Numerical Spray Model of the Fluidized Bed Coating Process

In this study, a new model for the batch top-spray fluidized bed coating process is presented. The model is based on the one-dimensional (axial) discretization of the bed volume into different control volumes, in which the dynamic heat and mass balances for air, water vapor, droplets, core particles, and coating material were established. The coupling of the droplet phase's mass and heat transfer terms with the gas and solid phases was established by means of a droplet submodel in which droplet trajectories were individually simulated.

The model calculation method combines a Monte Carlo technique for the simulation of the particle exchange with the first-order Euler's method for solving the heat and mass balances, enabling the prediction of both the dynamic coating mass distribution and the one-dimensional (axial) thermodynamic behavior of the fluidized bed during batch operation. The simulation results were validated using experimental two-dimensional spatial air temperature and air humidity distributions, which were measured in a fluidized bed pilot reactor using a scanning probe.

Sensitivity analysis was carried out to study the effect of controllable process variables, such as fluidization air and atomization air properties, as well as the properties of the spraying liquid upon the simulated dynamic temperature and humidity distributions. Also, the effects of relevant process variables on growth rate uniformity and process yield were studied. Based on these sensitivity studies it was concluded that nozzle parameters, such as air pressure and positioning with respect to the bed, are as important as the fluidization air properties (humidity, temperature, and flow rate) for the coating growth rate uniformity and process yield.     

Spray Freeze Drying in a Fluidized Bed at Normal and Low Pressure

The aim of this study is to develop the spray freeze drying process and its hardware and to investigate its capabilities to dry thermosensible substances such as pharma-proteins at normal and low pressures. As the result, the spray freeze fluidized–bed dryer was constructed. During the study, the drying kinetic comparison between classical and spray freeze–drying technologies was done. Spray freeze drying has shown short process times and allows advanced control, product particle shape and size uniformity, and high solubility. This shows that the fluidized-bed freeze-drying process could be an alternative for classical freeze-drying processes. Identified problems are the low yield of the primary drying phase and the strong electrostatic effects during the secondary drying step. However, the innovative process has shown an excellent capability to dry and stabilize the thermosensitive substances, such as pharma-proteins.     

Spray Freeze Drying in a Fluidized Bed at Normal and Low Pressure

The aim of this study is to develop the spray freeze drying process and its hardware and to investigate its capabilities to dry thermosensible substances such as pharma-proteins at normal and low pressures. As the result, the spray freeze fluidized-bed dryer was constructed. During the study, the drying kinetic comparison between classical and spray freeze-drying technologies was done. Spray freeze drying has shown short process times and allows advanced control, product particle shape and size uniformity, and high solubility. This shows that the fluidized-bed freeze-drying process could be an alternative for classical freeze-drying processes. Identified problems are the low yield of the primary drying phase and the strong electrostatic effects during the secondary drying step. However, the innovative process has shown an excellent capability to dry and stabilize the thermosensitive substances, such as pharma-proteins.     

A Comparative Study Between Spray-Drying and Fluidized Bed Coating Processes for the Preparation of Pramipexole Controlled-Release Microparticles for Orally Disintegrating Tablets

In the present study, controlled-release microparticles for orally disintegrating tablets (ODT) were prepared using two different processes, spray drying and fluidized bed coating processes. Pramipexole dihydrochloride monohydrate (PRM), an anti-Parkinson's disease agent, was selected as a model drug. The in vitro release rate and morphology of microparticles were evaluated and compared. The size of microparticles prepared by spray drying (SD microparticles) and fluidized bed coating (FC microparticles) was around 10 and 200 µm, respectively. The latter size was defined by the size of an inert core bead. The release behavior of SD microparticles was characterized by a large initial burst release prior to slow release. In the case of FC microparticles, the initial burst release was smaller than that of SD microparticles and the compression process damaged the release-controlling layer, which led to a change in release rate. The results indicated the importance of carefully considering the manufacturing process for microparticles during the design of controlled-release ODT.     

Investigation of Temperature Distribution and Heat Transfer in Fluidized Bed Using a Combined CFD-DEM Model

Fluidized beds are widely used in many industries because they are effective for both mixing and drying. The distinct element method (DEM) has recently received more attention for investigating the phenomena of multiphase flow because the technique is effective in gathering detailed information on complex phenomena without physically disturbing the flows. However, most studies have focused on the aerodynamics of the particles. In this study, a combined computational fluid dynamics (CFD)-DEM model, which allows prediction of gas and particle temperature profiles and heat transfer coefficients in a two-dimensional fluidized bed, was developed. The predicted results were compared with the experimental results at the superficial gas velocities of 2.04, 2.22, and 2.41 m/s and at the controlled inlet temperature of 343 K. Based on the comparison between the predicted and experimental results, it was found that the developed model performed adequately in predicting the gas temperature profiles, and the predicted particle temperature profiles were higher than the experimental data. The predicted heat transfer coefficient was slightly higher than the experimental data. However, the predicted and experimental results had a similar trend in which the heat transfer coefficient increased as a function of an increase in superficial gas velocity. In addition, the minimum fluidization velocity predicted by the developed model agreed well with the experimental data. Such predictions can provide essential information on temperature and heat transfer coefficients inside the fluidized bed for design and scale-up.     

流化床喷雾造粒制备MTO薄层催化剂实验研究简

根据甲醇制烯烃流化床反应一再生工艺对催化剂反应性能、球形度、耐磨强度等的要求,利用流化床喷雾造粒法制备了MTO薄层催化剂。实验研究了进料流率、分子筛组合物与粘结剂质量比、分子筛组合物浓度对薄层生长速率的影响并比较了分别以分子筛和成型催化剂为原料造粒时的薄层生长速率。实验结果表明,当分子筛组合物浓度高、进料流率大时,催化剂涂层生长速率快,表面活性成分负载量大。     

顶喷流化床中干燥过程研究

本文对用于造粒和包涂过程的顶喷流化床内的干燥过程进行了较为详细的实验和理论研究。从传质传热过程中分析可知，床层可分为三段。影响生产能力的最大允许喷淋速度受流化空气流量和入口温度影响最大。     

Modeling of the Spray Zone for Particle Wetting in a Fluidized Bed

In a spray agglomeration process the particle wetting influences the agglomerate growth and particle dynamics in the granulator. The mass of binder liquid that is deposited on single particles affects the amount of energy dissipation during particle contacts. For the agglomeration of colliding particles the whole impact energy has to be dissipated due to viscous and capillary adhesion forces in the liquid film and plastic deformation of the material. Therefore, a detailed knowledge of the particle wetting is necessary to model the agglomeration process. This contribution uses a coupled DEM‐CFD approach to describe the spray zone of a two‐fluid nozzle in a fluidized bed agglomerator. Droplets modeled as discrete elements showed the formation of a spray zone with a conical shape. Simulations of the spray zone and the wetting of single particles are in good agreement with experimental results.     

Combined Microwave/Fluidized Bed Drying of Fresh Peppercorns

Abstract

A fluidized bed dryer (FBD) and a combined microwave/fluidized bed dryer (CMFD) are used to dry the fresh ripe peppercorns. The average moisture content vs. elapsed drying time, and drying rate vs. average moisture content are experimentally investigated. It is found that the microwave field from the CMFD can increase the potential of the conventional fluidized bed drying. The drying rates of both dryers are dependent on the inlet air temperature and velocity. For the CMFD, the effects of the air velocity on the drying rate are found to be opposite to our previous results tested with white pepper seeds i.e., the drying rates of the fresh ripe peppercorns decreased with increasing air velocity. By using a CMFD, the drying time required to reach the desired moisture content can be reduced to 80–90% of the drying time required for a FBD at the same drying air temperature and velocity. The color of the product dried by a CMFD is also attractive: it becomes flaming yellow, instead of black as obtained from a FBD. The physical structure of the peppercorn, before and after the drying process is also investigated by a metallurgical macroscope and an image analyzer. Different from drying by a FBD, the external form and matter of the white pepper seed are still maintained, even after passing through the drying process.     

Combined Microwave/Fluidized Bed Drying of Fresh Peppercorns

A fluidized bed dryer (FBD) and a combined microwave/fluidized bed dryer (CMFD) are used to dry the fresh ripe peppercorns. The average moisture content vs. elapsed drying time, and drying rate vs. average moisture content are experimentally investigated. It is found that the microwave field from the CMFD can increase the potential of the conventional fluidized bed drying. The drying rates of both dryers are dependent on the inlet air temperature and velocity. For the CMFD, the effects of the air velocity on the drying rate are found to be opposite to our previous results tested with white pepper seeds i.e., the drying rates of the fresh ripe peppercorns decreased with increasing air velocity. By using a CMFD, the drying time required to reach the desired moisture content can be reduced to 80-90% of the drying time required for a FBD at the same drying air temperature and velocity. The color of the product dried by a CMFD is also attractive: it becomes flaming yellow, instead of black as obtained from a FBD. The physical structure of the peppercorn, before and after the drying process is also investigated by a metallurgical macroscope and an image analyzer. Different from drying by a FBD, the external form and matter of the white pepper seed are still maintained, even after passing through the drying process.     

CFD Modeling of Microwave-Assisted Fluidized Bed Drying of Moist Particles Using Two-Fluid Model

The drying behavior of moist spherical particles in a microwave-assisted fluidized bed dryer was simulated. The two-fluid Eulerian model incorporating the kinetic theory of granular flow was applied to simulate the gas–solid flow. The simulations were carried out using the commercial computational fluid dynamics (CFD) package Fluent 6.3.26. The effects of different levels of microwave power densities as well as initial gas temperature on the prediction of solids moisture content, gas temperature, and gas absolute humidity were investigated. The effect of microwaves was incorporated into calculations using a concatenated user-defined function (UDF). The simulation results were compared with experimental data obtained from drying of soybeans in a pilot-scale microwave-assisted fluidized bed dryer and reasonable agreement was found. The mean relative deviation for prediction of solids moisture content, gas temperature, and gas absolute humidity were less than 3, 10, and 5%, respectively. Further work is needed to validate the proposed model for large-scale plants.     

Simulation and Validation of Microwave-Assisted Fluidized Bed Drying of Soybeans

A general mathematical model of heat and mass transfer was developed to simulate the microwave-assisted fluidized bed drying of bulk grain. The model was solved using the well-known Runge-Kutta-Gill method. The model is capable of predicting the moisture content of soybean as well as the drying air parameters (i.e., drying air temperature and moisture content) during drying. The values of mean relative deviation (MRD) were less than 8 and 10% for prediction of grain moisture content and outlet air parameters, respectively, which reflects an acceptable accuracy. In comparison with conventional fluidized bed drying of soybean, microwave-assisted fluidized bed drying led to 83.39–98.07% savings in drying time and 82.07–95.22% savings in specific energy consumption when reducing soybean moisture content from 18.32 to 12% (db).     

己二酸生产中沸腾床干燥和气流干燥工艺性能比较

在目前己二酸生产中,用于固体物料干燥的代表性工艺是气流式及沸腾床式2种,对2种T艺在己二酸干燥中应用进行了综合性比较。     

离心流化床干燥器的流体力学及传热性能

以９种颗粒物料为研究对象,找出了影响离心流态化干燥系统的流体力学及传热性能的主要因素,回归得到了流体力学及传热的无因次准数关联式,为进一步研究此设备的干燥性能打下了基础。     

Drying Characteristics of Coriander Seed Particles in a Reduced Pressure Superheated Steam Fluidized Bed

Drying characteristics of coriander seed particles were experimentally analyzed in a reduced pressure superheated steam fluidized bed. The typical moisture gain, reported in some other studies during the warm-up period of the process, was reduced in most of the cases by supplying additional heat into the column. The experimental results demonstrated that the drying rate increases and the equilibrium moisture content decreases by increasing the operating temperature. However, variation of the operating pressure (40–67 kPa) and the superficial steam velocity (2.3–4.0 m/s) did not present significant effects on the moisture contents. The degree of superheating was found to be the most important parameter for the process. The experiments also showed that the equilibrium moisture content decreases upon increasing the degree of superheating. Finally, employing a reduced pressure superheated steam fluidized bed appears as an option to carry out drying processes at relatively lower temperatures.     

Numerical Analysis of Drying Characteristics of Wet Material Immersed in Fluidized Bed of Inert Particles

The drying characteristics of a relatively large wet material immersed in a fluidized bed of inert particles were examined theoretically. Calculations of heat transfer and evaporation of water on the material surface were included in a discrete element method–computational fluid dynamics (DEM-CFD) simulation. Only the preheating and constant drying rate periods were considered in the simulation.

Our simulation made it possible to calculate the relation between the behavior of the fluidizing particles and the drying characteristics. The drying rate increased with an increase in the number of fluidizing particles in contact with the material and the number of fluidizing particles changed with time; that is, the drying rate fluctuated. When the drying rate increased, the fluid temperature decreased and the vapor content of the fluid increased around the material; that is, the temperature and vapor content of the fluid were associated with the behavior of the fluidizing particles.     

Drying of Pepper Seed Particles in a Superheated Steam Fluidized Bed Operating at Reduced Pressure

A series of drying experiments was performed in a reduced-pressure superheated steam fluidized bed, employing pepper seed particles and some novel data were obtained. Experiments were carried out using different chamber pressures (40–67 kPa), temperatures (90–122°C), steam velocities (2.35–4.10 m/s), and mass flow rates (0.0049–0.0134 kg/s). In the majority of the experiments, the moisture gain observed in some other studies in the warm-up period of the process was prevented through some supplementary heat provided to the column. The drying rate was found to be increasing by operating temperature; however, it was not affected much by the superficial gas velocity and the operating pressure. Nevertheless, the reduced pressure operation increases the degree of superheating that appears as the most important parameter of the process. The experimental results showed that the equilibrium moisture content decreases by the increasing degree of superheating. On the other hand, the critical moisture content assumes higher values for the greater degrees of superheating. It was concluded that a relatively lower temperature process can be achieved through a reduced-pressure superheated steam fluidized bed.     

Coupled CFD-PBE Simulation of Nucleation in Fluidized Bed Spray Granulation

Fluidized bed spray granulation is used to produce porous granular particles from suspensions, solutions, and melts. It is the general aim of our work to provide a physics-based simulation tool for this process. For this the process-relevant mechanisms such as droplet deposition, dust integration, and drying are implemented using computational fluid dynamics (CFD) to generate growth kinetics of the granules and of the dust particles. The latter gives rise to the nucleation rate. This kinetics is applied to simulate the development of the particle size distribution of granules for a continuously operated fluidized bed spray granulation process using population balance equations of the granules.     

流化床甲醇制汽油的研究进展

由于石油类资源的使用紧张以及醇类资源的相对过剩,甲醇制汽油工艺作为一个很有前景的研究方向而更加引人关注,流化床甲醇制汽油工艺相比于固定床工艺具有产物收率高,汽油品质优良等特点。主要介绍了使用流化床甲醇制汽油工艺的反应机理,催化剂的几种改性方式以及改性之后对于产物的影响,同时阐述了流化床工艺与固定床工艺的不同之处。