Automated Deep Learning Empowered Breast Cancer Diagnosis Using Biomedical Mammogram Images

Biomedical image processing is a hot research topic which helps to majorly assist the disease diagnostic process. At the same time, breast cancer becomes the deadliest disease among women and can be detected by the use of different imaging techniques. Digital mammograms can be used for the earlier identification and diagnostic of breast cancer to minimize the death rate. But the proper identification of breast cancer has mainly relied on the mammography findings and results to increased false positives. For resolving the issues of false positives of breast cancer diagnosis, this paper presents an automated deep learning based breast cancer diagnosis (ADL-BCD) model using digital mammograms. The goal of the ADL-BCD technique is to properly detect the existence of breast lesions using digital mammograms. The proposed model involves Gaussian filter based pre-processing and Tsallis entropy based image segmentation. In addition, Deep Convolutional Neural Network based Residual Network (ResNet 34) is applied for feature extraction purposes. Specifically, a hyper parameter tuning process using chimp optimization algorithm (COA) is applied to tune the parameters involved in ResNet 34 model. The wavelet neural network (WNN) is used for the classification of digital mammograms for the detection of breast cancer. The ADL-BCD method is evaluated using a benchmark dataset and the results are analyzed under several performance measures. The simulation outcome indicated that the ADL-BCD model outperforms the state of art methods in terms of different measures.     

Deep learning and optimization algorithms for automatic breast cancer detection

Breast cancer is caused by the abnormal and rapid growth of breast cells. An early diagnosis can ensure an easier and effective treatment. A mass in the breast is a significant early sign of breast cancer, even though differentiating the cancerous mass's tissue from normal tissue for diagnosis is a difficult task for radiologists. The development of computer-aided detection systems in recent years has led to nondestructive and efficient cancer diagnostic techniques. This paper proposes a comprehensive method to locate the cancerous region in the mammogram image. This method employs image noise reduction, optimal image segmentation based on the convolutional neural network, a grasshopper optimization algorithm, and optimized feature extraction and feature selection based on the grasshopper optimization algorithm, thereby improving precision and decreasing the computational cost. This method was applied to the Mammographic Image Analysis Society Digital Mammogram Database and Digital Database for Screening Mammography breast cancer databases and the simulation results were compared with 10 different state-of-the-art methods to analyze the proposed system's efficiency. Final results showed that the proposed method had 96% Sensitivity, 93% Specificity, 85% PPV, 97% NPV, 92% accuracy, and better efficiency than other traditional methods in terms of Sensitivity, Specificity, PPV, NPV, and Accuracy.     

Meta-heuristics for Feature Selection and Classification in Diagnostic BreastCancer

One of the most common kinds of cancer is breast cancer. The early detection of it may help lower its overall rates of mortality. In this paper, we robustly propose a novel approach for detecting and classifying breast cancer regions in thermal images. The proposed approach starts with data preprocessing the input images and segmenting the significant regions of interest. In addition, to properly train the machine learning models, data augmentation is applied to increase the number of segmented regions using various scaling ratios. On the other hand, to extract the relevant features from the breast cancer cases, a set of deep neural networks (VGGNet, ResNet-50, AlexNet, and GoogLeNet) are employed. The resulting set of features is processed using the binary dipper throated algorithm to select the most effective features that can realize high classification accuracy. The selected features are used to train a neural network to finally classify the thermal images of breast cancer. To achieve accurate classification, the parameters of the employed neural network are optimized using the continuous dipper throated optimization algorithm. Experimental results show the effectiveness of the proposed approach in classifying the breast cancer cases when compared to other recent approaches in the literature. Moreover, several experiments were conducted to compare the performance of the proposed approach with the other approaches. The results of these experiments emphasized the superiority of the proposed approach.     

An approach for classification of malignant and benign microcalcification clusters

The only reliable and successful treatment of breast cancer is its detection through mammography at initial stage. Clusters of microcalcifications are important signs of breast cancer. Manual interpretation of mammographic images, in which the suspicious regions are indicated as areas of varying intensities, is not error free due to a number of reasons. These errors can be reduced by using computer-aided diagnosis systems that result in reduction of either false positives or true negatives. The purpose of the study in this paper is to develop a methodology for distinguishing malignant microcalcification clusters from benign microcalcification clusters. The proposed approach first enhances the region of interest by using morphological operations. Then, two types of features, cluster shape features and cluster texture features, are extracted. A Support Vector Machine is used for classification. A new set of shape features based on the recursive subsampling method is added to the feature set, which improves the classification accuracy of the system. It has been found that these features are capable of differentiating malignant and benign tissue regions. To investigate the performance of the proposed approach, mammogram images are taken from Digital Database for Screening Mammography database and an accuracy of 94.25% has been achieved. The experiments have shown that the proposed classification system minimizes the classification errors and is more efficient in correct diagnosis.     

Fire Detection Method Based on Improved Fruit Fly Optimization-Based SVM

Aiming at the defects of the traditional fire detection methods, which are caused by false positives and false negatives in large space buildings, a fire identification detection method based on video images is proposed. The algorithm first uses the hybrid Gaussian background modeling method and the RGB color model to perform fire prejudgment on the video image, which can eliminate most non-fire interferences. Secondly, the traditional regional growth algorithm is improved and the fire image segmentation effect is effectively improved. Then, based on the segmented image, the dynamic and static features of the fire flame are further analyzed and extracted in the area of the suspected fire flame. Finally, the dynamic features of the extracted fire flame images were fused and classified by improved fruit fly optimization support vector machine, and the recognition results were obtained. The video-based fire detection method proposed in this paper greatly improves the accuracy of fire detection and is suitable for fire detection and identification in large space scenarios.     

Evaluation of a novel method of noise reduction using computer-simulated mammograms

A novel method of noise reduction has been tested for mammography using computer-simulated images for which the truth is known exactly. This method is based on comparing two images. The images are compared at different scales, using a cross-correlation function as a measure of similarity to define the image modifications in the wavelet domain. The computer-simulated images were calculated for noise-free primary radiation using a quasi-realistic voxel phantom. Two images corresponding to slightly different geometry were produced. Gaussian noise was added with certain properties to simulate quantum noise. The added noise could be reduced by >70% using the proposed method without any noticeable corruption of the structures. It is possible to save 50% dose in mammography by producing two images (each 25% of the dose for a standard mammogram). Additionally, a reduction of the anatomical noise and, therefore, better detection rates of breast cancer in mammography are possible.     

Optimized Identification with Severity Factors of Gastric Cancer for Internet of Medical Things

The Internet of Medical Things (IoMT) emerges with the vision of the Wireless Body Sensor Network (WBSN) to improve the health monitoring systems and has an enormous impact on the healthcare system for recognizing the levels of risk/severity factors (premature diagnosis, treatment, and supervision of chronic disease i.e., cancer) via wearable/electronic health sensor i.e., wireless endoscopic capsule. However, AI-assisted endoscopy plays a very significant role in the detection of gastric cancer. Convolutional Neural Network (CNN) has been widely used to diagnose gastric cancer based on various feature extraction models, consequently, limiting the identification and categorization performance in terms of cancerous stages and grades associated with each type of gastric cancer. This paper proposed an optimized AI-based approach to diagnose and assess the risk factor of gastric cancer based on its type, stage, and grade in the endoscopic images for smart healthcare applications. The proposed method is categorized into five phases such as image pre-processing, Four-Dimensional (4D) image conversion, image segmentation, K-Nearest Neighbour (K-NN) classification, and multi-grading and staging of image intensities. Moreover, the performance of the proposed method has experimented on two different datasets consisting of color and black and white endoscopic images. The simulation results verified that the proposed approach is capable of perceiving gastric cancer with 88.09% sensitivity, 95.77% specificity, and 96.55% overall accuracy respectively.     

基于神经网络的图像边缘检测方法

提出了一种基于神经网络的图像边缘检测新方法.该方法首先基于邻域灰度极值提取边界候选图像,然后以边界候选象素及其邻域象素的二值模式作为样本集,输入边缘检测神经网络进行训练.边缘检测神经网络采用BP网络,为加快网络的训练速度,采用了滚动训练和权值随机扰动的方法.实验表明,该方法提高了神经网络的学习效率,获得的边缘图像封闭性好,边缘描述真实.     

Digital Image Processing Technique for Breast Cancer Detection

Breast cancer is the most common cause of death in women and the second leading cause of cancer deaths worldwide. Primary prevention in the early stages of the disease becomes complex as the causes remain almost unknown. However, some typical signatures of this disease, such as masses and microcalcifications appearing on mammograms, can be used to improve early diagnostic techniques, which is critical for women’s quality of life. X-ray mammography is the main test used for screening and early diagnosis, and its analysis and processing are the keys to improving breast cancer prognosis. As masses and benign glandular tissue typically appear with low contrast and often very blurred, several computer-aided diagnosis schemes have been developed to support radiologists and internists in their diagnosis. In this article, an approach is proposed to effectively analyze digital mammograms based on texture segmentation for the detection of early stage tumors. The proposed algorithm was tested over several images taken from the digital database for screening mammography for cancer research and diagnosis, and it was found to be absolutely suitable to distinguish masses and microcalcifications from the background tissue using morphological operators and then extract them through machine learning techniques and a clustering algorithm for intensity-based segmentation.     

基于OCT成像的淡水无核珍珠内部缺陷自动检测方法

光学相干层析技术(OCT)作为一种高分辨率的无损光学检测手段,已被用于珍珠的内部质量检测。针对淡水无核珍珠质层内部缺陷检测的需求,提出一种通过光学相干层析图像实现淡水无核珍珠内部缺陷自动检测的方法。根据珠层灰度变化的特点,识别图像中缺陷区域的梯度特征和缺陷位置变化特征,并利用缺陷特征建立反向传播神经网络模型。实验中采集了内部无缺陷和内部有多种类型缺陷淡水无核珍珠的光学相干层析图像各20幅,对图像进行预处理并提取特征,利用K-means算法检测样本类型与所提取特征的匹配度,用特征与类型相匹配的样本特征训练反向传播神经网络模型,使用反向传播网络模型对淡水无核珍珠内部缺陷层进行分类识别。实验结果表明该方法提取特征的匹配度为92.5%,分类准确率达到100%,验证了该方法的可行性和有效性,提出的方法能够作为淡水无核珍珠内部缺陷识别和自动分类的有效手段。     

Mammographic Images Enhancement and Denoising for Breast Cancer Detection Using Dyadic Wavelet Processing

Mammography is the most effective method for the early detection of breast diseases. However, the typical diagnostic signs such as microcalcifications and masses are difficult to detect because mammograms are low-contrast and noisy images. In this paper, a novel algorithm for image denoising and enhancement based on dyadic wavelet processing is proposed. The denoising phase is based on a local iterative noise variance estimation. Moreover, in the case of microcalcifications, we propose an adaptive tuning of enhancement degree at different wavelet scales, whereas in the case of mass detection, we developed a new segmentation method combining dyadic wavelet information with mathematical morphology. The innovative approach consists of using the same algorithmic core for processing images to detect both microcalcifications and masses. The proposed algorithm has been tested on a large number of clinical images, comparing the results with those obtained by several other algorithms proposed in the literature through both analytical indexes and the opinions of radiologists. Through preliminary tests, the method seems to meaningfully improve the diagnosis in the early breast cancer detection with respect to other approaches.     

Enhancing breast pectoral muscle segmentation performance by using skip connections in fully convolutional network

The precise detection and segmentation of pectoral muscle areas in mediolateral oblique (MLO) views is an essential step in the development of a computer-aided diagnosis system to access breast malignant lesions or parenchyma. The goal of this article is to develop a robust and fully automatic algorithm for pectoral muscle segmentation from mammography images. This paper presents an image enhancement approach that improves the quality of mammogram scans and a convolutional neural network-based fully convolutional network architecture enhanced with residual connections for automatic segmentation of the pectoral muscle from the MLO views of a digital mammogram. For this purpose, the model is tested and trained on three different mammogram datasets named MIAS, INBREAST, and DDSM. The ground truth labels of the pectoral muscle were identified under the supervision of experienced radiologists. For training and testing, 10-fold cross-validation was used. The proposed model was compared with baseline U-Net-based architecture. Finally, we used a postprocessing step to find the actual boundary of the pectoral muscle. Our presented architecture generated a mean Intersection over Union (IoU) of 97%, dice similarity coefficient (DSC) of 96% and 98% accuracy on testing data. The proposed architecture for pectoral muscle segmentation from the MLO views of mammogram images with high accuracy and dice score can be quickly merged with the breast tumor segmentation problem.     

PSO-Gabor-CNN算法在印刷品套印缺陷的检测

目的二维Gabor滤波器含有多个参数,在印刷品套印缺陷检测中,二维Gabor滤波器使用不同参数增强图像特征的效果差别较大,为了获得二维Gabor在某印刷品套印缺陷检测下的优化参数。方法在印刷品套印缺陷检测中,提出一种PSO-Gabor-CNN算法,采用Sobel算子对印刷品图像进行边缘检测,以粒子群算法(PSO)对二维Gabor滤波器的中心最大频率kmax、带宽σ、模板窗口window进行参数寻优,处理后的图像与模板图像采用加权欧式距离进行评价。然后用优化后的Gabor滤波器对图像进行滤波,最后采用卷积神经网络(CNN)对印刷品套印缺陷进行检测和分类。结果通过粒子群算法,确定了二维Gabor中心最大频率kmax为6.0476、带宽σ为0.1444、模板窗口window为27×27取得最佳效果,此时加权欧式距离为1.1927×10-33。卷积神经网络经过70次训练的均方误差为0.0035,测试样本正确率为96.93%。该方法与无数据预处理的BP神经网络(BPNN)、Sobel预处理的BP神经网络(Sobel-BPNN)、无数据预处理的卷积神经网络(CNN)、Sobel预处理的卷积神经网络(Sobel-CNN)对比,表现出了较好的识别效果。结论该方法可以获取二维Gabor滤波器的较优参数,从而获得较好的滤波效果,将其应用于套印缺陷检测,具有一定的应用价值。     

A hybrid approach for oestrogen receptor status evaluation

Abstract

The aim of this work is to assist pathologists in the evaluation of tumour cells in microscopic breast images where we distinguish three kinds of cells: positive tumour cells for oestrogen receptor, negative tumour cells for oestrogen receptor, and non-tumour cells. This work has proven to be very difficult because of the variability of cells’ size, shape (morphology) and distribution. Conventional methods for segmentation like thresholding and edge detection are unable to resolve this problem. The herein proposed method is a hybrid approach combining segmentation and classification to ensure better results. While the morphological processes are used for artefact elimination and cell segmentation, the classification algorithm is used to automatically classify all existing cells in the image. The paper contains also a comparative study between fuzzy c-means clustering algorithm and neural network-based classification. The proposed approach was applied on several microscopic breast cancer cells images corresponding to eight patients. The experimental results are efficient and the found values are near to those announced by experts. To better interpret these results, we performed a statistical analysis in terms of sensitivity, specificity and accuracy of detected tumour cells. The statistics proved the efficacy of the proposed approach since a percentage exceeding 90% was recorded for sensitivity, specificity and accuracy for the totality of the studied images. When using neural networks, the statistics are slightly above those gathered with fuzzy c-means. We recorded over 97% for sensitivity, specificity and accuracy of detected cells, reaching an error rate below 3%. Furthermore, it should be kept in mind that analysing breast cells images using the proposed approach gives us important information such as number of tumour cells, and number and percentage of positive tumour cells. Moreover, it is so much less time-consuming than experts’ evaluation.     

基于IMB-CNN的薄壁件超声铣削颤振辨识方法

针对薄壁件超声铣削加工时产生的颤振严重影响工件质量,加剧刀具磨损的问题,搭建了颤振图像监测系统,利用卷积神经网络(CNN)进行颤振图像辨识,综合运用趋磁细菌算法(MB)、爬山算法(HC)和禁忌算法(TS)的优点,改进MB算法进行超参数优化,提出了一种基于改进趋磁细菌卷积神经网络(IMB-CNN)的薄壁件超声铣削颤振辨识方法。首先,通过MB算法进行全局搜索,再以最优解为初始点,通过HC算法进行邻域搜索,避免了MB算法在最优解附近的振荡;同时,通过禁忌列表跳过已搜索的节点,减小计算规模,加快计算效率;最后,将获得的最优超参数用于CNN,实现颤振图像的精确辨识。与其他方法相比,该方法实现了97.69%的识别率,判断时间为363ms,能有效地进行颤振监测,且整体性能较优。     

基于脉冲神经网络的钢材表面缺陷识别研究

目的 针对现有钢材缺陷识别算法特征图利用不充分、识别准确率低、参数量大等问题,基于脉冲神经网络,提出一种用于钢材缺陷识别的稠密卷积脉冲神经网络(DCSNN)模型,减少系统消耗和内存占用。方法 首先,采用卷积编码,对输入图片进行特征提取和编码。其次,采用稠密连接算法搭建稠密卷积脉冲神经网络,实现特征重复利用,抑制梯度消失,并通过替代梯度下降算法进行网络训练。最后,在带钢数据集上进行测试,实现带钢缺陷识别。结果 实验结果显示,DCSNN在测试集上的准确率为98.61%,参数量为0.5万,结论 在钢材表面缺陷识别问题上表现出良好效果。     

Rule Extraction from Trained Artifical Neural Networks

The neural network rule extraction problem is aimed at obtaining rules from an arbitrarily trained artificial neural network. Recently there have been several approaches to rule extraction. Approaches to rule extraction implement a priori knowledge of data or rule requirements into neural networks before the rules are extracted. Although this may lead to a simplified final phase of acquitting the rules from particular type of neural networks, it limits the methodologies for general-purpose use. This article approaches the neural network rule extraction problem in its essential and general form. Preference is given to multilayer perceptron networks (MLP networks) due to their universal approximation capabilities. The article establishes general theoretical grounds for rule extraction from trained artificial neural networks and further focuses on the problem of crisp rule extraction. The problem of crisp rule extraction from trained MLP networks is first approached on theoretical level. Present ed theoretical results state conditions guaranteeing equivalence between classification by an MLP network and crisp logical formalism. Based on the theoretical results an algorithm for crisp rule extraction, independent of training strategy, is proposed. The rule extraction algorithm can be used even in cases where the theoretical conditions are not strictly satisfied; by offering an approximate classification. An introduced rule extraction algorithm is experimentally demonstrated.

     

基于引力搜索神经网络的风电机组传动链故障识别

针对风电机组传动链故障识别由风电场制定合理维修策略可减少停机时间、降低维修费用问题,将引力搜索算法用于BP神经网络初始权值及阈值优化,提出基于引力搜索神经网络的风电机组传动链故障识别方法。算例结果表明,所提方法精度较BP神经网络高,能准确识别齿轮磨损、齿轮断齿、轴承松动等风电机组传动链典型故障,验证该方法的有效性。     

Evolutionary feature selection applied to artificial neural networks for wood-veneer classification

This paper presents the application of FeaSANNT, an evolutionary algorithm for optimization of artificial neural networks, to the training of a multi-layer perceptron for identification of defects in wood veneer. Given a fixed artificial neural network structure, FeaSANNT concurrently evolves the input feature vector and the network weights. The novelty of the method lies in the implementation of the embedded approach in an evolutionary feature selection paradigm. Experimental tests show that the proposed algorithm produces high-performing solutions with robust learning results. A significant reduction of the set of veneer features is obtained. Experimental comparisons are made with a previous method based on statistical filtering of the input features and a standard genetic wrapper algorithm. In the first case, FeaSANNT greatly reduces the feature set with no degradation of the neural network accuracy. Moreover, FeaSANNT entails lower design costs, since feature selection is fully automated. In the second case, the proposed algorithm achieves superior results in terms of identification accuracy and reduction of the feature set. FeaSANNT involves also lower computational costs than the standard evolutionary wrapper approach and eases the algorithm design effort. Limited overlapping is observed between the patterns of features selected by the three algorithms. This result suggests that the full feature set contains mainly redundant attributes.     

A grid-enabled protein secondary structure predictor

We present an integrated Grid system for the prediction of protein secondary structures, based on the frequent automatic update of proteins in the training set. The predictor model is based on a feed-forward multilayer perceptron (MLP) neural network which is trained with the back-propagation algorithm; the design reuses existing legacy software and exploits novel grid components. The predictor takes into account the evolutionary information found in multiple sequence alignment (MSA); the information is obtained running an optimized parallel version of the PSI-BLAST tool, based on the MPI Master-Worker paradigm. The training set contains proteins of known structure. Using Grid technologies and efficient mechanisms for running the tools and extracting the data, the time needed to train the neural network is dramatically reduced, whereas the results are comparable to a set of well-known predictor tools.