Working memory capacity and aphasia.

The talk presents a capacity theory of syntactic comprehension disorders in aphasia. The work described was done in collaboration with Patricia Carpenter and Akira Miyake. The theory assumes that aphasic patients still possess the structural (syntactic) and procedural knowledge necessary to perform syntactic analysis, but that they suffer from reductions in working memory capacity for language. The theory explains how reductions in working memory capacity can lead to the pattern of comprehension breakdown observed in aphasic patients. According to a resource-reduction view of comprehension impairments in aphasia, patients are assumed to have intact structural and procedural knowledge to parse various sentences, but suffer from consequences of severely reduced working memory resources. Two types of experiments provide relevant supporting data. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Working memory and executive control

A major problem in analysing the executive processes that seem to depend upon the prefrontal cortex stems from the absence of a well developed cognitive model of such processes. It is suggested that the central executive component of an earlier model of working memory might provide a suitable framework for such an analysis. The approach is illustrated using one proposed component of executive control, namely the capacity to combine two concurrent tasks. The application of the approach to patients suffering from Alzheimer's disease, and patients with acquired brain damage is discussed. Finally, a study is described in which the dual task performance of patients with known frontal lesions is shown to be associated with observed behavioural problems. The paper concludes with the discussion of the prospects for extending the approach to include a range of other executive processes, and to the way in which such an analysis may subsequently lead to a more integrated model of the central executive, and a better understanding of its relationship to the prefrontal cortex.     

Defects of immediate memory in Broca''s and conduction aphasia

The effects of local anesthetic agents (lidocaine, procaine, cocaine) and diphenylhydantoin (DPH) were studied on the slow electrical responses induced by isoproterenol or caffeine in cardiac muscle preparations rendered inexcitable by tetrodotoxin (TTX) or by partial depolarization with elevated K+ (26 mM). In such inexcitable cells, we previously demonstrated that addition of some positive inotropic agents, such as catecholamines, histamine, and methylxanthines, rapidly increase the number of available slow Ca2+--Na+ channels, thus allowing slowly rising electrical responses resembling the plateau component of the cardiac action potential. In embryonic chick (16-20-day-old) myocardial cells (ventricular) studied as intact perfused hearts or as reaggregated cell cultures of trypsin-dispersed cells, high concentrations (10-(3) M) of all of the above drugs blocked the induced slow responses with their associated contractions; low concentrations (10-(5) M) of these agents reduced the maximal rate of rise (+Vmax) of the slow responses and depressed the contractions. For comparison with their effects on the slow response, the actions of these drugs on the normal action potential were also studied. As with the slow response, all of these drugs depressed the rate of rise of the action potential (10-(4) M) or blocked it at higher concentrations (10-(3) M); in contrast, low concentrations (10-(5) M) of lidocaine and DPH increased +V max. These findings suggest that local anesthetics, which interact with the lipid phase of the cell membrane, lead to blockade of the slow Ca2+--Na+ channels as well as of the fast Na+ channels in the myocardial sarcolemma.     

Working memory and changing-state hypothesis.

Effects of secondary tasks on serial short-term memory were investigated to test conflicting predictions derived from the working-memory model (A. D. Baddeley, 1986, 1997) and the changing-state hypothesis (D. M. Jones, P. Farrand, G. Stuart, & N. Morris, 1995). In Experiments 1 and 2, disruptions due to the changing-state characteristic of secondary tasks occurred in the encoding phase of spatial and verbal serial memory tasks but not in a retention interval. Experiments 3 and 4 revealed changing-state effects on tasks relying on central-executive resources. In Experiments 5 and 6, interference between central-executive demanding secondary tasks and serial short-term memory was larger during the encoding phase than the retention interval. Crossover dissociations emerged between spatial and verbal serial short-term memory. The results extend the findings of D. M. Jones et al. (1995) and support the working-memory account for interference in short-term memory. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Working memory and focal attention.

Measures of retrieval speed indicated that only a small subset of representations in working memory falls within the focus of attention. An n-back task, which required tracking an item 1, 2, or 3 back in a sequentially presented list, was used to examine the representation and retrieval of recent events and how control processes can be used to maintain an item in focal attention while concurrently processing new information. A speed–accuracy trade-off procedure was used to derive measures of the availability and the speed with which recent events can be accessed. Results converge with other time course studies in demonstrating that attention can be concurrently allocated only to a small number of memory representations, perhaps just 1 item. Measures of retrieval speed further demonstrate that order information is retrieved by a slow search process when an item is not maintained within focal attention. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Short-term memory scan in normal individuals and individuals with aphasia

Ten matched pairs of normal adults and adults with aphasia participated in a short-term memory, visual recognition paradigm wherein each determined whether or not a probe digit appeared in a subset of digits previously presented. Reaction times, measured in milliseconds from onset of probe digits until completion of visual-motor responses, were analyzed as a function of increasing subset size (two, four, and six digits) and the positive versus the negative response condition. Reaction times were significantly slower for the subjects with aphasia. Both groups of subjects demonstrated linear increases in reaction time across levels of subset size. For both groups, increases in reaction time were similar in the positive vs the negative-response conditions. Resulting parallel slopes suggested that both groups of subjects used a serial exhaustive scan of short-time memory. Results from this study did not support results obtained by others in previous studies which may have been confounded by group differences in visual retention spans.     

Working memory across nostrils.

Whether olfactory working memory involves verbal representations or neural images of odor per se remains unclear. This study investigated whether verbal representation influences performance in an olfactory delayed-match-to-sample task and used monorhinal presentation to generate hypotheses as to the underlying anatomy of this mechanism. The main findings were that (a) nameable odorants were easier to remember than hard-to-name odorants and (b) the nameability effect was more pronounced when the evaluation was done across nostrils. Considering these results within a proposed model implies dual representation in olfactory working memory: All odors, nameable and hard to name, are represented both perceptually and verbally. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Working memory and individual differences in comprehension and memory of text.

Attempted to determine whether working memory processes measured by the Reading Span Test would be strongly associated with the ability to integrate information from different parts of a passage to infer an idea not explicitly stated in the passage. The study also assessed the influence of working memory processes on ability to encode explicitly stated and inferred information into long-term memory. 29 undergraduates were administered a letter span test and a reading span test. The ability to store and process information in working memory was shown to be positively related to (a) scores on a standardized reading comprehension test, (b) long-term memory encoding and retrieval of explicitly stated text information, and (c) integration of text information for the purpose of drawing inferences. Variations in only the storage capacity of working memory were not related to these measures. It is concluded that the ability to coordinate storage and process functions in working memory may be an important determinant of text processing skill, especially with respect to encoding information into long-term memory. (12 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Working memory in Alzheimer-type dementia.

Reviews experimental studies of working memory in dementia of the Alzheimer type (DAT), mainly focusing on investigations using A. D. Baddeley and G. J. Hitch's (1974) working memory model as a framework (e.g., Baddeley, see record 1992-26150-001). These studies show that the articulatory or phonological loop system is intact in early dementia, with a substantial impairment in the central executive system. The neural basis for this impairment is discussed, as are the practical implications of the working memory deficits for the diagnosis and management of Alzheimer's disease (AD). (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Working memory in aged rats.

The performances of young and aged rats were compared on a spatial (spatial delayed nonmatching-to-sample) and a nonspatial (object delayed nonmatching-to-sample) test of working memory. Although evidence was found that aging slowed acquisition of both of these tasks, performance over different retention intervals of up to 60 sec was normal once the task was mastered. An impairment was found, however, in the performance of the spatial test when the number of locations to be remembered on each trial was increased from one to two. The conclusions of this study are that under some conditions, the retention capabilities of aged rats may not change and that some acquisition impairments do not reflect alterations in learning or memory per se, but, in common with other studies, deficits in the remembrance of spatial locations may be found. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Working memory in learning disability subgroups

The purpose of this study was to investigate (a) the degree to which working memory differences between learning-disabled and nondisabled children reflect a specific or generalized deficit, and (b) whether limitations in the enhancement of learning-disabled student's working memory performance are attributable to process or storage functions. To this end, performances of reading-disabled, math-disabled, chronological age (CA)-matched, and achievement-matched children were compared on verbal and visual-spatial working memory measures under initial, gain, and maintenance conditions. The results indicated that: (a) learning-disabled subtypes were not differentiated by their performance on verbal and visual-spatial working memory measures; and (b) learning-disabled children's working memory performance was inferior to CA-matched and superior to achievement-matched counterparts across initial, gain, and maintenance conditions. The results suggest that learning-disabled children suffer generalized working memory deficits, possibly due to storage constraints in the executive system.     

Working memory and work with memory: visual-spatial and further components of processing

Empirical and theoretical evidence for the concept of working memory is considered. We argue that the major weakness of this concept is its loose connection with the knowledge about background perceptive and cognitive processes. Results of two relevant experiments are provided. The first study demonstrated the classical chunking effect in a speeded visual search and comparison task, the proper domain of a large-capacity very short term sensory store. Our second study was a kind of extended levels-of-processing experiment. We attempted to manipulate visual, phonological, and (different) executive components of long-term memory in the hope of finding some systematic relationships between these forms of processing. Indeed, the results demonstrated a high degree of systematicity without any apparent need for a concept such as working memory for the explanation. Accordingly, the place for working memory is at all the interfaces where our metacognitive strategies interfere with mostly domain-specific cognitive mechanisms. Working memory is simply our work with memory.     

Working memory and the syndromes of schizotypal personality

The aim of this study was to investigate dorsolateral prefrontal function, as assessed by a spatial working memory task, in relation to the syndromal features of schizotypal personality. We found a weak association between a self-report measure of schizotypy and the working memory performance. Those with a high score on the schizotypal personality questionnaire tended to make more errors on the spatial working memory task. One sub-scale of the schizotypal personality questionnaire that taps into social functioning was significantly correlated with working memory deficit. This result suggests the presence of subtle prefrontal deficit in a sub-group of psychometrically ascertained schizotypic individuals and renders support for the past reports of working memory deficit in schizophrenia and schizotypy.     

Working memory and the vividness of imagery.

The working memory framework was used to investigate the factors determining the phenomenological vividness of images. Participants rated the vividness of visual or auditory images under control conditions or while performing tasks that differentially disrupted the visuospatial sketchpad and phonological loop subsystems of working memory. In Experiments 1, 2, and 6, participants imaged recently presented novel visual patterns and sequences of tones; ratings of vividness showed the predicted interaction between stimulus modality and concurrent task. The images in experiments 3, 4, 5, and 6 were based on long-term memory (LTM). They also showed an image modality by task interaction, with a clear effect of LTM variables (meaningfulness, activity, bizarreness, and stimulus familiarity), implicating both working memory and LTM in the experience of vividness. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Working and strategic memory deficits in schizophrenia.

Working memory and its contribution to performance on strategic memory tests in schizophrenia were studied. Patients (n?=?18) and control participants (n?=?15), all men, received tests of immediate memory (forward digit span), working memory (listening, computation, and backward digit span), and long-term strategic (free recall, temporal order, and self-ordered pointing) and nonstrategic (recognition) memory. Schizophrenia patients performed worse on all tests. Education, verbal intelligence, and immediate memory capacity did not account for deficits in working memory in schizophrenia patients. Reduced working memory capacity accounted for group differences in strategic memory but not in recognition memory. Working memory impairment may be central to the profile of impaired cognitive performance in schizophrenia and is consistent with hypothesized frontal lobe dysfunction associated with this disease. Additional medial-temporal dysfunction may account for the recognition memory deficit. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Working memory costs of task switching.

Although many accounts of task switching emphasize the importance of working memory as a substantial source of the switch cost, there is a lack of evidence demonstrating that task switching actually places additional demands on working memory. The present study addressed this issue by implementing task switching in continuous complex span tasks with strictly controlled time parameters. A series of 4 experiments demonstrate that recall performance decreased as a function of the number of task switches and that the concurrent load of item maintenance had no influence on task switching. These results indicate that task switching induces a cost on working memory functioning. Implications for theories of task switching, working memory, and resource sharing are addressed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Working memory, short-term memory, and general fluid intelligence: A latent-variable approach.

A study was conducted in which 133 participants performed 11 memory tasks (some thought to reflect working memory and some thought to reflect short-term memory), 2 tests of general fluid intelligence, and the Verbal and Quantitative Scholastic Aptitude Tests. Structural equation modeling suggested that short-term and working memories reflect separate but highly related constructs and that many of the tasks used in the literature as working memory tasks reflect a common construct. Working memory shows a strong connection to fluid intelligence, but short-term memory does not. A theory of working memory capacity and general fluid intelligence is proposed: The authors argue that working memory capacity and fluid intelligence reflect the ability to keep a representation active, particularly in the face of interference and distraction. The authors also discuss the relationship of this capability to controlled attention, and the functions of the prefrontal cortex. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Working memory span and the role of proactive interference.

The author investigated the possibility that working memory span tasks are influenced by interference and that interference contributes to the correlation between span and other measures. Younger and older adults received the span task either in the standard format or one designed to reduce the impact of interference with no impact on capacity demands. Participants then read and recalled a short prose passage. Reducing the amount of interference in the span task raised span scores, replicating previous results (C. P. May, L. Hasher, & M. J. Kane, 1999). The same interference-reducing manipulations that raised span substantially altered the relation between span and prose recall. These results suggest that span is influenced by interference, that age differences in span may be due to differences in the ability to overcome interference rather than to differences in capacity, and that interference plays an important role in the relation between span and other tasks. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Working memory and retrieval: A resource-dependent inhibition model.

Four experiments examined individual differences in working memory (WM) capacity and how those differences affect performance on retrieval from both primary and secondary memory. The results showed that WM differences appear only in retrieval from primary memory and then only under conditions that lead to interference or response competition within the task. This suggests that WM capacity is important to retrieval that is based on controlled effortful search but not search that is based on automatic activation. A view is presented suggesting that individual differences in attentional resources lead to differences in the ability to inhibit or suppress irrelevant information. The paradigm also allowed more general comparisons between the processes involved in retrieval from primary and secondary memory. As expected, it was found that retrieval from primary memory was a function of set size. However, for sets larger than 2 items, retrieval from secondary memory was independent of set size. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Working memory and the developmental analysis of probability judgment.

Focuses on data generated by simple probability-judgment problems that require children to predict the results of consecutive random draws from sets consisting of small numbers of objects. A general work space is constructed for such tasks to meet the requirements of individual problem variations. This working-memory system is composed of 4 types of storage operations: storing starting-frequency counts, traces of previous responses, traces of previously sampled elements, and information resulting from the integration of the 1st and 3rd stores. Three types of processing operations are also proposed: retrieving traces, integrating information, and activating response rules. 12 experiments investigated these distinctions in 278 5-yr-olds and 247 8-yr-olds. At both age levels the relationship between objective probability and Ss' predictions was imperfect, apparently as a consequence of retrieval failures. These retrieval failures were products of limitations in the available work space, rather than of specific knowledge deficits. Age changes in probability judgment were directly related to age changes in frequency retrieval, which were in turn related to age changes in constraints on work-space capacity. (80 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)