试论学习型社会中的数字图书馆建设

创建数字图书馆是适应现代化发展,满足新时期人类需求的必由之路.本文从学习型社会及数字图书馆的关系入手,指出了在学习型社会中数字图书馆的地位与作用,提出了如何打造服务全民的精品数字图书馆的建议,为创建学习型社会做出更大贡献.     

运用网络提高图书馆的科学管理

随着网络的盛行以及在日常生活各个领域的渗透,信息技术革命带给人们生活巨大变化,图书馆的面貌也随之发生剧变:由传统图书统逐步演进为数字图书馆,传统的索书方式被电脑和网络所替代.在瞬息万变的现代信息社会,如何使图书馆进行科学化管理,适应整个社会的发展需求,是当今许多学者关注的一个课题.     

关于数字图书馆知识产权保护问题的探讨

随着数字化时代的到来与网络的飞速发展,数字图书馆的建立健全是社会信息化全面深入发展的必然趋势与要求.但就现阶段数字图书馆的发展状况来看,如何保护数字图书馆知识产权是数字时代发展过程中面临的一个重要问题.本文笔者就此问题进行探讨浅析.     

浅谈图书馆的数字化建设

本文通过分析网络信息技术对传统图书馆的影响和在现代图书馆建设中所发挥的作用,提出了硬件建设、人才储备等数字图书馆建设中应解决的主要问题并进行了阐述.     

高校数字图书馆的建设及作用

数字图书馆是高校图书馆建设的发展方向,建设高校数字图书馆是高等教育发展的必然趋势。从分析数字图书馆与传统图书馆的区别入手,着重介绍数字图书馆的概念及建设高校数字图书馆的条件、高校数字图书馆的重要作用。     

浅谈金昌市数字图书馆建设

金昌市图书馆虽然已基本实现了计算机现代化管理，但是要提供在广域网上高速横向跨库连接的电子存取服务和以用户为主导的全方位服务，差距还有待于缩小。数字图书馆的建设是图书馆建设的发展方向，数字图书馆是未来图书馆的存在形式。文章着重介绍了我馆的概况、数字图书馆的定义、建立数字图书馆的意义、数字图书馆的特点、数字图书馆的模块、及数字图书馆建设中应解决的主要问题。     

基于“图书馆消亡”问题的思考

论述了“图书馆消亡”论产生的社会背景,分析了传统图书馆持久存在的原因,提出了图书馆发展的新模式:传统图书馆与数字图书馆并存。     

浅谈数字图书馆的信息资源建设

数字图书馆作为一种新型的信息资源组织模式,受到世界各国的普遍重视.但数字图书馆作为一个新生事物,无论其平台技术、信息资源组织方法,还是信息服务策略都在研究、探索和实践之中.数字图书馆信息资源库的建设是研究的主题,也是现阶段数字图书馆组建中的重点.     

网络环境下包钢数字图书馆建设构想

介绍了数字图书馆的概念及意义,探讨了网络环境下包钢建立数字图书馆的必要性,阐述了建设数字图书馆的过程。     

借鉴国外经验 探索中国数字图书馆建设

发达国家数字图书馆的建设已经走在世界前列，我国数字图书馆尚在起步阶段，如何以高校为龙头，迅速推进我国数字图书馆建设？国外先进数字图书馆建设的经验对建设具有中国特色的数字图书馆不无借鉴意义。其经验主要有科学家主导，分步骤进行；高校牵头，迅速扩展空间；点面结合，全面规划；注重技术与学科的一致性。     

Kojic acid production by Aspergillus flavus using gelatinized and hydrolyzed sago starch as carbon sources

Radiography in an emergency setting is a demanding task, in technical as well as in logistical terms. Rapid acquisition of high quality radiographs under difficult conditions, for example severely injured patients with multi-organ trauma is important. All image data and radiological reports must be transmitted to the trauma surgeon as soon as possible. To meet these needs with the promising means of modern X-ray technology, we decided to implement a completely digital X-ray division inside the new outpatient trauma department. In the setting of an outpatient emergency department digital radiography and PACS cannot be realised without problems. We present our first experience with the installation and 10 month filmless routine in the X-ray division for traumatology outpatients at the university of Innsbruck department of radiology.     

提高图书馆图书利用率的几点思考

文章阐述了图书馆在服务经济建设、教学科研、普及科学文化知识等中的作用,并对图书馆利用率进行了简要的论述。提高图书馆的利用率,是图书馆事业立足和发展的根本。     

Neuroradiologic diagnosis of space compression processes caused by orbital tumors or pseudotumors

In thirty-year period are presented 110 patients with spatio-compressive orbital processes diagnosed by ophtalmoradiological methods. Out of those, 100 patients were surgically treated and histopathologically verified in our institution. All the entities of spatio-compressive processes are presented, benign and malignant tumors as well as pseudotumors of inflammatory and vascular nature. All the methods known in the world up to day are chronologically alleged, from classic to modern digital methods, as well as their diagnostic efficacy. The most efficacious algorhitm is established in the choice of radiological examination procedures on the basis of former experience. The collaboration of neuroradiologist, ophthalmologist and neurosurgeon was of the utmost significance in solving the spatio-compressive orbital processes.     

现代数字化智能测绘技术在地质勘查工程中的应用

我国测绘技术的发展逐步上升到新的高度,现代测绘技术逐步走向智能化和数字化。传统的测绘方式存在着效率低下等问题,提出基于数字化智能测绘技术的地质勘查工程方法。通过调整使用数字化智能测绘技术进而优化地质勘查的测绘过程,最终完善对地质勘查的评估。     

Information retrieval patterns and needs among practicing general surgeons: a statewide experience

Information retrieval has progressed from a reliance on traditional print sources to the modern era of computer databases and online networks. Surgeons, many from remote areas not served by professional medical libraries, must develop and maintain skills in information retrieval and management in both electronic and standard formats. One hundred thirty-three New Mexico general surgeons were surveyed to identify their information-seeking patterns in five areas: retrieval purposes, retrieval sources, barriers to access, techniques used, and continuing education needs. Ninety-nine (74.4%) surgeons responded to the survey. Ninety-five percent utilize professional meetings, the medical literature, and physician colleagues as information sources. Only 17% utilize the outreach services of the state's only medical school library. Common retrieval barriers were practice demands (71%), isolation from medical schools (30%), computer illiteracy (28%), and rural environment (25%). Continuing education topics related to information management would be valuable to 61% of the surgeons. Sixty-nine percent believe their current ability to access biomedical information is adequate, despite most frequently accessing their personal libraries for information related to decision-making or patient management. These data suggest that, despite significant information needs, surgeons have not embraced newer forms of information retrieval. It is imperative that surgeons acquire and maintain modern information retrieval skills as a means of remaining up-to-date in their profession. Professional surgical organizations and medical librarians should collaborate on these continuing education ventures.     

Brugia pahangi: differential induction and regulation of jird inflammatory responses by life-cycle stages

A novel, miniaturized high-throughput screening format is described for assay of combinatorial libraries generated on beads. This approach, which is ideally suited to encoded libraries synthesized on beads, utilizes the photolytic cleavage of individual compounds into a high-density well array (>6500 wells within a standard 96-well microtiter plate footprint) with well volumes as low as 0.37 microl. As a model study, an encoded dipeptide library (324 members) acylated with isobutyl succinate was assayed using this format to search for potential inhibitors of matrilysin, a member of the matrix metalloproteinase superfamily. In situ release of compounds from solid support was accomplished by photochemical cleavage after beads and enzyme were distributed to the wells. After the addition of a fluorogenic substrate to the array, the extent of enzyme inhibition and identification of active compounds was quantitated by imaging of the fluorescence emission upon uv irradiation. The structure-activity relationship data generated from the identified inhibitors in this study corroborate previous findings, thus validating the utility of this approach as a means of high-throughput screening of bead-based libraries.     

Use of reference libraries and hybridisation fingerprinting for relational genome analysis

The concept of relational genome analysis by hybridisation has been developed into a working system. Various genomic and cDNA libraries have been generated and are distributed via a reference system. Analysis procedures have been tested successfully in the mapping of the entire Schizosaccharomyces pombe genome. In another test-case for their refinement, analyses on the Drosophila genome are well under way. Human and mouse libraries are being studied on all levels, from generating YAC maps to partially sequencing representative cDNA libraries. The automation of the involved processes and the development of improved image detection and analysis are well advanced.     

Electrochemical oxidation of N-acyldopamines and regioselective reactions of their quinones with N-acetylcysteine and thiourea

Affinity selection from peptide libraries is a powerful tool that has been used for determining the sequence specificities of a number of enzymes and protein binding domains, including protein kinases, src homology 2 domains, and PDZ domains. We have extended this approach to protein tyrosine phosphatases using peptide libraries containing a nonhydrolyzable phosphotyrosine analog, difluorophosphonomethylphenylalanine. A size-exclusion method is used to separate enzyme-peptide complexes from free peptide, providing several advantages over the traditional immobilized protein affinity column approach. In addition, the feasibility of using mass spectrometric detection to quantitate peptides rapidly and reproducibly is demonstrated as an alternative to quantitation by peptide sequencing. The validity of this analysis is demonstrated by synthesizing individual peptides and comparing their affinity for enzyme with the predictions from the affinity selection process. As a model for these studies the protein tyrosine phosphatase PTP1B is used, providing additional insights into the sequence specificity of this enzyme. In particular, a selection for aromatic amino acids at the pY - 1 position (immediately N-terminal to the phosphotyrosine), as well as a broad pY + 1 selectivity, is observed in addition to the general preference for acidic residues N-terminal to the phosphotyrosine. The approach described here should prove applicable to protein tyrosine phosphatases in general as well as for the study of nonpeptidyl combinatorial libraries.