Bilateral frontal lobe disease and selective delayed response deficits in humans.

Compared the performance of 6 male patients (aged 24–65 yrs) with frontal lobe disease; 17 amnesic male patients (12 with etiology of alcoholic Korsakoff's disease [mean age 53.6 yrs] and 5 with surgically treated ruptured anterior communicating artery aneurysm [mean age 45.6 yrs]), and 12 male alcoholic controls (mean age 39.7 yrs) with no memory impairment on delayed alternation (DA) and delayed response (DR) tasks, known to be sensitive to frontal lobe damage in nonhuman primates. Ss (except the Korsakoff and alcoholic Ss) completed the Wechsler Memory Scale, and all Ss completed the Wechsler Adult Intelligence Scale (WAIS) and the Wisconsin Card Sorting Test. Results show that bilateral frontal lobe damage was associated with impairment on both tasks. There was no relation between performances on DA and DR and performance on the Wechsler Memory Scale, strengthening the suggestion that the former tasks are not sensitive to anterograde amnesia in humans. (41 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Validity of a Draw-A-Person and Bender Gestalt tests as measures of impulsivity with adolescents.

Designated 214 adolescents (aged 12 yrs 1 mo to 18 yrs 9 mo) as impulsive or nonimpulsive (reflective) based on the Matching Familiar Figures Test, a behavior rating scale, and an impulsive behavior checklist. Impulsive and nonimpulsive Ss from the 100 psychiatric inpatients and the 114 junior and senior high school students involved were administered the Draw-A-Person test and the Bender Gestalt Test and were compared to determine signs of impulsivity on these instruments. Results show that impulsivity was highly related to drawing performance on both tests in both groups of Ss. Significant differences were found in mean scores for impulsive and nonimpulsive Ss in both groups. Analysis showed that Draw-A-Person variables were slightly better than Bender Gestalt variables in discriminating among impulsives and nonimpulsives. There was consistently high correlation between the criterion measures of impulsivity in the hospital and school samples. (54 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Recall of pleasant and unpleasant words in depressed subjects.

In Exp I, 20 clinically depressed inpatients (mean age 39.9 yrs), 20 nondepressed inpatients (mean age 42.65 yrs), and 20 nonpatients (mean age 44 yrs) were shown a word list containing pleasant and unpleasant words. One-half of Ss in each group were given free-recall instructions, the other half were asked to rate each word on a pleasantness scale prior to recall. Results show that only depressed Ss given free-recall instructions recalled more unpleasant words than pleasant words. In Exp II, 30 clinically depressed inpatients (mean age 39.33 yrs) were shown a word list consisting of either (1) pleasant and unpleasant words, (2) unpleasant words, or (3) pleasant words. Results show that only Ss receiving the mixed list recalled more unpleasant than pleasant words. Findings support the hypothesis that depressed Ss selectively process unpleasant words and that this processing is at the expense of attention to pleasant words. (20 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Neuropsychological performance and positive and negative symptoms in schizophrenia.

Examined cognitive functions in 11 positive-symptom (mean age 36 yrs), 10 negative-symptom (mean age 33.8 yrs), and 23 mixed-symptom (mean age 31.4 yrs) schizophrenics; 15 bipolar patients (mean age 34.7 yrs); and 12 normal controls (mean age 34.8 yrs) to explore the relation between symptoms and performance. Ss were administered a neuropsychological test battery including the Purdue Pegboard, the Revised Visual Retention Test, and the Block Design subtest of the Wechsler Adult Intelligence Scale—Revised (WAIS—R). Group comparisons revealed generalized deficits in schizophrenics. Positive-symptom schizophrenics scored below normal Ss and negative-symptom Ss on 2 measures tapping verbal memory. Multiple regression analyses revealed that negative symptom ratings were inversely associated with performance on visual-motor tasks, whereas positive symptoms were inversely associated with verbal memory performance. Findings are not consistent with the notion that cognitive deficits are uniquely associated with negative symptoms. Instead, results suggest that there may be specific cognitive correlates of both the positive and negative symptom dimensions. (38 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Bias in a neuropsychological test classification related to education, age, and ethnicity.

159 brain-damaged or non-brain-damaged male inpatients (mean age 47.5 yrs) were classified by the Background Interference Procedure version of the Bender-Gestalt Test. Correctly and incorrectly classified Ss were compared in age, education, IQ, and racial-ethnic group. Differences were consistent with the hypothesis that certain S characteristics would lead to classification as neurologically impaired regardless of neurological condition. (3 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Expectancies, mood, and performance of depressed and nondepressed psychiatric inpatients on chance and skill tasks.

The learned helplessness model of depression predicts that, compared with nondepressed patients, depressed patients will demonstrate psychomotor deficits, provide lower subjective evaluations of their performance, and perceive reinforcement in skill tasks as more response independent. These predictions were tested in 32 depressed (mean age 35 yrs) and 32 nondepressed (mean age 38 yrs) psychiatric inpatients, who had been administered the Quick Test and the Beck Depression Inventory. Ss performed card- and peg-sorting tasks in which measures of performance, ratings of mood and expectancy of success, and subjective evaluations of performance were obtained under chance and skill reinforcement conditions. Although some support was obtained for the prediction that depressives provide lower evaluations of their performance than nondepressives, the other predictions were not supported. Comparisons between depressed and nondepressed schizophrenics indicate that the mood of depressed schizophrenics was especially sensitive to task outcome for both skill and chance conditions. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Verbal and visuospatial performance in male alcoholics: A test of the premature-aging hypothesis.

Tested the premature-aging hypothesis of generalized dysfunction, using a paired-associate learning test that has separate verbal and visuospatial subtests of the same structure and method. Ss were 36 hospitalized White male chronic alcoholics (mean age 42.4 yrs), 36 control Ss (mean age 42.5 yrs), and 24 elderly Ss (mean age 71.4 yrs). Ss were also administered the Shipley Institute of Living Scale for Measuring Intellectual Impairment and Memory-for-Designs test. Results show that elderly control Ss performed significantly worse than middle-aged control Ss on both learning subtests. For Ss between 30 and 80 yrs of age, increasing age resulted in increasing errors. According to the generalized dysfunction hypothesis, the performance of alcoholics should be similar to that of the elderly, showing impairment compared to control Ss on both learning tests. However, alcoholics performed at the same level as the middle-aged control Ss on verbal learning and were significantly poorer on visuospatial learning. The generalized dysfunction version of the premature-aging hypothesis for performance of alcoholics on neuropsychological tests was not supported. (23 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Defective interhemispheric transfer in schizophrenia.

Groups of schizophrenics, nurses, and psychiatric controls were trained to perform a manual shape discrimination task. The 20 schizophrenics included 17 outpatients and 3 short-term inpatients: 10 males (mean age 36 yrs) and 10 females (mean age 37.6 yrs). Nurse control Ss were 10 male (mean age 26.3 yrs) and 10 female (mean age 22 yrs) psychiatric nurses or student nurses. Psychiatric control Ss were 8 males (mean age 36.1 yrs) and 10 females (mean age 32.6 yrs). On both of the tasks included in the experiment, the schizophrenic group, but not the control groups, displayed defective intermanual transfer. The performances of the schizophrenics resembled those previously obtained with split-brain monkeys on similar tasks; therefore, it is concluded that the schizophrenics tested suffered from incomplete transfer of stereognostic shape information from 1 cerebral hemisphere to the other. Experiments suggesting poor interhemispheric transfer on auditory tasks in schizophrenics are discussed along with the possibility that certain schizophrenic symptoms are related to defective interhemispheric communication. (21 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Left hemisphere dysfunction and left hemisphere overactivation in schizophrenia.

Reports 2 experiments relating schizophrenia to functional brain asymmetry. In Exp I, 24 schizophrenics (mean age, 30.8 yrs) were compared to 24 matched controls (mean age, 37.3 yrs) on 2 tachistoscopic tasks (Syllable Test and Dot Location Test) designed to measure verbal and spatial information processing in the 2 hemispheres. Unlike the controls, the schizophrenics showed a right hemisphere superiority both on the verbal and on the spatial tests, indicating left hemisphere dysfunction in the initial processing of verbal information. In Exp II, lateral eye movements, as an index of contralateral hemispheric activation, were measured in a group of 24 paranoid schizophrenics (mean age, 28.9 yrs), 24 nonparanoid schizophrenics (mean age, 32.7 yrs), and 24 matched controls (mean age, 31.2 yrs). The eye movements were elicited by presenting the Ss with verbal neutral, verbal emotional, spatial neutral, and spatial emotional questions. The schizophrenics had significantly more rightward eye movement, compared to controls, regardless of question type, indicating left hemisphere overactivation. Results suggest that schizophrenia is associated with a pattern consisting of both left hemisphere dysfunction and overactivation. (63 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The Seashore Tonal Memory Test as a neuropsychological measure.

Evaluated the sensitivity of the Seashore Tonal Memory Test to impaired brain function and compared it with that of the Halstead-Reitan Neuropsychological Test Battery and the Trail Making Test. Neurologic Ss consisted of 102 individuals (mean age 26.45 yrs) with histories of head trauma or epilepsy, and control Ss consisted of 68 individuals (mean age 27.22 yrs) without histories of neurological problems. In general, the Tonal Memory Test differentiated the normal and neurologic Ss on either an S-by-S or group-by-group basis as well as did the other neuropsychological measures, and without excessive overlap with them. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Cross-modal and intramodal transfer as predictors of mental development in full-term and preterm infants.

25 full-term (FT) and 33 preterm (PT) infants who had participated in studies of cross-modal (CM) and intramodal (IM) transfer at 12 mo of age were seen at older ages to assess the predictive validity of these early measures for later cognition. FT Ss were administered the Bayley Scales of Infant Development at 24 mo of age; PT Ss were administered these scales at 12 and 24 mo of age, the Stanford-Binet Intelligence Scale (Form L-M) at 34 and 40 mo of age, and the Wechsler Intelligence Scale for Children—Revised and the Developmental Test of Visual-Motor Integration at 6 yrs of age. For FT Ss, both 12-mo measures were significantly related to 24-mo Bayley Mental Development Index (MDI) scores; for PT Ss, both 12-mo measures were related not only to 24-mo Bayley MDI but to each subsequent measure of cognitive outcome through 6 yrs. 12-mo IM scores were highly correlated with the 6-yr assessment of visual–motor integration. A measure of object permanence obtained at 12 mo was also related to cognitive outcome, but not so consistently as were the other 2 12-mo measures. Although parental education was a significant predictor beginning at 24 mo, multiple regression analyses indicated that the CM and the IM measures substantially increased the percentage of variance in outcome that could be accounted for by parental education alone. (61 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Hyperactive and hypoxic children: Signal detection, sustained attention, and behavior.

Two parameters from signal detection theory—perceptual sensitivity and decision criterion cutoff scores—were used in the analysis of vigilance performance of 30 hyperactive (mean age 8.5 yrs), 30 hypoxic (mean age 9 yrs), and 47 normal (mean age 8.8 yrs) children. Signal detection analyses of 3 Continuous Performance Test conditions indicated that with increasing age, Ss obtained significantly more hits, fewer false alarms, higher perceptual sensitivity, and responded with greater caution. Overall deficits in signal discrimination (perceptual sensitivity level) were obtained for both the hyperactive and hypoxic Ss when compared to normal age-mates. Whereas the hypoxic Ss demonstrated additional decrements in sustaining attention (sensitivity decrement over time), the hyperactive Ss were impaired by low-response caution, reflecting difficulty inhibiting impulsive responses. Possible differences in hyperactive sample characteristics across studies and time-related recovery factors following hypoxia are discussed. (43 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Neuropsychological stability in multiple sclerosis.

Compared the neuropsychological performances of 14 patients who had multiple sclerosis (MS) and who received repeated testings spaced over time by at least 1 yr with identical evaluations of 14 patients who had neurological involvement but not MS. Ss in each group were individually matched on CA at first testing (38.0 yrs for MS Ss and 37.0 yrs for controls), length of test-retest interval, sex, and years of formal education. Tests included the WAIS, the Wide Range Achievement Test, the Tactual Performance Test, the Seashore Rhythm Test, the Finger Angosia Test, and the Maze Coordination Test among others. Performance decrements attributable to the demyelination process of MS were primarily manifested on tasks requiring motor proficiency or complex sensory discriminations. Tests of higher order cognitive functions (e.g., abstractions, speech perception) were less adversely affected, except for measures having significant motor components. Preliminary MMPI data are also presented. Results indicate relative preservation or only mild deterioration for most intellectual abilities despite worsened motor-sensory functioning. (15 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Conflict in families of adolescents: The impact on cohesion and power structures.

Investigated 3 characteristics (locus, content, and frequency) of conflict (CF) in families of adolescents. Ss were 134 parents and 170 early (mean age 11.5 yrs), 109 middle (mean age 16.3 yrs), and 47 late (mean age 18.7 yrs) adolescents. Ss reported family CF on T. M. Gehring and S. S. Feldman's (see record 1989-14119-001) Family System Test and in an interview. CF in marital (MADs) and parent–adolescent dyads (PADs) was frequently reported. Across adolescence, reports of PAD CF increased, especially those related to autonomy. CF decreased cohesion and changed power relations in the representations of family structure. CF in the MAD was related to decreased cohesion and increased cross-generational coalitions. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Relationship of age and education to Halstead test performance in different patient populations

Examined the effects of age and education on Halstead Neuropsychological Test Battery performance in a cross-validation of the A. Vega and O. A. Parsons's study (see record 1968-01419-001). Ss in the present study were 32 male and 3 female brain-damaged patients (mean age, 34.6 yrs) and 18 male and 7 female non-brain-damaged medical-surgical and psychiatric controls (mean age, 33.2 yrs). Age was significantly correlated with performance on the Category Test, Tactual Performance Test Time, Memory, Location, and the Impairment Index but not with Speech, Rhythm, or Tapping in brain-damaged patients. In medical-surgical and psychiatric patients, however, age was significantly correlated with all Halstead test performances. Education was not significantly correlated with performance in brain-damaged or psychiatric patients but was correlated with 6 Halstead tests in the medical-surgical group. Differences between correlation in psychiatric patients and medical-surgical control Ss are discussed. The importance of taking age into consideration as well as differences in various "control" or reference groups when making clinical inferences about the presence of brain dysfunction is stressed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Psychometric parameters of the Average Impairment Rating scale.

Determined the psychometric soundness of the Average Impairment Rating derived from the Halstead-Reitan Neuropsychological Test Battery (HRNB) by administering the HRNB and the WAIS to 313 Ss (mean age 46.3 yrs) who were brain damaged and to 103 control Ss (mean age 43.7 yrs). Results show that the Average Impairment Rating was psychometrically sound. (4 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Age differences in the speed of mental rotation.

66 Ss in 4 age groups (mean ages 20.9, 32.4, 50.9, and 63.3 yrs) participated in a mental rotation task for 4 consecutive days. ANOVAs revealed significant age differences in the linear function relating median RT to degrees of rotation: Older Ss had higher intercepts and higher slopes. There were no significant age differences in error rates. Practice reduced slopes and intercepts for all groups, but it neither eliminated nor systematically reduced age differences in mental rotation performance. Mental rotation slopes and intercepts were significantly correlated with performance on the Figures subtest of the Primary Mental Abilities Test but not the Vocabulary subtest of the Nelson-Denny Reading Test. Results point toward age changes in the speed of spatial information processing that may contribute to age changes in performance on tests of spatial ability. (32 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Patient behavior in hospitals: Helplessness, reactance, or both?

48 male inpatients hospitalized for 1, 3, or 9 wks and 24 male outpatients (mean age of all Ss, 39.9 yrs) were tested on cognitive tasks; poor performance and depressive symptoms increased with length of hospitalization, even as illness resolved. Further, increased hospitalization made patients more susceptible to the debilitating effect of uncontrollable events. Taken together, these results imply that the passive, compliant, and inanimate behavior of the "good patient" may be the result of learned helplessness engendered by hospitalization. (25 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Neuroticism and extraversion in Turner's Syndrome.

Administered the Maudsley Personality Inventory to 5 groups of female Ss: (a) 13 Turner Syndrome Ss (mean age 19 yrs 2 mo) with karyotype 45X, (b) 18 Turner Syndrome (TS) Ss (mean age 26 yrs 11 mo) with other types of sex chromosomal abnormalities, (c) 16 sisters of Ss (mean age 24 yrs 2 mo), (d) 9 Ss with growth retardation and primary amenorrhea (mean age 22 yrs 4 mo), and (e) 19 nurses (mean age 22 yrs 8 mo). The results are compared to English and American normative values. The total group of TS Ss obtained a low Neuroticism (N) score compared to the control groups. When the total group was divided on the basis of their karyotypes, the low N score could be referred solely to Ss with karyotype 45X, who scored significantly lower than any other group tested so far with the MPI. TS Ss with chromosomal abnormalities other than 45X scored within normal limits. No variables other than karyotype 45X were related to an extremely low N score. It is concluded that exceptional emotional stability, as reflected in a very low N score on the MPI, is concomitant with the total absence of one sex chromosome, which is probably due to a developmental abnormality of the CNS. (7 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effects of cognitive effort and word distinctiveness on learning disabled and nondisabled readers' recall.

Explored the notion that differences in word recall between skilled and learning disabled (LD) readers are related to cognitive effort in 3 experiments. Ss were 12 skilled readers (mean age 13.6 yrs) and 12 LD readers (mean age 13.5 yrs) in Exp I, 12 skilled readers (mean age 12.20 yrs) and 12 LD readers (mean age 11.63 yrs) in Exp II, and 24 skilled readers (mean age 8.75 yrs) and 24 LD readers (mean age 8.55 yrs) in Exp III. Cognitive effort represents the mental input to which a limited-capacity attentional system expands to produce a response. Manipulation of primary task difficulty (anagram solutions) and subsequent performance on a secondary task (word recall of correctly solved anagrams) was used to infer cognitive effort. The primary task included manipulations of word list organization and task orientation instructions. In general, after a difficult primary task, secondary task performance was higher for skilled readers than it was for LD readers. Ability group interactions occurred for word list organization and task orientation instructions. It is suggested that the amount of cognitive effort that can be effectively expended to produce a distinctive memory trace is related to individual differences in attentional capacity. Specifically, skilled readers' encoded memory traces under high-effort conditions contained more distinct semantic information than did the traces of LD readers. (35 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)