The treatment of Eikenella corrodens soft tissue infection in an injection drug user

Despite the frequent occurrence of mucosal candidiasis in patients infected with HIV, systemic candidiasis is uncommon and usually associated with intravenous catheters, parenteral nutrition, or antibiotics and neutropenia. Most of the fungal isolates are usually Candida albicans, Candida tropicalis or Candida parapsilosis. The authors report a case of infective endocarditis due to Candida zeylanoides that occurred in a patient infected with HIV in the absence of the usual risk factors for systemic candidiasis.     

Fistula carcinoma in chronic soft tissue infection

Squamous cell carcinoma without accompanying osteomyelitis is a rare complication in chronic soft tissue inflammation. We report on a patient with soft tissue squamous cell carcinoma developing only two years after a war accident.     

Necrotizing dermatitis, infections of soft tissue and deep fascia: classification and treatment

Using the model systems of Pb-Sr intoxication on the white rats was found out, that incorporated Pb and Sr had influenced on the activity of lipoperoxidation in tissue of rat's internal organs. The intensification of the activity of lipoperoxidation was observed in liver, heart, spleen, less in kidneys after five days Pb-Sr intoxication. Twenty-days Pb-Sr intoxication was accompanied the depression of the activity of lipoperoxidation in liver, heart, kidneys; the activity of lipoperoxidation's activation was continued in spleen. Using phlamicare--polyextract of mountain ash, is resulted in normalisation of lipoperoxidation in rat's internal organs during Pb-Sr intoxication and contributed to removing of incorporated Pb and Sr.     

Circulatory disturbances following transient soft tissue compression trauma

Circulatory changes following standardized compression trauma to the hind leg in dogs were evaluated using an electromagnetic flow meter and repeated angiography. A transient increase of flow to the injured limb and within the traumatized region was observed. Good agreement was found between the electromagnetic flow recordings and estimates of relative changes in flow by the angiographic method.     

Analysis of sweat during soft tissue breakdown following pressure ischaemia

This paper examines the nature of tissue metabolites collected in thermally induced sweat following the application of different loading regimes on the soft tissues of able-bodied subjects. Loading was produced by 1) external application on the forearm via both a tourniquet and a uniaxial indenter system, and 2) ischial support on a wheelchair and sacral support on an examination bed. In each case sweat pads were attached to the tissue areas of a group of able-bodied subjects and interface pressures were recorded. After a prescribed period, the pads were removed and a quantitative analysis of a range of metabolites was performed. Results indicated that tissues subjected to pressure ischemia produced a general increase in concentrations of lactate, chloride, urea, and urate associated with a decreased sweat rate. In the reperfusion phase, some of these metabolites returned to unloaded levels. It is proposed that specific metabolites may be used as an indicator of soft tissue damage.     

Acute necrotizing cutaneous streptococcal infection following bites or scratch by dog or cat

INTRODUCTION: Domestic animal bites or scratches are quite frequent. Among banal bacteria isolated from infected bites or scratches, group A streptococcus seems to be frequently associated with severe infections. CASE REPORTS: Three cases of acute necrotizing cutaneous streptococcal infections, following cat or dog bite or scratch are reported. Twice, group A streptococcus was isolated from cutaneous swabs. In the third case, previous antibiotic therapy had sterilised bacteriological samples. Diagnosis was ascertained on the basis of clinical presentation and significant antistreptococcal antibodies elevation. Skin necrosis around the inoculation area was observed in the 3 cases. Cicatrisation required an average of two months under appropriate treatment. DISCUSSION: An evolution towards cutaneous necrosis localized to the initially injured area is common to these three cases. This peculiar evolution is worth to be known in order to choose an effective anti streptococcal antibiotherapy whenever domestic animals bites and scratches are to be treated.     

Mandibular soft tissue mass as the initial presentation of Burkitt's lymphoma

A six-year-old girl was evaluated for an intraoral mass of 5 months duration, which had been treated with antibiotics in a district hospital. Extraoral examination showed a firm, non-tender swelling at the angular region of the left mandible with regional lymphadenopathy. Intraoral examination revealed a mass extending from the left mandibular primary first molar to the retromolar region, interfering normal occlusion. The mass was painful and firm, peduculated and reddish in appearance. The remainder of the oral examination was unremarkable. Panoramic radiograph and CT scan showed a large multilocular radiolucency beginning from the bud of second premolar, extending to the mandibular ramus that displaced the bud of second molar. Incisional biopsy of the intraoral mass was performed and the result was reported as Burkitt's lymphoma. The child was treated with chemotherapy and radiation, with recurrence.     

A comparison of various methods of soft tissue management following the immediate placement of implants into extraction sockets

This study included 10 subjects with sensorineural hearing loss. They had not previously used hearing aids. The hearing aid fitting with "behind-the-ear' aids was based on the NAL method. Judging the sounds in their ordinary home environment, three sound situations (programmes) were selected, permitting the subjects to listen to one programme with speech, another with music and a third with "background noise'. For the group as a whole, significant differences were found between the sound quality judgements with and without the hearing aid. When the judgements of the programmes with background noise were excluded in the analysis, there were significant differences over time in the group as a whole on the scales for clarity and total impression.     

Buttockectomy as a limbsaving procedure for locally advanced soft tissue sarcoma of the buttock region

Cord blood was obtained from 164 neonates at birth and investigated for the presence of aflatoxins. 14 of the samples were neonates without jaundice and 150 from neonates with jaundice. There was significant reduction (P > 0.05) in birth weight of jaundiced neonates with aflatoxin. Neonates with jaundice have high mean concentration of aflatoxin B1 (32.3 ng/ml and 35.6 ng/ml). Aflatoxin G1 was not detected in any of the groups. The rate of detection was higher in wet (81.8%) than dry season (50.0%). These findings show that neonates are exposed to aflatoxin prenatally and that high incidence of jaundice occurred in the wet warm months.     

Methadone maintenance as a setting for treating drug abusers with HIV infection.

Discusses the role of methadone maintenance treatment in the HIV epidemic. Methadone maintenance is useful in both preventing HIV infection and treating HIV-infected patients. Treatment programs use special techniques (health and psychological services) to cope with the difficulties of these patients. Treatment can be effective and can also provide a platform for delivering medical services to HIV-infected drug abusers. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Facilitating outpatient treatment entry following detoxification for injection drug use: A multisite test of three interventions.

A multisite, randomized trial within the National Drug Abuse Treatment Clinical Trials Network (CTN) was conducted to test 3 interventions to enhance treatment initiation following detoxification: (a) a single session, therapeutic alliance intervention (TA) added to usual treatment; (b) a 2-session, counseling and education, HIV/HCV risk reduction intervention (C&E), added to usual treatment; and (c) treatment as usual (TAU) only. Injection drug users (n = 632) enrolled in residential detoxification at 8 community treatment programs were randomized to 1 of the 3 study conditions. TA participants reported entering outpatient treatment sooner and in greater numbers than TAU participants. Reported treatment entry for C&E fell between TA and TAU with no significant differences between C&E and the other conditions. There were no differences among the interventions in retention, as measured by weeks of outpatient treatment for all participants who reported treatment entry. Alliance building interventions appear to be effective in facilitating transfer from detoxification to outpatient treatment, but additional treatment engagement interventions may be necessary to improve retention. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Seroprevalence and risk factors associated with HTLV-I/II infection in injection drug users in northern New Jersey

Data from an AIDS Demonstration Research project in Paterson, NJ, that enrolled out-of-treatment injection drug users (IDUs) were analyzed to detect demographic patterns and risk factors associated with infection with human immunodeficiency virus (HIV) and human T-lymphotropic virus types I or II (HTLV-I/II). Of 410 IDUs screened, 44.2% were HIV-positive and 19.3% were HTLV-I/II-positive. African-Americans were significantly more likely than other racial groups to be HTLV-I/II-seropositive and to be HIV-seropositive. Over one-fifth of African-Americans--but no Latinos or whites--were doubly infected with HIV and HTLV-I/II. In logistic regression analysis, African-American race, long-term injection drug use, and age were significant predictors of HTLV-I/II-seropositivity. While the associations between recent needle practices and HTLV-I/II-seropositivity fell short of significance, the trends in the data were consistent with a hypothesis that HTLV-I/II is transmitted through the sharing of injection equipment. Public health implications of the data are discussed.     

Gland atrophy following retrograde injection of methyl violet as a treatment in chronic obstructive parotitis

BACKGROUND: The growth and progression of prostate cancer depends on the stromal-epithelial interaction which is under paracrine control. Hepatocyte growth factor (HGF), produced by mesenchymal cells, is a multifunctional growth factor stimulating the movement and growth of epithelial cells including cancer cells. We therefore assessed the relationship between the invasive potential of prostate cancer and HGF in vitro. METHODS: Three human prostate cancer cell lines were used including PC-3 and DU145 (androgen-independent), and LNCaP (androgen-dependent). We studied the expression of the HGF receptor c-met proto-oncogene (c-met) by Western blot analysis, and also determined the effects of HGF on cell scattering, and the mechanisms of invasion and proliferation, by microscopic observation, the matrigel invasion chamber assay, and the MTT assay. RESULTS: c-met was detected in PC-3 and DU145 cells, but not in the LNCaP cells. There was increased cell motility in the scatter assay and an increased cell invasive potential in the matrigel invasion chamber assay by stimulation with HGF only with DU145 cells. CONCLUSION: HGF plays an important role in the invasion and metastasis of the DU145 cell line through a paracrine mechanism mediated by the c-metreceptor. In the PC-3 cell line, the lack of downstream signal transduction after the c-met receptor is suggested.     

Malignant cartilaginous tumors of the mediastinum: clinicopathological study of six cases presenting as extraskeletal soft tissue masses

BACKGROUND: The number of foreign or Chilean physicians with pre or postgraduate studies abroad, seems to be increasing. AIM: To report the experience of CONACEM in the certification of specialties for Chilean or foreign physicians that studied abroad. MATERIALS AND METHODS: The certification process for 90 physicians (38 Chilean and 52 foreign) with studies abroad is reported. Criteria for certification of specialties were the same used for physicians with studies in Chile and results were compared with those obtained by the latter. RESULTS: Physicians with studies abroad required additional evaluations with a greater frequency than local physicians, due to the fact that foreign training programs are not well known by CONACEM members. Eighty five percent of foreign physicians required those further evaluations, compared with 66.6% of all physicians certified by the commission. Fifty five percent of Chilean physicians with studies abroad did not accept this additional assessment. Applications for specialties of physicians with studies abroad, were rejected with a greater frequency than those of Chilean physicians (31% and 13%, respectively). CONCLUSIONS: Physicians with studies abroad applying for certification of medical specialties required more evaluations and were rejected with a greater frequency than Chilean physicians.