共查询到19条相似文献,搜索用时 203 毫秒
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将N-(2-吡咯甲酰基)-β-丙氨酸甲酯(Ⅲ)与卤代烃经烷基化反应得到的产物水解,得到N-(1-烷基-2-吡咯甲酰基)-β-丙氨酸(Ⅱa~Ⅱc),收率84.7%~91.2%;以化合物Ⅱ为原料,在多聚磷酸-P2O5作用下,经分子内环化反应合成了标题化合物1-烷基-6,7-二氢-1H,5H-吡咯并[2,3-c]氮杂-4,8-二酮(Ⅰa~Ⅰc),收率69.1%~77.2%。3步反应总收率为61.8%~69.1%。测定了3个标题化合物对α-葡萄糖苷酶的抑制作用。 相似文献
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报道了2-叔丁氧羰基-9-乙氧羰基-2,7-二氮杂-螺[4.4]壬烷的合成方法,即以甘氨酸乙酯盐酸盐■为起始原料,与丙烯酸乙酯■经迈克尔加成、 Boc保护和分子内迪克曼缩合生成3-乙氧羰基-4-吡咯酮(■)和2-乙氧羰基-3-吡咯酮(■)后,经Krapcho脱羧反应生成N-Boc-3-吡咯酮(■),随后与磷酰乙酸三乙酯经Witting-Horner-Emmons反应生成α,β-不饱和羧酸乙酯(■),再经[1,3]-偶极环加成反应生成螺环双吡咯烷(■),最后经氢解脱去苄基等7步反应得到标题化合物2-叔丁氧羰基-9-乙氧羰基-2,7-二氮杂-螺[4.4]壬烷(TM),总收率为11%,中间体和目标产物结构经~1H NMR和MS确证。 相似文献
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N,N′-二正辛基-3,3′-二硫代二丙酰胺的合成 总被引:1,自引:0,他引:1
研究了异噻唑啉酮的关键中间体N,N′-ZiE辛基-3,3′-二硫代二丙酰胺的合成。以丙烯酸甲酯为原料,经亲核加成、脱硫精制及酰胺化反应制得目的产物,总收率可达80%。同时详细讨论了反应物配比、反应温度及时间等因素对收率的影响。 相似文献
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5-(4-烷基苯基)-2-(4-氰基苯基)-嘧啶的合成 总被引:1,自引:0,他引:1
对 5 (4 烷基苯基 ) 2 (4 氰基苯基 ) 嘧啶的合成进行了研究 ,以 5 (4 正己基苯基 ) 2 (4 氰基苯基 ) 嘧啶 (Ⅳ )的合成为例 ,论述了以 4 己基苯乙酸为原料 ,先依次制得 4 己基苯乙酰氯 ,1 二甲氨基 3 二甲亚胺基 2 (4 正己基苯基 ) 丙烯 高氯酸盐 (Ⅰ ) ,得率 84%。进而在甲醇钠存在下与 4 溴苯基脒盐酸盐 (Ⅱ )相对接 ,合成 5 (4 正己基苯基 ) 2 (4 溴苯基 ) 嘧啶 (Ⅲ ) ,得率 87%。最后Ⅲ和CuCN反应合成了液晶化合物Ⅳ ,得率 78%。其结构由1HNMR和IR光谱所证实 ,同时还测定了其DSC。另外在合成Ⅱ时 ,必须在无水条件下进行 ,而且在通入氯化氢气体时 ,反应温度保持 - 5~ 0℃ ,其反应得率 97%。 相似文献
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The hydroperoxides of methyl linoleate, 1-palmitoyl-2-linoleoyl-phosphatidylcholine and trilinolein each produced similar
fluorescent substances through reaction with amino compounds after decomposition by heme methyl ester. Fluorescent substances
formed from methyl linoleate with 1-aminopentane revealed characeristic fluorescence peaks on HPLC, while those obtained from
1-palmitoyl-2-linoleoyl-phosphatidylcholine and trillinolein were not eluted under the same conditions. However, when both
of these fluorescent substances were transesterified to methyl ester, the same fluorescence peaks were observed. This result
suggests that fluorescent substances formed from oxidized membrane lipids with amino compounds remain attached to phospholipids
without being released from their glycerol backbone. 相似文献
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以3-氨基-2-噻吩甲酸甲酯为原料,经氯磺化、甲胺化、N-烷基化、环合等反应合成了替诺昔康的中间体4-羟基-3-甲基-2H-噻吩并[2,3-e]-1,2-噻嗪-2-羧酸甲酯-1,1-二氧化物(MHTTCD)。氯磺化时在大大减少溶剂(醋酸)用量的条件下,收率为78%,甲胺化收率为81.6%。环合反应在甲醇钠的甲醇溶液中进行,合适的甲醇钠浓度为1mol/L。回流反应1h,该步收率达55.5%。合成路线反应总收率为11.11%。通过GC-MS确认了各中间体的结构。由于N-烷基化时以氯乙酸乙酯代替肌氨酸乙酯盐酸盐以及收率的提高,降低了合成成本。 相似文献
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Michael Qian Cara Nelson Scott Bloomer 《Journal of the American Oil Chemists' Society》2002,79(7):663-667
The aroma compounds in Blue cheese were studied with a dynamic headspace-GC/olfactometry (GC/O-DH) technique and evaluated
by both aroma extract dilution analysis (AEDA) and the Osme technique to identify and assign importance to aroma compounds.
AEDA aroma dilution values were obtained by sequential reduction of sample size, and Osme values were obtained based on aroma
intensity and duration. The most important compounds contributing to Blue cheese aroma were diacetyl, 2-methylpropanal, 3-methylbutanal,
ethyl butanoate, ethyl hexanoate, methional, dimethyl trisulfide, 2-heptanone, and 2-nonanone. Compounds central to the characteristic
Blue cheese aroma and typically derived from milkfat included 2-heptanone, 2-nonanone, butanoic acid, hexanoic acid, and ethyl
esters. Since the methyl ketones contributed the characteristic Blue cheese aroma, a flavor concentrate enriched in methyl
ketones to impart characteristic Blue cheese aroma was synthesized using Penicillium roqueforti spores in a model system. A fivefold enhancement in methyl ketone production was obtained by providing aerobic conditions.
The addition of sucrose and serine, compounds known to affect mold spore metabolism, did not enhance methyl ketone production
but caused generation of an uncharacteristic fruity, floral aroma. 相似文献
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A. W. Schwab W. K. Rohwedder L. W. Tjarks L. E. Gast 《Journal of the American Oil Chemists' Society》1973,50(9):364-366
Sulfur compounds derived from photochemical addition of hydrogen sulfide to methyl oleate and linoleate were separated by
preparative gas chromatography. The major compounds were investigated by NMR, mass and IR spectroscopy and by elemental analysis.
The primary product of the methyl oleate reaction was methyl 9(10)-mercaptostearate. Gas chromatograms of the product from
methyl linoleate showed four principal peaks. From mass spectra and NMR data, we identified methyl 9-(2-pentyl-1-thiolan-5-yl)nonanoate,
methyl 8-(2-hexyl-1-thiolan-5-yl)octanoate and methyl 9-(3-hexyl-1,2-dithiolan-5-yl)nonanoate. Evidence for the formation
of methyl mercapto-octadecenoates and methyl dimercaptostearates was also obtained.
ARS, USDA. 相似文献
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用Wittig和Wittig-Horner反应合成藏红花酸二甲酯 总被引:1,自引:0,他引:1
以短碳链化合物1,4-二溴-2-丁烯、丙酮醛缩二甲醇、2-溴丙酸甲酯和氯乙醛为起始原料,首先分别合成2,7-二甲基-2,4,6-辛三烯-1,8-二醛和γ-氯代惕各酸甲酯,然后将两者结合而成藏红花酸二甲酯。合成过程中碳碳双键的形成为关键步骤。通过比较Wittig和Wittig-Horner反应在双键形成中的作用,得出结论:合成2,7-二甲基-2,4,6-辛三烯-1,8-二醛时,宜用Wittig-Horner反应,产率为58.7%;合成γ-氯代惕各酸甲酯和藏红花酸二甲酯时,宜用Wittig反应,产率分别为74.3%和78.6%。 相似文献
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Chemical shift reagents (CSR) can substantially increase the amount of structural information obtainable from NMR studies
of saturated and unsaturated lipid derivatives. It is theoretically possible to obtain even more information from CSR studies
of unsaturated lipid derivatives by introducing additional CSR-active functional groups into those molecules through derivatization
of their double bonds. However additional CSR coordination sites complicate spectral interpretation, because they increase
the number of signals that overlap. Therefore two model compounds were investigated to test the feasibility of attempting
other CSR analyses of polyfunctional molecules of unknown structure. This paper describes successful CSR studies of methyl
ricinoleate and methyl 12-hydroxystearate. A series of complementary interpretive techniques was used to assign proton signals
in spectra obtained during incremental Eu(fod)3 addition studies with these compounds. Individual proton signals can be observed and assigned for all the protons in methyl
ricinoleate, except those on carbons 5, 6 and 7. Information obtained for methyl 12-hydroxystearate is less specific. Signals
are observed for all protons in methyl 12-hydroxystearate, although in some cases several proton signals overlap.
Presented in part at the JOCS-AOCS Joint Meeting, Los Angeles, April 1972. 相似文献