共查询到19条相似文献,搜索用时 109 毫秒
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研究无规共聚物P(AA-co-BA)作为高分子表面活性剂的可行性。以丙烯酸(AA)和丙烯酸丁酯(BA)为单体,采用自由基溶液聚合法成功制备了5种投料比的无规共聚物P(AA-co-BA),其热稳定性良好。研究比较了表面张力法和电导法对该聚合物临界胶束浓度(cmc)的测试,结果表明,两种方法在测试聚合物cmc时结果一致,电导法虽简便,但表面张力法更适合进行物质的表面活性研究。当单体投料比m(BA)∶m(AA)=1∶10~1∶5时,聚合物的cmc为0.6~0.9?g/L,对应的表面张力为44.8~49.5?mN/m,这表明适当投料比的无规共聚物P(AA-co-BA)可以作为高分子表面活性剂。 相似文献
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采用溶液聚合法合成了苯乙烯-马来酸酐无规共聚物,用IR、NMR、DSC及乌氏粘度计对共聚物进行了表征。 相似文献
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由疏水性单体甲基丙烯酸甲酯(MMA)和亲水性单体甲基丙烯酸(MAA)进行自由基溶液共聚,合成了一系列配比不同的两亲性无规聚合物P(MMA-co-MAA),用红外光谱、核磁共振和凝胶渗透色谱对聚合物结构进行了表征。采用一种操作过程简单、快捷、环保的新方法制备了聚合物胶束,即将一定质量的聚合物溶于碱性水溶液中,通过中和原理进行自组装,并得到球形胶束。通过透射电子显微镜(TEM)和激光光散射(DLS)法,研究了聚合物中基团摩尔比例不同时对胶束形貌和流体动力学半径(Rh)的影响。 相似文献
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由疏水性单体甲基丙烯酸甲酯(MMA)和亲水性单体甲基丙烯酸(MAA)进行自由基溶液共聚,合成了一系列配比不同的两亲性无规聚合物P(MMA-co-MAA),用红外光谱、核磁共振和凝胶渗透色谱对聚合物结构进行了表征。采用一种操作过程简单、快捷、环保的新方法制备了聚合物胶束,即将一定质量的聚合物溶于碱性水溶液中,通过中和原理进行自组装,并得到球形胶束。通过透射电子显微镜(TEM)和激光光散射(DLS)法,研究了聚合物中基团摩尔比例不同时对胶束形貌和流体动力学半径(Rh)的影响。 相似文献
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苯乙烯—马来酸酐无规共聚物合成研究 总被引:2,自引:2,他引:2
以过氧化二异丙苯为引发剂,采用本体聚合法合成了苯乙烯-马来酸酐无规共聚物,用IR、NMR、DSC及乌氏粘度计对共聚物进行了表征,同时对反应条件作了初步探讨。 相似文献
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以丙烯酸(AA)、丙烯酸甲酯(M A)为共聚单体,以过硫酸铵和亚硫酸氢钠为氧化还原引发体系,以异丙醇为链转移剂,以水为溶剂,采用溶液聚合法合成了P(AA-M A)无规共聚物。采用红外光谱仪、表面张力仪、透射电子显微镜、热分析仪对共聚物的组成、结构、表面张力、透射形貌和热性质进行了表征。结果表明聚合条件为单体AA/M A(摩尔比)=6/1,异丙醇、过硫酸铵、亚硫酸氢钠添加量都为2%(均以单体计),加料时间30m in,聚合温度60℃,反应时间1.5h。产物为浅黄色黏稠液体,有两头尖的椭球形和球形的两种形态、较好的表面活性和热稳定性。 相似文献
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本研究以丙烯酸(AA)、丙烯酸甲酯(MA)为共聚单体,以过硫酸铵和亚硫酸氢钠为氧化还原体系引发剂,异丙醇为链转移剂,以水为溶剂,采用溶液聚合方法合成了P(AA-MA)无规共聚物。采用表面张力仪、热分析仪对共聚物的表面张力和热力学性质进行分析,利用红外光谱、透射电子显微镜对共聚物的结构和形貌进行了表征。 相似文献
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Novel pH-responsive membranes were prepared by blending pH-responsive amphiphilic copolymers with pol-yethersulfone (PES) via a nonsolvent-induced phase separation (NIPS) technique. The amphiphilic copolymers bearing Pluronic F127 and poly(methacrylic acid) (PMAA) segments, abbreviated as PMAAn–F127–PMAAn, were synthesized by free radical polymerization. The physical and chemical properties of the blend membranes were evaluated by scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectrum, water con-tact angle, Zeta potential and X-ray photoelectron spectroscopy (XPS). The enrichment of hydrophilic PMAA seg-ments on the membrane surfaces was attributed to surface segregation during the membrane preparation process. The blend membranes had significant pH-responsive properties due to the conformational changes of surface-segregated PMAA segments under different pH values of feed solutions. Fluxes of the blend membranes were larger at low pH values of feed solutions than that at high pH values. The pH-responsive ability of the mem-branes was enhanced with the increase of the degree of PMAA near-surface coverage. 相似文献
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Ultra-thin films of cationic amphiphilic block and statistical copolymers were applied on silica surfaces from aqueous solutions through electrostatic interactions, and the resulting modification in the wettability of the surfaces was studied. A copolymer series from 2-(dimethylamino)ethyl methacrylate with methyl methacrylate and butyl methacrylate was polymerized by ATRP. Subsequently, the conformation of the polymers in aqueous solutions was studied by surface tension measurements, dynamic light scattering, 1H NMR and cryogenic transmission electron microscopy. Unimeric conformation, equilibrium micelles or frozen micellar structures were observed, depending on polymer composition and the ionic strength of the solution. The polymers were applied on silica from aqueous solutions by either spin coating or adsorption. The formed ultra-thin film surfaces were studied by AFM and water contact angle measurements. The spin-coated surfaces were highly hydrophilic with rapidly dropping contact angles, whereas the surfaces prepared by adsorption had stable water contact angles between 30-60°, depending on polymer. The difference between the spin-coated and adsorbed surfaces is explained by the formation of a monolayer in the adsorbed surfaces. 相似文献
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A novel synthetic route for preparing high molecular weight poly(oxyalkylene) block copolymers has been developed by using 2,4,6-trichloro-1,3,5-triazine (cyanuric chloride, cc) as the coupling core. The coupling reaction involves the selective substitutions of oligo(oxyalkylene)-amines onto three chlorides of the triazine ring in a stepwise manner at 0, 25 and 130 °C. By judiciously selecting the starting amines and reaction conditions, one can tailor the copolymer structures with different block configurations (tri-block, multi-block, random and alternating block). The prepared copolymers can have a high molecular weight, up to 25,600 g/mol (GPC polydispersity=1.48), and also high thermal stability due to the presence of triazine functionalities. The copolymers with hydrophilic and hydrophobic oligo(oxyalkylene) blocks are of versatile properties in solubility (water soluble or water insoluble) and morphology (crystalline or amorphous). With a specific structure of alternating oligo(oxyethylene)/oligo(oxypropylene) blocks (2000 g/mol each block), the copolymer exhibits the property of self-association. It reduces the interfacial tension of toluene/water as low as 0.5 dyne/cm at the critical micelle concentration of 0.01 wt%. 相似文献
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作者介绍了两亲嵌段共聚物的活性阴离子聚合、基团转移聚合、开环歧化聚合、活性阳离子聚合、活性/可控自由基聚合、缩聚法、嵌段共聚物化学改性法等合成方法,并对其自组装形成聚合物纳米胶束的制备方法、形成机理以及在药物控制释放领域的应用进行了综述,并对其未来发展趋势进行了展望。 相似文献
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A linear amphiphilic multiblock copolymer (PNIPAm-PtBA-PNIPAm)m was successfully synthesized by a two-step reversible addition-fragmentation transfer (RAFT) polymerization in the presence of a cyclic trithiocarbonate as RAFT agent. The micelle behavior of (PNIPAm-PtBA-PNIPAm)m multiblock copolymer in aqueous solution was then investigated by means of normal TEM, cryo-TEM, static and dynamic light scattering. The morphology, size, and size distribution of (PNIPAm-PtBA-PNIPAm)m micelles were found to be dependent on the initial concentration of multiblock copolymer in THF. Spherical micelles, associated aggregates of spherical micelles, cage-like micelles, layered structures, and vesicular micelles were experimentally observed, which were in good agreement with the prediction of theory and simulations on linear amphiphilic multiblock copolymer in selective solvent. The (PNIPAm-PtBA-PNIPAm)m micelles also exhibit thermo-sensitive behavior in aqueous solution because of the PNIPAm blocks. 相似文献
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Synthesis and characterization of biodegradable and biocompatible amphiphilic block copolymers bearing pendant amino acid residues 总被引:1,自引:0,他引:1
Polylactide (PLA)-based biodegradable and biocompatible amphiphilic block copolymers bearing pendant amino acid residues were synthesized through a relatively easy and efficient way. The composition and structure of these copolymers were characterized by gel permeation chromatography (GPC) and 1H nuclear magnetic resonance (1H NMR) spectroscopy. The self-assembly behavior of the copolymers was investigated by fluorescence (FL), dynamic light scattering (DLS), and transmission electron microscope (TEM). It was shown that aggregates less than 100 nm in average size were formed by these copolymers, which changed from micelles to vesicles with the variation of the block length. In addition, the in vitro cytotoxicity of these copolymers was determined and compared with that of PEO-b-PLA in the presence of Bel-7402 cells. The result suggested that the block copolymers PAGE/cys-b-PLA exhibited better biocompatibility. Therefore, these PLA-based copolymers are expected to find promising applications in drug delivery or tissue engineering. 相似文献
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Preparation and evaluation of novel amphiphilic glycopeptide block copolymers as carriers for controlled drug release 总被引:1,自引:0,他引:1
In the present study we describe a synthesis and self-assembly and an in vitro evaluation of a kind of novel amphiphilic glycopeptide block copolymers as carriers for controlled drug release. Initially, an amphiphilic ABA triblock copolymer comprising polytetrahydrofuran (PTHF) as a central hydrophobic block flanked by poly(l-lysine)s (PLLs) as outer hydrophilic blocks was synthesized through the ring-opening polymerization of ?-benzyloxycarbonyl-l-lysine N-carboxyanhydride with a distal amine-terminated PTHF as a macroinitiator, followed by removal of the protecting group. Afterwards the resulting triblock copolymer was allowed to react with d-gluconolactone and lactobionolactone in the varying feeding ratios in the presence of diisopropylethylamine leading to the target glycopeptide block copolymers with high yields. They were found to easily self-assemble into nano-sized aggregates in water. The critical aggregation concentrations (CACs) were assessed by fluorescence measurement with N-phenyl-1-naphthylamine employed as a molecular probe. The particle sizes of the aggregates before and after doxorubicin loading were determined by dynamic light scattering (DLS) and the aggregate morphologies were evidenced by transmission electron microscopy (TEM) measurements. Finally, the in vitro doxorubicin loading capacity and release behavior were investigated with these glycopeptide copolymers as carriers for controlled release. 相似文献
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Solution-grown lamellar single crystals of PCL homopolymer and amphiphilic block copolymers of PCL-b-PEO-b-PCL and PCL-b-PEO-FG (functional groups FG = NH2, OCH3) were prepared by self-seeding procedures. The crystal structure and morphology of these single crystals were mainly studied by means of transmission electron microscopy (TEM) and atomic force microscopy (AFM). The results indicated that the shorter PEO blocks as well as the functional groups bonded to the end of PEO block are in an amorphous state and located in the surface of single crystals. The enzymatic degradation of single crystals prepared from these homopolymer and amphiphilic block copolymers has been well-studied to demonstrate the effects of chemical structure on degradation behavior. The single crystals showed similar morphologies before enzymatic degradation but very different surface character after enzymatic degradation. Such differences resulted from the PEO block and functional end groups. The results of this work indicated the important role of chemical structure in determining biodegradation behavior. 相似文献
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The adsorption behavior of several amphiphilic polyelectrolytes of poly(maleic anhydride-alt-styrene) functionalized with naphthyl and phenyl groups, onto amino-terminated silicon wafer has been studied by means of null- ellipsometry, atomic force microscopy (AFM) and contact angle measurements. The maximum of adsorption, Γplateau, varies with the ionic strength, the polyelectrolyte structure and the chain length. Values of Γplateau obtained at low and high ionic strengths indicate that the adsorption follows the “screening-reduced adsorption” regime. Large aggregates were detected in solution by means of dynamic light scattering and fluorescence measurements. However, AFM indicated the formation of smooth layers and the absence of aggregates. A model based on a two-step adsorption behavior was proposed. In the first one, isolated chains in equilibrium with the aggregates in solution adsorbed onto amino-terminated surface. The adsorption is driven by electrostatic interaction between protonated surface and carboxylate groups. This first layer exposes naphtyl or phenyl groups to the solution. The second layer adsorption is now driven by hydrophobic interaction between surface and chains and exposes carboxylate groups to the medium, which repel the forthcoming chain by electrostatic repulsion. Upon drying some hydrophobic naphtyl or phenyl groups might be oriented to the air, as revealed by contact angle measurements. Such amphiphilic polyelectrolyte layers worked well for the building-up of multilayers with chitosan. 相似文献