可移动式生物电势测量系统模拟前端设计

本文介绍了一种应用于可移动式生物电势测量系统的连续可变增益/带宽的模拟前端电路设计。本模拟前端可以对不同类型的生物电势信号进行放大和整形。为了优化电路功耗和简化电路结构,模拟前端只采用了两级放大电路。此外,对于关键晶体管的设计使电路不再需要斩波电路。系统的等效输入噪声为1.19μVrms (0.48-200Hz). 芯片在SMIC 0.18μm 工艺下进行流片。测试结果显示,虽然芯片的功耗在3V的电压下功耗只有32.1μW ,但却能成功地抓取到生物电势信号。     

Design of an analog front-end for ambulatory biopotential measurement systems

A continuously tunable gain and bandwidth analog front-end for ambulatory biopotential measurement systems is presented.The front-end circuit is capable of amplifying and conditioning different biosignals.To optimize the power consumption and simplify the system architecture,the front-end only adopts two-stage amplifiers.In addition, careful design eliminates the need for chopping circuits.The input-referred noise of the system is only 1.19μVrms (0.48-2000 Hz).The chip is fabricated via a SMIC 0.18μm CMO...     

针对可扩展交换网络的健壮性评价方法

分析了现有指标不能评价大规模可扩展交换网络顽健性的问题,结合可扩展交换网络拓扑特性和故障模型,提出了一种基于故障影响的顽健性评价方法,并进一步提出了该方法评价指标的优化算法.通过实验比较了故障影响方法与现有方法对于可扩展交换网络的评价效果,结果表明故障影响方法可以有效地评价大规模可扩展交换网络的顽健性.     

Noninvasive measurement and analysis of intestinal myoelectrical activity using surface electrodes

Intestinal myoelectrical activity (IMA), which determines bowel mechanical activity, is the result of two components: a low-frequency component [slow wave (SW)] that is always present, and a high-frequency component [spike bursts (SB)] which is associated with bowel contractions. Despite of the diagnostic significance of internal recordings of IMA, clinical application of this technique is limited due to its invasiveness. Thus, surface recording of IMA which is also called electroenterogram (EEnG) could be a solution for noninvasive monitoring of intestinal motility. The aim of our work was to identify slow wave and spike burst activity on surface EEnG in order to quantify bowel motor activity. For this purpose, we conducted simultaneous recordings of IMA in bowel serosa and on abdominal surface of five Beagle dogs in fast state. Surface EEnG was studied in spectral domain and frequency bands for slow wave and spike burst energy were determined. Maximum signal-to-interference ratio (7.5 dB +/- 36%) on SB frequency band was obtained when reducing upper frequency limit of signal analysis. Energy of external EEnG in reduced SB frequency band (2-7.9 Hz) presented a high correlation (0.71 +/- 7%) with internal intensity of contractions. Our results suggest that energy of SB can be quantified on external EEnG which could provide a noninvasive method for monitoring intestinal mechanical activity.     

Polypyrrole/reduced graphene oxide coated fabric electrodes for supercapacitor application

Flexible and wearable energy storage devices are strongly demanded to power smart textiles. Herein, reduced graphene oxide (RGO) and polypyrrole (PPy) were deposited on cotton fabric via thermal reduction of GO and chemical polymerization of pyrrole to prepare textile-based electrodes for supercapacitor application. The obtained PPy–RGO-fabric retained good flexibility of textile and was highly conductive, with the conductivity of 1.2 S cm⁻¹. The PPy–RGO-fabric supercapacitor showed a specific capacitance of 336 F g⁻¹ and an energy density of 21.1 Wh kg⁻¹ at a current density of 0.6 mA cm⁻². The RGO sheets served as conductor and framework under the PPy layer, which could facilitate electron transfer between RGO and PPy and restrict the swelling and shrinking of PPy, thus resulting in improved electrochemical properties respect to the PPy-fabric device.     

Novel dry polymer foam electrodes for long-term EEG measurement

A novel dry foam-based electrode for long-term EEG measurement was proposed in this study. In general, the conventional wet electrodes are most frequently used for EEG measurement. However, they require skin preparation and conduction gels to reduce the skin-electrode contact impedance. The aforementioned procedures when wet electrodes were used usually make trouble to users easily. In order to overcome the aforesaid issues, a novel dry foam electrode, fabricated by electrically conductive polymer foam covered by a conductive fabric, was proposed. By using conductive fabric, which provides partly polarizable electric characteristic, our dry foam electrode exhibits both polarization and conductivity, and can be used to measure biopotentials without skin preparation and conduction gel. In addition, the foam substrate of our dry electrode allows a high geometric conformity between the electrode and irregular scalp surface to maintain low skin-electrode interface impedance, even under motion. The experimental results presented that the dry foam electrode performs better for long-term EEG measurement, and is practicable for daily life applications.     

A power and efficiency measurement technique for active patchantennas

In this paper, the power input to the radiating element of an active microstrip patch antenna is measured using a small sensing patch, which is weakly coupled to a radiating edge. Combined with an estimate of patch radiation efficiency, this also yields a measurement of total radiated power. The method has advantages of convenience, insensitivity to room reflections, and a weakly frequency-dependent calibration factor     

A new method for noninvasive measurement of multilayer tissue conductivity and structure using divided electrodes

This paper outlines a new method for measuring multilayer tissue conductivity and structure by using divided electrodes, in which current electrodes are divided into several parts. Our purpose is to estimate the multilayer tissue structure and the conductivity distribution in a cross section of the local tissue by using bioresistance data measured noninvasively. The effect of the new method is assessed by computer simulations using a typical two-dimensional (2-D) model. In this paper, the conductivity distribution in the model is analyzed based on a finite difference method (FDM) and a steepest descent method (SDM). Simulation results show that the conductivity values of skin, fat, and muscle layers can be estimated with an error of less than 0.1%. When random noise at various levels is added to the measured resistance values, estimates of the conductivity values for skin, fat, and muscle layers are still reasonably precise: their root mean square errors are about 1.06%, 1.39%, and 1.61% for 10% noise. In a 2-D model, increasing the number of divided electrodes permits simultaneous estimates of tissue structure and conductivity distribution. Optimal configuration for divided electrodes is examined in terms of dividing pattern.     

机载杂波测量雷达有源校准器的设计与分析

对机载杂波测量雷达有源校准器的基本原理和设计方法进行了介绍,描述了其各部分的性能,并对该设备在校准实验中所测得的结果进行了研究,证明了它成功用于机载杂波测量雷达定标的有效性。     

Thermal fracture toughness measurement for underfill during temperature change

The failure of organic packages during thermal cycling is often associated with failure of the underfill by fracture. The fracture toughness of underfills measured by applying a mechanical stresses to the material at a constant temperature is used as a measure of the propensity of underfill fracture. However, this fracture toughness does not take into account transient temperature effects during thermal cycling. To include temperature effects a fracture toughness induced by applying thermal stresses is defined and a method to measure this thermally induced fracture toughness is described. Results on two commercial underfills are presented. Comparison of the conventional, mechanically induced fracture toughness and the new, thermally induced fracture toughness shows that underfill fracture toughness including thermal effects is significantly smaller than the conventional values. This indicates that the mechanical toughness method overestimates the underfill/package reliability that becomes subject to temperature change. The difference is explained using fracture energy concept.     

EWMA forecast of normal system activity for computer intrusion detection

Intrusions into computer systems have caused many quality/reliability problems. Detecting intrusions is an important part of assuring the quality/reliability of computer systems by quickly detecting intrusions and associated quality/reliability problems in order to take corrective actions. In this paper, we present and compare two methods of forecasting normal activities in computer systems for intrusion detection. One forecasting method uses the average of long-term normal activities as the forecast. Another forecasting method uses the EWMA (exponentially weighted moving average) one-step-ahead forecast. We use a Markov chain model to learn and predict normal activities used in the EWMA forecasting method. A forecast of normal activities is used to detect a large deviation of the observed activities from the forecast as a possible intrusion into computer systems. A Chi square distance metric is used to measure the deviation of the observed activities from the forecast of normal activities. The two forecasting methods are tested on computer audit data of normal and intrusive activities for intrusion detection. The results indicate that the Chi square distance measure with the EWMA forecasting provides better performance in intrusion detection than that with the average-based forecasting method.     

A triaxial accelerometer and portable data processing unit for theassessment of daily physical activity

The present study describes the development of a triaxial accelerometer (TA) and a portable data processing unit for the assessment of daily physical activity. The TA is composed of three orthogonally mounted uniaxial piezoresistive accelerometers and can be used to register accelerations covering the amplitude and frequency ranges of human body acceleration. Interinstrument and test-retest experiments showed that the offset and the sensitivity of the TA were equal for each measurement direction and remained constant on two measurement days. Transverse sensitivity was significantly different for each measurement direction, but did not influence accelerometer output (<3% of the sensitivity along the main axis). The data unit enables the on-line processing of accelerometer output to a reliable estimator of physical activity over eight-day periods. Preliminary evaluation of the system in 13 male subjects during standardized activities in the laboratory demonstrated a significant relationship between accelerometer output and energy expenditure due to physical activity, the standard reference for physical activity (r=0.89). Shortcomings of the system are its low sensitivity to sedentary activities and the inability to register static exercise. The validity of the system for the assessment of normal daily physical activity and specific activities outside the laboratory should be studied in free-living subjects     

A system for automatic measurement of circadian activity deviations in telemedicine

A system for the automatic measurement of the circadian activity deviations in telemedicine has been developed within the framework of a "Health Integrated Smart Home Information System" (HIS2). HIS2 is an experimental platform for the evaluation and the development of technologies in order to ensure the security and quality of life for patients who need home based medical monitoring. Location sensors are placed in each room of the HIS2, allowing the monitoring of patient's successive activity phases within the patient's home environment. We proceeded with a sampling in an hourly schedule to detect weak rhythmic variations. Based on numerous measurements, we established a mean value with confidence limits. These also allowed us to define a zone within which the patient's activity is qualified to be "predictable." Alerts are set off if the patient's activity deviates from this zone.     

Microscopic image analysis for quantitative measurement and featureidentification of normal and cancerous colonic mucosa

The development of an automated algorithm for the categorization of normal and cancerous colon mucosa is reported. Six features based on texture analysis were studied. They were derived using the co-occurrence matrix and were angular second moment, entropy, contrast, inverse difference moment, dissimilarity, and correlation. Optical density was also studied. Forty-four normal images and 58 cancerous images from sections of the colon were analyzed. These two groups were split equally into two subgroups: one set was used for supervised training and the other to test the classification algorithm. A stepwise selection procedure showed that correlation and entropy were the features that discriminated most strongly between normal and cancerous tissue (P<0.0001). A parametric linear-discriminate function was used to determine the classification rule. For the training set, a sensitivity and specificity of 93.1% and 81.8%, respectively, were achieved, with an overall accuracy of 88.2%. These results mere confirmed with the test set, with a sensitivity and specificity of 93.1% and 86.4%, respectively, and an overall accuracy of 90.2%     

一种测量液体旋光特性的共光路外差干涉技术

为了提高旋光特性检测的灵敏度,设计搭建了一套基于塞曼效应的共光路外差干涉仪应用于旋光液体的旋光特性检测.采用塞曼效应激光器作为光源能发出两束正交线偏光,简化了实验装置的复杂性;且在系统中利用平衡检测与差动放大器,可降低激光器本身与外部环境所造成的大部分噪声,从而提高检测灵敏度.结果表明,对(0～50)mg/dL的低浓度葡萄糖水溶液的旋光特性测量,其检测灵敏度可达2.3×10-5(°).这种结构简单的干涉仪可应用于固态、液体或气态旋光物质的旋光特性分析中.     

Preparation and photocatalytic activity of Ag/bamboo-type TiO2 nanotube composite electrodes for methylene blue degradation

Photocatalysis phenomena in TiO₂ have been intensively investigated for its potential application in environmental remediation. The present work reports improved photocatalytic degradation of methylene blue dye in aqueous solution by using bamboo-type TiO₂ nanotubes deposited with Ag nanoparticles via electrochemical deposition. The photocatalytic processes are performed on Ag-modified TiO₂ bamboo-type nanotube arrays, Ag-modified smooth-walled nanotube arrays, and bare smooth-walled nanotube arrays. Both Ag-modified bamboo-type and smooth-walled nanotube arrays show improved photocatalytic degradation efficiencies (64.4% and 52.6%) compared to smooth-walled TiO₂ nanotubes of the same length (44.4%), due to the enhanced electron–hole seperation and more surface area provided by bamboo ridges. The photocatalytic activity and kinetic behavior of Ag-modified bamboo-type nanotube arrays are also optmized by tuning pulse deposition time of Ag nanoparticles. Bamboo-type nanotubes deposited with Ag nanoparticles via pulse deposition time of 0.5 s/1.5 s shows the highest methylene blue degradation efficiency of 78.5%, which represents 21.9% and 76.8% enhancement of efficiency compared to those of bare bamboo-type and smooth-walled nanotubes, respectively, indicating that a proper amount of Ag nanoparticles on TiO₂ can maximize the photocatalytic processes. In addition, overly long pulse deposition time will not further increase photocatalytic activity due to agglomeration of Ag paticles. For example, when the pulse deposition time is increased to 2 s/6 s, Ag-modified bamboo-type nanotube array exhibits a lower photocatalytic degradation efficiency of 62.9%.     

A model for the measurement of patient activity in a hospital suite.

At the time of hospitalization, it is essential to evaluate the general health status of a patient and to follow up the trends during therapy. Our work is focused on a set of tools for the measurement of patient activity. In this paper, we propose a few indicators of the patient activities of daily living, such as mobility, agitation, repartitions of stays, and displacements. As a result of this work, a diagnostic system was developed that could lead to a deeper knowledge of human activity rhythms in normal situations.     

Simplified calibration of single-plunge bipolar electrode array for field measurement during defibrillation

In an earlier study, the authors presented a calibration technique for a triaxial bipolar electrode array (EA) that used 72 data points collected during a global sweep of the electric field vector relative to the EA axes. Although necessary for the initial characterization of the EAs, this data requirement has to be significantly reduced for the technique to become a practical tool. Therefore, in the present study, an analysis is performed to determine the relation between the number of data points used in the calibration and the mean root-mean-square error. The analysis shows that 18 data points can produce results nearly identical to those obtained with the 72-point calibration, thus reducing the required amount of data fourfold.     

激光手术时热效应的估计与实验测量

本文用计算机数值模拟求得了激光辐照时生物组织中的一维温度场和相间边界移动速率,进而估计了其热损伤大小和烧蚀组织数量,并对热损伤区大小和切割深度进行了实验检验。结果表明：该估算结果与实验数据符合得很好。