共查询到19条相似文献,搜索用时 78 毫秒
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壳聚糖在物理、化学及生物学方面具有独特的特性,是制备药物缓控释制剂理想的天然高分子材料。本文从发展历程和研究热点两个方面简要分析了关于壳聚糖在药物缓释和控释系统上的专利应用进展,希望能够为相关的学术研究和产业发展提供参考。 相似文献
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采用壳聚糖(CS)对钠基蒙脱石(MMT)进行改性制备有机蒙脱石(CS-MMT),对改性后的蒙脱石进行红外光谱(FT-IR)和X射线衍射(XRD)等分析表征.以5-氟尿嘧啶(5-FU)为药物模型制备出壳聚糖改性蒙脱石载药复合物(5-FU/CS-MMT),并以钠基蒙脱石载药复合物(5-FU/MMT)作为对照,探究载药复合物在模拟人工胃液、人工小肠液和人工结肠液中的药物释放情况.结果 表明,当CS的用量是MMT的1.0倍阳离子交换容量时,形成的有机蒙脱石的层间距增大,且对5-FU的载药量达到393 mg/g,而同等情况下,MMT的载药量为239 mg/g.体外释放试验的结果表明,5-FU/CS-MMT中5-FU的体外释放能力主要受释放介质pH值的影响,当pH值为7.4时,5-FU的累积释放率最大,在pH值为1.5时的结果最小. 相似文献
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可生物降解药物载体——纳米/亚微米壳聚糖微球的制备及性能 总被引:9,自引:2,他引:9
利用聚电解质的离子凝胶反应,在溶液中壳聚糖为聚阳离子电解质与带反相电荷的聚阴离子三聚磷酸钠(TPP)发生离子凝胶反应,在合适的浓度和适当的搅拌速度下,得到亚微米级的壳聚糖微球。利用环己烷作为油相,以壳聚糖溶液为水相,配制澄清透明的W/O反相微乳清液,滴加质量浓度为5mg/mL的TPP溶液于已配制好的微乳清液中,制得纳米级壳聚糖微球。采用上述两种方法制得的纳米/亚微米壳聚糖微球用作生物降解药物载体,载药实验结果表明,释放初期无明显暴释现象,具有良好的药物缓释作用。 相似文献
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高分子载体药物是随着药物学研究、生物材料科学和临床医学的发展而新兴的给药技术。高分子材料作为药物的载体越来越多的被应用于化工医药领域,这一技术受到了研究者们的重视,并且得到了较好的发展。文章介绍近年来研究比较广泛的高分子药物载体的应用情况、有关机理以及制备方法。 相似文献
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《国际聚合物材料杂志》2012,61(10):789-802
Novel pH-dependent, biodegradable interpolymeric network (IPN) hydrogels were prepared for controlled drug release investigations. The IPN hydrogels were prepared by irradiation of solutions of N-acryloyglycine (NAGly), polyethylene glycol diacrylate (PEGDA) mixed with chitosan, in the presence of a lower amount of glutaraldehyde as the crosslinker and using 2,2-dimethoxy-2-phenyl acetophenone as the photo-initiator. The equilibrium swelling studies were carried out for the gels at 37°C in buffer solutions of pH 2.1 and 7.4 (simulated gastric and intestinal fluids, respectively). 5-Fluorouracil (5-FU) was entrapped, as a model therapeutic agent, in the hydrogels and equilibrium-swelling studies were carried out for the drug-entrapped gels at 37°C. The in-vitro release profiles of the drug were established at 37°C in pH 2.1 and 7.4. 相似文献
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The aim of this article was to investigate the drug release kinetics of spray-dried chitosan microspheres using various kinetic models. The mean particle size and encapsulation efficiency of cross-linked chitosan microspheres was between 3.8 and 4.2 μm and 96.3 and 98.7%, respectively. Spray-dried chitosan microspheres were spherical in shape with smooth surface. The surface morphology of spray-dried chitosan microspheres was affected by the crystallinity of the loaded drug and cross-linking agent. The release data of the spray-dried chitosan microspheres were treated with zero-order, first-order, Higuchi, Korsmeyer, and Kopcha kinetic models and best fit was observed with Higuchi model, indicating the release of drug from spray-dried chitosan microspheres followed Fick's law of diffusion. 相似文献
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The aim of this article was to investigate the drug release kinetics of spray-dried chitosan microspheres using various kinetic models. The mean particle size and encapsulation efficiency of cross-linked chitosan microspheres was between 3.8 and 4.2 μm and 96.3 and 98.7%, respectively. Spray-dried chitosan microspheres were spherical in shape with smooth surface. The surface morphology of spray-dried chitosan microspheres was affected by the crystallinity of the loaded drug and cross-linking agent. The release data of the spray-dried chitosan microspheres were treated with zero-order, first-order, Higuchi, Korsmeyer, and Kopcha kinetic models and best fit was observed with Higuchi model, indicating the release of drug from spray-dried chitosan microspheres followed Fick's law of diffusion. 相似文献
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S. Saranya 《Polymer-Plastics Technology and Engineering》2013,52(15):1636-1646
Biodegradable polymeric nanoparticles have attracted attention as potential drug delivery devices due to its bioavailability, biocompatibility, encapsulation, controlled drug release and in drug targeting to organs/tissues, as carriers of DNA in gene therapy, deliver proteins, peptides and genes. Controlled release systems increases therapeutic activity reducing the number of drug administration. This review presents the most outstanding contributions in the field of biodegradable polymeric nanoparticulate systems including poly (lactic-co-glycolic acid), polylactic acid, chitosan, gelatin, poly hydroxy alkaonates, poly caprolactone and poly alkyl cyanoacrylate used as drug delivery system, their synthesis, encapsulation process and drug release mechanisms. 相似文献