熟料粒度对骨粉/磷酸钙生物骨水泥结构与性能的影响

采用新方法首次将动物骨中的鱼骨引入到磷酸三钙和磷酸氢钙等原料体系中通过高温烧结制备磷酸钙基生物骨水泥（CPC）,以柠檬酸和柠檬酸钠的缓冲液为固化液、按一定的液固比制备固化试样,通过扫描电子显微分析（SEM）和力学性能测试等方法,研究了熟料粒度对其固化试样结构与抗压强度的影响.结果表明：制备过程中骨水泥粉末的粒度对其固化试样的微观结构及其抗压强度有着较为显著的影响,通过调整骨水泥粉末的粒度可达到优化其固化试样的微观结构和改善其力学性能的目的.     

磷酸钙骨水泥修复兔颅骨缺损新骨生长计算机图像分析

利用计算机图像处理技术对磷酸钙水泥修复兔颅骨缺损组织切片标本的光镜图像进行采集,对采集到的原始图像进行滤波、分割和数学开矿学等图像处理,计算不同视野新生骨生长的面积百分比,并对不同视野的结果进行生物统计分析,得到兔颅骨修复过程中新生骨定量生长情况,用计算机图像处理方法将成风过程从传统的组织形态学光镜观察的定性分析上升到了定量分析,为磷酸钙骨水泥修复骨缺损成骨机理和临床材料选择提供了定量的依据。     

碳纤维增强磷酸钙骨水泥

以碳纤维为增强相,Na2HPO4/柠檬酸为调和液,α-磷酸三钙、磷酸四钙、磷酸二氢钙、羟基磷灰石和碳酸钙为原料制备骨水泥,研究不同掺杂比例的短碳纤维对其性能的影响。在磷酸钙骨水泥中掺杂碳纤维能够提高样品的致密性,缩短固化时间,提高抗压强度。当掺杂质量分数0.5%的碳纤维时,骨水泥的初凝、终凝时间分别为9.3和24.9min,模拟体液中浸泡28d后抗压强度最大为38.24MPa。掺杂的碳纤维对浸泡液pH影响不大,pH在小范围内浮动,均在人体安全范围内。     

可注射磷酸钙骨水泥的研究

可注射磷酸钙骨水泥具有良好的生物相容性、骨传导性、可降解性、易操作性及可塑性等优点，临床上可用于非负重部位骨缺损的修复、药物或生物因子载体、牙根管的充填、松质骨螺钉的加固以及骨折的固定等方面，在植入学、骨创伤学及放射介入学等领域中具有广泛的应用前景。目前可注射磷酸钙骨水泥已经成为骨水泥研究中的主要课题，就其最新研究进展进行了讨论。     

以α-磷酸三钙和磷酸四钙为主要原料的磷酸盐骨水泥的制备及其性能比较

分别以α-磷酸三钙和磷酸四钙为基本原料，添加羟基磷灰石、磷酸氢钙、碳酸钙等其他辅助原料，钙磷比均为1．50，制备了2种类型的骨水泥。对固化骨水泥样品进行了Ringer’s模拟液浸泡实验。测定浸泡液pH值、样品的抗压强度和样品的断面显微形貌随浸泡时间的变化。结果表明：2种骨水泥的凝结时间基本相同，初凝时间为5min左右，终凝时间为19．5min；但两者浸泡液的pH值变化和抗压强度等性能有较大的差别，以α-磷酸三钙为主要原料的骨水泥的主要性能明显优于以磷酸四钙为主要原料的骨水泥。     

磁化水影响水泥性能的研究

本文对磁化水影响水泥性能进行了试验研究。结果表明,磁化水对水泥强度、凝结时间有较大影响。     

以α-磷酸三钙和磷酸四钙为主要原料的磷酸盐骨水泥的制备及其性能比较

分别以α 磷酸三钙和磷酸四钙为基本原料,添加羟基磷灰石、磷酸氢钙、碳酸钙等其他辅助原料,钙磷比均为1.50,制备了2种类型的骨水泥。对固化骨水泥样品进行了Ringer's模拟液浸泡实验。测定浸泡液pH值、样品的抗压强度和样品的断面显微形貌随浸泡时间的变化。结果表明:2种骨水泥的凝结时间基本相同,初凝时间为5min左右,终凝时间为19.5min;但两者浸泡液的pH值变化和抗压强度等性能有较大的差别,以α 磷酸三钙为主要原料的骨水泥的主要性能明显优于以磷酸四钙为主要原料的骨水泥。     

针状硅灰石对磷酸盐骨水泥性能的影响

以磷酸氢二钾和磷酸二氢钾为固化液,以磷酸四钙、α-磷酸三钙、磷酸氢钙、焦磷酸钙、羟基磷灰石和碳酸钙为原料合成骨水泥,向其添加针状硅灰石,研究了针状硅灰石对其性能的影响。结果表明,在磷酸钙骨水泥中添加针状硅灰石可以缩短凝结时间,提高抗压强度。当针状硅灰石的添加量为3%,骨水泥性能达到最佳;其初凝时间、终凝时间分别为14和28 min,样品在Ringer’s模拟液溶液中浸泡2周后抗压强度达49.23 MPa,浸泡液的pH值变化幅度小(7.1~7.8),在安全范围之内。     

聚合硫酸铝制备工艺及絮凝性能研究

用硫酸铝为原料，采用减法制备聚合硫酸铝絮凝剂，进行了最佳碱化剂选择，确定了最佳聚合反应温度、最佳碱化度及最佳pH值，并且针对其稳定性相对较差的特点，进行了聚合硫酸铝稳定剂的筛选，制得了性能好的聚合硫酸铝絮凝剂。     

生物聚合铁的制备及其除浊性能研究

利用恒化器原理,研究了生物聚合铁连续制备的可行性。实验表明,通过控制一定的工况,可实现生物聚合物的连续化制备,产品性质稳定。系统地分析了生物聚合铁的性质,考察了共除浊性能。研究确定,生物聚合铁为除浊性能优良的新型高效絮凝剂。     

Preparation of a Novel Calcium Phosphate Cement Using N-methylene Phosphonic Chitosan as a Gelling Agent

1Introduction Self hardeningcalciumphosphatecements(CPC)consistingoftetracalciumphosphate(TTCP)anddicalci umphosphate(DCPAorDCPD)havebeendeveloped since1986.ThereactionbetweenDCPAandTTCPis[1]:2CaHPO4 2Ca4(PO4)2OH2OCa10(PO4)6(OH)2.CPC isreadilyosseointegra…     

Preparation of a Novel Calcium Phosphate Cement Using N-methylene Phosphonic Chitosan as a Gelling Agent

A modified chitosan （ N-methylene phosphonic Chitosan, NMPC） was synthesized to improve solubility and ability to bind calcium ion. The properties of the raw material chitosan and its derivative NMPC were characterised using FTIR , ^1H- NMR . The aim of this study was to enhance the compressive CPC by reinforcing with NMPC. A formulation consisting of CPC powder , buffer solution and gelling agent was used for preparation of the CPC. CPC powder coasisted of tetracalcium phosphate（ TTCP ） and dicalcium phosphate anhydrous （ DCPA ）. NMPC which acted as the gelling ageut was dissohed into KH2PO4-Na2 HPO4 buffer solution. Each specimen in the mold was sandciched between two fritted glass sides and kept for 24 hours. Compressive strengths were determined, the setting product was identified using X-ray diffraction and scanning electron microscopy was used to investigate the hydroxyapatite particles size and porosity. The experimental results showed that the dominating influence on the compressive strengths of CPC-AMPC was the HA panicle size, its uniformity and appropriate porosity.     

原料及配比对磷酸镁水泥性能影响的研究

采用磷酸二氢铵、磷酸二氢钾和磷酸氢二铵作为引入磷的材料,不同细度的重烧镁砂以及不同掺量硼砂作为缓凝剂,通过测定其标准稠度需水量、凝结时间和抗压强度,结合X射线衍射分析和扫描电镜分析,研究了不同的磷酸盐原料及配比对磷酸镁水泥性能的影响。结果表明,磷酸盐水泥的凝结时间和强度随原料及配比变化有较大差异,磷酸二氢钾与磷酸二氢铵的性能较为接近,而采用磷酸氢二铵既加大了标准稠度用水量,也大幅度延长了凝结时间;同时采用磷酸氢二铵试样的强度相对也远小于采用磷酸二氢钾与磷酸二氢铵的试样;硼砂作为缓凝剂也可明显延长磷酸镁水泥的凝结时间。     

Preparation and Compressive Strength of Calcium Phosphate Bone Cement Containing N, O-carboxymethyl Chitosan

N, O-carboxymethyl chitosan （ CMCTS ）, a kind of biodegradable organic substance, was added to calcium phosphate bone cement （CPC） to prodnce a composite more similar in composition to human bone. The compressive strength of the new material was inereased by 10 times compared with conventional CPC.     

Preparation and Compressive Strength of Calcium Phosphate Bone Cement Containing N,O-carboxymethyl Chitosan

1Introduction Calciumphosphatebonecement(CPC)hasbeen preparedbyBrownandChowin1985[1].Thematerial consistsofcementpowderandbuffersolution.Thepow dercontainsteracalciumphosphate(TetCP)anddicalci umphosphate(DCPA).Thebuffersolutionismadeupof phosphateandwate…     

Evaluation of Calcium Phosphate Cement As a Root Canal Sealer Filling Material

Calcium phosphate cement for root end seeding was obtained by mixing α-tricalcium phosplitue and additives with an aqueous solution of citric . Powder and liquid were mixed at a ratio of 1.25 g/ mL. The biocompatibility of this material was investigated primarily by subcutaneous implantation tests . Then calcium phos-phate cement was used to fill three adult dogs ' root canal, both calcium hydroxide paste and hydroxyapatite paste as control. The animals were killed at 4,12,20 weeks postoperatively respectively. The effects of different materials on the apical closure, restoration of periapical tissues and adaptability to the dentinal surface were examined by optical and electronic microscope . The observation at 20 weeks shows that the calcium phosphate cement, has the potentialities of being a root canal sealer filling material available for pulpless teeth with open-apex and destructive periapical tissue.     

The In-situ Reinforcement of Calcium Phosphate Cement and Its Micro-structural Analysis

1Introduction CPC(calciumphosphatecements)havebecomethe hotspotoftheresearchofbonesubstitutematerialssince BrownandChow[1]hadreported.Theyhaveexcellent propertiessuchasself setting,biocompatibilityandosteo conductivity,etc[2,3].Tillnow,theyhavebecomewell …     

无水硫酸钙对α-磷酸三钙骨水泥的结构与性能的影响

将无水硫酸钙（CSA）引入磷酸钙骨水泥（CPC）中,结合热分析（TG-DSC）、扫描电子显微分析（SEM）和力学性能测试等方法,通过对比试验研究了CSA对α-磷酸三钙（α-TCP）体系骨水泥结构与性能的影响.结果表明：CSA的加入对α-TCP骨水泥的结构与性能有一定的影响,是一种可提高骨水泥的抗压强度,调控固化时间的有效添加成分.