解决了装置丁二烯聚合问题,自2006年装置使用至今,减少了机泵的堵塞次数,装置的生产周期由1年延长至3年。     

新型阻聚剂在乙腈法丁二烯萃取系统中的应用

分析了中韩(武汉)石油化工有限公司130 kt/a乙腈法抽提丁二烯装置萃取系统堵塞原因,以及丁二烯自聚物的产生及阻聚机理,检修后在萃取系统的缓冲罐中加入新型阻聚剂Petroflo 20 Y3103,其用量为2.79 kg/h,但在注入初期阻聚剂用量为正常用量的2倍,待其在溶剂中含量达到180 mg/kg后恢复到正常用量。结果表明,机泵清理过滤网频率明显降低,装置生产周期延长。     

丁二烯抽提装置的技术改进

本文摘要叙述了大庆丁二烯抽提装置自开工以来,通过消化吸收引进设备的技术特点,探索装置运行中的规律,解决生产技术难题的独特方法,从工艺参数的优化、工艺流程的改进和设备改造入手,增强装置运行可靠性,节能降耗,提高经济效益的一些经验。     

协同阻聚剂Styrex 310在苯乙烯装置的应用

随着人们对生活环境和企业对经济效益的不断关注,苯乙烯精馏阻聚剂开始向低毒、高阻聚性能方面发展,10万吨/年苯乙烯装置对协同阻聚剂的成功应用,为其它苯乙烯装置对这种新型阻聚剂的应用起到了示范作用.     

碳三阻聚剂的注入优化

碳三阻聚剂的注入是保证乙烯装置长周期运行的关键因素之一。如何根据实际情况优化碳三阻聚剂的注入，延长相关设备的运行周期，是值得关注的问题。文中从结垢的机理出发，提出了优化碳三阻聚剂注入的方法并予以实施，取得了一定的效果。     

优化丁二烯装置提高装置经济效益

本文从4个方面分析了扬子石化烯烃厂丁二烯装置的优化改造。优化改造后,延长了运行周期,提高了生产负荷及自动化水平,降低了生产成本,进而增强了装置的盈利能力。     

丁二烯抽提装置自聚物的预防

在不断的实践和探索过程中,对丁二烯自聚物、过氧化物的产生、危害及预防上认识也是逐渐加深的。丁二烯自聚物的存在不仅增大了单体消耗,而且往往堵塞设备、管线、阀门等,影响装置的长周期运行,严重时,会使设备损坏,造成火灾爆炸等恶性事故,对安全生产威胁极大。因此,为了确保安全、稳定、长周期、满负荷生产,必须采取积极措施,防止丁二烯自聚物的形成。本文旨在根据本套装置实际,结合日常生产管理上的一些做法,对长周期开车过程中防止丁二烯自聚物生成的预防做进一步探讨。     

Combinatorial Pharmacophore-Based 3D-QSAR Analysis and Virtual Screening of FGFR1 Inhibitors

The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) signaling pathway plays crucial roles in cell proliferation, angiogenesis, migration, and survival. Aberration in FGFRs correlates with several malignancies and disorders. FGFRs have proved to be attractive targets for therapeutic intervention in cancer, and it is of high interest to find FGFR inhibitors with novel scaffolds. In this study, a combinatorial three-dimensional quantitative structure-activity relationship (3D-QSAR) model was developed based on previously reported FGFR1 inhibitors with diverse structural skeletons. This model was evaluated for its prediction performance on a diverse test set containing 232 FGFR inhibitors, and it yielded a SD value of 0.75 pIC₅₀ units from measured inhibition affinities and a Pearson’s correlation coefficient R² of 0.53. This result suggests that the combinatorial 3D-QSAR model could be used to search for new FGFR1 hit structures and predict their potential activity. To further evaluate the performance of the model, a decoy set validation was used to measure the efficiency of the model by calculating EF (enrichment factor). Based on the combinatorial pharmacophore model, a virtual screening against SPECS database was performed. Nineteen novel active compounds were successfully identified, which provide new chemical starting points for further structural optimization of FGFR1 inhibitors.     

Combination Strategies Involving Immune Checkpoint Inhibitors and Tyrosine Kinase or BRAF Inhibitors in Aggressive Thyroid Cancer

Thyroid cancer is the most common (~90%) type of endocrine-system tumor, accounting for 70% of the deaths from endocrine cancers. In the last years, the high-throughput genomics has been able to identify pathways/molecular targets involved in survival and tumor progression. Targeted therapy and immunotherapy individually have many limitations. Regarding the first one, although it greatly reduces the size of the cancer, clinical responses are generally transient and often lead to cancer relapse after initial treatment. For the second one, although it induces longer-lasting responses in cancer patients than targeted therapy, its response rate is lower. The individual limitations of these two different types of therapies can be overcome by combining them. Here, we discuss MAPK pathway inhibitors, i.e., BRAF and MEK inhibitors, combined with checkpoint inhibitors targeting PD-1, PD-L1, and CTLA-4. Several mutations make tumors resistant to treatments. Therefore, more studies are needed to investigate the patient’s individual tumor mutation burden in order to overcome the problem of resistance to therapy and to develop new combination therapies.     

顺丁橡胶装置丁二烯系统氧含量的控制

通过对大庆石化公司顺丁橡胶装置生产过程的实践和分析,提出几种降低丁二烯系统氧含量的工艺方法和控制手段。从而减少丁二烯系统自聚物的生成,提高装置运行的安全性和稳定性,为装置的长周期运行提供有力保障。     

影响丁二烯装置长周期运行的原因分析

抚顺乙烯化工有限公司丁烯装置在长周期运行后期，会出现许多的问题，对其中有代表性的萃取系统的聚合堵塞和精馏系统丁二烯聚合问题，从工艺生产的角度进行分析，同时提出相应的防范措施，为装置实现二年一修创造条件。     

Analysis of Binding Determinants for Different Classes of Competitive and Noncompetitive Inhibitors of Glycine Transporters

Glycine transporters are interesting therapeutic targets as they play significant roles in glycinergic and glutamatergic systems. The search for new selective inhibitors of particular types of glycine transporters (GlyT-1 and GlyT-2) with beneficial kinetics is hampered by limited knowledge about the spatial structure of these proteins. In this study, a pool of homology models of GlyT-1 and GlyT-2 in different conformational states was constructed using the crystal structures of related transporters from the SLC6 family and the recently revealed structure of GlyT-1 in the inward-open state, in order to investigate their binding sites. The binding mode of the known GlyT-1 and GlyT-2 inhibitors was determined using molecular docking studies, molecular dynamics simulations, and MM-GBSA free energy calculations. The results of this study indicate that two amino acids, Gly373 and Leu476 in GlyT-1 and the corresponding Ser479 and Thr582 in GlyT-2, are mainly responsible for the selective binding of ligands within the S1 site. Apart from these, one pocket of the S2 site, which lies between TM3 and TM10, may also be important. Moreover, selective binding of noncompetitive GlyT-1 inhibitors in the intracellular release pathway is affected by hydrophobic interactions with Ile399, Met382, and Leu158. These results can be useful in the rational design of new glycine transporter inhibitors with desired selectivity and properties in the future.     

丁二烯装置腐蚀、聚合的原因分析及防止措施

在以乙腈作为溶剂生产丁二烯的装置中,由于无法避免O2、铁锈、水等诱发因子的存在,使得丁二烯装置经常面对腐蚀和聚合的难题。本文经过对这些问题的形成和解决方法进行分析,最后对这些共性问题提出一些可行性建议,来提高装置稳定运行。     

几种丁二烯抽提技术的比较

根据上海石洞口煤气制气有限公司利用现有资源及设施条件,拟建一套24kt/a丁二烯抽提装置,通过对DMF,NMP和ACN法进行比较,并结合企业实际情况,推荐采用DMF法。