Extending the activity restriction model of depressed affect: Evidence from a sample of breast cancer patients.

Survey data from 95 women with Stage 1 (n?=?36), Stage 2 (n?=?49), or Stage 3 (n?=?10) breast cancer both confirm and extend prior research indicating that restriction of normal activities is an important factor in depressed affect. Illness severity was directly related to more restricted routine activities, and more activity restriction was associated with higher public self-consciousness and less social support. Beyond the effects of age, self-consciousness, illness severity, and social support, activity restriction explained significant additional variance in symptoms of depression. Moreover, activity restriction mediated the impact of pain, public self-consciousness, and social support on depressed affect, which implies that these factors foster symptoms of depression by disrupting normal activities. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Empirical evidence of the association between the presence of musculoskeletal pain and physical disability in community-dwelling senior citizens

The proportion of people 65 years of age and older who report musculoskeletal pain and physical disability is high. The main objective of this study was to determine whether physical disability was associated with the presence of musculoskeletal pain in a sample of senior citizens. Self-administered questionnaires were sent to a sample of 1306 community-dwelling senior citizens in London, Ontario, Canada between August and October 1995. The questionnaire included questions about pain, difficulty performing activities, depressive symptoms, chronic conditions, and demographic information. A total of 887 seniors completed the questionnaire (70.7% response rate, aged 65-94, 41.2% men, 58.8% women). Logistic regression analysis, without controlling for potential confounding variables, revealed that those who reported having musculoskeletal pain were seven times more likely to have some difficulty performing three or more activities listed in the questionnaire (OR = 6.91 95% CI 4.92-9.69). When significant confounding variables were controlled in the analysis, seniors who reported musculoskeletal pain were still three times more likely to have some difficulty with three or more activities (OR = 2.93, 95% CI 1.96-4.38). Although no causal relationship can be inferred, thorough pain assessment and pain management may be important in the maintenance of independent living for adults 65 years of age or older.     

The structure of depression among elderly institution residents: affective and somatic correlates of physical frailty

BACKGROUND: Confounding of depression with somatic illness and anxiety, a problem in any age group, may be especially troublesome in frail older persons. This paper examined this problem in a factor analytic study of the structure of depressive symptomatology, identifying affective and somatic symptom clusters and relating those clusters to health and functional variables cross-sectionally and prospectively over a 1-year interval. METHODS: The factor structure of a DSM-IV symptom checklist was examined among 1,245 elderly long-term care residents. Regression analyses examined the association of resulting factors with cognition, functional disability, self- and physician-rated health, and pain at baseline and a year later. One-year mortality was also examined. RESULTS: Factor analysis revealed three unique symptom clusters: depressed mood, somatic symptoms, and psychic anxiety. Depressed mood and somatic symptoms were associated cross-sectionally with all functional health variables, but psychic anxiety was associated only with pain. Longitudinally, depressed mood was the only independent predictor of decline in cognition, functional ability, physician-rated health, and mortality; the last effect, however, did not withstand control for baseline health and functioning. Somatic symptoms at baseline predicted decrement in self-rated health a year later. Effects varied as a function of cognitive status. CONCLUSIONS: These data suggest that concerns about the confounding role of somatic symptoms in the association of depression with physical health are unfounded. Although somatic symptoms of depression and anxiety were associated with health and functional status cross-sectionally, depressed mood was by far the stronger predictor of health declines over time.     

The central role of restricted normal activities in adjustment to illness and disability: A model of depressed affect.

Research has consistently indicated that health-related stressors affect depressive symptoms largely to the extent that they restrict routine activities. Beyond the impact of illness severity, psychosocial variables (age, income adequacy, social support, and personality) also contribute to restricted activities. Moreover, after controlling for illness severity and psychosocial factors, activity restriction explains significant portions of the variance in symptoms of depression. Thus, depressed affect is at least partially a function of restricted activities. Further specifying the processes through which activities come to be restricted should not only provide clues about points of intervention but also aid in early identification of individuals at risk for poor adaptation. In addition to treating illness symptoms and depression, interventions can be designed to increase participation in routine activities, even in the presence of illness symptoms, depression, or both. Implications of activity restriction studies for intervention are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

"The cenral role of restricted normal activities in adjustment to illness and disability: A model of depressed affect": Correction.

Reports a correction in the original article by Gail M. Williamson (Rehabilitation Psychology, 1998, Vol 43(4), 327–347). The article should have been identified as a Commentary. (The following abstract of this article originally appeared in record 1999-00481-005). Research has consistently indicated that health-related stressors affect depressive symptoms largely to the extent that they restrict routine activities. Beyond the impact of illness severity, psychosocial variables (age, income adequacy, social support, and personality) also contribute to restricted activities. Moreover, after controlling for illness severity and psychosocial factors, activity restriction explains significant portions of the variance in symptoms of depression. Thus, depressed affect is at least partially a function of restricted activities. Further specifying the processes through which activities come to be restricted should not only provide clues about points of intervention but also aid in early identification of individuals at risk for poor adaptation. In addition to treating illness symptoms and depression, interventions can be designed to increase participation in routine activities, even in the presence of illness symptoms, depression, or both. Implications of activity restriction… (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Depression without sadness: functional outcomes of nondysphoric depression in later life

OBJECTIVES: We hypothesized that depressive symptoms not meeting full standard criteria for Major Depression would be associated with significant functional impairment among older adults over the course of a 13-year follow-up interval. Specifically, we developed criteria for a form of depression whose core symptoms did not include sadness or dysphoria. DESIGN: Population-based 13-year follow-up survey. SETTING: Community-dwelling adults living in East Baltimore in 1981. PARTICIPANTS: Subjects were the 1612 participants of the Baltimore sample of the Epidemiologic Catchment Area Program aged 50 years and older at the initial interview in 1981. MEASUREMENTS: The subjects were sorted into four categories based on their responses at baseline: (1) persons meeting standard criteria for Major Depression; (2) persons meeting alternative criteria for depression with dysphoria or (3) without dysphoria; and (4) a comparison category of persons not meeting any criteria for depression ("noncases"). The mortality and functional status of each group were compared after a 13-year follow-up interval. RESULTS: Compared with non-cases, participants aged 50 years and older who reported depressive symptoms but who denied sadness or dysphoria (nondysphoric depression) were at increased risk for death (relative risk (RR) = 1.70; 95% confidence interval (CI) (1.09, 2.67)), impairment in activities of daily living (RR = 3.76; 95% CI (1.73, 8.14)), impairment in instrumental activities of daily living (RR = 5.07; 95% CI (2.24, 11.44)), psychologic distress (RR = 3.68; 95% CI (1.47, 9.21)), and cognitive impairment (RR = 3.00; 95% CI (1.31, 6.89)) after a 13-year follow-up interval. The findings were not wholly explained by potentially influential baseline characteristics such as age, education, selected comorbid medical conditions, and functional status. CONCLUSION: Among adults aged 50 years and older, nondysphoric depression may be as important as Major Depression in relation to the development of functional disability and other long-term outcomes.     

An analysis of diversity in the cognitive performance of elderly community dwellers: Individual differences in change scores as a function of age.

This longitudinal study investigated whether age is associated with increases in interindividual variability across 4 ability domains using a sample of 426 elderly community dwellers followed over 3.5 years. InterindividuaI variability in change scores increased with age for memory, spatial functioning, and speed but not for crystallized intelligence for the full sample and in a subsample that excluded dementia or probable dementia cases. Hierarchical regression analyses indicated that being female, having weaker muscle strength, and having greater symptoms of illness and greater depression were associated with overall greater variability in cognitive scores. Having a higher level of education was associated with reduced variability. These findings are consistent with the view that there is a greater range of responses at older ages, that certain domains of intelligence are less susceptible to variation than others and that variables other than age affect cognitive performance in later life. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Consequences of major and minor depression in later life: a study of disability, well-being and service utilization

BACKGROUND: The consequences of major depression for disability, impaired well-being and service utilization have been studied primarily in younger adults. In all age groups the consequences of minor depression are virtually unknown. In later life, the increased co-morbidity with physical illness may modify the consequences of depression, warranting special study of the elderly. With rising numbers of elderly people, excess service utilization by depressed elderly represents an increasingly important issue. METHODS: Based on a large, random community-based sample of older inhabitants of the Netherlands (55-85 years), the associations of major and minor depression with various indicators of disability, well-being and service utilization were assessed, controlling for potential confounding factors. Depression was diagnosed using a two-stage screening design. Diagnosis took place in all subjects with high depressive symptom levels and a random sample of those with low depressive symptom levels. The study sample consists of all participants to diagnostic interviews (N = 646). RESULTS: As in younger adults, associations of both major and minor depression with disability and well-being remained significant after controlling for chronic disease and functional limitations. Adequate treatment is often not administered, even in subjects with major depression. As the vast majority of those depressed were recently seen by their general practitioners, treatment could have been provided in most cases. Bivariate analyses show that major and minor depression are associated with an excess use of non-mental health services, underscoring the importance of recognition. In multivariate analyses the evidence of excess service utilization was less compelling. CONCLUSIONS: Both major and minor depression are consequential for well-being and disability, supporting efforts to improve the recognition and treatment in primary care. However, controlled trials are necessary to assess the impact this may have on service utilization.     

Physical illness and symptoms of depression among elderly outpatients.

Elderly outpatients were assessed to clarify relations between symptoms of depression and physical illness, disability, pain, and selected psychosocial variables. Three types of assessments were made: (1) medical evaluations by physicians, (2) self-reported symptoms of depression and physical health, and (3) demographic and psychosocial data relating to participants' life circumstances. Both objective (physician-rated illness symptoms) and subjective (self-reported health, activity restriction, and use of pain medications) indicators of health accounted for independent variance in symptoms of depression. After controlling for these factors, additional variance was explained by health-related concerns (e.g., health care expenses, service needs), social support, and "other worries" (e.g., feeling useless, becoming a burden to others). (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Genetic and environmental contributions to depression symptomatology: Evidence from Danish twins 75 years of age and older.

The heritability symptoms of depression were investigated in a sample of 406 same-sex Danish twin pairs 75 years of age and older. Twins completed an interview assessment that included symptoms of depression, which were scored on the following 3 scales: Somatic, Affect, and Total. Heritability estimates (h–2) for the Total (h–2?=?.34), Somatic (h–2?=?.31), and Affect (h–2?=?.27) scales were all moderate and statistically significant. For not one of the scales did h–2 vary significantly over the age range sampled, and although the observed twin correlations were substantially smaller among men as compared with women, none of the sex differences in heritability were statistically significant. Multivariate analyses indicated that all of the heritable effects on the Affect and Somatic subscales could be attributed to a single genetic factor. Depression symptoms in older adults may thus be more heritable than indicated in previous studies, although nonshared environmental factors clearly account for a majority of the variance. The implications of these findings for understanding the nature of late-life depression symptomatology are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Influence of functional impairment and social support on depressive symptoms in persons with diabetes.

Tested the hypothesis that, among patients with higher levels of illness-related impairment, adequate social support would act as a buffer against depression. 158 Ss (aged 17–78 yrs) with insulin-dependent diabetes mellitus completed the Beck Depression Inventory, a health status measure, and 2 measures of social support. Depressive symptoms correlated positively with functional impairment and negatively with adequacy of social support. In addition, social support moderated depression in the face of greater impairment such that, among Ss who reported the most illness-related functional disabilities, adequate support provided a relative protection from depression. Individuals with inadequate support seem to be most at risk for depression when disability related to illness increases. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Social support as a mediator in the relation between functional status and quality of life in older adults.

The relations among physical functioning, social support, depressive symptoms, and life satisfaction were examined in a national sample of 4,734 adults age 65 and older. Regression analyses were used to examine the relative importance of objective and subjective support measures in understanding the relation between physical impairment and quality of life. Impairment was associated with fewer friendship contacts, fewer family contacts, less perceived belonging support, and less perceived tangible aid, but only measures of perceived support predicted depressive symptomatology. A structural equation modeling approach was then used to explore the mediational role of perceived social support in the relation between impairment and quality of life variables. Results are consistent with the hypothesis that lower reported social support is an important reason for decreases in life satisfaction and increases in depressive symptoms found among older adult populations. Implications for understanding the role of social support in attenuating the effects of physical disability in older adults are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Field evaluation of two bait delivery systems for the oral immunization of dogs against rabies in Tunisia

In a study of the relation between foot pain and disability, a cross-sectional analysis was performed using baseline data (1992-1995) from the Women's Health and Aging Study, a population-based study of 1,002 disabled women aged 65 years and older living in Baltimore, Maryland. Chronic and severe foot pain, defined as pain lasting 1 month or longer in the previous year, plus pain in the previous month rated severe (7-10 on a scale of 0 to 10), was reported by 14% of the women. Severe foot pain was more common in women who were younger (aged 65-74 years), obese, or had hand or knee osteoarthritis. Walking speed and five repeated chair stands were slower in women with foot pain. After adjustment for age, body mass index, race, education, self-rated health, smoking status, comorbidities, and number of other pain sites, severe foot pain was independently associated with increased risk for walking difficulty (adjusted odds ratio = 1.69, 95% confidence interval 1.10-2.59) and disability in activities of daily living (adjusted odds ratio = 1.91, 95% confidence interval 1.21-3.01). These findings suggest that severe foot pain may play a key role in disability in older women. Further studies are warranted to confirm these results longitudinally and to determine whether interventions to alleviate foot pain could reduce or prevent disability in older women.     

Depressive symptoms and physical decline in community-dwelling older persons

CONTEXT: Significant symptoms of depression are common in the older community-dwelling population. Although depressive symptoms and disability may commonly occur in the same person, whether depressive symptoms contribute to subsequent functional decline has not been elucidated. OBJECTIVE: To determine whether depressive symptoms in older persons increase the risk of subsequent decline in physical function as measured by objective performance-based tests. DESIGN: A 4-year prospective cohort study. SETTING: The communities of Iowa and Washington counties, Iowa. PARTICIPANTS: A total of 1286 persons aged 71 years and older who completed a short battery of physical performance tests in 1988 and again 4 years later. MAIN OUTCOME MEASURES: Baseline depressive symptoms were assessed by the Center for Epidemiological Studies Depression Scale. Physical performance tests included an assessment of standing balance, a timed 2.4-m (8-ft) walk, and a timed test of 5 repetitions of rising from a chair and sitting down. RESULTS: After adjustment for baseline performance score, health status, and sociodemographic factors, increasing levels of depressive symptoms were predictive of greater decline in physical performance over 4 years (odds ratio for decline in those with depressed mood vs those without, 1.55; 95% confidence interval [CI], 1.02-2.34). Even among those at the high end of the functional spectrum, who reported no disability, the severity of depressive symptoms predicted subsequent decline in physical performance (odds ratio for decline, 1.03; 95% CI, 1.00-1.08). CONCLUSIONS: This study provides evidence that older persons who report depressive symptoms are at higher risk of subsequent physical decline. These results suggest that prevention or reduction of depressed mood could play a role in reducing functional decline in older persons.     

Does the association of risk factors and atherosclerosis change with age? An analysis of the combined ARIC and CHS cohorts. The Atherosclerosis Risk in Communities (ARIC) and Cardiovascular Health Study (CHS) investigators

INTRODUCTION: A decrease in the estimated relative risk of cerebrovascular and cardiovascular diseases associated with known disease risk factors has been observed among elderly cohorts, perhaps suggesting that continued risk factor management in the elderly may not be as efficacious as with younger age groups. In this paper, the differential magnitude of the association of risk factors with atherosclerosis across the age spectrum from 45 years to older than 75 years is presented. METHODS: Subclinical atherosclerosis as measured by carotid ultrasonography and risk factor prevalence were assessed using similar methods among participants aged 45 to 64 years in the Atherosclerosis Risk in Communities (ARIC) study and among participants 65 years and older in the Cardiovascular Health Study (CHS). Pooling these two cohorts provided data on the relationship of risk factors and atherosclerosis on nearly 19,000 participants over a broad age range. Regression analyses were used to assess the consistency of the magnitude of the association of risk factors with atherosclerosis across the age spectrum separately for black and white participants in cross-sectional analyses. RESULTS: As expected, each of the risk factors was globally (across all ages) associated with increased atherosclerosis. However, the magnitude of the association did not differ across the age spectrum for hypertension, low density lipoprotein cholesterol (LDL-c), fibrinogen, or body mass index (BMI). For whites, there was a significantly greater impact of smoking and HDL-C among older age strata but a smaller impact of diabetes. For black women, the impact of HDL-C decreased among the older age strata. CONCLUSIONS: These data suggest that most risk factors continue to be associated with increased atherosclerosis at older ages, possibly suggesting a continued value in investigation of strategies to reduce atherosclerosis by controlling risk factors at older ages.     

Chronic pain and depression: role of perceived impact and perceived control in different age cohorts

Chronic pain adversely affects individuals' physical as well as emotional well-being. A cognitive-behavioral model has been proposed to explain the role of cognitive appraisal variables in mediating the development of emotional distress following pain of long duration. There is little evidence linking the prevalence of depression in chronic pain patients to life stage, but there are suggestions in the literature that the link between medical illness and depression may be stronger in elderly patients. One purpose of this study was to replicate the efficacy of a previous study of the cognitive-behavioral mediation model in explaining the association between pain and depressed affect. A second purpose of this study was to extend the cognitive-behavioral model to evaluate relationships among pain, cognitive appraisal variables, and depressive affect in the elderly chronic pain population. One hundred chronic pain patients were divided into two age groups (< or = 69 years and > or = 70 years). A path analysis conducted for the total sample supported the cognitive-behavioral mediation model of depression in chronic pain, in which cognitive appraisal variables mediate the pain-depression relationship. Correlations among variables in each of the two age groups, however, revealed different patterns of association. Consistent with the cognitive-behavioral model, the younger patients demonstrated a low and non-significant correlation between pain severity and depression (r = 0.01). Conversely, a strong direct association was observed in the older patients between these variables (r = 0.51). These results suggest that the relationship between pain and depression varies substantially depending upon age cohort.     

Combined medical and psychological symptoms: impact on disability and health care utilization of patients with arthritis

OBJECTIVES: Many reports indicate that patients with combined chronic illness and depressive symptomatology have more disability than those with illness alone, which may influence physician visits. Studies suggest that these combined conditions are unevenly accommodated by the delivery system and nonpsychiatric physicians often fail to recognize or treat these symptoms. To address this need, this study aimed to provide further information on combined conditions and report on relations found among arthritis disease symptoms, depression, and disability. METHODS: The data was derived from a series of statewide surveys assessing the influence of psychosocial factors on disease course and treatment in a community sample of 277 patients under the care of a rheumatologist. A multivariate model was developed to assess these interrelationships, using measures of symptom severity, depression (CESD), disability (activities of daily living, days of restrictive activities, days in bed), service utilizations, and a few personal and health variables. RESULTS: Even after removing somatic items from the CESD to reduce the risk of inflation due to physical disease, evidence was found for additive impact of depression on one measure of disability, days of restrictive activities. Patients with comorbid conditions also were a high-service utilization group. Very few patients reported receiving help in dealing with emotional problems, suggesting presence of substantial unmet need. CONCLUSIONS: Nonpsychiatric physicians need to be aware of the mental health status of chronically ill patients. Although the association between medication use and depression suggests some awareness of the need to treat depression, especially in physically compromised patients, there may be some need to dispense psychological and psychosocial support to those in need.     

Chicken microchromosomes are hyperacetylated, early replicating, and gene rich

Persons with chronic pain often report a range of physical symptoms beyond their primary pain complaint itself. We predicted that non-specific physical symptom complaints would correlate more strongly with pain-related distress than with general measures of distress, and that they would contribute directly to disability. Results from 210 adults with chronic pain showed that collateral physical complaints are common in persons with chronic pain. Correlational analyses showed that greater reporting of physical complaints was associated with reports of higher pain severity, higher levels of depression, more cognitive, escape/avoidance, fearful appraisal, and physiological symptoms of pain-related anxiety and more physical and psychosocial disability. Regression analyses showed that, with pain-related anxiety variables entered either before or after depression, physiological symptoms of pain-related anxiety significantly predicted physical complaints. In comparison with cognitive and somatic depression symptoms physiological symptoms of pain-related anxiety were the stronger predictor.     

Psychometric evaluation of the Beck Anxiety Inventory with older medical patients.

Disadvantaged older medical outpatients (N?=? 197; ages 55–92) completed the Beck Anxiety Inventory (BAI). The instrument demonstrated high internal consistency and no significant differences by sex or race, suggesting that it is appropriate to use with diverse populations. Total BAI score correlated negatively with age. Confirmatory factor analysis revealed a good fit to a 4-factor model consisting of cognitive, autonomic, neuromotor, and panic symptoms. Although scores on the BAI and 2 widely used depression scales were significantly correlated, factor analysis distinguished BAI and depression scale items, suggesting that the instruments measure distinct constructs. These findings suggest that the BAI could serve as a valuable screening test for anxiety symptoms among primary care patients who are older and have low income. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Disability and coping as predictors of psychological adjustment to rheumatoid arthritis.

Rheumatoid arthritis (RA) patients have been identified as a medical population at risk for psychological disorder, largely because of the pain and functional disability that are the hallmarks of the disease. This study examined the degree to which self-reported functional disability and coping efforts contribute to psychological adjustment among adult RA patients over a 6-month period. Adaptive outcomes included maintaining a sense of worth, mastery, and positive affect despite the illness. Hierarchical multiple regression analyses indicated that increases in disability were related to decreased acceptance of illness and increased negative affect. Coping efforts were related to increases in positive affect. The findings provide modest support for the role individual coping efforts play in shaping illness-related outcomes. Although disability is not easily reversed, knowledge about coping strategies that moderate its psychological impact may provide a useful basis for designing psychological interventions to promote adjustment. (PsycINFO Database Record (c) 2010 APA, all rights reserved)