Restricted stimulus control and inferred attentional deficits in autistic and retarded children.

Seven autistic, 7 Down's syndrome, and 7 normal children (mean CAs 83.1, 65.7, and 45.3 mo; mean MAs 42, 36.7, and 50.6 mo; mean IQs 46.3, 45.3, and 98.6, respectively) were initially trained on a single dimension, simultaneous match-to-sample problem. Following criterion performance, each S's simultaneous matching of 4 new dimensions (2 attributes/dimension) was assessed in order to clarify the relation between autism, retardation, and attentional deficits. The Down's syndrome Ss matched significantly fewer attributes than did the autistic and normal Ss, who were equivalent in their performances. Based on these results, it is suggested that Down's syndrome and not autistic children suffer from attentional deficits. Performance in this simultaneous match-to-sample paradigm, which better assesses attentional mechanisms, was related to performances in previous serial and simultaneous discrimination paradigms, in which autistic children reportedly evidenced overselective attention. (23 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

How feedback from a listener affects children's referential communication skills.

Investigated how feedback from a listener helps young children attend to message quality and how such feedback affects speaking and listening skills. 84 kindergartners watched a speaker doll and a listener doll play a communication game in which the speaker was supposed to verbally distinguish one item from among several for the listener. In fact, however, the speaker always gave ambiguous messages. The listener attempted to select the item described by the speaker and either made a correct selection, made an incorrect selection, or asked for more information. Ss then evaluated the adequacy of the speaker's message. One week later they completed a speaking and a listening task. Results indicate that at this age children learn to assess message adequacy through observing listeners flounder with inadequate messages. Only with explicit feedback detailing the nature of the ambiguity, however, do children improve their own speaking and listening skills. (18 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Diarrhea caused by Cryptosporidium as the initial manifestation of AIDS in an elderly man

Reproductive history of mothers of 115 Down's syndrome children was studied and compared with 200 control mothers who gave birth to normal children. The frequency of spontaneous abortions in mothers of Down's syndrome babies was found to be elevated significantly (p < 0.05). The data suggest that the maternal health and reproductive potential have a prominent aetiological significance in the occurrence of Down's syndrome.     

Superior visual search in autism.

Children with a diagnosis of autism and normally developing children, matched for age and general ability, were tested on a series of visual search tasks in 2 separate experiments. The children with autism performed better than the normally developing children on difficult visual search tasks,. This result occurred regardless of whether the target was uniquely defined by a single feature or a conjunction of features, as long as ceiling effects did not mask the difference. Superior visual search performance in autism can be seen as analogous to other reports of enhanced unique item detection in autism. Unique item detection in autism is discussed in the light of mechanisms proposed to be involved in normal visual search performance. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Determination of pefloxacin and its main active metabolite in human serum by high-performance liquid chromatography

BACKGROUND: Investigation to see if there are key psychological risk indicators for autism in a random population study of children at 18 months of age; and to assess how well these discriminate children who receive a diagnosis of autism from other forms of developmental delay. METHOD: Sixteen thousand children in the southeast of England were screened for autism by their health visitor or GP, during their routine 18-month-old developmental check-up, using the CHAT (Checklist for Autism in Toddlers). From a previous high-risk study we predicted that children at 18 months of age who failed three items ('protodeclarative pointing', 'gaze-monitoring', and 'pretend play') would be at risk for receiving a diagnosis of autism. From other evidence, we further predicted that those 18-month-olds who failed one or two of the key items (either pretend play, or protodeclarative pointing and pretend play) would be at risk for developmental delay without autism. RESULTS: Twelve children out of the total population of 16,000 consistently failed the three key items. Of these, 10 (83.3%) received a diagnosis of autism. Thus, the false positive rate was 16.6% (2 out of 12 cases), and even these 2 cases were not normal. When the 10 children with autism were reassessed at 3.5 years of age, their diagnosis remained the same. Thus the false positive rate among the cases diagnosed with autism was zero. In contrast, of 22 children who consistently failed either protodeclarative pointing and/or pretend play, none received a diagnosis of autism, but 15 (68.2%) received a diagnosis of language delay. CONCLUSIONS: Consistent failure of the three key items from the CHAT at 18 months of age carries an 83.3% risk of autism; and this pattern of risk indicator is specific to autism when compared to other forms of developmental delay.     

Hyperthyroidism in a girl with Down's syndrome

We report an adolescent girl with Down's syndrome, who presented with hyperthyroidism. Autoimmune thyroid disorders can occur in children with Down's syndrome, hypothyroidism developing more frequently. Hyperthyroidism can also be associated with Down's syndrome, and should not be missed.     

Studies of directed forgetting in older adults

Younger and older adults were compared in 4 directed forgetting experiments. These varied in the use of categorized versus unrelated word lists and in the use of item by item versus blocked remember-forget cueing procedures. Consistent with L. Hasher and R. T. Zacks's (1988) hypothesis of impaired inhibitory mechanisms in older adults, a variety of findings indicated that this age group is less able than younger adults to suppress the processing and retrieval of items designated as to be forgotten (TBF). Specifically, in comparison with younger adults, older adults produced more TBF word intrusions on an immediate recall test (Experiments 1A and 1B), took longer to reject TBF items (relative to a neutral baseline) on an immediate recognition test (Experiment 3), and recalled (Experiments 1A, 1B, and 2) and recognized (Experiment 1B and 2) relatively more TBF items on delayed retention tests in which all studied items were designated as targets.     

A family study of autism: cognitive patterns and levels in parents and siblings

First-degree relatives of 99 autism probands and of 36 Down's syndrome controls were assessed with standardised tests of intellectual functioning, reading, and spelling. Higher mean verbal IQ scores, and discrepancies in favour of verbal scores, were characteristic of autism relatives. No consistent differences were found on performance scales, reading, and spelling tests. Among autism relatives, siblings affected with the broad phenotype of autism had significantly lower IQ scores and poorer reading and spelling performances than unaffected siblings. However, the small size of the cognitive difference and the lack of a distinctive cognitive profile indicates that standardised cognitive measures used in this study are unlikely to improve the operationalised definition of the broad phenotype of autism. The slightly superior verbal performance of relatives in the autism group might represent some form of heterozygote advantage.     

A comparison of speaking and mute individuals with autism and autistic-like conditions on the Autism Behavior Checklist

The item, total, and subscale scores on the Autism Behavior Checklist (ABC) were compared for 155 mute and 335 speaking individuals with autism spectrum disorders. Although no significant difference was observed between the groups on the ABC total score, the mute group demonstrated significantly more pathology on 21 of 57 items and 3 of 5 subscales. The speaking group obtained significantly higher scores on only 8 items and 1 subscale (Language). The appropriateness of providing greater pathology scores on expressive language items to speaking, rather than to mute, individuals is called into question. The authors speculate whether the expressive language items are weighted too heavily, in regard both to the Language subscale and to the ABC total score. If the expressive language items were removed, the mute group would have significantly higher ABC total scores and therefore a greater degree of autism severity.     

Development of relational reasoning and avoidance of premature closure.

First-, third-, fifth-, and sixth-grade children were administered 20 relational reasoning problems in which they had to deduce the possible sizes of one item relative to two others on the basis of a visual comparison of the sizes of the two other items and a written clue concerning the location(s) of the biggest or smallest of the three items. Some problems had single solutions, whereas others had multiple solutions. Although a high frequency of flawless performance on the single-solution problems was not seen until sixth grade, reasoning errors were less frequent than would be expected by chance even among the first-grade children. A ready facility for detecting the possibility of more than one correct solution to multiple-solution problems also did not emerge until sixth grade. Corrective feedback substantially improved the frequency with which first- through fifth-grade children detected multiple solutions on reassessment; however, this training failed to raise their performance to the level displayed spontaneously by the sixth-grade children. (20 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A laboratory model for dental radiographic studies

A 3-year-old girl with Down's syndrome and myelopathy caused by atlanto-axial subluxation (AAS) was treated by C-1 to C-2 posterior fusion with a one-piece cervical device (OPCD). Instrumentation was required because the posterior arch of C-1 was too tiny and fragile to tolerate wiring. Postoperative immobilization was another major problem in this mentally retarded young child, but a hard plastic cervical corset effectively restrained the neck. She had been confined to bed by severe quadriparesis, but became able to walk without assistance 8 months after surgery. We recommend OPCD instrumentation and postoperative immobilization using a hard plastic corset for the treatment of AAS associated with Down's syndrome in young children.     

Effect of routine screening for Down's syndrome on the significance of isolated fetal hydronephrosis

OBJECTIVE: To determine the risk of Down's syndrome in fetuses with isolated hydronephrosis at 18-23 weeks in an unselected general population after routine screening for Down's syndrome, using first trimester nuchal translucency measurement and second trimester maternal serum biochemistry. POPULATION: All pregnant women undergoing a routine 18-23 week ultrasound scan, from a population who had been offered screening for Down's syndrome. SETTING: A district general hospital serving a low risk obstetric population. METHODS: Prospective study of all routine 18-23 weeks ultrasound scans. The prevalence of isolated hydronephrosis and Down's syndrome was determined and the relative risk for Down's syndrome was calculated for different ultrasound findings. RESULTS: 10,971 women were scanned at 18-23 weeks during the study period. Down's syndrome was diagnosed in 14 of 20 cases before this stage using first trimester nuchal translucency measurement and second trimester maternal serum biochemistry. Isolated fetal hydronephrosis was diagnosed in 423 pregnancies (3.9%); none of these pregnancies were affected by Down's syndrome. The relative risk for Down's syndrome was 0.18 (95% CI 0.06-0.53) for women with a normal scan (n = 9983). When multiple ultrasound markers were found (n = 565), the relative risk for Down's syndrome was 2.00 (95% CI 0.18-22.10) and 9.00 (95% CI 1.14-71.30) for all other aneuploidies. CONCLUSION: The finding of isolated fetal hydronephrosis does not significantly increase the age-related risk for Down's syndrome. The presence of multiple ultrasound markers is associated with an increased risk of aneuploidies other than Down's syndiome. These findings are explained by the reduced prevalence of Down's syndrome as a result of prior screening and diagnosis of this condition.     

Memory for where, but not what, is used during visual search.

Although the role of memory in visual search is debatable, most researchers agree with a limited-capacity model of memory in visual search. The authors demonstrate the role of memory by replicating previous findings showing that visual search is biased away from old items (previously examined items) and toward new items (nonexamined items). Furthermore, the authors examined the type of memory representations used to bias search by changing an item's individuating feature or location during search. Changing the individuating feature of an item did not disrupt normal search biases. However, when the location of an item changed, normal search biases were disrupted. These results suggest that memory used in visual search is based on items' locations rather than their identity. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

In Cinderella's slippers? Story comprehension from the protagonist's point of view.

Research on text comprehension shows that readers construct a model of the situation described in a narrative. A major factor in constructing a situational model is the perspective from which the action of the narrative is imagined. J. B. Black, T. J. Turner, and G. H. Bower (1979) found that adults recall a deictic verb of motion more accurately if it is spatially consistent with the point of view of the main protagonist. Recall is more accurate for the verbs come and bring if they describe a movement toward the protagonist; recall is more accurate for go and take if they describe a movement away from the protagonist. Thus, adults interpret movements in a narrative from the perspective of the protagonist. This study indicates that 3- and 4-year-old children show the same pattern of recall. They accurately recall verbs of motion that are consistent with the protagonist's perspective but make substitution errors on verbs inconsistent with that perspective. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Social combination models, persuasive arguments theory, social comparison theory, and choice shift.

Individuals and 5-person groups responded 3 successive times to 4 standard choice-dilemma items in the order of either individual–group–individual or individual–individual–individual; 288 male undergraduates served as Ss. Decisions were made for oneself, for a friend, and for a stranger (the hypothetical protagonist of the standard choice-dilemma instructions). Decisions for the stranger were more risky than decisions for a friend, and decisions for a friend were more risky than decisions for oneself. As predicted from persuasive arguments theory, the best fitting social combination model on the most risky item was risk-supported wins; the best fitting model on the most conservative item was conservative-supported wins; and the best fitting model on 2 less extreme items was majority wins. It is emphasized that social combination models and theories of group-interaction processes, such as persuasive arguments theory or social comparison theory, are complementary rather than rival explanations of collective decision making. (26 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Associations between congenital malformations and childhood cancer. A register-based case-control study

This report describes a population-based case-control study that aimed to assess and quantify the risk of children with congenital malformations developing cancer. Three sources of data were used: the Victorian Cancer Register, the Victorian Perinatal Data Register (VPDR) and the Victorian Congenital Malformations/Birth Defects Register. Cases included all Victorian children born between 1984 and 1993 who developed cancer. Four controls per case, matched on birth date, were randomly selected from the VPDR. Record linkage between registers provided malformation data. A matched case-control analysis was undertaken. Of the 632 cancer cases, 570 (90.2%) were linked to the VPDR. The congenital malformation prevalence in children with cancer was 9.6% compared with 2.5% in the controls [odds ratio (OR) 4.5, 95% CI 3.1-6.7]. A strong association was found with chromosomal defects (OR=16.7, 95% CI 6.1-45.3), in particular Down's syndrome (OR=27.1, 95% CI 6.0-122). Most other birth defect groups were also associated with increased cancer risk. The increased risk of leukaemia in children with Down's syndrome was confirmed, and children with central nervous system (CNS) defects were found to be at increased risk of CNS tumours. The report confirms that children with congenital malformations have increased risks of various malignancies. These findings may provide clues to the underlying aetiology of childhood cancer, as congenital malformations are felt to be a marker of exposures or processes which may increase cancer risk. The usefulness of record linkage between accurate population-based registers in the epidemiological study of disease has also been reinforced.     

Effects of jumping skill training on walking balance for children with mental retardation and Down's syndrome

In the present study, we hypothesized that the enhancements obtained from the practice of jumping activity could be transferred to improve the walking balance in children with mental retardation (MR) and Down's syndrome (DS). SUBJECTS: Fourteen children with the diagnosis of MR or DS, aged 3 to 6 years, were recruited from a day care institution. They were ambulant but without jumping ability. Sixty-one non-handicapped children was used to serve as a normative comparison group. METHOD: Before the training program, the performances of walking balance, jump skills and jumping distances were assessed individually by one physical therapist. The balance sub-test in the Bruininks Oseretsky Test of Motor Proficiency (BOTMP) was administered to assess the walking balance. Motor Skill Inventory (MSI) was used to assess the qualitative levels of jumping skills. A jumping skill training lesson that included horizontal jumps and vertical jumps was designed and integrated into the educational program. The recruited children received 3 sessions of training per-week for 6 weeks. A post-training test and a follow-up test were administered to the handicapped children. RESULT: In BOTMP scores, statistical differences exited between the pre-training and post-training tests in the tested items of floor walk and beam walk. However, no significant difference was found in the items of floor stand, beam stand and floor heel-toe walk. MSI scales revealed there were significant differences between pre-training and post-training tests. There was no significant difference between the scores of post-training test and the follow-up test. DISCUSSION: The results implicated that the jumping activity might effectively evoke the automatic and dynamic postural control. Moreover, the significant improvements of the floor walk and beam walk performances might be due to the transferred effects via the practice of dynamic jumping activity. Furthermore, implications and suggestions are discussed.     

Is depression taxonic, dimensional, or both?

The current investigation examines the potential importance of item selection in the ongoing discussion regarding the taxonicity of depression. Following J. C. Coyne (1994), we contrast the taxonicity of "distress" with the taxonicity of a syndrome more focused on somatic symptoms (i.e., the involuntary defeat syndrome). Using 4 samples of 984 undergraduates, we fast replicate the J. Ruscio and A. M. Ruscio (2000) results, by showing that distress item indicators are dimensional. We then demonstrate taxonicity using items focused on somatic symptoms and reflective of disruption of multiple homeostatic mechanisms. Results suggest that item selection is central to the determination of taxonicity in depression. (PsycINFO Database Record (c) 2010 APA, all rights reserved)