共查询到20条相似文献,搜索用时 15 毫秒
1.
Mohamed A.-F. Elkaschef Farouk M. E. Abdel-Megeid Salah M. A. Yassin 《Advanced Synthesis \u0026amp; Catalysis》1974,316(3):363-368
The title compound reacts with two moles of Grignard reagents with 1,2-addition to give the alcohol 4 , and/or the oxazoline 5 , or with 1,4-addition to give the amino ketone 6 . A reaction mechanism is proposed. Diazomethane is always added to the exocyclic double bond in 1 , but diphenyldiazomethane, in addition, replaces the carbonyl-oxygen by a benzhydrylidene group to give compound 9 . 相似文献
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酰腙类化合物是由酰肼与醛或酮缩合而成的一类Schiff碱类化合物,具有独特的生物活性和较强的的抑菌、抗病毒和抗肿瘤的生物活性。本文以甲基丙烯酸甲酯、乙酰乙酸乙酯为反应物,分别与水合肼反应,生成了甲基丙烯酰肼与二乙酰肼,进一步缩合,得到未见报道的环戊酮甲基丙烯酰腙和丙酮二乙酰腙。 相似文献
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α,β-不饱和环戊酮的Mannich碱和α,β-不饱和环己酮的Mannich碱具有显著的抗炎活性,为了寻求新的具有抗炎活性的环酮类化合物,设计了3,4-二氢-4-(1-哌啶甲基)-5H-1-苯并氧杂-5-酮盐酸盐作为目标化合物。以苯酚、γ-丁内酯、甲醛和哌啶等原料合成了目标化合物,并利用熔点、红外光谱、核磁共振氢谱等手段确定了其结构。采用二甲苯致小鼠耳肿胀法,测定了该化合物的抗炎活性,实验结果表明在200mg/kg剂量下该化合物对二甲苯所致小鼠耳肿胀的抑制率为54.5%。采用Born's比浊法测定了该化合物的抗血小板聚集活性,实验结果表明该化合物的抗血小板聚集活性比噻氯匹啶强约23倍。 相似文献
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Aoi Isono Dr. Mieko Tsuji Dr. Yu Sanada Akari Matsushita Prof. Dr. Shinichiro Masunaga Dr. Tasuku Hirayama Prof. Dr. Hideko Nagasawa 《ChemMedChem》2019,14(8):823-832
We developed new 10B carriers for boron neutron capture therapy (BNCT) that can effectively transport and accumulate boron clusters into cells. These carriers consist of a lipopeptide, mercaptoundecahydrododecaborate (BSH), and a disulfide linker. The carriers were conceived according to the structure of pepducin, a membrane-penetrating lipopeptide targeting protease-activated receptor 1 (PAR1). To improve the membrane permeability of BSH, the structure was optimized using various lipopeptides possessing different peptides and lipid moieties. These synthesized lipopeptides were conjugated with BSH and evaluated for intracellular uptake using T98G glioblastoma cells. Among them, the most effectively incorporated and accumulated in the cells was compound 5 a , which contains a peptide of 13 residues derived from the intracellular third loop of PAR1 and a palmitoyl group. For further improvement of 10B accumulation in cells, the introduction of an amine linker was investigated; intracellular uptake similar to that of 5 a was observed for compound 14 , which has a piperazine linker. Both compounds 5 a and 14 showed a stronger radiosensitizing effect than BSH along on T98G cells under mixed-neutron beam irradiation. The results demonstrate that lipopeptide conjugation is effective for enhancing intracellular delivery and accumulation of BSH and improving the cytotoxic effect of BNCT. 相似文献
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A stereoselective total synthesis of (±)-ptilocaulin 1 , an antimicrobial anticancer agent as well as of its 7-epimer 23 is described. The strategy involves an aldol condensation of the dilithio dianion of the Z-aldoxime ( 13 ) with a ketone 6 to produce 11 and the stereospecific intramolecular cycloaddition of the nitrile oxide 5 , generated in situ from 11. The resulting isoxazoline 4 was converted to hydroxy ketone 3 which serves as a starting point for introduction of the fourth stereocenter at C-7. Lithium in ethylamine reduction of 3 produces stereospecifically the 7β-methyl compound which leads to ptilocaulin 1 , while catalytic hydrogenation of 3 introduces the 7α-methyl substituent and finally 7-epiptilocaulin 23. H- and C NMR analysis permits differentiation between isomers of intermediates. When, in the last step of the synthesis of 1 or 23 from 19 or 22 and guanidine, a higher temperature (>130 °C) was applied, an interesting disproportionation to aminopyrimidine 25 or 28 and cyclic guanidine 24 or 27 was observed. 相似文献
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Miloslav Suf
k 《应用聚合物科学杂志》1968,12(9):2153-2168
The influences of small amounts (up to 2%) of methyl vinyl ketone in chloroprene on properties of polychloroprene and kinetics of the emulsion polymerization of chloroprene with mercaptans as regulators has been studied. Methyl vinyl ketone causes a substantial increase in molecular weight of polymer, which results in increased viscosity, gel formation, lowered plasticity of polymer, deterioration of processability, decreased tensile strength, and high modulus of vulcanizates. Methyl vinyl ketone interferes with the regulation of molecular weight by both primary and tertiary dodecylmercaptan; some differences are due to lower reactivity of tertiary dodecylmercaptan. In the presence of diisopropyl xanthogene disulfide as a molecular weight regulator the polychloroprene properties are not affected by methyl vinyl ketone. All changes in polymer properties have been proved to be caused by the addition reaction of dodecylmercaptan on methyl vinyl ketone, yielding 1-dodecylthiobutan-3-one. This compound itself has no influence on the polymerization of chloroprene. Methyl vinyl ketone has a marked promoting effect on polymerization rates, which accounts for its high reactivity and solubility in the water phase. A fast polymerization of methyl vinyl ketone takes place in the water phase of emulsion polymerization system simultaneously with the reaction of methyl vinyl ketone with dodecylmercaptan. 相似文献
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Jędrzejczak R Wojciechowski M Andruszkiewicz R Sowiński P Kot-Wasik A Milewski S 《Chembiochem : a European journal of chemical biology》2012,13(1):85-96
N(3)-Oxoacyl derivatives of L-2,3-diaminopropanoic acid 1-4, containing either an epoxide group or a conjugated double bond system, inactivate Saccharomyces cerevisiae glucosamine-6-phosphate (GlcN-6-P) synthase in a time- and concentration dependent manner. The results of kinetics studies on inactivation suggested a biphasic course, with formation of the enzyme-ligand complex preceding irreversible modification of the enzyme. The examined compounds differed markedly in their affinity to the enzyme active site. Inhibitors containing a phenyl ketone moiety bound much more strongly than their methyl ketone counterparts. The molecular mechanism of enzyme inactivation by phenyl ketone compounds 1 and 3 was elucidated by using a stepwise approach with 2D NMR, MS and UV-visible spectroscopy. A substituted thiazine derivative was identified as the final product of a model reaction between an epoxide compound, 1, and L-cysteine ethyl ester (CEE); and the respective cyclic product, found as a result of reaction between 1 and CGIF tetrapeptide, was identical to the N-terminal fragment of GlcN-6-P synthase. On the other hand, the reaction of a double-bond-containing compound, 3, with CEE, CGIF and GlcN-6-P synthase led to the formation of a C-S bond, without any further conversion or rearrangement. Molecular mechanisms of the reactions studied are proposed. 相似文献
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泰拉菌素的合成工艺改进 总被引:1,自引:0,他引:1
以阿奇霉素A(Ⅰ)为原料,经苄氧羰酰氯保护2'位羟基得到保护的阿奇霉素A(Ⅱ),然后经Albright-Goldman方法氧化4″位羟基得到Cbz保护的酮(Ⅲ),酮通过Wittig-Horner反应得到保护的烯(Ⅳ),烯经双氧水氧化得到保护的环氧化合物(Ⅴ),保护的环氧化合物在Pd/C催化下脱保护得到脱保护的环氧化合物(Ⅵ),脱保护的环氧化合物与正丙胺反应开环得到泰拉菌素粗品,粗品泰拉菌素成磷酸盐纯化,最后解析得到泰拉菌素(Ⅶ),总收率为42.0%,经HPLC测定w(Ⅶ)=98.0%。该法改进了文献合成方法,不需采用极低温反应。 相似文献
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Alan P. Kozikowski Xue-Min Cheng Chun-Sing Li James G. Scripko 《Israel journal of chemistry》1986,27(1):61-65
A new synthesis of 4- and 7-carbon-substituted indoles is described. The overall sequence involves the addition of a nitrile oxide to 1 carboethoxy-2-(or 3-) allylpyrrole, hydrogenation of the intermediate isoxazoline to β-hydroxy ketone and cyclization of the ketol using magnesium or zinc triflate to the substituted indole. This new indole-forming strategy can also accommodate the introduction of oxygen functionality into the indole 6-position. Possible mechanistic aspects of the reaction are detailed. 相似文献
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A. Stephen K. Hashmi Lothar Schwarz J. W. Bats 《Advanced Synthesis \u0026amp; Catalysis》2000,342(1):40-51
The allenyl p‐methoxybenzyl ketone 3a and allenyl p‐siloxybenzyl ketones 6b selectively delivered three different products with three different transition metal‐catalysts. With Hg(II)‐catalysts a spiro[4.5]decene 9 , with Ag(I)‐catalysts a 2‐substituted furan ( 10/11 ) and with Pd(II)‐catalysts a 2,4‐disubstituted furan ( 8/12 ) was formed. Only with perchloric acid the intermolecular addition of water to the allene, leading to 1,3‐dicarbonyl compounds 7 , was observed. While with the corresponding allenyl o‐methoxybenzyl ketone 3b the Ag(I)‐ and Pd(II)‐catalysts provided the expected products, the mercury‐catalyst led to a new and interesting side‐product rac‐ 17 which combined both the furan moiety and the spiro[4.5]decene moiety. Efforts to prepare allenyl hydroxybenzyl ketones failed, in one case a small amount of a 5H‐benzo[b]oxepin‐4‐one 21 was isolated. It also was not possible to extend the spirocyclization to allenyl p‐siloxyphenyl ketone 6a or allenyl 2‐(p‐siloxyphenyl)ethyl ketone 6c . 相似文献
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Summary Electrophylic vinyl reagents can be reacted with a protonated tertiary amine supported by a polymeric chain. We determined the mechanism of this addition in the case of vinyl methyl ketone and poly (4 vinyl pyridinium bromide). The first step is the addition of the vinyl compound on the tertiary amine, then protonation of the intermediate species occurs. The velocity constant at 268 K is 0.087 1. mole–1. mn–1 and the activation energy is 10 kcal.mole–1. 相似文献
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Minoru Tsuda Setsuko Oikawa Akira Yokota Mitsuo Yabuta Wataru Kanai Ken-Ichi Kashiwagi Isamu Hijikata Hisashi Nakane 《Polymer Engineering and Science》1983,23(18):993-999
A dry developable negative working resist composition comprised of poly(methyl isopropenyl ketone) (PMIPK) and 4-methyl-2,6-di(4′-azido-benzylidene) cyclohexanone-1 was examined. The main photochemical product formed in the resist pattern was found to be a secondary amine which crosslinks PMIPK. Post-annealing forms a hydrogen-bonded product which shows a powerful electronic excitation energy quenching effect. The quencher is more powerful than the aromatic compound arising from the azide by post-annealing only. The residual resist thickness of the negative pattern is about 80 percent of the initial thickness of the coating in spite of all the azide compound remaining in the resist coating. The obtained dry developed resist pattern has a high dry etch resistance. Etchings of Si and SiO2 were performed by plasma and reactive ion etching, respectively. 相似文献
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1-(反式-4-烷基环己基)-苯基-2-含氟苯基取代乙炔类液晶的合成与性能 总被引:1,自引:0,他引:1
以烷基环己酮和溴苯为起始原料,通过格氏反应、氢解、傅克酰化、维格特氧化、乙酰氯加成、脱氯化氢等9步反应,合成了末端为4-F、3,4-F,F、3-F及3,5-F,F基团的4个1-(反式-4-烷基环己基)-苯基-2-含氟苯基取代乙炔类液晶化合物,总收率为6.7%~7.6%,产物结构经IR,1HNMR确认。其中氯代二芳基取代乙烯(Ⅷ)的合成采用简便的乙酰氯加成反应得到,使反应缩短了两步。化合物添加到液晶的基础配方中,能同时改善基础配方的低温和高温性能,提高其双折射率,增加响应速度。 相似文献
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Host-guest binding of anions in organic solvents may find attractive applications in ion sensing and transport, if the host can extract the negatively charged guest species from its solvation sphere. The most powerful means to dismantle the anionic guest from solvent molecules that is required for selective binding is to provide positive charges in the host compound. They have to be counterbalanced by negatively charged subsites in order to conserve electroneutrality, but must avoid collapse into ion pairing with the cationic sites. According to this concept the cage compound 3 was constructed by attachment of anionic tetraphenylborate moieties to the parent macrotricyclic amine 1 . The betainic product 3 was shown to be soluble in water-immiscible dipolar organic solvents like propylene carbonate and formed inclusion complexes with chloride and bromide in the gas phase as well as in solution. 相似文献
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概述了国内外对沙棘资源的开发利用研究状况,分析了黄酮类化合物的结构和药用价值,论述了从沙棘中提取黄酮类化合物的可行性工艺流程及其用途。利用沙棘叶和沙棘油废渣提取黄酮类化合物,原料来源充足易得、成本低,同时可以减少“三废”污染。 相似文献