Child and mother cardiac vagal tone: Continuity, stability, and concordance across the first 5 years.

In this prospective longitudinal study, vagal tone and heart period were measured at 2 months and at 5 years in children and their mothers to evaluate the development of vagal regulation at rest and during an environmental task. Child baseline vagal tone and heart period were discontinuous; mother baseline vagal tone was discontinuous, but heart period was continuous. Group mean baseline-to-task change in vagal tone and heart period were continuous in both children and mothers. Children reached adult levels of baseline vagal tone by 5 years and did not differ from their mothers in baseline-to-task change in vagal tone or heart period. Baseline vagal tone tended to be stable, but baseline heart period and baseline-to-task change in vagal tone and heart period were unstable in children; both were stable in mothers. Baseline-to-task change in vagal tone showed consistent child–mother concordance. These findings contribute to understanding psychophysiological development. especially the ontogenesis of the vagal system and its regulatory capacity. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Infant day care: Behavioral effects at preschool age.

Based on 8 mo of observation in the same setting, 19 3-4 yr olds who had been in day care from infancy were compared on 9 behavior traits (e.g., tolerance for frustration, cooperativeness with adults, and success in problem-solving) with matched Ss who had had no day-care experience prior to the study. The infant day-care group was significantly more aggressive, motorically active, and less cooperative with adults. Consideration of these results in the light of other findings with the same and other samples suggests that early day-care experience may not adversely affect adjustment with peers but may slow acquisition of some adult cultural values. (21 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Infant reactivity: Physiological correlates of newborn and 5-month temperament.

The relation between measures of heart period and vagal tone and infant reactivity was investigated in a longitudinal study of infants from birth to 5 months of age. At 2 days of age, electrocardiogram (EKG) was recorded and a pacifier-withdrawal task was administered. At 5 months of age, EKG was recorded, after which infants and mothers participated in a laboratory session designed to elicit positive and negative reactivity. Maternal ratings of 5-month infant temperament were also obtained. There was a significant concurrent relation between 5-month vagal tone and negative reactivity elicited in the laboratory and maternal ratings of activity level and smiling behavior. Newborn vagal tone predicted maternal ratings of frustration and fear. Moderate stability was found for infant reactivity. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Infant temperament and the brainstem auditory evoked response in later childhood.

Brainstern auditory evoked responses (BAERs) were evaluated on 10–12-year-old children (N?=?56) who had been classified as high or low reactive to unfamiliar stimuli at 4 months of age. BAER measurement was selected because high reactive infants tend to become inhibited or fearful young children, and adult introverts have a faster latency to wave V of the BAER than do extroverts. Children previously classified as high reactive at 4 months had larger wave V components than did low reactive children, a finding that possibly suggests greater excitability in projections to the inferior cofliculus. The fact that a fundamental feature of brainstem activity differentiated preadolescent children belonging to two early temperamental groups supports the value of gathering physiological data in temperament research. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Coronary hyperreactivity to adrenergic stimulation and increased nocturnal vagal tone trigger coronary vasospasm

The present study was undertaken to analyse the effect of fluoxetine upon murine T-lymphocyte proliferation. We found that fluoxetine exerted a dual effect, which depended on the degree of lymphocyte activation: at mitogenic concentration (2 microg/mL) of concavalin A (Con A), we observed an inhibitory effect on cellular proliferation, whereas, on submitogenic Con A concentration (1 microg/mL), fluoxetine stimulated the cellular response. Given these facts, we studied PKC activation and calcium mobilisation in both stimulatory and inhibitory effects of fluoxetine on T-cell proliferation. We observed that fluoxetine increased PKC translocation obtained with 1 microg/mL Con A concentration, whereas PKC was degraded when 2 microg/mL was used. This mechanism is thought to be mediated by calcium mobilisation. According to our results, fluoxetine seemed to modulate calcium influx, which, in turn, would influence PKC translocation, modulating the immune response.     

Functional abilities at age 4 years of children born before 29 weeks of gestation

OBJECTIVES: To assess the rate of impairment and disability among babies born very preterm and to investigate the association between such impairment and gestational age at birth. DESIGN: Cohort study of a geographically defined population of babies. SETTING: Oxford Regional Health Authority. SUBJECTS: All babies born alive before 29 weeks of gestation to mothers resident in the region during 1984-6. MAIN OUTCOME MEASURES: Survival rates and rates of impairment and disability among survivors at the age of 4 years. RESULTS: Of the 342 babies, half (170) survived to be discharged home. Of the 164 survivors to age 4 years, 153 (93%) were assessed. A total of 35 (23%; 95% confidence interval 16% to 30%) were severely disabled and only 54 (35%; 28% to 43%) were unimpaired. The risk of impairment and disability increased with decreasing gestational age at birth (p < 0.003). CONCLUSIONS: With the increasing survival rate among babies born before 29 weeks of gestation, we need urgently to establish reliable ways of monitoring the proportion of survivors who have a disability.     

Localization of glutathione S-transferases alpha and pi in human embryonic tissues at 8 weeks gestational age

Glutathione S-transferases (GST) are a family of enzymes involved in the detoxification of xenobiotics. In humans, GST are divided into four different classes, alpha, mu, pi and theta, with partly overlapping substrate specificity and a tissue-specific expression pattern. We studied the cellular distribution of GST alpha and pi in a variety of human embryonic organs obtained from an extra-uterine monozygotic twin pregnancy at 8 weeks' gestational age. Tissues were fixed in 4% paraformaldehyde and embedded in paraffin. Three 4 microm thick sections were used, one for routine haematein and eosin staining, the others for immunohistochemical determination using monoclonal and polyclonal antibodies against GST alpha and pi, respectively. Both GST alpha and pi were present in hepatocytes, gastrointestinal epithelium, adrenal gland medulla, and tela chorioidea in the telencephalon. GST pi, but not alpha, was found in the epithelium of pancreatic and pulmonary glands, trachea, nephrons and urinary collecting ducts, as well as in the pia mater of the telencephalon and in developing nerve tissue in the gastrointestinal muscularis mucosae. In summary, we have demonstrated that immunoreactive protein for both GST alpha and pi is expressed in the human embryo at 8 weeks' gestational age. The early expression of GST alpha and pi in the epithelia of the urinary and digestive tracts and the respiratory system supports the importance of GST in the detoxification of potentially toxic or carcinogenic compounds. Our results suggest that the embryo itself is capable of detoxifying noxious compounds that are generated intracellularly or that cross the trophoblastic tissue.     

Selection for body weight at eight weeks of age. 11. Ovulation and oviposition patterns

Two experiments were conducted to study oviposition patterns and ovarian activity at various physiological ages in S15 and S16 generation pullets from lines selected bidirectionally for high (HWS) and low (LWS) juvenile body weight. The fixed periods of lay for random samples of pullets from the date of first egg were 20, 40, 60, and 80 days in the first experiment and 40, 80, 120, and 160 days in the second experiment. HWS pullets matured significantly earlier than LWS pullets in both generations. The frequency and the percentage hen-day production (%HDP) of defective eggs were significantly greater in the HWS than LWS line in both generations. Delayed sexual maturity did not significantly change the pattern of defective egg production for a fixed period of lay. In the HWS line the %HDP of defective eggs progressively increased until about 40 days of lay and tended to decline thereafter, while in the LWS line the percentage decreased from 20 to 40 days and then stabilized. The frequency of normal unbroken eggs to 80 days of production did not differ among lines either in the S15 or S16 generation. When measurements were extended to 160 days of lay in the S16 generation HWS pullets produced significantly more normal eggs than LWS pullets. Possible effects of ovarian activity on the egg production pattern during the laying cycle are discussed. There was a significantly higher incidence of internal laying and atrecia of the growing follicles in the HWS than in the LWS pullets. Ovarian activity, evidenced by the number of developing and ruptured follicles, was significantly greater in the HWS than the LWS line, as was the incidence of ova developing in pairs. Product moment correlations and multiple regressions among the measurements of ovarian activity were calculated within lines. In the HWS line, 62.5% of the variation in %HDP of defective eggs could be accounted for by the %HDP of normal eggs and the number of developing follicles while in the LWS line these variables accounted for only 7.29% of the variation in %HDP of defective eggs.     

Dental trauma in schoolchildren six to twelve years of age

The prevalence of dental injuries in Spanish children living in an urban area was studied in 4000 schoolchildren ages six to twelve years. A total of 227 children experienced dental injuries. Simple enamel fracture was the predominant injury (46.2 percent). Boys showed a higher prevalence than girls In the majority of cases (74.9 percent), the trauma affected one tooth only. The maxillary central incisor was the most frequently affected tooth (87.9 percent). The most common fracture site was the mesioincisal angle (40.6 percent) followed by distoincisal angle (27.3 percent). Twenty-four percent of the children with dental injuries had an overjet of more than 3 mm.     

Determination of gestational age from lunar age assessments in human fetal remains

Occasionally forensic fetal remains are submitted to the office of the medical examiner for age determination. A variety of literature and many techniques are available for this assessment depending upon the overall condition of the remains. If one uses traditional forensic anthropological sources, then age is calculated in lunar months; if one uses other sources--embryological, anthropological and sonographic--then age is reported as gestational weeks. For comparison between ages derived from these various studies, especially in cases involving age assessments of incomplete fetal remains that may be partially damaged by taphonomic factors, it is necessary to convert between lunar age and gestational age. The objective of this study is to present a conversion table for exact correspondence between lunar months and gestational weeks from the point of conception to term. This information is useful for developing a forensic profile at any gestational age as well as providing a means to assess the probability of viability at the time of death.     

Successful twin pregnancy and delivery following free rectus abdominis muscle flap at 15 weeks gestational age

Although a vertical rectus abdominis flap would not have been selected for reconstruction of the patient's defect had her pregnancy been detected preoperatively, the present case does demonstrate the remarkable resiliency and integrity of the anterior abdominal wall after rectus abdominis muscle flap surgery. Meticulous closure of the abdominal wall is of utmost importance in maintaining abdominal wall competence. Although the merits of muscle splitting techniques and the use of mesh are beyond the scope of this report, there is no evidence that modification of technique should be performed in the patient considering future pregnancy. Our case supports other reports that rectus abdominis flap surgery is not a contraindication to future pregnancy. Intuitively waiting at least 1 year, as recommended by Chen et al., seems reasonable, although the present case demonstrated a successful pregnancy and delivery of twins after a vertical rectus abdominis flap was harvested during pregnancy.     

Influence of birth weight on educational outcomes at age 9: the Miami site of the Infant Health and Development Program

BACKGROUND: The Quality of Surgical Care Project (QSCP) was established in May 1996, to evaluate surgical outcomes and where indicated, recommend changes to improve the quality of surgical care in Western Australia (WA). The purpose of this study is to establish benchmark standards in WA for operative mortality, 5-year survival and length of stay in all patients who were surgically treated for aneurysm of the abdominal aorta (AAA) in WA. METHODS: The WA Linked Database was used to link the morbidity and mortality records of all patients admitted and surgically treated for AAA in WA from 1985 to 1994. The linked chains of de-identified hospital morbidity and death records were selected using diagnostic and procedure codes pertaining to AAA. Three groups were separated for analysis: those admitted for rupture, those admitted for elective repair, and those who were admitted to hospital as an emergency without mention of rupture but who underwent repair for AAA. Independent analysis for gender and patients 80 years or more were included in the study. Patients were excluded from the study if they were less than 55 years of age. RESULTS: A total of 1475 cases (1257 males, 218 females) were identified. The mean age in elective cases was 70.4 years in males and 72.4 years in females, and for rupture the mean ages were 71.9 and 74.8 years, respectively. Median length of stay for males was 12 days for elective cases. Admission type or age did not significantly influence length of stay. Thirty-day mortality in males was 4.4% for elective repair and 36.7% for ruptured AAA and 5-year survival was 71.7 and 47.7%, respectively. The overall case fatality rate for ruptured AAA was 79.3% which included those cases who died from rupture without being admitted to hospital. CONCLUSIONS: These community-wide data provide a realistic measure of surgical performance for open repair of AAA. The outcomes for elective and rupture repair for AAA compare favourably with standards reported by international centres of excellence. They also support the use of this procedure in patients over 80 years of age with rupture. This information can be used for ongoing audit purposes and as a benchmark for the introduction of new treatment modalities.     

Antecedents of adult interpersonal functioning: Effects of individual differences in age 3 temperament.

We examined whether temperamental differences at age 3 are linked to interpersonal functioning in young adulthood. In a sample of over 900 children, we identified 5 distinct groups of children based on behavioral observations: Well-adjusted, undercontrolled, reserved, confident, and inhibited. At age 21, we assessed the children's interpersonal functioning in 4 social contexts: in the social network, at home, in romantic relationships, and at work. We found 3 patterns of relations: (a) Well-adjusted, reserved, and confident children defined a heterogeneous range of normative adult interpersonal behavior, (b) inhibited children had lower levels of social support but normative adjustment in romantic relationships and at work, and (c) undercontrolled children had lower levels of adjustment and greater interpersonal conflict across adult social contexts. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Infant attachment strategies, infant mental lag, and maternal depressive symptoms: predictors of internalizing and externalizing problems at age 7

The predictive relations between assessments in infancy and parent- and teacher-reported behavior problems at age 7 were investigated within a low-income sample. Infancy assessments indexed family adversity, parent-infant interaction at home, infant attachment, infant anger-distress at home, gender, and cognitive functioning. Among children at age 7 identified by teachers as highly externalizing, 83% were both disorganized in their attachment behavior in infancy and below the national mean in mental development scores at 18 months, compared with 13% of nonexternalizing children. Avoidant attachment behavior in infancy was associated with later internalizing symptoms rather than with externalizing symptoms. The behavior problem data reported by mother suggested the possibility of attachment-related biases in maternal report data. The results indicate that child mental lag in the context of a disorganized attachment relationship constitutes 1 early step on the pathway to school-age externalizing behavior.     

Nicotine excites cardiac vagal neurons via three sites of action

Clinicopathological data were collected for six children with ameloblastoma less than 16 years old. They were all treated initially by conservative surgery and satisfactory results without jaw deformities were finally attained. One of the histological characteristics of ameloblastoma in children is the prevalence of the plexiform type, which is thought to behave less aggressively than the follicular type. Conservative treatment is acceptable initial treatment of ameloblastoma in children who can be followed up in a precise, detailed manner.     

Genetic influence on tester-rated infant temperament as assessed by Bayley's Infant Behavior Record: Nonadoptive and adoptive siblings and twins.

Reports results for the 1st sibling adoption study of temperament in infancy, using tester ratings on the Infant Behavior Record (IBR) at 1 and 2 yrs of age for a sample of 95 pairs of nonadoptive siblings and 80 pairs of adoptive siblings. Twin data reported by A. P. Matheny (1980) for 85 identical and 50 fraternal twin pairs on the same measure at the same ages were combined with the sibling adoption data in maximum-likelihood model-fitting analyses for 3 IBR factors (affect-extraversion, activity, and task orientation). Both the sibling adoption and twin data yielded evidence for significant genetic influence for the 3 IBR factors at 12 and 24 mo: Heritability estimates ranged from 35–57%. Shared environment contributed little to the total variance for any of the 3 traits. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Survival and disability at 7-8 years of age in New Zealand infants less than 28 weeks gestation

AIMS: To determine the survival and disability rates at 7-8 years in infants of less than 28 weeks gestation born in New Zealand in 1986 and admitted to a neonatal unit. METHODS: In 1986, all infants with birthweight less than 1500 g and admitted to neonatal units were enrolled in a prospective audit of retinopathy of prematurity. Surviving infants, including the subset born at less than 28 weeks gestation, have been assessed at a home visit. Parents completed a comprehensive questionnaire and children underwent a visual assessment and were tested on the Wechsler Intelligence Scale for Children. RESULTS: Of 126 liveborn infants less than 28 weeks gestation, 80 (64%) survived to 7-8 years. Sixty eight children (97% survivors resident in New Zealand) were assessed: 72% had no, and 86% no or only mild disability, 77% had some visual problem, with close to one-third having myopia, strabismus or requiring spectacles and 32% received Ministry of Education funded special needs assistance. CONCLUSIONS: There have been few long-term follow-up studies of infants of less than 28 weeks gestation born in a defined geographical area. The outcome for New Zealand infants is comparable with that in other published data.     

Big tales and cool heads: Academic exaggeration is related to cardiac vagal reactivity.

Students who exaggerate their current grade point averages (GPAs) report positive emotional and motivational orientations toward academics (Gramzow & Willard, 2006; Willard & Gramzow, 2007). It is conceivable, however, that these self-reports mask underlying anxieties. The current study examined cardiovascular reactivity during an academic interview in order to determine whether exaggerators respond with a pattern suggestive of anxiety or, alternatively, equanimity. Sixty-two undergraduates were interviewed about their academic performance. Participants evidenced increased sympathetic activation (indexed with preejection period) during the interview, suggesting active task engagement. Academic exaggeration predicted parasympathetic coactivation (increased respiratory sinus arrhythmia). Observer ratings indicated that academic exaggeration was coordinated with a composed demeanor during the interview. Together, these patterns suggest that academic exaggeration is associated with emotional equanimity, rather than anxiety. The capacity for adaptive emotion regulation--to keep a cool head when focusing on academic performance--offers one explanation for why exaggerators also tend to improve academically. These findings have implications for the broader literature on self-evaluation, emotion, and cardiovascular reactivity. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Trajectories of externalizing behavior from age 2 to age 9: Relations with gender, temperament, ethnicity, parenting, and rater.

Trajectories of children's externalizing behavior were examined using multilevel growth curve modeling of data from the NICHD Study of Early Child Care and Youth Development. According to ratings by both mothers and caregivers/teachers when children were 2, 3, 4, 7, and 9 years old, externalizing behavior declined with age. However, mothers rated children as higher in externalizing behavior than did caregivers and teachers. Higher levels of age 9 externalizing behavior were predicted by the following factors: child male gender (for caregiver/teacher reports only), infant difficult temperament (for children with harsh mothers only), harsher maternal attitude toward discipline, higher level of maternal depression (for maternal reports only), and lower level of maternal sensitivity (especially for boys). Caregivers and teachers reported higher levels of externalizing behavior in African American children than in European American children, increasingly so over time; mothers' ratings revealed the reverse. The declining slope of externalizing behavior was predicted by infant difficult temperament for mother reports only. Additional analyses suggested that the association between parenting and externalizing behavior was bidirectional. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Normal laboratory values in Beagle dogs of twelve to eighteen months of age

Analyses of several body fluids are reported on Beagle dogs and compared with previous studies. All of the spinal fluid data and most of the urine data have not been previously reported in Beagles. Values of creatine phosphokinase, urine 5-hydroxyindoleacetic acid, and urine vanillymandelic acid are reported in the present study.