羟基磷灰石明胶复合材料的研究进展

主要是介绍羟基磷灰石明胶复合材料的研究进展。分析了羟基磷灰石明胶物理复合方法和化学复合方法。及该系统在其他方面的应用．最后对羟基磷灰石明胶复合材料的发展进行了展望。     

超声处理对羟基磷灰石／明胶复合材料性能的影响

为了研究超声反应对制备羟基磷灰石/明胶复合材料的影响,制备性能优异的生物材料,在湿法共沉淀制备羟基磷灰石/明胶复合材料的基础上,采用超声处理,并采用戊二醛对明胶进行交联,重点研究了超声时间对复合材料结构和性能的影响.结果表明,超声处理3 h制备的复合材料的两相分布均匀,平均尺寸大约为30 nm×100 nm,平均长径比在2～3,晶粒形态与天然骨相似,其拉伸强度和抗压强度达到66.4 MPa和67.8 MPa.研究表明,超声处理3 h可以较好地改善羟基磷灰石的结晶状态,提高复合材料的力学性能.     

超声时间对羟基磷灰石/明胶复合材料生物学性能的影响

在湿法共沉淀制备羟基磷灰石/明胶复合材料的基础上,采用超声辅助处理,重点研究了超声时间对复合材料生物学性能的影响,研究表明,超声处理3 h制备的复合材料两相分布均匀,材料内部呈支架结构,具有良好的生物降解性能和生物活性,可作为临床骨修复材料使用.     

羟基磷灰石-明胶复合物的制备及表征

对均相沉淀法制备HAP-GEL粉体及溶胶进行了研究,结果表明:采用均相沉淀法可以制得小尺寸且分布均匀的颗粒;HAP-GEL溶胶可以稳定三个月以上;热分析图谱及TEM照片表明,在HAP-GEL结构中HAP微晶和GEL高分子产生了键连作用,且HAP沿着GEL纤维上呈现自组装结构。初步探索了Ca∶P、pH值、温度、搅拌强度、滴加速度、超声时间对产物性能、尺寸及稳定性的影响。采用琼脂糖凝胶电泳和钙红染色法对制备的HAP-GEL作了表面电位定性测试。     

羟基磷灰石复合材料的应用进展

羟基磷灰石具有良好的生物相容性、生物活性、吸附性能、力学性能等优越性能,在生物医学、吸附分离以及力学等方面具有广阔的应用前景。但羟基磷灰石在使用过程中存在脆性大、易团聚、不易回收等弊端。因此,为了最大程度的发挥其优势,往往使羟基磷灰石与其它合适的材料进行复合,弥补在应用过程中的不足。本文分别从生物医学、力学、吸附以及新材料研究等领域出发,综述了羟基磷灰石复合材料的应用进展。     

羟基磷灰石复合材料研究进展

对羟基磷灰石与金属、天然生物材料、高分子材料的研究应用与进展进行了总结,并对羟基磷灰石复合材料的发展趋势进行了探讨.     

羟基磷灰石/壳聚糖复合材料研究进展

综述了羟基磷灰石/壳聚糖复合材料的研究现状,对其制备、特点、性能进行了探讨,羟基磷灰石基人工骨作为最有前途的生物硬组织替代材料之一,在生物医用材料和医学研究领域有着广泛的应用前景。主要从化学的角度对材料复合、表征、应用进行了阐述。进而对壳聚糖/羟基磷灰石复合材料的研究发展前景予以展望。     

聚乳酸/羟基磷灰石复合材料研究进展

综述了近年聚乳酸/羟基磷灰石复合材料的制备及改性方法,包括溶液共混法、熔融共混法和原位共聚法等。同时对聚乳酸/羟基磷灰石复合材料在人工骨修复以及生物固定支撑材料等领域的应用前景进行了展望。聚乳酸/羟基磷灰石复合材料的高性能化和降解速率可控将是新一代聚乳酸/羟基磷灰石复合材料的追求目标。     

聚乳酸/羟基磷灰石复合材料研究进展

综述了近年聚乳酸/羟基磷灰石复合材料的制备及改性方法,包括溶液共混法、熔融共混法和原位共聚法等。同时对聚乳酸/羟基磷灰石复合材料在人工骨修复以及生物固定支撑材料等领域的应用前景进行了展望。聚乳酸/羟基磷灰石复合材料的高性能化和降解速率可控将是新一代聚乳酸/羟基磷灰石复合材料的追求目标。     

羟基磷灰石生物复合材料的应用进展

综述了羟基磷灰石(HA)与无机、有机及金属材料的三种复合材料的研究应用与进展;分析了目前各种复合材料存在的主要问题;讨论了羟基磷灰石复合材料的发展方向。     

明胶/羟基磷灰石复合物微球中明胶对无机相影响的研究

在油包水的乳液体系中,通过原位合成的方法使羟基磷灰石(HAP)在明胶链上化学沉积,改变明胶溶液的浓度,制得了一系列的明胶/HAP复合物微球.采用X射线衍射仪(XRD)、傅里叶变换红外光谱仪(FTIR)、扫描电子显微镜(SEM)、透射电子显微镜(TEM)和热失重分析仪(TGA)等对产物的组成、形貌以及热失重情况进行了表征.结果表明,明胶用量对复合物微球中HAP的形成具有重要影响.在明胶溶液浓度为0.025 g/mL时,明胶分子链提供的结合位点恰好与溶液中游离的Ca2+、PO43-等离子达到平衡状态,复合物微球中无机相含量达40%,这是明胶与HAP以化学键合的形式结合所能得到的最大值.     

Preparation of Polymethylmethacrylate-Reinforced Functionally Graded Hydroxyapatite Composites

A functionally graded hybridization approach has been used in the formation of polymer-ceramic composites of polymethylmethacrylate (PMMA) and hydroxyapatite (HAp). HAp was successfully reinforced by sedimentary HAp distributions on a PMMA matrix using a centrifuge to avoid stress convergence on the interface. The stress-strain curves of the functionally graded PMMA-HAp composite showed sufficient mechanical strength with reduced brittleness. Scanning electron micrographs also showed evidence of exposed HAp on the surface of the composites.     

水热条件下针状羟基磷灰石单晶体的均相合成

用水热法制备出结晶度高、纯净均一的针状羟基磷灰石单晶体。从X-射线衍射谱、红外吸收光谱、透射电镜分析等方面确认了所得晶体为羟基磷灰石单晶体。根据透射电子衍射谱测量计算出的晶面间距d值与羟基磷灰石卡片的d值非常接近,由标定的晶面指数计算出的晶面夹角与实际测量值有很好的吻合,从而确定所得晶体为单晶。     

羟基磷灰石/聚乳酸复合材料制备的研究进展

聚乳酸是一类重要的生物降解聚合物,羟基磷灰石是人体骨骼的基本成分。以羟基磷灰石为增强材料、聚乳酸为基体制备的羟基磷灰石/聚乳酸复合材料,是无机/有机生物复合材料的典型代表,具有良好的力学性能与生物相容性,在很多领域有重要的应用。本文主要综述了羟基磷灰石/聚乳酸复合材料的制备方法。     

溶胶–凝胶法制备纳米羟基磷灰石粉体

以四水合硝酸钙和五氧化二磷为原料,无水乙醇为溶剂,采用溶胶一凝胶法制备了含co}的羟基磷灰石（hydroxy印atite,HAP）粉体。采用热重-差热分析、X射线衍射、透射电子显微镜、Fourier变换红外光谱等研究了反应体系pH值、反应温度及前驱体热处理温度等因素对产物结构与性能的影响规律,结果表明：采用溶胶-凝胶工艺,调控反应体系的pH、反应温度及前驱体的热处理温度是获得纯度高、分散性较好的纳米HAP粉体的关键。pH值为8．0、反应温度为30℃,经600℃热处理可获得到粒径为40~50nm的HAP纳米粉体。     

A Biomimetic Hybrid Hydrogel Based on the Interactions between Amino Hydroxyapatite and Gelatin/Gellan Gum

In this work, a gelatin (Gel)‐oxidized gellan gum (OG)/amino hydroxyapatite (mHap) hybrid hydrogel with Schiff base linkages is reported. The mHap is obtained by modifying hydroxyapatite with tetraethyl orthosilicate and 3‐aminopropyl‐triethoxysilane. The effects of different mHap contents on the structure, morphology, and properties of hydrogels are particularly investigated. Scanning electron microscopy coupled with energy dispersion spectroscopy reveals that mHap of around 100 nm is uniformly distributed inside the hydrogel with interconnected porous structures. Notably, the hydrogel with 1 wt% mHap possesses the highest compressive stress (2.01 ± 0.10 MPa) at 90% strain, as well as the lowest equilibrium swelling ratio (97% ± 5%) and degradation rate than other hydrogels. Besides, an ultra‐high compressive stress equivalent to 91% of the initial stress can be obtained by this hydrogel after 50 loading‐unloading cycles (85% strain). Meanwhile, after being swollen, this improved hydrogel also exhibits better structural stability than Gel‐OG hydrogel. The in vitro 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay further shows that all hydrogels are nontoxic against mouse fibroblasts. This work provides a biomimetic strategy to construct the organic/inorganic hydrogels with excellent interactions, elasticity, reversibility, and biocompatibility, which is of great importance for the practical applications in cartilage tissue engineering.     

Synthesis of a Hydroxyapatite/Collagen/Chondroitin Sulfate Nanocomposite by a Novel Precipitation Method

A hydroxyapatite/collagen/chondroitin sulfate nanocomposite that partly mimicked the composition of cartilage was synthesized through a novel precipitation method, using a calcium hydroxide suspension and phosphoric acid solutions that contained several mixing ratios of type II collagen (Col) and chondroitin sulfate (ChS). The precipitates were shaped and consolidated via filter pressing and subsequent cold isostatic pressing, respectively. A preferential alignment of the crystallographic c -axis of the hydroxyapatite nanocrystals along the longitudinal direction of the Col and ChS mixture was observed. The fracture strength and Vickers hardness of the nanocomposites were in the ranges of 35–50 and 119–219 MPa, respectively. This nanocomposite may be applicable for use as a bone substitute, because of its potential capability of bone remodeling through endochondral ossification.     

Properties of New Composite Materials Based on Hydroxyapatite Ceramic and Cross-Linked Gelatin for Biomedical Applications

The main aim of the research was to develop a new biocompatible and injectable composite with the potential for application as a bone-to-implant bonding material or as a bone substitute. A composite based on hydroxyapatite, gelatin, and two various types of commercially available transglutaminase (TgBDF/TgSNF), as a cross-linking agent, was proposed. To evaluate the impacts of composite content and processing parameters on various properties of the material, the following research was performed: the morphology was examined by SEM microscopy, the chemical structure by FTIR spectroscopy, the degradation behavior was examined in simulated body fluid, the injectability test was performed using an automatic syringe pump, the mechanical properties using a nanoindentation technique, the surface wettability was examined by an optical tensiometer, and the cell viability was assayed by MTT and LDH. In all cases, a composite paste was successfully obtained. Injectability varied between 8 and 15 min. The type of transglutaminase did not significantly affect the surface topography or chemical composition. All samples demonstrated proper nanomechanical properties with Young’s modulus and the hardness close to the values of natural bone. BDF demonstrated better hydrophilic properties and structural stability over 7 days in comparison with SNF. In all cases, the transglutaminase did not lead to cell necrosis, but cellular proliferation was significantly inhibited, especially for the BDF agent.     

Dispersing Behavior of Hydroxyapatite Powders Produced by Wet-Chemical Synthesis

Three hydroxyapatite powders with different surface properties were produced by wet-chemical synthesis and characterized. The electrokinetic properties of powders dispersed in water were investigated by electroacoustic spectroscopy measurements. The different surface reactivity (pH_iep and ζ potential versus pH curves) was related to the interplay of dissolution and adsorption of Ca²⁺ ions. With a view toward the preparation of porous bodies by sponge impregnation, the behavior of powder suspensions was studied. Four deflocculants were tested, and the optimum dispersing conditions for each powder were found. Anionic polyelectrolytes resulted in the best effective dispersing agent, with different optimum amounts added to the suspensions.     

PA1010/羟基磷灰石复合材料的制备与性能

利用熔融共混法制备了聚酰胺1010(PA1010)/羟基磷灰石(HA)复合材料,采用傅立叶变换红外光谱、热重分析仪和差示扫描量热仪测试了PA1010/HA复合材料的结构特征和热稳定性,利用电子万能试验机测试了PA1010/HA复合材料的力学性能。结果表明:复合材料中PA1010与HA之间通过氢键作用结合,而氢键作用的主要发生位置在PA1010酰胺键的氨基与HA的羟基之间;PA1010/HA复合材料具有良好的热稳定性,HA的加入对PA1010/HA复合材料的熔点基本没有影响,随着HA含量的增加,其熔融焓和结晶焓都降低。HA的加入,增强了PA1010/HA复合材料的拉伸性能和弯曲性能,与纯PA1010相比,分别提高了33.4%,98.3%。