胶原、明胶和水解胶原蛋白的护肤功能比较

通过乌氏黏度法测定胶原、明胶和水解胶原蛋白的相对黏度和特性黏数,三硝基苯磺酸(TNBS)法测定样品的自由氨基质量摩尔浓度,在不同相对湿度环境下测定样品的吸湿性和保湿性,荧光标记样品方法观察它们在大白鼠皮肤表层的分布和渗透情况以及角质形成细胞培养实验评价3种样品的生物活性,研究了3种样品的物理化学性能和护肤功能差异。结果表明:胶原的相对黏度是明胶和水解胶原蛋白的5倍左右,其特性黏数也明显大于明胶和水解胶原蛋白;胶原的自由氨基质量摩尔浓度最小,其次是明胶,水解胶原蛋白最大;胶原的吸湿性优于明胶和水解胶原蛋白;胶原、明胶和水解胶原蛋白都能渗透至毛囊中,但只有胶原仍均匀分布于皮肤表面,显示其优良的保湿功能;只有胶原能明显促进细胞的生长和繁殖,而在明胶和水解胶原蛋白上培养的角质形成细胞的生长情况与参比样相似。因此,胶原比明胶和水解胶原蛋白具有更优良的吸湿、保湿性能以及抗皮肤衰老功效。     

水解胶原蛋白的研制及应用

水解胶原蛋白的制备方法,分析结果与应用情况作简要论述。     

食物对保健美容的功效及应用

在护肤方面 ,我国有着悠久的传统和有效的方法。随着人们物质文化生活水平的提高 ,人们对保健美容的兴趣更为浓厚。保健美容也就是通过良好的生活、饮食和卫生习惯 ,经常而有规律地采取一些保养形体和皮肤的措施 ,增进机体健康 ,延缓衰老 ,使面容、形体等保持青春状态 ,达到增进外形美的目的。其手段有饮食美容、运动美容、卫生美容等。本文主要介绍一些具有食药两用的天然动植物对于美化皮肤和容貌及乌发等方面的功效和具体应用。１乳制品及蛋白质类食品很多人喜欢在早餐时饮用牛奶 ,这是一个很好的习惯。牛奶是天然的理想食物 ,建议不论大…     

一种水解胶原蛋白与燕麦蛋白复合物的作用机理及保湿效果研究

冬春季节我国大部分地区气候寒冷、干燥,皮肤缺水容易出现发紧、脱皮等现象。水解胶原蛋白与燕麦蛋白的复合物协同作用,对皮肤更具渗透性,更具有补充皮肤胶原蛋白的作用,能增强皮肤的保水效果。通过临床试验和功效测定,对复合物的保湿效果进行研究。     

驴骨胶原蛋白开发为化妆品原料的安全与功效性评价

初步探究驴骨胶原蛋白开发为化妆品原料的安全性与功效性。以驴骨胶原蛋白作为研究对象,通过细胞毒性试验、鸡胚绒毛尿囊膜试验、3D皮肤模型、自由基清除试验等对驴骨胶原蛋白的安全性、功效性进行分析。结果显示,10 mg/mL以下浓度的驴骨胶原蛋白对 HaCaT 细胞和 NHDFs 细胞无毒性,且有一定促细胞增殖作用;驴骨胶原蛋白无光毒性作用,无眼刺激性/腐蚀性作用,无皮肤刺激性/腐蚀性作用。1.5%驴骨胶原蛋白能够显著修复受损皮肤屏障、抑制IL-1α的表达,效果接近于地塞米松。驴骨胶原蛋白对DPPH自由基具有良好的清除作用,IC_(50) 为3.83%。结果表明,驴骨胶原蛋白具有开发为化妆品原料的安全性与功效价值。     

口服水解胶原蛋白对改善皮肤肤质的研究进展

本文对水解胶原蛋白以及皮肤肤质的影响因素进行了简要介绍,阐述了水解胶原蛋白在人体中的生物利用,对比了其他功能性食物与水解胶原蛋白在改善皮肤肤质上的疗效,并列举了口服水解胶原蛋白在临床前试验中改善皮肤肤质的疗效。     

不同条件下苏木素与水解胶原蛋白作用研究

苏木素是天然植物苏木的提取物,常被人们作为染料使用。为了使苏木染料能够运用在皮革上,通过对苏木素染料性质的研究及用水解胶原蛋白作模拟物,运用紫外分光光度法和荧光光谱法研究水解胶原蛋白与金属离子改性后再与苏木素染料作用,以了解其作用信息。     

胶原蛋白肽的性质、应用及发展前景的研究综述

胶原蛋白肽过去一直也称作胶原蛋白,是胶原完全水解后的产物。它的分子量小,且小分子胶原肽比相同组成的蛋白质和氨基酸吸收利用率更好。胶原蛋白肽不仅具有优良的营养作用,而且还具有很好的生理调节功能。胶原蛋白肽具有许多优异特性,这使其在众多领域中具有巨大的应用潜质并日趋广泛,特别是在生物医学、美容化妆品和保健食品领域中。胶原蛋白肽现已在世界范围内非常受欢迎且需求量快速增长,拥有很好的发展前景。     

胶原蛋白的应用研究现状

胶原蛋白作为动物中丰富的天然高分子,具有可再生、可生物降解、良好的生物相容性和独特的理化性质等。阐述了胶原蛋白的结构特性,综述了国内外胶原蛋白在皮革工业、生物医学、污水处理、造纸行业及纺织等领域的应用,最后对胶原蛋白材料在制备过程中存在的难点进行了分析。     

Molecular Weight Analysis of Blue Shark (Prionace glauca) Collagen Hydrolysates by GPC-LS; Effect of High Molecular Weight Hydrolysates on Fibroblast Cultures: mRNA Collagen Type I Expression and Synthesis

High molecular weight (Mw) collagen hydrolysates have been demonstrated to produce a higher synthesis of collagen type I mRNA. Mw determination is a key factor maximizing the effect of collagen hydrolysates on collagen type I synthesis by fibroblasts. This work aimed to achieve a high average Mw in Blue Shark Collagen Hydrolysate, studying different hydrolysis parameters by GPC-LS analysis and testing its effect on mRNA Type I collagen expression. Analysis revealed differences in blue shark collagen hydrolysates Mw depending on hydrolysis conditions. Papain leads to obtaining a significantly higher Mw hydrolysate than Alcalase at different times of hydrolysis and at different enzyme/substrate ratios. Besides, the time of the hydrolysis factor is more determinant than the enzyme/substrate ratio factor for obtaining a higher or lower hydrolysate Mw when using Papain as the enzyme. Contrary, Alcalase hydrolysates resulted in similar Mw with no significant differences between different conditions of hydrolysis assayed. Blue shark collagen hydrolysate showing the highest Mw showed neither cytotoxic nor proliferation effect on fibroblast cell culture. Besides, it exhibited an increasing effect on both mRNA expression and pro-collagen I production.     

Synthesis,Properties, and Selected Technical Applications of Magnesium Oxide Nanoparticles: A Review

In the last few decades, there has been a trend involving the use of nanoscale fillers in a variety of applications. Significant improvements have been achieved in the areas of their preparation and further applications (e.g., in industry, agriculture, and medicine). One of these promising materials is magnesium oxide (MgO), the unique properties of which make it a suitable candidate for use in a wide range of applications. Generally, MgO is a white, hygroscopic solid mineral, and its lattice consists of Mg2+ ions and O2− ions. Nanostructured MgO can be prepared through different chemical (bottom-up approach) or physical (top-down approach) routes. The required resultant properties (e.g., bandgap, crystallite size, and shape) can be achieved depending on the reaction conditions, basic starting materials, or their concentrations. In addition to its unique material properties, MgO is also potentially of interest due to its nontoxicity and environmental friendliness, which allow it to be widely used in medicine and biotechnological applications.     

Biological Functions and Applications of Virus-Related Bacterial Nanoparticles: A Review

Accumulating evidence suggests that microorganisms produce various nanoparticles that exhibit a variety of biological functions. The structure of these bacterial nanoparticles ranges from membrane vesicles composed of membrane lipids to multicomponent proteinaceous machines. Of bacterial nanoparticles, bacterial phage tail-like nanoparticles, associated with virus-related genes, are found in bacteria from various environments and have diverse functions. Extracellular contractile injection systems (eCISs), a type of bacterial phage tail-like nanostructure, have diverse biological functions that mediate the interactions between the producer bacteria and target eukaryote. Known gram-negative bacterial eCISs can act as protein translocation systems and inject effector proteins that modulate eukaryotic cellular processes by attaching to the target cells. Further investigation of the functions of eCISs will facilitate the application of these nanomachines as nano-sized syringes in the field of nanomedicine and vaccine development. This review summarises the recent progress in elucidating the structures and biological functions of nanoparticles that resemble the tail components of phages that infect bacteria and discusses directions for future research to improve the clinical applicability of virus-related bacterial nanoparticles.     

高线密度胶原蛋白/PVA共混纤维的制备及其结构性能

在胶原蛋白与聚乙烯醇(PVA)共混溶液中,改变原液中胶原蛋白和聚乙烯醇的组成,由湿法纺丝得到初生纤维,经热拉伸、热定形、缩醛化反应制得线密度大于25dtex的胶原蛋白/PVA共混纤维。共混纤维横截面呈圆形,纤维内部无孔洞及裂纹,表面光滑,断裂强度和初始模量分别达到4.63cN/dtex和160.2cN/dtex,断裂伸长率为25.4%,结晶度为48.6%,水中软化点和回潮率分别为104℃和13.67%。     

Antioxidative and Functional Properties of Pumpkin Oil Cake Globulin Hydrolysates

Cucurbitin extracted from pumpkin (Cucurbita pepo) oil cake was enzymatically hydrolysed with three different enzymes viz. alcalase, flavourzyme and pepsin. Antioxidative and functional properties of cucurbitin hydrolysates with different degrees of hydrolysis (DH) were investigated. The antioxidant activity of the hydrolysates was strongly dependent on the enzyme used. The hydrolysates obtained by alcalase and pepsin showed antioxidative potential whereas flavourzyme hydrolysates did not demonstrate these activities. Reducing power and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) scavenging activity of cucurbitin hydrolysate were positively related to DH. The highest antioxidant activity was found in the hydrolysate obtained by alcalase at DH 25.6 % [reducing power of 0.25 ± 0.01 A700 nm and ABTS scavenging activity of 3.34 ± 0.02 mmol/L Trolox equivalent antioxidant coefficients (TEAC)]. Hydrolysis by all enzymes increased the protein solubility within the studied pH range. The best emulsion activity and stability index (EAI = 143.28 ± 3.05 m²/g and ESI = 87.5 ± 1.96 min) have hydrolysates produced by flavourzyme (DH 9.2 %) whereas alcalase produced hydrolysates with the best foaming capacity (FC = 242 ± 3.21). The results demonstrate that hydrolysates produced in the present study have good functional properties as well as antioxidant activity indicating their possible use in different food systems.     

浅谈硅胶的类型结构、性能特点及其应用

在涂料工业中,硅胶是最重要的无机消光剂。硅胶层析技术在中药化学中的应用越来越广泛。现在,硅胶的应用技术已经渗透到各行各业。分别介绍了基础硅胶,微粉硅胶,功能化硅胶的组织结构、功用原理及其特点,同时分别阐述了硅胶在工业生产中的典型应用,硅胶在涂料工业中的典型应用,硅胶在其他行业中的典型应用。     

Immunobiological Properties and Clinical Applications of Interleukin-38 for Immune-Mediated Disorders: A Systematic Review Study

Exponential growth in the usage of “cytokines” (as seroimmunobiomarkers) has facilitated more accurate prognosis, early diagnosis, novel, and efficient immunotherapeutics. Numerous studies have reported immunopathophysiological and immunopathological processes of interleukin-38 (IL-38). Therefore, in this systematic review article, the authors aimed to present an updated comprehensive overview on the immunobiological mechanisms, diagnostic, and immune gene-based therapeutic potentials of IL-38. According to our inclusion and exclusion criteria, a total of 216 articles were collected from several search engines and databases from the January 2012 to July 2021 time interval by using six main keywords. Physiologic or pathologic microenvironments, optimal dosage, and involved receptors affect the functionalities of IL-38. Alterations in serum levels of IL-38 play a major role in the immunopathogenesis of a wide array of immune-mediated disorders. IL-38 shows anti-inflammatory activities by reduction or inhibition of pro-inflammatory cytokines, supporting the therapeutic aspects of IL-38 in inflammatory autoimmune diseases. According to the importance of pre-clinical studies, it seems that manipulation of the immune system by immunomodulatory properties of IL-38 can increase the accuracy of diagnosis, and decipher optimal clinical outcomes. To promote our knowledge, more collaboration is highly recommended among laboratory scientists, internal/infectious diseases specialists, oncologists, immunologists, diseases-specific biomarkers scientists, and basic medical researchers.