结晶技术在医药生产中的应用

论述了溶液结晶、熔融结晶和反应结晶等传统结晶技术及耦合、物理场促进结晶等新型结晶技术的特点及其在医药生产中的应用进展,并展望了医药结晶技术的应用前景及其未来发展方向。     

熔融结晶及其耦合技术研究的进展

介绍逐步冻凝熔融结晶过程和悬浮熔融结晶过程以及各自特点,综述了近年来新型熔融结晶技术与设备的应用研究进展;着重介绍了耦合技术在熔融结晶过程中的应用研究动态;最后展望了熔融结晶技术与设备的发展趋势与方向。     

膜结晶技术的发展及其在蛋白质结晶中的应用

膜结晶技术作为一种新兴的分离净化技术近几年得到了较快发展。阐述了膜结晶技术的产生背景、膜结晶器的类型、膜结晶技术的基本过程、原理及其优点,介绍了膜结晶蛋白质的优点及膜结晶技术在蛋白质结晶中的应用情况,最后展望了膜结晶技术的发展前景。     

旋转流变仪在线研究聚合物结晶行为进展

介绍了利用旋转流变仪在线研究聚合物结晶行为的工作原理,对近几年国内外利用旋转流变仪在线研究聚合物结晶行为的成果进行了综述,最后展望了旋转流变仪在聚合物结晶行为研究中的应用前景。     

结晶分离技术在香料生产中的应用

为了提高香料产品的纯度 ,加强香料独特的香气和香味 ,作为一种高效率低能耗的分离提纯手段 ,结晶已被广泛用于香料的工业生产。本文综述了溶液结晶、熔融结晶、耦合结晶、反应结晶、升华结晶等分离提纯技术在香料生产中的应用情况 ,并对各种结晶技术的特点进行了讨论 ;最后阐述了香料结晶技术发展前景。     

物理场强化溶液结晶应用研究进展

结晶是食品和化工分离中的一个重要单元操作。文章阐述了溶液结晶的原理，综述了超声场、微波场、静电场、磁场等物理场在溶液结晶中的应用，分析和探讨了它们对溶液结晶的影响机理，并且对今后的发展进行了展望。     

层状结晶二硅酸钠在无磷浓缩洗衣粉中的应用

探讨了层状结晶二硅酸钠在无磷浓缩洗衣粉中的应用,着重讨论解决了层状结晶二硅酸钠的加入量、液体携带量、层状结晶二硅酸钠与沸石的复配、产品手感、产品流动性等问题。     

萃取结晶过程研究进展

分类讨论了目前萃取结晶技术在无机盐及有机物分离领域中的应用现状、发展趋势和相应的分离原理,概括得到萃取结晶的一般原理。与传统的蒸发、结晶过程相比,萃取结晶技术具有很多优势,必将得到更大的发展。     

钛白粉生产中真空结晶工艺技术的开发

钛白粉生产作为化工行业中的重要组成部分,采用真空结晶工艺技术可以提高钛白粉的生产质量与效率。因此本文将对真空结晶技术在钛白粉生产过程中的开发与应用进行分析,也会对关键设备国产化替代进口设备进行探讨。利用真空结晶工艺可以降低成本,增加结晶效率与生产能力,还可以有效减少能耗,因此应被大力推广并应用。     

过程分析技术（PAT）及其在原料药结晶过程的应用与展望

过程分析技术（Process Analytical Technology,PAT）可以实时在线监测原料药结晶过程的变化，通过对结晶过程的控制，从而保证工艺连续性和质量稳定性。首先，系统介绍了PAT概念、类型、工具及其特征；其次，综述了PAT在原料药结晶过程中的典型应用；最后，总结了PAT应用于原料药结晶过程控制的优势以及展望。     

结晶分离技术新进展

概述了结晶分离理论和模拟优化的发展,综述了冷却剂直接接触冷却结晶、反应结晶、蒸馏-结晶耦合、氧化还原-结晶液膜、萃取结晶、磁处理结晶等结晶分离方法.合理设计结晶器及结晶工艺是实现结晶分离工业化的可靠保证,对降膜结晶装置、Bremband结晶工艺和板式结晶器进行评价.指出今后需深入进行新型结晶分离装置与工艺、工艺的工业化、结晶过程传热传质机理方面的研究.     

连续管式结晶器研究进展

结晶是大多数化工生产过程中必不可缺的步骤。目前,大部分结晶过程采用间歇结晶,但间歇结晶的生产模式存在批次间差异、生产成本过高等缺点。因此,连续结晶作为新的结晶模式逐渐成为研究的重点。其中,连续管式结晶器具有较窄的停留时间分布和较高的生产效率等优势,已广泛应用于工业结晶。针对连续管式结晶器研究现状进行了详细介绍,总结了管式结晶器普遍存在的问题和解决方法,并介绍了辅助设备和技术在连续管式结晶器中的应用。最后,总结了管式结晶器的进一步发展方向。     

Effect of sinusoidal Taylor vortex flow on cooling crystallization of L-lysine

An elliptical Couette-Taylor (ECT) crystallizer with a unique sinusoidal Taylor vortex flow was developed to promote the recovery and size distribution of L-lysine crystals in cooling crystallization. When using the ECT crystallizer, the recovery was enhanced to a maximum of 100% with a mean residence time of only 15 min. When comparing the crystallization efficiency, the recovery and size distribution of the L-lysine crystals in the ECT crystallizer were over 33% and 50% higher, respectively, than those in the conventional MSMPR crystallizer and slightly higher than those in the circular Couette-Taylor (CT) crystallizer. This improved crystallization in the ECT crystallizer was explained in terms of the sinusoidal profile of the Taylor vortex intensity. Plus, since the nucleation and growth processes determine the recovery and crystal size distribution, the mean residence time, inner cylinder rotation speed, and feed concentration were all varied to investigate their influence on the crystallization efficiency.     

DTB连续结晶器在去除水合肼中十水碳酸钠的应用

去除水合肼中十水碳酸钠,传统工艺采用间歇结晶方式。间歇结晶方式存在许多缺点,如设备结疤严重、生产能力小、劳动强度大。介绍了采用连续冷却结晶设备（DTB冷却结晶器）去除水合肼中十水碳酸钠的方法。连续结晶工艺,克服了间歇结晶工艺的缺点。采用DTB冷却结晶器去除水合肼中的十碳酸钠,可使其质量分数由12.03%降低至0.55%。介绍了DTB冷却结晶器的工作原理,简述了冷却结晶设备及配套设备的设计要点。     

石膏两步法制硫酸钾中CaCO3及K2SO4结晶动力学研究

本文实验研究了石膏与氯化钾两步转化法生产硫酸钾中停留时间、进料质量分数及搅拌速率等重要操作参数对CaCO3、K2 SO4 结晶动力学的影响规律 ,得到相应的二次成核动力学方程式 ,其结果可为石膏两步法制硫酸钾工业化结晶器的设计与放大提供基础数据     

Effects of sweating time and cooling strategy on purification of N-vinyl-2-pyrrolidinone using a melt crystallizer

A melt crystallization process is proposed to produce high-purity n-vinyl-2-pyrrolidinone (NVP). To produce high purity products, operation strategy plays key role in the melt crystallizer. We investigated the cooling strategy and optimal sweating time using a batch-type melt crystallizer. A slow cooling followed by a slow heating was found to be an effective temperature profile to produce high purity of NVP. The optimal sweating time was found to be about 20 minutes. For industrial application, a cascade melt crystallizer which consists of four stages was constructed and the proposed crystallization/sweating scheme was applied. Using the new melt crystallizer, NVP more than 99.99% purity can be produced in semi-continuous mode.     

A process development for the bundling crystallization of aspartame

It is known that rod-like crystals of aspartame, in which several needle crystals appear to be bundled together (bundle-like crystals), have remarkably improved physical properties compared to the crystals obtained from a conventional stirred crystallizer. A crystallization process for obtaining bundle-like crystals has been developed for manufacturing practice. The conditions to obtain the bundle-like crystals are that crystallization must be carried out without stirring, with a high initial concentration of aspartame so that the amount of precipitated solid after cooling is about 10 g litre^?1 or more, and with rapid cooling to produce high supersaturation. A new type of crystallizer was developed for large-scale crystallization under these conditions. The pilot plant work was carried out in a 400-litre crystallizer, and it has been demonstrated that the crystallization process is technically possible and economically successful in the large-scale manufacturing of aspartame.     

Automated self seeding of batch crystallizations via plug flow seed generation

In this study, seed slurry from a single addition anti-solvent plug flow crystallization of benzoic acid was used to seed the equivalent batch cooling crystallization. The experimental conditions were carried out to simulate automated self-seeding. This involves withdrawal of solution from a batch crystallizer, which is then mixed with anti-solvent within a plug flow crystallizer, in order to generate a seed slurry which is fed directly back to the batch crystallizer. This seeding strategy allowed the final CSD of the batch crystallization to be controlled by variation of the crystal size from the plug flow seeding device at a constant seed loading. The ability to use unequal feed/anti-solvent inlet flowrates (in the Roughton vortex mixer) proved effective in controlling the batch CSD at 2% seed loading and constant feed composition.     

连续结晶过程非稳态特性的研究

建立了连续溶液结晶过程非稳态系统模拟软件,并应用该软件对过程内在不稳定性进行了分析.在10L及200L复杂结晶器内进行动态行为实验研究,观察晶粒粒度分布(CSD)的动态规律及系统参数对稳定性的影响趋向,实验与模拟分析的结果一致.     

混合式搅拌器在结晶罐中的应用及数值分析

针对国内某厂柠檬酸结晶罐的改造,以双螺带与框式混合搅拌器为模型,对一种新型冷却结晶罐的流场进行了数值研究。得到了罐内流场和速度分布情况,分析了搅拌器表面静压分布并预测了搅拌功率,为结晶操作中搅拌器的选择与设计提供了参考。最后通过现场数据测试对其进行了工程考核。结果表明,新型混合搅拌器使结晶率和产量均有很大的提高,产品质量较改造前得到明显改善,晶粒均匀,晶型规则,达到了预期目标。