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本研究采用正交设计法研究静电纺丝法工艺过程对聚己内酯纤维直径的影响因素.主要研究纺丝液浓度、纺丝电压、注射泵进料速率三个因素对于纤维直径的影响.结果表明溶液浓度是影响纤维直径最主要的因素,次要影响因素是纺丝电压、进料速率.同时成功制备了纤维直径分别为0.35±0.09μm,0.95±0.09 μm,6.48±0.50 ... 相似文献
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摘要：在聚己内酯(PCL)/冰乙酸(GAC)溶液体系中加入低毒低挥发性溶剂碳酸乙烯酯(EC),采用静电纺丝法成功制备纳米纤维,采用扫描电子显微镜研究了不同EC浓度对制得的纤维形貌和直径的影响。结果表明,当溶液中PCL质量分数为20%,EC体积分数从0%变化到9%时,纳米纤维数量增加,平均直径逐渐变小;当EC体积分数从9%变化到15%时,微米纤维或珠串状纤维数量开始增加,平均直径逐渐变大。对比研究了EC体积分数为9%的溶液与未加EC的溶液的纺丝稳定性,同时对比研究了由这两种溶剂分别制备的纳米纤维膜和微米纤维膜的结构和性能。结果表明,PCL/GAC/EC溶液体系黏度可在24 h内保持稳定,满足连续电纺要求;X射线衍射测试结果表明两种纤维膜结晶构型一致,只是结晶度和晶粒大小有所区别;傅里叶变换红外光谱分析结果表明EC对PCL的化学结构没有影响;与微米纤维膜相比,纳米纤维膜的比表面积提高了362.6%,平均孔直径有所减小,接触角有所增大;纳米纤维膜的拉伸断裂应力稍大但断裂应变明显小于微米纤维膜。 相似文献
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采用四氢呋喃和无水乙醇为溶剂,利用静电纺丝法制备了聚己内酯(PCL)/聚乙二醇(PEG)共混纳米纤维。研究了共混配比、溶液浓度、无水乙醇的加入以及电纺电压、接收距离等工艺参数对纤维形态和性能的影响。测试结果表明:聚乙二醇和聚己内酯以一定比例共混后改善了聚己内酯纤维毡的亲水性和细胞相容性;随着纺丝原液浓度增加,电纺产品由高分子微/纳米液滴结构渐变为珠状结构较少的平滑纤维,平均纤维直径逐渐增大;一定范围内,纤维平均直径随电压的上升而增大,但与接收距离关系不大;此外,加入无水乙醇后,共混溶液电导率增加,有利于喷射流的劈裂,减少了珠状结构的数量。 相似文献
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摘要：选用聚己内酯作为载体材料、5-氟尿嘧啶作为承载药物,研究了静电纺丝过程中纺丝液浓度、纺丝电压及收集距离对纤维直径的影响,对制备的聚己内酯载药纤维膜进行元素检测分析及力学性能测试,通过体外药物释放实验,验证了聚己内酯载药纤维膜药物控释的效果。结果表明,随着纺丝液的浓度和收集距离增加,纤维的平均直径增大;随着纺丝电压增加,纤维的平均直径减小。通过元素检测,验证了聚己内酯纤维膜内5-氟尿嘧啶的存在。在纺丝液浓度0.4 g/mL、纺丝电压10 kV、收集距离20 cm、载药量0.8 g的情况下,聚己内酯载药纤维膜纤维平均直径最小,达到13.92 μm,对应的拉伸强度为2.88 MPa。使用磷酸缓冲盐溶液模拟体液,在温度(37±0.5)℃下进行了体外释药实验,结果表明,该纤维膜在1000 h内,可以实现药物的控制释放。为确定静电纺丝法制备聚己内酯载药纤维膜工艺参数提供了有益借鉴,并为下一步优化工艺参数奠定了基础。 相似文献
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利用静电纺丝法在Q345钢表面制备聚己内酯(PCL)与缓蚀剂二巯基苯并噻唑(MBT)的纳米纤维膜PCL/MBT,然后在其表面旋涂环氧树脂(EP),得到复合涂层。通过电化学阻抗谱技术研究了复合涂层的防腐蚀性能。结果表明:在温度为25 ℃、湿度20%、纺丝电压15 kV、接收距离18 cm、V(氯仿)∶V(丙酮)=2∶3的条件下,PCL质量分数为12%,MBT质量浓度为0.01 g/mL时,静电纺丝得到的纳米纤维表面光滑,粗细均匀。电化学测试结果表明:EP/PCL/MBT复合涂层的防腐性能优于EP/PCL或EP涂层。 相似文献
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《合成纤维》2017,(2):43-48
以六氟异丙醇(HFIP)为溶剂,采用静电纺丝技术制备丝素(SF)-聚己内酯(PCL)复合纳米纤维膜。采用热场发射扫描电镜、Image-Pro Plus图像分析和力学拉伸的方法表征了纳米纤维膜的结构与力学性能。通过设计的三因素四水平正交试验对复合纳米纤维膜的多个指标进行了分析,采取归一化数据处理及平均权重分配的方式量化了复合纳米纤维膜的品质,确定了共混复合纳米纤维膜制备的最优工艺参数,并且采用最佳工艺参数制备了SF-PCL复合纳米纤维膜,分析了其力学性能。结果表明:在溶质质量分数为6%、溶质SF与PCL质量比为3∶2、纺丝流速1.2 mL/h时,SF-PCL复合纳米纤维膜具有较好的品质;双轴拉伸时的破坏机制与单轴不同,其断裂应力和应变只是单轴时的一半左右,膜的力学性能表现为各向同性。 相似文献
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吴闯;王海翔;孙基桔 《工程塑料应用》2023,51(12):137-144
随着组织工程人工血管领域的不断发展,目前由聚己内酯(PCL)制备的人工血管因为存在疏水性、力学性能差和生物相容性不足等问题,限制了其在组织工程人工血管领域的发展。为解决该问题,采用PCL和热塑性聚氨酯(TPU)作为静电纺丝的原料,利用静电纺丝设备制备出人工血管,其次通过浸渍工艺使一种从葎草茎中提取的高长径比植物纳米纤维素(H-CNC)浸入到人工血管中,用无水氯化钙进行交联,最终得到一种包含葎草茎植物纳米纤维素的PCL人工血管。通过研究该人工血管的微观形貌、力学性能、孔隙率、接触角以及对生物相容性的影响,发现加入葎草茎植物纳米纤维素制备的人工血管的力学性能、孔隙率、水接触角等性能均优于单纯制备的PCL人工血管。在生物相容性方面,葎草茎纳米纤维素的加入使得细胞在人工血管表面黏附和铺展,更加有效地促进细胞的增殖、分化,符合细胞的生长规律并有较大的促进作用。 相似文献
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引导组织再生膜在引导组织再生术中发挥着关键作用,高性能的引导组织再生膜能更好地促进组织再生修复。本文以纳米羟基磷灰石(n-HA)、聚己内酯(PCL)、明胶(Gel)为原料,通过静电纺丝法制备了不同含量n-HA增强的PCL/Gel/n-HA纤维膜,并对其形貌、组成、力学性能及降解性能进行了研究。SEM结果表明,纤维膜中的纤维形态良好,纤维直径大致分布于200～400nm之间,交联后纤维直径明显增加;TEM结果表明,n-HA较均匀分散在纤维中,随着n-HA含量的增加,n-HA在纤维膜表面发生聚集。力学测试结果表明,随着n-HA含量的增加显著提高了纤维膜的拉伸强度和断裂伸长率,当n-HA含量约为15%时,其拉伸强度和伸长率分别达到9.18MPa和180%。n-HA加入后,纤维膜的降解速率明显降低,n-HA含量约为15%的复合纤维膜体外降解12周以后约降解25%。本文制备的PCL/Gel/n-HA纤维膜的力学性能和降解速率能满足临床对引导组织再生膜的性能要求。 相似文献
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组织工程支架的关键作用是起到引导细胞繁殖、生长;促进组织修复的一个过程。纳米纤维支架由于具有特殊的纳米效应;而更有利于细胞的黏附、增殖、功能化;因而被广泛应用于组织工程。本文分别介绍了纳米纤维支架在各类组织工程中应用;包括皮肤和创伤敷料组织工程、血管组织工程、神经组织工程、骨组织工程、软骨组织工程中应用的研究进展;同时介绍了纳米纤维支架药物控制释放中的应用。指出目前纳米技术还不成熟;需要从制备工艺的优化、基因工程的引入及纳米材料安全性能的科学评价等几方面解决纳米纤维支架在组织修复工程中面临的问题。 相似文献
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综合评述了纳米纤维工艺技术的发展以及近期各公司、科研院所和大学的研发成果、生产动向及市场预测等.结果表明,纳米纤维是一种新型纺织纤维、功能纤维和增强纤维,主要采用静电纺丝法制取,可生产出其他常规纺丝法所不能制备的各种新型有机、无机、生物质等纳米纤维,具有十分广阔的应用前景,被认为是引领未来新材料发展的重要战略材料. 相似文献
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纤维素具有良好的生物相容性和可降解性,在生物组织工程领域作为支架材料的研究近年来受到研究者的关注。文章介绍了组织工程支架的性能要求,以及纤维素、细菌纤维素用于组织工程支架的研究现状。针对组织工程支架的分子设计、纳米化趋势,提出了纳米纤维素纤维用于组织工程支架的设想。并综述了纳米纤维素纤维制备的最新研究进展,预测了未来纤维素组织工程支架的发展趋势及前景。 相似文献
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Polymeric electrospun fibers have the potential to be utilized for a variety of applications such as tissue engineering, filtration, and textiles, owing to their high surface area per unit mass. However, these applications have some form of dependency on the mechanical properties of fiber meshes. Therefore, the current study is aimed at understanding the mechanical behavior of electrospun fiber systems at different length scales in order to establish a correlation between their structure and mechanical properties. Micro‐/nano‐fiber meshes of polystyrene were fabricated by the process of electrospinning and were subjected to uniaxial tensile testing. High‐resolution imaging during tensile testing revealed the macroscopic and microscopic structural evolution of these fibers. Further, the dependence of tensile strength, % elongation, and toughness of fiber meshes on the orientation of the fibers were also experimentally observed. The continuum mechanics simulation studies of fiber meshes with different orientations corroborated well with these experimental studies. Comprehensively, these studies demonstrated the changes in mechanical behavior of electrospun fiber meshes owing to the reorientation and alignment of fibers in meshes at microscopic and macroscopic length scale during tensile testing. Such study can be extrapolate for the design and fabrication of load‐bearing tissues scaffolds, and filtration devices. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134, 45012. 相似文献
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静电纺丝制备有序纳米纤维的研究进展 总被引：5，自引：0，他引：5
2000年以来,静电纺丝技术成为高分子材料和纳米技术研究领域的一个新的热点。综述了近年来采用静电纺丝法制备有序纳米纤维的研究进展,并讨论了有序纳米纤维的潜在应用。 相似文献
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《国际聚合物材料杂志》2012,61(18):1154-1166
AbstractIn the study graphene and multi- walled carbon nanotube (MWCNT) - containing polycaprolactone (PCL) scaffolds were prepared by solvent casting-particulate leaching method for cartilage tissue engineering applications. Graphene nanopowders or MWCNTs were added to the system at different concentrations namely 1, 3, 5 and 10?wt%. Mechanical, thermal and electrical properties of the scaffolds were measured as a function of additive concentration. Response of prechondrogenic ATDC5 cells seeded on the composite constructs were tested using XTT method and live-dead cell viability assay. Alkaline phosphatase activity of the cells was also tested to investigate differentiation behaviour. Results showed that electrically conductive composite scaffolds prepared in the study have potential to be used in tissue engineering. 相似文献
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BACKGROUND: Electrospinning is known as a novel fabrication method to form nanofibrous scaffolds for tissue‐engineering application. Previously, many natural biopolymers of protein have been electrospun. However, keratin has not attracted enough attention. In this study, keratin and gelatin were co‐electrospun with polylactide (PLA), respectively. RESULTS: The resulting nanofibers were characterized by a field emission scanning electron microscope (FE‐SEM), an attenuated total reflection‐Fourier transform infrared spectroscopy (ATR‐FTIR), and an electron spectroscopy for chemical analysis (ESCA). The biodegradation of mats in the presence of trypsin solution was studied. Cell attachment experiments showed that NIH 3T3 cells adhered more and spread better onto the PLA/keratin and PLA/gelatin nanofibrous mats than that onto the blank PLA mats. MTT and BrdU assay showed that PLA/keratin and PLA/gelatin nanofibrous mats could both accelerate the viability and proliferation of fibroblast cells as compared to PLA nanofibrous mats. CONCLUSION: The present study suggests that the introduction of gelatin and keratin can both improve cell‐material interaction, especially, the former is more effective. Copyright © 2008 Society of Chemical Industry 相似文献
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Rouhollah Mehdinavaz Aghdam Siamak Najarian Saeed Shakhesi Samaneh Khanlari Keyvan Shaabani Shahriar Sharifi 《应用聚合物科学杂志》2012,124(1):123-131
In the field of tissue engineering there is always a need for new engineered polymeric biomaterials which have ideal properties and functional customization. Unfortunately the demands for many biomedical applications need a set of properties that no polymers can fulfill. One method to satisfy these demands and providing desirable new biomaterials is by mixing two or more polymers. In this work, random nanofibrous blends of poly (ε‐caprolactone) (PCL) and polyglycolic acid (PGA) with various PCL/PGA compositions (100/0, 80/20, 65/35, 50/50, and 0/100) were fabricated by electrospinning method and characterized for soft‐tissue engineering applications. Physical, chemical, thermal, and mechanical properties of PCL/PGA blend nanofibers were measured by scanning electron microscopy (SEM), porosimetry, contact angle measurement, water uptake, attenuated total reflectance Fourier transform‐infrared spectroscopy (ATR‐FT‐IR), X‐ray diffraction (XRD), differential scanning calorimetric (DSC), dynamic mechanical thermal analysis (DMTA), and tensile measurements. Morphological characterization showed that the addition of PGA to PCL results in an increase in the average diameter of the nanofibers. According to these results, when the amount of PGA in the blend solution increased, the hydrophilicity and water uptake of the nanofibrous scaffolds increased concurrently, approaching those of PGA nanofibers. Differential scanning calorimetric studies showed that the PCL and PGA were miscible in the nanofibrous structure and the mechanical characterization under dry conditions showed that increasing PGA content results in a tremendous increase in the mechanical properties. In conclusion, the random nanofibrous PCL/PGA scaffold used in this study constitutes a promising material for soft‐tissue engineering. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012 相似文献
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Dariush Semnani Elham Naghashzargar Mehdi Hadjianfar Fahimeh Dehghan Manshadi Sajjad Mohammadi Saeed Karbasi 《国际聚合物材料杂志》2017,66(3):149-157
In this investigation, a nanofibrous scaffold was fabricated through electrospinning of polycaprolactone (PCL) and chitosan (CS) using a novel collector to make better orientation and pore size for cell infiltration. PCL/CS nanofibers with 90-rpm collector speed and 40° angle between collector wires of the new collector have fewer diameters with better pore, size and nanofibers orientation. Mechanical properties, roughness parameters, topology, structure, hydrophilicity, and cell growing were considered for liver tissue engineering. The cell culture was done using epithelial liver mouse cells. The developed electrospun PCL/CS scaffold using novel collector would be an excellent matrix for biomedical applications especially liver tissue engineering. 相似文献
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静电纺丝素纳米纤维支架材料在组织工程领域具有广阔的应用前景。本文综述了三种不同溶剂静电纺丝素纳米纤维支架材料及其在组织工程领域的研究进展。 相似文献