重离子束的Bragg峰定位于麦粒的自由基探针技术

为了实现定点定位诱变，提出了一种利用ＥＳＲ波谱术对离子束Ｂｒａｇｇ峰在麦粒中的定位方法，即自由基探针技术，采用该技术有效地测定出２１ＭｅＶ／ｕ氮离子束的Ｂｒａｇｇ峰位于小麦胚部，注入深度不超过１．０±０．２ｍｍ，而４８ＭｅＶ／ｕ氮离子束贯穿全麦粒，不能实现定点定位诱变。     

采用电离室测定重离子束的Bragg峰位

从探索定点定位诱变要求出发，提出了重离子束Ｂｒａｇｇ峰可作为一个有用手段，阐述了测量重离子束Ｂｒａｇｇ峰的原理和实验装置，采用一对电离室测定初始能量为５０ＭｅＶ／ｕ左右＾１４Ｎ＾７＋离子束在物质密度归一到小麦材料后的Ｂｒａｇｇ峰位。最终得到峰位深度约为４．８５ｎｍ，离子束的最大射程为５．５ｍｍ左右。     

用CR－39固体径迹探测器测定重带电粒子的Bragg峰位

采用ＣＲ－３９固体径迹探测器，根据辐射损伤密度沿粒子的径迹分布规律，测定了经３、４ｃｍ空气降能和φ１ｍｍ孔准直的α粒子（５．１５ＭｅＶ）的Ｂｒａｇｇ峰位。对于通过３ｃｍ空气后能量降至～１２ＭｅＶ的α粒子，在ＣＲ－３９中的Ｂｒａｇｇ峰位大约在７μｍ深度处，理论计算值在６．１４μｍ，实验值与理论值符合得较好。     

75MeV/u￣(12)C离子Bragg曲线及黑色素瘤细胞失活的测量

用双电离室法测定了ＨＩＲＦＬ提供的７５ＭｅＶ／ｕ１２Ｃ离子经不同厚度降能片后的相对剂量，将降能片厚度等效为组织等效材料一水中的深度，得到了碳离子在水介质中的Ｂｒａｇｇ曲线，与计算的Ｂｒａｇｇ曲线进行了比较。同时测定了离子经不同厚度降能片后对黑色素瘤（Ｂ１６）细胞的失活效应，得到了离子束在不同贯穿深度上的Ｂ１６细胞存活数据。     

一台用于IMP重离子治癌线上的电离室

介绍一种用于中国科学院近代物理研究所(IMP)重离子肿瘤治疗线上、于纵向场常压下工作的气体电离室,其灵敏面积为250 mm×250 mm,极间距离为10 mm,电离室工作气体为P10,在85kPa下流气式工作.用75 MeV/u 12C离子入射,测量了电离室的坪曲线.发现电离室工作坪区900-3000 V,12C的Bragg峰位于13.73 mm,峰的极大值半高宽(FWHM)为0.19 mm.     

290MeV/u ~9C离子束在液态水靶中输运的蒙特卡洛模拟

9C离子束是双重辐射源于在治疗肿瘤有明显优势。我们用蒙特卡洛程序FULKA模拟了290 MeV/u 9C离子束在水靶中的输运,研究其能量沉积、核碎片分布以及核碎片注量的深度分布,可为9C离子束肿瘤治疗剂量学提供参考。     

Creation of microstructures using heavy ion beam lithography

In this work, three-dimensional (3D) structures were produced in PMMA and CR-39 polymer resists using a carbon ion microbeam. To investigate possible advantages of heavy ions compared to the well-established proton beam lithography, the same resist materials were also irradiated with protons that had a range in the materials studied here similar to that of carbon ions. The microstructures produced in different resists were analysed after chemical etching. The quality of the bottom and side walls of the structures produced by protons and carbon ions were compared using scanning electron microscopy (SEM) and atomic force microscopy (AFM). The results showed that, for the resist materials tested, lithographic structures made with the 8 MeV carbon beam had more rough lateral and bottom surfaces compared to those made with 0.6 MeV proton beam lithography.     

AFM characterization of model nuclear fuel oxide multilayer structures modified by heavy ion beam irradiation

This work explored a potential new model dispersion fuel form consisting of an actinide material embedded in a radiation tolerant matrix that captures fission products (FPs) and is easily separated chemically as waste from the fuel material. To understand the stability of this proposed dispersion fuel form design, an idealized model system composed of a multilayer film was studied. This system consisted of a tri-layer structure of an MgO layer sandwiched between two HfO₂ layers. HfO₂ served as a surrogate fissile material for UO₂ while MgO represented a stable, fissile product (FP) getter that is easily separated from the fissile material. This type of multilayer film structure allowed us to control the size of and spacing between each layer. The films were grown at room temperature by e-beam deposition on a Si(1 1 1) substrate and post-annealed annealing at a range of temperatures to crystallize the HfO₂ layers. The 550 °C annealed sample was subsequently irradiated with 10 MeV Au³⁺ ions at a range of fluences from 5 × 10¹³ to 3.74 × 10¹⁶ ions/cm². Separate single layer constituent films and the substrate were also irradiated at 5 × 10¹⁵ and 8 × 10¹⁴ and 2 × 10¹⁶, respectively. After annealing and irradiation, the samples were characterized using atomic force imaging techniques to determine local changes in microstructure and mechanical properties. All samples annealed above 550 °C cracked. From the AFM results we observed both crack healing and significant modification of the surface at higher fluences.     

重离子束辐照细胞研究的文献计量学分析

应用文献计量学方法和相应的应用软件,借助Web of Science平台对重离子束辐照细胞这一研究主题的相关文献、作者、期刊、机构以及关键词进行定量和系统考察。结果显示,重离子束辐照细胞研究在1990年之后日益活跃并深入;不同品质的重离子束辐照诱导不同类型细胞会产生不同的生物学效应、旁观者效应及其机制、重离子束辐照细胞生物学效应评估模型、重离子束治疗癌症过程中辐照品质选择与控制模型以及相应的计算机程序是该研究主题的重要内容;引入特定指数推测所得该研究主题重要学术期刊与Nature,Proceedings of the National Academy of Sciences of the United States of America,Cancer Research等期刊之间有较高的共被引频次,表明更多科学前沿的突破性成果和思路应用于该主题研究中;此外,该研究主要集中于少数国家、少数机构、少数作者,并且合作相对较少。     

Phoswich探测器的重离子束测试

利用一套由１ｍｍ厚的ＰＩＬＯＴ－Ｕ和４０ｍｍ厚的ＮＥ１１５塑料闪烁体组成的Ｐｈｏｓｗｉｃｈ（光叠层望远镜）探测器测量了４０Ａｒ（２５ＭｅＶ／ｕ）＋１９７Ａｕ反应中出射的产物，粒子鉴别采用Ｐｈｏｓｗｉｃｈ的快慢成分方法．结果表明该方法能清楚地分辨出粒子的电荷．对Ｚ＝１的粒子，ｐ、ｄ和ｔ亦能分开．     

Unique capabilities of heavy ion elastic recoil detection with gas ionization detectors

Specific aspects of heavy ion elastic recoil detection (ERD) with gas ionization detectors have been studied using representative measurements. A particular strength of the technique is the detection and direct quantification of elements with atomic numbers in the range Z=2–8, which are often not accessible with other ion beam techniques. Within the wider spectrum of analytical techniques in materials science, heavy ion ERD has unique capabilities, when the particular problem requires in addition the analysis of heavy elements or hydrogen detection. Whenever only heavy element analysis or only hydrogen profiling is of interest, alternative techniques tend to be superior.     

Study of heavy ion range in different solid state nuclear track detector materials

The range of several heavy ions as ²³⁸U, ²⁰⁸Pb, ¹⁹⁷Au, ¹³⁹La, ⁵⁸Ni and ⁵⁶Fe in sodalime glass; ¹⁹⁷Au and ⁵⁸Ni in muscovite mica and Lexan polycarbonate; ²⁰⁹Bi and ¹⁹⁷Au in CR-39 have been determined experimentally. The calculations of range for these projectile–target combinations have been made using the Benton and Henke [10], Mukherjee and Nayak [11], Ziegler et al. [12] and Hubert et al. [14] semiempirical formulations. Finally a comparison has been made with the experimental results.     

中能碳离子束对不同贯穿深度上黑色素瘤B16细胞的辐照存活效应

测量了49．30MeV/u及经脊形过滤器展宽的Bragg峰的74.55MeV/u^12C离子束在不同贯穿深度上辐射后黑色素瘤B16细胞的存活率。结果显示,在以存活为终点的B16细胞生物学效应与碳离子束能量沉积同步增大。即Bragg或展宽的Bragg峰区内细胞存活率远低于离子束入射或出射通道处的细胞存活率。通过实验测量与剂量平均LET结合的线性平方模型理论计算存活曲线的比较,发现在实验测量误差范围内两者符合较好。提示：剂量平均LET结合线性平方模型可能是预测中能重离子束贯穿深度上B16细胞存活效应的一种有效的方法。     

重离子束均匀度的测定及治癌束流成形的模拟试验

采用５０μｍ厚聚碳酸酯薄膜，利用核径迹测技术测得φ４０ｍｍ的２５ＭｅＶ／ｕ＾４０Ａｒ＾１４＋离子束的均匀度在散焦情况下为３２．７％，在Ｄ“散焦＋样品旋转”情况下为５２．４％。还采用多层聚碳酸酯薄膜组件作为肿瘤块等效材料，进行了重离子束治癌束流成形模拟试验。     

重离子辐照柠檬酸菌株的诱变选育

应用不同剂量重离子束12C+6对黑曲霉出发菌株4﹟进行辐照选育,选育出的高产酸菌株进行发酵试验,应用酸碱中和法测定发酵液中柠檬酸的含量。结果表明:当重离子12C+6的辐照剂量为60 Gy时,正突变率最大,为21%。诱变后的菌株通过酸斑法初筛、摇瓶复筛选育出1株菌株H4002,其发酵液中柠檬酸含量比出发菌株4﹟提高了18%。这说明利用重离子束12C+6辐照处理黑曲霉产生菌可以得到高产柠檬酸突变菌株,其诱变效果显著。     

Spreading of a heavy ion beam with the dual-ring double scattering method

A flat radiation field for heavy ion beams is used in research experiments and clinical treatments. When a flat field is required, a beam spreading system must be installed for a beam line; thus a simple and affordable method is desirable. To achieve the carbon ion beam spreading, we employed a dual-ring double scattering method (DDSM), which consists of an initial scattering foil and a dual-ring subsequent scatterer. The scatterers for the DDSM were designed and tested to verify the flatness of the radiation field of the carbon ion beam. We obtained 100 mm of the flat radiation field in the isocenter plane for the 2D radiation field, as expected. For the 3D radiation field, we obtained a field size of 80 mm. With a 60-min setup time, using the DDSM system, and by placing only two scatterers, we can form the flat radiation field.     

Development of function-graded proton exchange membrane for PEFC using heavy ion beam irradiation

The graded energy deposition of heavy ion beam irradiation to polymeric materials was utilized to synthesize a novel proton exchange membrane (PEM) with the graded density of sulfonic acid groups toward the thickness direction. Stacked Poly(tetrafluoroethylene-co-hexafluoropropylene) (FEP) films were irradiated by Xe⁵⁴⁺ ion beam with the energy of 6 MeV/u under a vacuum condition. The induced trapped radicals by the irradiation were measured by electron spin resonance (ESR) spectroscopy. Irradiated films were grafted with styrene monomer and then sulfonated. X-ray photo-electron spectroscopy (XPS) spectra showed that the densities of sulfonic acid groups were controlled for injection “Surface” and transmit “Back” sides of the fabricated PEM. The membrane electrode assembly (MEA) fabricated by the function-graded PEM showed improved fuel cell performance in terms of voltage stability. It was expected that the function-graded PEM could control the graded concentration of sulfonic acid groups in PEM.     

3D visualization of heavy ion beam energy deposition in two different target shapes

Heavy ion beams have favorable energy deposition behavior because they can penetrate and deposit their energy well inside the target. Ion beams have potential uses in fields including heavy ion beam fusion, high-energy density physics and material processing. Intense heavy ion beams can generate high-energy density matter in the laboratory under extreme density and pressure conditions. Additionally, in heavy ion fusion, a stringent requirement for successful fuel ignition and sufficient fusion energy release is that the ion energy deposition profiles are calculated precisely in the energy absorber layer. In this work, the OK2 code was used to simulate the heavy ion beam energy deposition in various target materials, and a computer program was written to provide 3D visualization of the results. The heavy ion beams used in this work were composed of lead, uranium, and cesium ions with energies of 8 GeV and carbon ions with energies of 5 MeV. The targets included two shapes: a monolayer sphere that can be used in direct-driven fusion and a cylindrical shape that is common in indirectly driven heavy ion fusion.     

Effects of low-dose heavy ion irradiation on male germ cell adaptation and genetics

1 Introduction Ionizing irradiation has been widely reported to damage organism by attacking proteins, nucleic acid and lipids in cells.[1,2] However, irradiation hormesis after low dose irradiation has been becoming the focus of research in radiobiology in recent years.[3,4] Many studies have shown that low dose ionizing irradiation can produce stimulating effects on the immune sys-tems and induce adaptative response to harmful ef-fects of subsequent high-dose radiation exposure.[3,5-7] Furth…     

The role of autophagy in cell survival from heavy ion irradiation in the plateau region

To study cytotoxic effect of heavy ion irradiation in the plateau region, and investigate whether autophagy in- duced by heavy ion irradiation is cytoprotective, HeLa cells were irradiated with 350 MeV/u carbon ions beams, and the clonogenic survival was analyzed. The results showed that cell survival decreased with increasing doses. It was also found that G2/M-phase cells increased, and the autophagy-related activity was significantly higher than the control. When autophagy was blocked by 3-methyladenine in carbon-ion irradiated cells, G2/M phase arrest and the percentage of apoptosis cells were further elevated, and cell survival decreased significantly, in- dicating the induction of cytoprotective autophagy by carbon-ion irradiation. Our results demonstrated that autophagy induced by carbon ion irradiation provided a self-protective mechanism in HeLa ceils, short-time inhibition of autophagy before carbon-ion irradiation could enhance radiation cytotoxicity in HeLa cells.