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以乙酰二茂铁和蒽醛为原料,KOH作催化剂,经固相研磨合成新型化合物1-二茂铁基-3-(9蒽基)丙烯酮,以~1H-NMR、~(13)C-NMR、IR和LC-MS对其进行了结构表征,并研究了化合物的抑菌性能。 相似文献
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由化合物邻菲啰啉及苯胺合成了4,5-二氮杂芴-9-酮和4,5-二氮杂芴-9-苯亚胺,它们的结构由IR及1H NMR谱、元素分析得以确认,并且通过紫外光谱法、循环伏安法等对其电化学行为进行了测试,结果表明,这些化合物具有较高的电子亲和势和电离势,说明他们的电子传输性能优良。 相似文献
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从克拉霉素的前体 6 O 甲基 2′, 4″ 二 (三甲基硅 ) 红霉素A 9 ( 1 异丙氧基环己基 )肟出发,在φ(C2H5OH) =50%的乙醇水溶液中加入甲酸,加热回流 2h脱去保护得到 6 O 甲基红霉素A9 肟,将它悬浮于水中,在w(HCl) =1%的盐酸水溶液作用下水解去除 3 克拉定糖得到目标化合物 3 羟基 6 O 甲基红霉素A9 肟,它是合成对耐药菌有优良活性的第三代红霉素酮内酯和酰内酯的重要中间体, 收率为 73 3%。为了简化反应步骤,试探了在脱保护一步不分离产物而在w(C2H5OH) =95%的乙醇和w(HCl) =2%的盐酸水溶液反应体系中直接水解脱糖的方法,得到了目标化合物,总收率为 69 0%。通过1HNMR、13CNMR和MR确定了目标化合物的结构。 相似文献
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以N-叔丁氧羰基-1,4-丁二胺和N-(4-溴丁基)邻苯二甲酰亚胺为原料,经取代及保护两步反应合成N1-(4-邻苯二甲酰亚胺)丁基-N1,N4-二叔丁氧羰基-1,4-丁二胺(Ⅳ),然后肼解得N1-氨基丁基-N1,N4-二叔丁氧羰基-1,4-丁二胺(Ⅴ),3步反应总收率38%;Ⅴ与9-蒽甲醛缩合后用NaBH4还原,产物提纯后脱保护得目标产物N1-(4-氨基丁基)-N4-(9-蒽甲基)-1,4-丁二胺盐酸盐(Ⅶ),3步反应总收率约7 5%。化合物Ⅳ~Ⅶ的结构经13CNMR,1HNMR和ESI-MS确证,并对反应条件进行了初步优化。 相似文献
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Díaz-Gavilán M Conejo-García A Cruz-López O Núñez MC Choquesillo-Lazarte D González-Pérez JM Rodríguez-Serrano F Marchal JA Aránega A Gallo MA Espinosa A Campos JM 《ChemMedChem》2008,3(1):127-135
A series of eleven 2- and 6-substituted (R,S)-9-(2,3-dihydro-1,4-benzoxathiin-3-ylmethyl)-9H-purine derivatives was obtained by applying a standard Mitsunobu protocol that led to a six-membered ring contraction from (R,S)-3,4-dihydro-2H-1,5-benzoxathiepin-3-ol via an episulfonium intermediate. The signal approximately delta=151 ppm, which corresponds to the C4' carbon atom, is unequivocal proof of the N9' regioisomer. The potential of the target molecules as anticancer agents is reflected in their activity against the MCF-7 cancer cell line. The most active compounds have IC(50) values of (6.18+/-1.70) and (8.97+/-0.83) microM. The results indicate that the anticancer activity for the most active compounds is correlated with their capacity to induce apoptosis. 相似文献
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磷光配体3-[4-(2-吡啶基)苯基]-9-(4-氟苯基)-9H-咔唑的合成 总被引:1,自引:1,他引:0
以对溴苯胺为原料,经重氮化、Gomberg-Bachmann偶联、硼酸化反应得到4-(2-吡啶基)苯硼酸;再与对氟苯基取代的咔唑,通过四(三苯基磷)钯催化,于90℃进行Suzuki偶联合成出标题磷光配体,收率82.03%。对目标物用核磁共振氢谱和元素分析进行了表征,并测得它在二氯甲烷中的紫外吸收光谱和荧光光谱。由于受咔唑基团的影响,磷光配体最大吸收峰波长红移56 nm,且吸收的强度增加,Stokes位移154 nm,相对荧光量子效率为0.17。 相似文献
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乙基乙烯基酮与4,4-乙二氧撑-2-甲基环乙酮2 c的手性亚胺进行不对称Michael加成,生成2,2-双取代环烷酮5,5经过克莱森缩合得到(-)-6,6-乙二氧撑-1,10-二甲基-1(9)-八氢萘酮-2(-)(1 c)。 相似文献
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Darryl C. Sutton Nikki S. Johnson Caswell Hlongwane Folahan O. Ayorinde 《Journal of the American Oil Chemists' Society》2009,86(7):675-680
A water-soluble, foaming epoxyalkene sulfonate, sodium (+)-(12S,13R)-epoxy-cis-9-octadecenyl sulfonate, was synthesized from vernonia oil (VO) by a series of simple reactions that include transesterification,
metal hydride reduction, tosylation, and SN2 reactions. Conversion of VO into vernonia oil methyl esters (VOME) using sodium methoxide was quantitative. Subsequent reduction
of VOME with lithium aluminum hydride yielded (+)-(12S,13R)-epoxy-cis-9-octadecenol (94%), along with minor amounts of hexadecenol, octadecenol, cis-9-octadecenol, and cis-9,12-octadecandienol. The (+)-(12S,13R)-epoxy-cis-9-octadecenol, was tosylated with p-toluenesulfonyl chloride to give (+)-(12S,13R)-epoxy-cis-9-octadecenyl tosylate at 96% yield. Iodination of the tosylate with sodium iodide and subsequent SN2 reaction with sodium sulfite afforded (+)-(12S,13R)-epoxy-cis-9-octadecenyl sulfonate (63% yield). This study demonstrates the ability to produce an epoxyalkenyl sulfonate, belonging to
a class of anionic surfactants, from VO without destroying the epoxy functionality in the (+)-(12S,13R)-epoxy-cis-9-octadecenyl moiety of VO. The critical micelle concentration of the synthesized sulfonate was also determined. 相似文献
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(Z)-9-Tetradecen-1-ol acetate [(Z)-9-TDA], identified originally as the sex pheromone of the fall armyworm,Spodoptera frugiperda (J.E. Smith), acted as a secondary sex pheromone when it was tested in sticky traps in field tests. Low-level synergism was obtained when 2 and 10% quantities of (Z)-9-TDA were added to 100 g of (Z)-9-dodecen-1-ol acetate, which is now considered the primary sex pheromone.Lepidoptera: Noctuidae.In cooperation with the University of Georgia College of Agriculture Experiment Stations, Coastal Plain Station, Tifton, Georgia 31794.Mention of a proprietary product does not constitute endorsement by the USDA. 相似文献
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In field trapping experiments, 161 and 321 blends of (Z)-9-tetradecen-1-ol formate (Z-9-TDF) and (Z)-9-tetradecenal (Z-9-TDAL) caught as manyHeliothis virescens (F.) as 3 virgin females and virelure, the synthetic pheromone of this species [a 161 mixture of (Z)-11-hexadecenal (Z-11-HDAL) and (Z)-9-tetradecenal]. Z-9-TDF and (Z)-7-dodecen-1-ol formate (Z-7-DDF) are structurally similar to Z-11-HDAL and Z-9-TDAL, respectively. The sensory input elicited by Z-9-TDF appears to substitute for the sensory input of Z-1 1-HDAL. In contrast, Z-7-DDF had no significant effect on catches of maleH. virescens when used alone, in combination with either Z-11-HDAL or Z-9-TDF as a bait in traps, or as a disruptant of pheromone communication via permeation of the atmosphere. Furthermore, Z-9-TDF may be a more stable and economical attractant forH, virescens males than is Z-1 1-HDAL.This paper reports the results of research only. Mention of a pesticide in this paper does not constitute a recommendation for use by the U.S. Department of Agriculture nor does it imply registration under FIFRA as amended. Also, mention of a commercial or proprietary product in this paper does not constitute a recommendation or an endorsement of that product by the USDA. 相似文献
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Barry F. Herron Marvin O. Bagby Terry A. Isbell Wm. Craig Byrdwell Ron Plattner David Weisleder 《Journal of the American Oil Chemists' Society》1997,74(3):229-234
Allylic amination of methyl oleate with bis(N-p-toluenesulfonyl) sulfodiimide results in a mixture of methyl 11-amino-(N-p-toluenesulfonyl)-9-E-octadecenoate and methyl 8-amino-(N-p-toluenesulfonyl)-9-E-octadecenoate in 58% yield. These novel products were isolated and characterized by nuclear magnetic resonance, infrared
spectroscopy, mass spectrometry, and melting point. The reaction was analyzed by highperformance liquid chromatography and
thin-layer chromatography. 相似文献