Asthma and COPD proteomics: Current approaches and future directions

Although asthma and chronic obstructive pulmonary disease COPD represent the two most common chronic respiratory diseases worldwide, the mechanisms underlying their pathobiology need to be further elucidated. Presently, differentiation of asthma and COPD are largely based on clinical and lung function parameters. However, the complexity of these multifactorial diseases may lead to misclassification and to inappropriate management strategies. Recently, tremendous progress in MS has extended the sensitivity, accuracy, and speed of analysis, enabling the identification of thousands of proteins per experiment. Beyond identification, MS has also greatly implemented quantitation issues allowing to assess qualitative–quantitative differences in protein profiles of different samples, in particular diseased versus normal. Herein, we provide a summary of recent proteomics-based investigations in the field of asthma/COPD, highlighting major issues related to sampling and processing procedures for proteomic analyses of specific airway and parenchymal specimens (induced sputum, exhaled breath condensate, epithelial lining fluid, bronchoalveolar and nasal lavage fluid), as well as blood-derived specimen (plasma and serum). Within such a context, together with current difficulties and limitations mainly due to lack of general standardization in preanalytical sampling procedure, our discussion will focus on the challenges and possible benefits of proteomic studies in phenotypic stratification of asthma and COPD.     

3D geo-database research: Retrospective and future directions

3D geo-database research is a promising field to support challenging applications such as 3D urban planning, environmental monitoring, infrastructure management, and early warning or disaster management and response. In these fields, interdisciplinary research in GIScience and related fields is needed to support the modelling, analysis, management, and integration of large geo-referenced data sets, which describe human activities and geophysical phenomena. Geo-databases may serve as platforms to integrate 2D maps, 3D geo-scientific models, and other geo-referenced data. However, current geo-databases do not provide sufficient 3D data modelling and data handling techniques. New 3D geo-databases are needed to handle surface and volume models. This article first presents a 25-year retrospective of geo-database research. Data modelling, standards, and indexing of geo-data are discussed in detail. New directions for the development of 3D geo-databases to open new fields for interdisciplinary research are addressed. Two scenarios in the fields of early warning and emergency response demonstrate the combined management of human and geophysical phenomena. The article concludes with a critical outlook on open research problems.     

Group awareness tools for learning: Current and future directions

Group awareness has become an important concept since it was introduced into the field of computer-supported collaborative learning. This paper discusses current trends and future directions in this research field. It is argued that the development and implementation of tools should be complemented by systematic explorations into the mechanisms that moderate the relationship between group awareness and learning. It is suggested that variations in tool design features are a starting point for furthering our understanding of the processes involved in group awareness. Based on the contributions in this special issue, eight areas for future empirical investigations are identified. The paper concludes with some theoretical considerations on the nature of group awareness.     

Usability of Geographic Information: Current challenges and future directions

The use of Geographic Information or GI, has grown rapidly in recent years. Previous research has identified the importance of usability and user centred design in enabling the proliferation and exploitation of GI. However, the design and development of usable GI is not simply a matter of applying the tried and tested usability methods that have been developed for software and web design. Dealing with data and specifically GI brings with it a number of issues that change the way usability and user centred design can be applied. This paper describes the outcomes of a workshop held in March 2010 exploring the core issues relating to GI usability. The workshop brought together an international group of twenty experts in both human factors and GI, from a wide range of academic and industrial backgrounds. These experts considered three key issues, the stakeholders in GI, key challenges applying usability to GI and the usability methods that can be successfully applied to GI. The result of this workshop was to identify some areas for future research, such as the production of meaningful metadata and the implications of blurring of the line between data producers and data consumers.     

Cognitive neuroscience and robotics: Advancements and future research directions

In recent years, brain-based technologies that capitalise on human abilities to facilitate human–system/robot interactions have been actively explored, especially in brain robotics. Brain–computer interfaces, as applications of this conception, have set a path to convert neural activities recorded by sensors from the human scalp via electroencephalography into valid commands for robot control and task execution. Thanks to the advancement of sensor technologies, non-invasive and invasive sensor headsets have been designed and developed to achieve stable recording of brainwave signals. However, robust and accurate extraction and interpretation of brain signals in brain robotics are critical to reliable task-oriented and opportunistic applications such as brainwave-controlled robotic interactions. In response to this need, pervasive technologies and advanced analytical approaches to translating and merging critical brain functions, behaviours, tasks, and environmental information have been a focus in brain-controlled robotic applications. These methods are composed of signal processing, feature extraction, representation of neural activities, command conversion and robot control. Artificial intelligence algorithms, especially deep learning, are used for the classification, recognition, and identification of patterns and intent underlying brainwaves as a form of electroencephalography. Within the context, this paper provides a comprehensive review of the past and the current status at the intersection of robotics, neuroscience, and artificial intelligence and highlights future research directions.     

The cyber threat landscape: Challenges and future research directions

Cyber threats are becoming more sophisticated with the blending of once distinct types of attack into more damaging forms. Increased variety and volume of attacks is inevitable given the desire of financially and criminally-motivated actors to obtain personal and confidential information, as highlighted in this paper. We describe how the Routine Activity Theory can be applied to mitigate these risks by reducing the opportunities for cyber crime to occur, making cyber crime more difficult to commit and by increasing the risks of detection and punishment associated with committing cyber crime. Potential research questions are also identified.     

Current state and future directions of multirate filter banks and their applications

This paper provides an overview of the basic concepts, current state and future directions of uniform and nonuniform multirate filter banks and their applications. Research in the areas of multidimensional filter banks, and wavelet transforms, as a direct extension to the topic is still proceeding at a rapid rate. Different design techniques and algorithms that are currently of interest are investigated from hardware complexity and reconstructed signals' quality points of view. Important similarities and differences between different filters categories are noted, which lead to a discussion of important issues that need to be resolved. Distortions and quantization effects present in the filter banks are reviewed and some solutions for controlling different types of distortions are introduced. The problem of designing QMF banks that can provide good frequency resolution while allowing for exact or near perfect reconstruction of the signal is quite challenging, because so many dissimilar types of distortion must be minimized and/or eliminated in the same design context. Recently, the perfect reconstruction cosine-modulated filter bank and filter banks with block sampling have emerged as an attractive choice of filter bank with respect to implementation complexities and design cost. New trends and future directions including selective multirate filter banks, filter banks with nonuniform decimation ratio, filter banks with discrete coefficients, multidimensional filter banks, nonlinear filter banks and data dependent decompositions are presented. Finally, some selected applications of multirate filter banks are described; namely transmultiplexers, speech and image coding, analog voice privacy systems and wavelets based signal and image compression.     

Cloud services selection: A systematic review and future research directions

Cloud computing has developed in popularity as a large-scale computing paradigm that offers a range of computing resources as a service through the internet on a pay-as-you-go basis. The expansion in demand and commercial availability of cloud services brings new challenges to cloud services selection. Several research studies have been conducted to develop enhanced methodologies to assist service consumers in selecting appropriate services. In this paper, 105 primary studies published during January, 2011 to May, 2022 has been selected using a multi-stage scrutinizing approach. The selected preliminary studies were further classified based on various variables to answer the research questions stated for this work. A systematic review of existing cloud service selection approaches is performed, which are analyzed along eight dimensions: decision-making methods, context, purposes, cloud service performance parameters, simulation/language tools, domain, datasets, and experiment/validation methods. After a thorough review and comparison of these approaches across the above-mentioned dimensions, several open research issues in the current literature have been identified. The contribution of this research is fourfold: focusing on state-of-the-art cloud services selection approaches, highlighting the benefits and drawbacks of various cloud services selection methodologies and their future directions, offering a taxonomy based on a thorough literature study, and identifying nine critical challenges in cloud services selection that require further investigation. This systematic review study is anticipated to benefit both academics and business experts.     

Time and information technology in teams: a review of empirical research and future research directions

Information technology (IT) is intricately bound up with time in teams. Yet a comprehensive review of what is known about time in IT-mediated teams is lacking. This paper addresses this gap. We classify time into three categories: conceptions of time, mapping activities to time, and actors relating to time. Drawing upon this framework, we review empirical information systems (IS) research on IT-mediated teams over the past three decades. Our review reveals that the research has approached time predominantly using the clock view and has examined exclusively how to map a single activity to the continuum of time. As a result, most studies operate within a simplified temporal context by conceiving time as an objective attribute that ticks away. Meanwhile, a void exists in research that recognizes time as interpretive and experienced. Our analyses also indicate that past research has been primarily interested in the differences between face-to-face and IT-mediated teams and the communication function of IT. Overall, IT remains roughly conceptualized, and research has produced fragmented insights that have small cumulative effects. To advance more substantive theory building, we propose several research directions that invite richer theorizing about how IT is related to time in teams.     

Current directions in IS security research: towards socio-organizational perspectives

Abstract. The purpose of this paper is to map the current territory of information systems and security research. It uses the Burrell and Morgan framework as an intellectual map to analyse the socio-philosophical concerns in various information systems and security approaches. The paper's contributions are in its analysis of trends in information systems and security research, the former in stressing the socio-organizational perspectives and the latter in criticizing the preponderance of technical solutions. The paper also sets an agenda for a future research emphasis.     

Review of literature on decision support systems for natural hazard risk reduction: Current status and future research directions

Natural hazard risk is largely projected to increase in the future, placing growing responsibility on decision makers to proactively reduce risk. Consequently, decision support systems (DSSs) for natural hazard risk reduction (NHRR) are becoming increasingly important. In order to provide directions for future research in this growing area, a comprehensive classification system for the review of NHRR-DSSs is introduced, including scoping, problem formulation, the analysis framework, user and organisational interaction with the system, user engagement, monitoring and evaluation. A review of 101 papers based on this classification system indicates that most effort has been placed on identifying areas of risk and assessing economic consequences resulting from direct losses. However, less effort has been placed on testing risk-reduction options and considering future changes to risk. Furthermore, there was limited evidence within the reviewed papers on the success of DSSs in practice and whether stakeholders participated in DSS development and use.     

Categorical and dimensional affect analysis in continuous input: Current trends and future directions

In the context of affective human behavior analysis, we use the term continuous input to refer to naturalistic settings where explicit or implicit input from the subject is continuously available, where in a human–human or human–computer interaction setting, the subject plays the role of a producer of the communicative behavior or the role of a recipient of the communicative behavior. As a result, the analysis and the response provided by the automatic system are also envisioned to be continuous over the course of time, within the boundaries of digital machine output. The term continuous affect analysis is used as analysis that is continuous in time as well as analysis that uses affect phenomenon represented in dimensional space. The former refers to acquiring and processing long unsegmented recordings for detection of an affective state or event (e.g., nod, laughter, pain), and the latter refers to prediction of an affect dimension (e.g., valence, arousal, power). In line with the Special Issue on Affect Analysis in Continuous Input, this survey paper aims to put the continuity aspect of affect under the spotlight by investigating the current trends and provide guidance towards possible future directions.     

National occupational research agenda (NORA) future directions in occupational musculoskeletal disorder health research

Musculoskeletal disorders are among the most costly health care problems facing society today. The scientific literature has indicated that psychosocial factors, individual factors, workplace physical requirements, and workplace organizational factors have been associated with risk. Since musculoskeletal risk is multi-dimensional, the magnitude of risk attributable to various factors can be of importance to scientists and policy makers in designing countermeasures to reduce injury incidence. Traditionally, the disciplines of biomechanics, physiology, and psychophysics have dominated the body of knowledge that has defined exposure limitations to work. However, recent research has explored the association of psychosocial and work organization factors with musculoskeletal problems. Advances have been made to better quantify the levels of occupational exposure by improved exposure metrics, quantification of three-dimensional loads experienced by certain joints (e.g. the spine), identification of tissue tolerance limits and tissue response to mechanical stresses, and the impact of psychosocial stresses. However, efforts to quantitatively link epidemiological, biomechanical loading, soft tissue tolerance, and psychosocial studies should be pursued to establish a better understanding of the pathways of injury and resultant preventive strategies. Although we are beginning to understand how the major risk factors influence the load-tolerance relationship of human tissue, how these risk factors interact is virtually unexplored. Since the impact of the interactions may be far greater than that of any individual factor, the impact of the interactions between risk factors must be delineated so that work-related risk can be better quantified. Efforts to quantitatively link epidemiological, biomechanical loading, soft tissue tolerance, and psychosocial studies should be pursued to establish a better understanding of the pathways of injury and resultant preventive strategies.     

Mediated social touch: a review of current research and future directions

In this paper, we review research and applications in the area of mediated or remote social touch. Whereas current communication media rely predominately on vision and hearing, mediated social touch allows people to touch each other over a distance by means of haptic feedback technology. Overall, the reviewed applications have interesting potential, such as the communication of simple ideas (e.g., through Hapticons), establishing a feeling of connectedness between distant lovers, or the recovery from stress. However, the beneficial effects of mediated social touch are usually only assumed and have not yet been submitted to empirical scrutiny. Based on social psychological literature on touch, communication, and the effects of media, we assess the current research and design efforts and propose future directions for the field of mediated social touch.     

Cell formation in group technology: Review,evaluation and directions for future research

This paper discusses and reviews a fundamental issue in cellular manufacturing—cell formation. This problem is of strategic and operational importance in that it affects the fundamental structure and the overall layout of a cellular manufacturing system. We first provide a comprehensive mathematical formulation of the cell formation problem and then propose a methodology-based classification of prior research. This classification is used in reviewing the most recent literature on the cell formation problem. Based on a comparison and critical evaluation, we highlight the shortcomings of current approaches and also outline directions for future research.