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《Drug development and industrial pharmacy》2013,39(3):487-499
AbstractBased upon Okusa's observation (Chem. Pharm. Bull. 1975) that the slopes of a linear plot of logo log fraction of active substance degraded vs log time for first order decay kinetics and a linear plot of log of drug remaining vs log time for a zero order decay kinetics are both unity, an algorithm has been developed to resolve both the energy of activation (E) and the rate constant (Ko or Lo) at the desired shelf-life temperature (To) by analysis of the y-intercepts of parallel slopes at more than one elevated temperature (T).Preliminary estimates of both E and either Ko or Lo are then substituted into a series of mathematical expressions based upon well known Arrhenius relationship:k = A ·exp -E/1.987) (1/T-l/To) where A = Ko or LoUsing converging and interative techniques to treat elevated temperature data, the resulting mean loss rate (eithri Ko or Lo at the designated shelf-life temperature plus a residual error term thus obtained, is used to distinguish statistically between zero and first order treatments. A program called POTENCYLOSS, based upon the algorithm, has been written in business BASIC language for use with an IBM-PC micro-computer.The program is ideally suited for use in preformulation studies or in assigning provisional expiration dating and overage requirements during the early stages of formulation development when there is limited potency stability test data available at accelerated, elevated temperature storage conditions. 相似文献
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《IEEE sensors journal》2008,8(10):1620-1627
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Robert A. Nash 《Drug development and industrial pharmacy》1987,13(3):487-499
Based upon Okusa's observation (Chem. Pharm. Bull. 1975) that the slopes of a linear plot of logo log fraction of active substance degraded vs log time for first order decay kinetics and a linear plot of log of drug remaining vs log time for a zero order decay kinetics are both unity, an algorithm has been developed to resolve both the energy of activation (E) and the rate constant (Ko or Lo) at the desired shelf-life temperature (To) by analysis of the y-intercepts of parallel slopes at more than one elevated temperature (T).
Preliminary estimates of both E and either Ko or Lo are then substituted into a series of mathematical expressions based upon well known Arrhenius relationship:
k = A ·exp -E/1.987) (1/T-l/To) where A = Ko or Lo
Using converging and interative techniques to treat elevated temperature data, the resulting mean loss rate (eithri Ko or Lo at the designated shelf-life temperature plus a residual error term thus obtained, is used to distinguish statistically between zero and first order treatments. A program called POTENCYLOSS, based upon the algorithm, has been written in business BASIC language for use with an IBM-PC micro-computer.
The program is ideally suited for use in preformulation studies or in assigning provisional expiration dating and overage requirements during the early stages of formulation development when there is limited potency stability test data available at accelerated, elevated temperature storage conditions. 相似文献
Preliminary estimates of both E and either Ko or Lo are then substituted into a series of mathematical expressions based upon well known Arrhenius relationship:
k = A ·exp -E/1.987) (1/T-l/To) where A = Ko or Lo
Using converging and interative techniques to treat elevated temperature data, the resulting mean loss rate (eithri Ko or Lo at the designated shelf-life temperature plus a residual error term thus obtained, is used to distinguish statistically between zero and first order treatments. A program called POTENCYLOSS, based upon the algorithm, has been written in business BASIC language for use with an IBM-PC micro-computer.
The program is ideally suited for use in preformulation studies or in assigning provisional expiration dating and overage requirements during the early stages of formulation development when there is limited potency stability test data available at accelerated, elevated temperature storage conditions. 相似文献
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Mengkui WANG 《材料科学技术学报》2001,17(5)
[1]National Natural Science Foundation of China: Inorganic Nonmetal Material Science, Science Publishing House, Beijing, 1997, 31. (in Chinese)
[2]Mingtang WU and Xiaohua ZHOU: Inorganic Semiconductor Physics, Xi′an Communication University Publishing House, Xi′an, 1995, 126. (in Chinese)
[3]Shipu LI: Special Ceramics Technology, Wuhan University of Technology Publishing House, Wuhan, 1997,249. (in Chinese) 相似文献
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新兴的广告形态--网络广告 总被引:1,自引:0,他引:1
随着信息技术,互联网络在全球的发展,全球经济朝向数字化经济迈进,Internet的出现及其广泛应用,给传统广告业带来了巨大的冲击,网络广告应运而生,并成当今世界最热门的广告形态。 相似文献
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介绍了一种新型的ATM-PON系统,它采用在PON传输层上定义ATME层的方法取代传统的ATM层,并采用包含6byte信头的双向54byte信元格式,可获得较高的传输容量。在VP级上控制上行信号的发送和管理连接资源,可实现灵活的动态带宽分配。 相似文献
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介绍了红外光谱分析热固性树脂的一种新的制样方法热裂解法。该方法是把试样置于裂解管中 ,在酒精灯上加热裂解 ,取裂解物的冷凝液在盐片上成膜。与传统的卤化物压片法制样比较 ,它排除了无机填料和低分子有机物的干扰 ,得到的红外谱图清晰 ,信息量大 ,能够准确地进行定性分析 相似文献
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Mahmoud A. Mahmoud Abd El Naser Saad Reham El Shaer 《Quality and Reliability Engineering International》2015,31(5):851-861
In some statistical process control applications, the quality of a process or product is best represented by a functional relationship between a response variable and one or more explanatory variables. Different methods have been proposed in the literature to monitor phase II multiple linear regression profile. Most of the existing approaches assume the number of sample observations to be greater than the number of explanatory variables, a condition needed to estimate the model parameters and establish chart statistics. In practice, however, the sample size can be smaller than the number of the multiple linear regression parameters. None of the previous studies of multiple regression profiles approaches have tackled this problem. In the current study, two methods are proposed to handle the problem of profile monitoring with sample sizes smaller than the number of regression parameters. Simulation results show that both methods outperform the existing methods in the literature used to monitor multiple linear regression profile. Moreover, both methods work satisfactorily when existing methods cannot be applied, that is, when the sample size is smaller than the number of profile parameters. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
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John I. McCool 《技术计量学》2013,55(4):543-552
A general procedure is found for constructing good unbiased linear estimators of the location and scale parameters of a distribution for use with an uncensored sample of size n. It is presupposed that the coefficients of the best linear estimates are available for an uncensored sample of size m < n for the distribution under investigation. The coefficients of the proposed estimators are obtained as linear combinations of these with the aid of tabled values of the hypergeometric probability function. 相似文献
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介绍了一种在中,小范围内,采用激光定位,超声测距的新型测量仪器,该仪器以单片微处理器为核心,对不同的测量距离,采用不同频率的超声波,结合信号处理方法,从而实现0.6~14m范围内高精度实时测量目标距离,其测量相对误差优于1%。 相似文献