An auxiliary peptide required for the function of two activation domains in upstream stimulatory factor 2 (USF2) transcription factor

OBJECTIVE: In adolescents, conduct disorder (CD), attention deficit hyperactivity disorder (ADHD), and depression are frequently comorbid with substance dependence (SD). We hypothesized that the prevalence and severity of CD, major depressive disorder (MDD), and ADHD would differ by gender, and that these conditions would associate differentially with severity of SD in males and females. METHODS: We examined these issues, using standardized diagnostic interviews, in 285 male and 82 female adolescents referred for comorbid CD and SD. RESULTS: Males and females did not differ significantly in severity of substance involvement, MDD, or ADHD, but males had more severe CD. MDD severity was the only variable significantly associated with SD severity for females, while for males, severity of CD combined with MDD and ADHD was significantly associated with SD severity. CONCLUSIONS: Among referred adolescents, CD, MDD, and ADHD may all be important concomitants of SD in males, while in females, depression may be the primary variable related to SD.     

DAP-2, the Drosophila homolog of transcription factor AP-2

Between 1985 and 1995, fourteen patients affected by spinal meningiomas underwent surgery at our department. All patients were female, 86 per cent of tumors were thoracic, and the rest was cervical. Thoracic meningiomas occurred predominantly in the lower thoracic spine. One patient had multiple spinal meningiomas, while two other patients had concurrent spinal and cranial meningiomas. The cases are studied with respect to their epidemiology, tumor location, clinical presentation, type of surgical procedure, histopathology and outcome.