夏天无总碱对血小板内cAMP、cGMP含量的影响

夏天无总碱(COAMTA)系从伏生紫堇之块茎中分离出的有效成分。动物实验表明,COAMTA具有明显抑制血小板聚集、抑制血栓形成等作用。本文观察了COAMTA对家兔血小板内cAMP和cGMP含量的影响。结果0.08—0.16mg/ml PRP的COAMTA可明显提高血小板内cAMP含量;剂量为0.16mg/ml PRP还可使cGMP含量升高,但cAMP/cGMP的比值增加更为明显,提示COAMTA主要是通过影响cAMP含量而发挥抑制血小板功能的作用。     

夏天天总碱对血小板内cAMP、cGMP含量的影响

夏天无总碱（COAMTA）系从伏生紫堇之块茎中分离出的有效成分。动物实验表明，COAMTA具有明显抑制血小板聚集、抑制血栓形成等作用。本文观察了COAMTA对家兔血小板内cAMP和cGMP含量的影响。结果0．08－0．16mg/m1 PRP的COAMTA可明显提高血小板内cAMP含量：剂量为0．16mg/m1 PRP还可使cGMP含量升高，但cAMP/cGMP的比值增加更为明显，提示COAMTA主要是通过影响cAMP含量而发挥抑制血小板功能的作用。     

放射免疫显像病人的血清人抗鼠抗体监测

对一组接受＾９９ｍＴｃ标记抗ＣＥＡ单克隆抗体放射免疫显像的肠癌病人用反向间接血凝试验测定其血清中人抗鼠抗体（ＨＡＭＡ），结果发现７／１０血样品中有ＨＡＭＡ，其浓度随注射次数增加而增大。     

一些助阳药和滋阴药对环核苷酸系统反应性的调节作用

现代医学的实验研究发现cAMP和cGMP在调节细胞功能上有着极为广泛而重要的作用。鉴于扶正中药的药理作用是多方面的,但主要在于调整机体失调的功能,使之趋向相对平衡。因此,研究扶正中药与环核苷酸系统的关系是值得注意的一项工作。又鉴于血浆环核苷酸基础水平较低,波动幅度大,药物或病理引起的差异往往不易显示,为此,我们建立了几种动物病理模型,以β-肾上腺素能激动剂(异丙基肾上腺素简称异丙)引起体内cAMP含量升高及M-胆矸能激动剂(氨甲酰胆矸简称氨甲)引起体内cGMP含量升高为指标,主要观察了     

酸性铁蛋白放免分析中抗体纯化的可行性

用改进的工艺自人心肌组织中提取的高纯度酸性铁蛋白，与经溴化氰活化ＳｅｐｈａｒｏｓｅＣＬ－６Ｂ偶联，制得ＡＩＦ－ＳｅｐｈａｒｏｓｅＣＬ－６Ｂ亲和层析柱。用经柱纯化的兔抗ＡＩＦ抗血清来组建酸性铁蛋白放免分析法用四参数Ｌｏｇｉｓｔｉｃ数据处理程序处理数据。     

应用国产H BsAg-HBsAb固相放免双测定药盒检测HBsAg和抗-HBs

自Blumberg(1965)发现乙型肝炎表面抗原(HBsAg)以来,目前世界上约有2亿HBsAg无症状携带者,其中亚洲和西太平洋地区至少有一亿六千万,而我国就占了一亿人左右。这些无症状携带者实际上是乙型肝炎重要的传染源。有些无症状携带者,因肝功能正常,缺乏临床症状,或因医疗部门检测水平的限制,便作为献血员供血,引起受血者输血后乙型肝炎。所以,严格筛选献血员,阻断乙肝病毒的血源播散,这是涉及全世界的     

微机放射免疫测定仪

本文介绍的γ闪烁计数测量仪器以微处理器为基础,主要用于放射免疫测量和数据处理。文章列举了仪器的主要功能和技术指标,并结合系统的硬件与软件的特点扼要介绍了系统的原理和设计思想。     

An improved procedure for the determination of apparent strain

An improved procedure for theoretically determining the apparent strain is proposed. Based on the results of an experimental study into the behaviour of high temperature strain gages in a varying thermal environment a theoretical formula is developed. One of the significant features of the proposed formula lies in its ability to predict the apparent strain without actually carrying out the experiment, provided the relevant strain gage material parameters as also the coefficient of thermal expansion of the specimen material are known. A comparison study of the results obtained by using the proposed formula with the experimentally determined results shows excellent agreement. Its application to the development of improved temperature compensated gages is also indicated.     

冠心病患者血小板GMP—140RIA的研究

应用单克隆抗体ＳＺ－５１，通过放射免疫分析测定了９４例冠心病患者血小板α颗粒膜蛋白的活化分子数。实验结果表明：冠心病组患者血小板ＧＭＰ－１４０分子数比正常对照组明显增高；急性心肌梗塞患者用尿激酶溶栓治疗后１２ｈ的血小板ＧＭＰ－１４０的活化分子数比治疗前１ｈ明显降低。     

改进的激光多步共振电离实验技术

描述了一套改进了的利用于激光多步共振电离谱学研究的实验装置和技术.在此技术中,利用加热蒸发的方式产生高温难熔元素的原子流;对激光功率和中性原子流进行实时监测,对测量结果作归一化处理;采用V-F变换器对堆积了的光信号和离子信号作瞬时变换,企图得到堆积的事件个数; CAMAC多道定标获取系统与其联合操作实现原子流强度、共振电离生成的离子数和激光功率等参数的同步获取.通过离线数据分析,能够得到更精确的实验数据.     

本底个值质控图在放免仪长期稳定性监控中的应用

在放免仪短期稳定性评价的基础上制作了本底个值质控图并应用于长期稳定性的监控。结果表明，该方法可作为放免仪长期稳定性考核、量化的一个手段。     

外周血淋巴细胞M受体反应性的测定

从全血中分出淋巴细胞，在含钙Ｈａｎｋｓ’液或含磷酸二酯酶抑制剂的缓冲液中孵育，加Ｃａｒｂａｃｈｏｌ能使细胞内ｃＧＭＰ含量增高６６％－８０％，这种升高可被阿托品阻断，说明ｃＧＭＰ的增高是由Ｍ受体介导的特异性反应。据此建立了一种反映Ｍ受体ＣＧＭＰ系统功能状态的方法并对孵育和反应条件作了探讨，初步实验结果表明老年大鼠淋巴细胞ＣＧＭＰ基础含量显著低于青年大鼠，由ＣａｒｂａｃｈｏｌＧＩ起的ｃＧＭＰ升高反应也明显降低。     

放射性同位素免疫标记自动记录系统

文章叙述了放射性同位素免疫标记自动记录的原理以及整个系统设计在这个基础上提高放射性同位素免疫标记的准确性。     

An improved procedure for radiochemical processing of activated fusion-reactor-relevant V–Cr–Ti alloy

The most promising structural material for both demonstration and commercial fusion reactors with liquid metal coolants is vanadium–chromium–titanium (V–Cr–Ti) alloy. Since its base is expensive and scarce vanadium, it is desirable to return this material into fusion power engineering after the reactor decommissioning. This is feasible only after purification of the V–Cr–Ti alloy from activation products. We have developed extraction technology for reprocessing of the activated V–Cr–Ti alloy. Recycling of the alloy after such a reprocessing does not require shielding against ionizing radiation. The solution of di-2-ethyl-hexyl-phosphoric acid (D2EHPA) in a hydrocarbon thinner was chosen as an extraction solvent. The process flow sheet includes dissolution of the V–Cr–Ti alloy in a nitric acid, titanium extraction from a nitrate solution, vanadium extraction at pH 2.0–2.5 and chromium extraction at pH of 4.2–4.5. In previous studies parameters of the extraction processes were studied at static conditions. Experiments with extraction of vanadium and chromium performed in dynamic conditions have shown that maintenance of the necessary pH in a solution requires use of buffer systems (on basis of formate). Joint extraction of vanadium and chromium with required purification from the main activation products (Co-60 and Eu-152) appeared to be feasible using only one reagent.     

Modification of thermal hydraulic code,THEATRe, with fuel rod behavior models and its application to reactivity-initiated accident (RIA)

During reactor operation, many complex changes occur in fuel rod which affects its thermal, mechanical and material properties. These changes also affect the reactor response to the transient and accident situations. Realistic simulation of fuel rod behavior under transients such as reactivity-initiated accident (RIA) is of great significance. In this study, thermal hydraulic analysis code THEATRe (Thermal Hydraulic Engineering Analysis Tool in Real-time) has been modified by addition of fuel rod behavior models for dynamic simulation of nuclear reactor. Transient changes in gas-gap parameters were taken into account by modeling the gas-gap behavior. Thermo-mechanical behavior of fuel rod is modeled to take into account the thermal, elastic and plastic deformation. To simulate RIA, point reactor kinetics model is also incorporated in the THEATRe code. To demonstrate the transient fuel rod behavior, AP1000 reactor is modeled and three hypothetical RIA cases are simulated. The RIA is considered at three different reactor power levels, i.e. 100, 50 and 1% of nominal power. The investigated parameters are fuel temperature, cladding stress and strain, fuel and cladding thermal conductivity and heat transfer coefficient in gas-gap. Modified code calculates the fuel rod temperatures according to updated fuel, clad and gas-gap parameters at the onset of steady-state operation and during the transient. The modified code provides lower steady-state fuel temperature as compared to the original code. Stress and strain analyses indicate that the hoop and radial strain is higher at high power locations of the fuel rod; therefore, gap closure process will initially occur in the central portion of the fuel rod and it should be given more emphasis in the safety analysis of the fuel rod and nuclear reactor during accidents and transients.