Polarity and sex effect in genetic transmission of affective disorders. The single major locus hypothesis

A single major locus model of inheritance that incorporates polarity (bipolar-unipolar distinction) and sex effect was applied to family study data on bipolar and unipolar affective disorders. In the model tested, clinical polarity and sex-related thresholds determined a differential liability to major affective illness, whereby unipolar females and bipolar males represented two extremes on a genetic-environmental continuum. Bipolar males were more deviant, and unipolar females were less deviant genetically than bipolar females and unipolar males. The major locus hypothesis did not provide an acceptable fit to the data. The implications of these findings for genetic and biological research in affective disorders are discussed.     

Genetic linkage and bipolar affective disorder: progress and pitfalls

The history of linkage studies in bipolar affective disorder is a convoluted affair punctuated by upswings and setbacks, hope and skepticism. Advances in genomics and statistical techniques, and the availability of well-characterized clinical samples, have bolstered the search for disease genes, leading to a new crop of findings. Indeed, recent reports of putative loci on chromosomes 18, 21, X, 4, 6, 13 and 15 have rekindled a sense of optimism. The new findings are reviewed and scrutinized, with implications for future research.     

Marital interaction: Physiological linkage and affective exchange.

Studied 30 married couples during naturalistic interactions to determine the extent to which variation in marital satisfaction could be accounted for by physiological and affective patterns between and within spouses. Two hypotheses were tested: (a) Compared to nondistressed couples' interactions, distressed couples' interactions would show greater physiological interrelatedness or "linkage," more negative affect, and more reciprocity of negative affect. (b) These differences would be more pronounced when the interaction was high in conflict (discussing a marital problem) as opposed to low in conflict (discussing the events of the day). Heart rate, GSR, pulse transmission time, and somatic activity from both spouses were analyzed using bivariate time-series techniques to derive a measure of physiological linkage. Self-report affective data were analyzed using sequential analyses to derive a measure of affect reciprocity. The hypotheses were strongly supported; 60% of the variance in marital satisfaction was accounted for using measures of physiological linkage alone. Additional nonredundant variance was accounted for by the other physiological and affective measures. (25 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Quantitative models of the genetic transmission of schizophrenia.

Reviews research that has focused on specifying the genetic mechanisms involved in the familial transmission of vulnerability to schizophrenia. The importance of specifying the mechanism and methodological issues involved in genetic modeling are discussed. Models of genetic transmission are described and analyzed, including single major locus models, polygenic models (such as limited loci polygenic models and multifactorial polygenic models), and mixed models. Findings provide little support for the mechanism of single major locus inheritance. Although a mechanism involving 2, 3, or 4 loci cannot be ruled out, there is no compelling support for such models. The multifactorial polygenic model has received the most support and indicates that genetic factors play a greater role than cultural factors in familial transmission. At present, results neither support nor refute a mixed genetic model including both a multifactorial component and a single major locus. Implications of genetic heterogeneity and methodological deficiencies that limit the interpretability of these studies are discussed. (79 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Associative disturbance in schizophrenia, schizoaffective disorders, and major affective disorders: Comparisons between hospitalization and 1-year follow-up.

Word-association performance of 71 Research Diagnostic Criteria-diagnosed schizophrenic, schizoaffective, and affective disorder patients was assessed shortly after hospital admission to evaluate the diagnostic specificity of associative disturbance. The same Ss were assessed again 1 yr after discharge to investigate the longitudinal course of word-association behavior. Data regarding rehospitalization were included in the analyses of 4 primary word-association indices. Results indicate that thought disorder was not distinctively schizophrenic and that associative thought disorder was more characteristically associated with rehospitalization for affective disorder patients than for other diagnostic groups. Arousal and cognitive control mechanisms are discussed. (3 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Clinical judgment and affective disorders.

Addresses 3 limitations of previous work on counselor clinical judgment by the 1st author et al (see record 1983-11141-001) and R. F. Haase et al (see record 1983-26503-001). Results of the study of 20 practicing counselors suggest that the judgment process used by experienced counselors to make diagnoses of affective disorders differs depending on the type of diagnostic judgment and that attributions may play a role in at least certain types of judgments. (8 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Genetic susceptibility factors in type 1 diabetes: linkage, disequilibrium and functional analyses

Rehabilitation after soft-tissue autograft reconstructions is controversial because there is indirect evidence that some grafts fail by creeping over time. The vulnerability of soft-tissue grafts to creep over healing time and the effects of the load environment during healing on this vulnerability have never been studied specifically. We hypothesized that immobilization would decrease the magnitude of the vulnerability of ligament grafts to creep. Thirty-nine skeletally mature New Zealand White rabbits underwent a standardized medial collateral ligament autograft procedure to the right hindlimb, and 19 of the rabbits also had the limb rigidly pinned into flexion. Subgroups were killed at 3 or 8 weeks, and all isolated tibia/medial collateral ligament/femur complexes were tested for creep at 4.1 MPa under a standardized protocol. Eight normal medial collateral ligament controls were tested similarly. Results showed that all grafts were quantitatively more susceptible to cyclic and static creep than were normal medial collateral ligament controls (p < 0.05). By 3 weeks of healing, immobilization significantly increased the magnitude of the vulnerability of the grafts to cyclic, static, and total creep (all: p < 0.05). Furthermore, the grafts had more unrecovered creep strain than did the controls following a 20-minute recovery period. Contrary to our hypothesis, immobilization resulted in increased vulnerability of these ligament autografts to creep even with this relatively nonprovocative test of short duration and low stress. We postulate that following immobilization, this increase in the magnitude of susceptibility of the grafts to creep will result in functionally significant elongation of the graft if it is exposed to higher loads and over longer periods of time in vivo.     

Risk factors for substance use disorders among inpatients with major affective disorders in Taiwan Chinese

The explanation by differential diagnosis of pathological changes of the fundus may be particularly difficult in case of diseases of sporadic occurrence. The examination findings in a 19-year-old patient with a choroidal osteoma are presented. Large arciform, atrophic areas with distinct boundaries and star-shaped vascular structures were dominant in the fundus on both sides. With peripapillar manifestation, the optic nerve head was ophthalmoscopically noncontributory. A submacular bleeding had caused sudden reduction of visual acuity and caused the patient to visit the ophthalmologist. The most important diagnostic key was supplied by echography, which established peripapillar scleral calcification. The posterior eye segment was highly reflective in ultrasonic echography (B mode), showing concave deformation and causing the sound shadow. Visually evoked potentials indicated the onset of the compression of the optic nerve by the choroidal osteoma. Diagnostic and treatment possibilities are discussed.     

Pathways linking affective disturbances and physical disorders.

Comorbidity of psychological and physical disorders is substantial. This article presents a broad theoretical framework for identifying factors that contribute to and maintain comorbid conditions. The authors propose heuristic models of how co-occurrences of psychological and physical disorders are developed and maintained. The models specify biological, behavioral, cognitive, and social pathways that may account for comorbidity. Although the authors' discussion of psychological disorders is limited to the role of affective disturbances (subclinical negative moods as well as mood and affective disorders), the pathways they identify are thought to contribute to co-occurrences of other psychological disorders and physical disease as well. The authors emphasize that pathways linking comorbid states are bi-directional and that operative pathways differ depending on the specific affective response, illness behavior, disease, or disease stage. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Neuropsychobiology of affective disorders. Some methodological considerations

Amine hypothesis is neither an adequate nor a sufficient postulate in understanding the neuropsychobiology of affective disorders. Interactions and balance between various mechanisms and factors may be important. Better techniques and methodology need to be used and a more comprehensive approach seems to be necessary in formulating meaningful research strategies. The present paper reexamines someaspects of the available data and suggests a few approaches in the sutdy and elucidation of neruophychobiology of affective disorders.     

Diagnosis and treatment of affective disorders

The rates of major depression (5-12%) are considerably higher than for bipolar disorder (ca. 1%). Depressive disorder is most frequent in general practice. Although general practitioners recognise and manage efficiently a large number of depressed patients, at any consultation about half the patients are not diagnosed. Recognising depression is made difficult by the frequency in general practice of presentations with somatic symptoms (masked depression) and of depression related to physical disorder. The best method for the general practitioner to overcome these problems is by using a relatively direct interview for the main specific symptoms of depression. The general practitioner has a key role in the management of depression and as a gatekeeper with a prime responsibility to make appropriate referrals to specialists. Counselling members of the family or friends and recommending self-help groups are important to improve the therapeutic compliance of the patients.     

Phototherapy. An alternative for seasonal affective disorders or sleep disorders

Although clinicians have observed for centuries that som depressed patients become worse in the winter, it was first in 1984 that Norman Rosenthal and co-workers described a syndrome which they called seasonal affective disorder (SAD), characterised by winter depression, lethargy and a craving for carbohydrate. Phototherapy was proved to be an effective treatment right from the start. Recently it has been reported that not only depression, but also panic disorder and obsessive compulsive disorders may exhibit a seasonal pattern and thus benefit from phototherapy. Phototherapy may also benefit patients suffering from "sun-downing", a syndrome of confusion and agitation in the evening in persons with Alzheimer's disease. Based on the observation that bright light may both elevate brain serotonin and ameliorate sleep abnormalities, the authors report the results of phototherapy for treatment of non-seasonal depressions, either alone or in combination with antidepressants or sleep deprivation.     

Positive automatic cognition in major affective disorder.

This article reports 2 studies assessing the clinical validity of the Positive Automatic Thoughts Questionnaire (ATQ–P). In the 1st study, clinically depressed inpatients showed reliably lower ATQ–P scores than a nondepressed control group. In the 2nd study, the specificity of the ATQ–P to emotional distress was evaluated by examining responses in a chronic pain sample. Results indicated that depressed but not nondepressed pain patients had significantly lower scores on the ATQ–P than health control Ss. On the basis of these data, the ATQ–P appears to be an appropriate measure for assessing positive cognition in psychopathology. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Quantitative proton magnetic resonance spectroscopy of the basal ganglia in patients with affective disorders

We have retrospectively reviewed 53 cases (62 hips) with a diagnosis of slipped capital wedge epiphysis. After admission to our Hospital, a skin longitudinal traction was applied for 2 weeks, All patients were treated afterward with pinning in situ without manipulation in the operating room. Group A (31 hips) consisted of patients treated with smooth K wires and group B (31 hips) of patients treated with cannulated screws. We found a high incidence of pin penetration in group A (27 hips), whereas there was just one case in group B. Physical closure was considered when 75% of proximal growth plate disappeared in the frog lateral view and both groups showed similar values (7 months). Chondrolysis was observed in just three cases in group A, and one case had an avascular necrosis. Few complications were observed compared with the high rate of pin penetration, and we suggest that preoperative traction may be a relevant factor contributing to the low incidence of avascular necrosis (1.6%).     

Pharmacotherapy of schizophrenia and affective disorders: Behavioral correlates of diagnostic and demographic variables.

Time sampled observations of objectively defined ward behaviors in 116 schizophrenic, affective, and schizoaffective patients during baseline and medication periods revealed that schizophrenics displayed less scanning, social interaction, participation, and laughing/smiling. S. E. Tureff's (1978) Observational Record of Inpatient Behavior was used. The behavioral measures were relatively insensitive to demographic variables and strongly dependent on environmental context, but the measures did not change greatly over time for the major diagnostic categories, in spite of pharmacological interventions that included therapeutic doses of antipsychotic, antidepressant, and antimanic drugs. However, within diagnostic categories, patient clusters were extracted on the basis of amount and direction of behavior change, and for the affective patients, differential change was predictable from baseline response frequencies. Findings are discussed in terms of their potential usefulness for exploring dose-response and rate-dependence effects of psychotropic drugs in clinical populations and in terms of their potential for contributing to the resolution of the responder–nonresponder controversy in pharmacopsychiatry. (51 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Predicting relapse back to smoking: Contrasting affective and physical models of dependence.

Traditional models of physical dependence suggest that nicotine dependence should be reflected by the extent of drug exposure (e.g., smoking rate) and by evidence of physiological adaptation (e.g., withdrawal severity). An affective model suggests that nicotine dependence should be related to an individual's tendency to experience negative affect and expectations that nicotine use would ameliorate such affect. This research investigated the ability of these 2 models to predict relapse back to smoking at 6 months postquit, Logistic regression models were developed and tested in 505 heavy smokes participating in nicotine patch clinical trials. Results supported both models, but the most potent predictor of outcome was postquit negative affect, which accounted for much of the predictive validity of traditional measures of nicotine dependence. Affective reactivity appears to be a core constituent of dependence. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Influenza epidemics and incidence of schizophrenia, affective disorders and mental retardation in Western Australia: no evidence of a major effect

Alamar Blue in the microenvironment of activated cells, undergoes color change and also becomes fluorescent. By using the Alamar Blue dye, we have reported a non-radioactive colorimetric assay to indirectly determine proliferation of murine lymphocytes. We further show that the pattern of mitogen-induced proliferation assessed fluorometrically was comparable to the 3H-thymidine incorporation assay (3H-Tdr assay). Of practical importance is that the color/fluorescence changes were stable at 4 degrees C in the dark for 3-4 weeks. In immunological studies, it is important to further analyze lymphocytes that have undergone activation and/or proliferation. This is not possible with the standard 3H-Tdr assay, which requires lysis of cells. In contrast, the Alamar Blue-based non-radioactive assay does not require cell lysis. We therefore tested the hypothesis that further analysis of lymphocytes is possible, after assessing the proliferation using Alamar Blue. Following assessment of proliferation in a 72-h culture, the Alamar Blue dye was washed-off and cells were re-utilized to perform additional immunological analysis. Short-term exposure of lymphocytes to Alamar Blue was not detrimental to lymphocytes, as assessed by trypan blue exclusion and the propidium iodide (PI) assays. Exposure of dexamethasone-treated cells to Alamar Blue did not interfere with the performance of apoptosis assays, such as flow cytometric analysis of PI-stained cells and microscopic examination of ethidium bromide/acridine orange-stained cells. In addition, prior exposure of lymphocytes to Alamar Blue did not affect the analysis of chromosomal aberrations or the visualization of cell surface antigens by flow cytometry. Further, the expression of cytokine mRNA in lymphocytes previously exposed to Alamar Blue was similar to unexposed cells. Together, a notable advantage of this assay is that it now enables the investigator to maximize information by following or correlating proliferation with other immunologic events in the same cells.