IQ-memory discrepancies in normal and clinical samples.

The potential utility of IQ—Memory Index discrepancy scores derived from the Wechsler Adult Intelligence Scale—Revised (WAIS—R) and the Wechsler Memory Scale—Revised (WMS—R; D. Wechsler, 1987) was examined in a clinical sample, whose scores were then compared to those of subjects from the WMS—R standardization sample. The clinical sample included patients with diagnoses associated with memory deficits. Discrepancy scores between Full-Scale IQ and the Delayed Memory Index differentiated the groups, but material-specific discrepancies between IQ scores and immediate recall memory scores did not. The largest mean discrepancy and the greatest prevalence of scores beyond a criterion score of 15 were found in patients with presumed Alzheimer's disease. Issues related to limitations in the application of such discrepancy scores are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Factor-defined abilities in patients with unilateral brain lesions.

Administered a battery of 4 tests adapted from the structure of intellect model of differential abilities to 72 adults with right and left cerebral lesions and normals. Findings show that both brain-damaged groups exhibited slower response times than normals and that there was a relation between locus of the lesion and performance. However, results do not sufficiently demonstrate the advantage of factor-defined ability tests over tests of global intelligence and question the validity of these factor-defined tests in that they do not distinguish behaviors that are factorially distinct in normal populations. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Ideation in patients with unilateral or bilateral midline brain lesions.

Hypothesized that persons with left vs. right unilateral brain lesions differ in complicated ideational processes in 50 Ss with well localized lesions. On a multiple-discriminant analysis, 7 selected Rorschach variables differentiated the left, right, and midline-bilateral groups at the .0001 level. Interpretation of Discriminant I, ideation, yields a modus operandi of left-hemisphere Ss which is limited and constricted; of right-hemisphere Ss which is expansive and uncritically innovative. Discriminant II, uniqueness of pathology, indicates that left and right groups differ significantly and are significantly divergent, with the midline group undistinguished on this dimension. (18 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Sex differences in verbal IQ—Performance IQ discrepancies among patients with schizophrenia and normal volunteers.

Substantial verbal IQ (VIQ)–performance IQ (PIQ) discrepancies may reflect brain dysfunction. The authors examined 159 patients with schizophrenia ( 115 men and 44 women) or schizoaffective disorder (25 men and 19 women) and 79 normal participants (33 men and 46 women), calculated mean VIQ–PIQ discrepancy scores by sex and diagnosis, and identified persons with large VIQ–PIQ discrepancies (15-point difference in either direction). Schizophrenic/schizoaffective men had a larger mean VIQ–PIQ discrepancy than did other groups. The proportion of all patients with either VIQ?>?PIQ or PIQ?>?VIQ ( 17.8%) was not significantly different from that of normal participants (22.8%). However, significantly more men than women with schizophrenia exhibited a VIQ–PIQ pattern (20% vs. 3.2%). No unusual discrepancy patterns were noted among normal participants. Results were interpreted in light of theories of hemisphere dysfunction in schizophrenia. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The unilateral 6-hydroxydopamine lesion model in behavioral brain research. Analysis of functional deficits, recovery and treatments

Lesions with the neurotoxin 6-hydroxydopamine (6-OHDA) have provided an important tool to study dopamine neurons in the brain. The most common version of such lesions is the unilateral one where the toxin is placed in the area of mesencephalic dopamine cell bodies or their ascending fibers. This approach leads to a lateralized destruction of mesencephalic dopamine neurons and to a lateralized loss of striatal dopamine innervation. Such lesions have contributed substantially to neuroscientific knowledge both, at the basic and clinical level. Physiologically, they have been used to clarify the neuroanatomy, neurochemistry, and electrophysiology of mesencephalic DA neurons and their relationships with the basal ganglia; the relevant findings have been summarized in a previous review (Schwarting, R.K.W. and Huston, J.P. (1996) Unilateral 6-hydroxydopamine lesions of meso-striatal dopamine neurons and their physiological sequelae, Progress in Neurobiology 49, 215-266). Furthermore, 6-OHDA lesions have been used extensively to investigate the role of these dopamine neurons with respect to behavior, to examine the brain's capacity to recover from or compensate for specific neurochemical depletions, and to investigate the promotive effects of experimental and clinical approaches which are relevant for the treatment of Parkinson's disease. These findings are summarized here, including the spectrum of behavioral deficits (turning, sensory neglect, etc.), functional recovery and its possible mechanisms, the behavioral effects of widely used pharmacological challenges (amphetamines, apomorphine, selective receptor agonists, L-DOPA), and the effects of treatments which can promote recovery (like neuropeptides, neurotrophins, and grafts).     

Dopamine receptors status after unilateral nigral 6-OHDA lesion. Autoradiographic and in situ hybridization study in the rat brain

The physiological effects of dopamine (DA) are mediated by several distinct receptor subtypes. The effects of unilateral nigral 6-hydroxydopamine (6-OHDA) lesions on DA receptors were investigated by receptor autoradiography using the D1 selective ligand [3H]SCH 23390 as well as the D2 ligand [3H]spiroperidol. mRNA distribution was studied by in situ hybridization. Lesioned rats were sacrificed at different time intervals. Receptor binding studies were performed on tissue sections using selective ligands. [35S]UTP labeled RNA probes were prepared from the different cDNA (D1, D2, D3) and used for in situ hybridization. A specific loss of receptor binding sites and mRNA hybridization was found in the lesioned substantia nigra pars compacta (SNc) at all times examined. Receptor binding studies revealed a different time-dependent increase in both D1 and D2 receptors. In situ hybridization showed that only D2 receptor mRNA increased in the caudate-putamen (CPu) of the lesioned side 15 d after 6-OHDA. No changes were observed in D1 and D3 receptor mRNA during the entire time-course.     

Disorders of visuo-spatial attention in patients with unilateral brain damage

Visuo-spatial inattention (VSI) was examined in 390 patients with ischemic insult to the right or left cerebral hemispheres. VSI was revealed in 44 out of 80 patients with right parietal lobe damage and in 30 out of 70 subjects with right occipital lobe injury. Only one patient out of 100 with left hemisphere injury has shown the signs of VSI. These data confirm the suggestion that the right parietal and occipital regions are crucial for visuo-spatial attention, whereas the left hemisphere is of minor import.     

Verbal IQ–performance IQ discrepancies on the Wechsler Adult Intelligence Scale-Revised in patients with unilateral or bilateral cerebral dysfunction.

Administered the WAIS-R to 89 patients (mean age 42 yrs) with neurodiagnostically confirmed unilateral or bilateral cerebral disease. Similar to findings with previous editions of these tests, Ss with left-hemisphere disease obtained significantly lower Verbal IQ (VIQ) than Performance IQ (PIQ), and Ss with right or bilateral disease obtained lower PIQ than VIQ. It is cautioned that these VIQ–PIQ discrepancies in isolation are ineffective indexes of cerebral dysfunction and that patterns of performance must be viewed in the context of a complete neuropsychological examination and relevant medical and educational historical data. (5 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Recognition of prosody following unilateral brain lesion: influence of functional and structural attributes of prosodic contours

The perception of prosodic distinctions by adults with unilateral right- (RHD) and left-hemisphere (LHD) damage and subjects without brain injury was assessed through six tasks that varied both functional (i.e. linguistic/emotional) and structural (i.e. acoustic) attributes of a common set of base stimuli. Three tasks explored the subjects' ability to perceive local prosodic markers associated with emphatic stress (Focus Perception condition) and three tasks examined the comprehension of emotional-prosodic meanings by the same listeners (Emotion Perception condition). Within each condition, an initial task measured the subjects' ability to recognize each "type" of prosody when all potential acoustic features (but no semantic features) signalled the target response (Baseline). Two additional tasks investigated the extent to which each group's performance on the Baseline task was influenced by duration (D-Neutral) or fundamental frequency (F-Neutral) parameters of the stimuli within each condition. Results revealed that both RHD and LHD patients were impaired, relative to healthy control subjects, in interpreting the emotional meaning of prosodic contours, but that only LHD patients displayed subnormal capacity to perceive linguistic (emphatic) specifications via prosodic cues. The performance of the RHD and LHD patients was also selectively disturbed when certain acoustic properties of the stimuli were manipulated, suggesting that both functional and structural attributes of prosodic patterns may be determinants of prosody lateralization.     

Some failures of intermanual and cross-lateral transfer in chronic schizophrenia.

The suggestion that split-brain symptoms are present in schizophrenia was investigated by using tests of intermanual and cross-lateral transfer. Ss were 24 chronic schizophrenics (mean age 52.1 yrs), 6 matched depressive and anxious patients, and 6 normal controls. All Ss were right-handed. Disconnections were seen on a variety of manual and cross-lateral transfer tasks involving position location on the hands, the arms, and the body as well as on tasks of manual tapping transfer. These are interpreted as communication failures of the brain related to callosal disturbance. (7 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Transfer of learning but not memory after unilateral cerebellar lesion in rabbits.

Unilateral lesion of the cerebellum in rabbits completely and permanently abolishes previous learning and prevents new learning ipsilateral to the lesion. However, when training continues on the contralateral side, there is substantial savings in that it takes few trials to learn. This observation may imply that the memory survives the lesion. Rabbits were classically conditioned for an eyelid response and then the ipsilateral interpositus nucleus of the cerebellum was lesioned. Then the rabbits were trained on the contralateral side. There is no savings on the contralateral side without first trying to train on the lesioned side. It is concluded that the survival of a memory after the lesion probably does not account for the rapid transfer, but rather that the act of trying to train on the lesioned side in previous studies first induces a new memory on the contralateral side. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

An examination of verbal supraspan in normal adults and patients with head trauma or unilateral cerebrovascular accident.

Provided a normative data base for a measure of verbal supraspan based on 301 neurologically intact adults (aged 18–91 yrs) and examined the test's clinical sensitivity in 3 patient groups. Data from 55 patients with severe head trauma, 38 with right hemisphere and cerebrovascular accident (CVA), and 15 with left hemisphere CVA reveal significant age-related differences, with older Ss performing below levels obtained by younger ones. Group data reveal that Ss in all 3 groups performed significantly below levels obtained by age-matched controls. Supraspan scores did not correlate appreciably with years of education. However, scores on the supraspan test correlated modestly with Wechsler Adult Intelligence Scale—Revised (WAIS—R) Information and Block Design scores, suggesting that task performance may be dependent in part on the S's general level of cognitive functioning. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The interpretation of sentence ambiguity in patients with unilateral focal brain surgery

Interpretations of ambiguous sentences were studied in patients with unilateral anterior temporal lobectomy or selective amygdalo-hippocampectomy. The sentences represented lexical and syntactic ambiguities. In both left- and right-sided groups, regardless of type of surgery, total mean score on the test was below normal. Left-sided cases, regardless of type of surgery, provided significantly fewer alternative interpretations than right-sided cases. The results suggest greater left than right hemisphere specialization in both lexical and syntactic processing, but also suggest right hemisphere involvement in resolution of lexical ambiguity.     

Consistency of self-descriptions under different role sets in neurotic and normal adolescents and adults.

15 male Ss in each of 4 groups (neurotic adolescents, normal adolescents, neurotic adults, and normal adults) described themselves with a Q sort as they saw themselves in 3 different situations (self in general, self with family, and self with friends). The tendency to describe themselves inconsistently was characteristic of neurotic adolescents specifically and not of adolescents or of neurotics in general. Results were discussed in relation to adolescence as a time of "identity crisis" and with previously reported findings that neurotics tend to have inconsistent self-concepts. (27 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Multiple discrepancies and pay satisfaction.

In this study, a mail survey was used to measure pay satisfaction, current salary, 4 personal standards of comparison, and basic demographics for 169 mental health professionals. As predicted, pay satisfaction was determined by the simultaneous appraisal of current salary against several personal standards of comparison. Explained variance in pay satisfaction rose from 26.1% when only salary and demographics were used as predictors to 46.7% when discrepancy-related variables associated with 4 standards of comparison also were used. Furthermore, R–2 for the combined discrepancy-related variables associated with all 4 standards of comparison was significantly greater than R–2 for the discrepancy-related variables associated with any single standard. These discrepancy effects took both additive and nonadditive forms. Discrepancy effects were stronger when deserved salary or minimum salary was the standard of comparison than when other's salary or average salary was. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Prediction of unilateral brain dysfunction using Wechsler test scores.

This study investigated whether oblique factor scores for Wechsler tests discriminate right- and left-hemisphere brain dysfunction more effectively than subtest or scale scores. A criterion sample of 60 psychomotor-seizure epileptics was divided into 2 equal cross- validation groups with comparable proportions of right and left Ss. 3 measures of lateralization were used, with a criterion cut-off of at least 2 measures lateralizing each S. A computer-programmed, "stepwise" regression analysis was performed utilizing a double cross-validation design. Regular scale scores proved more effective than factor scores, although the latter were nearly comparable using a different factor-extraction matrix. (22 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A reanalysis of gender differences in IQ scores following unilateral brain lesions.

Meta-analyses of gender differences in the consequences of unilateral brain lesions have reported a positive correlation between the percentage of men in studies and the magnitude of the difference between Verbal (V) and Performance (P) IQ. Such findings are limited by both the indirectness of the methodology and the focus on V–P differences rather than on the separate effects of brain lesions on VIQ and PIQ. A repeated-measures analysis was conducted of studies that reported separate VIQ and PIQ means for men and women with unilateral lesions. Women showed lower IQ scores following lesions to the hemisphere thought to be nondominant for each function. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Implicit and explicit self-esteem discrepancies in paranoia and depression.

The main purpose of the present study was to examine implicit and explicit self-esteem (SE) in patients with persecutory delusions. In samples of paranoid patients, depressed patients, and healthy controls, implicit SE was assessed using the experimental go/no-go association task, whereas explicit SE was measured using 2 self-reporting questionnaires: the self-worth subscale of the World Assumption Scale (Janoff-Bulman, 1989) and the self-acceptance subscale of the Scales of Psychological Well-Being (Ryff & Keyes, 1995). Our analysis revealed that depressed patients showed lower explicit SE than did paranoid and healthy control participants. However, participants with persecutory delusions had significantly lower implicit SE scores than did healthy controls. We interpret the discrepancies observed between overt and covert measures in the paranoid group as psychological defense mechanisms. The present study stresses the clinical and theoretical importance of the use of implicit measures in psychopathology. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Intellectual stability in children with unilateral brain lesions

Developmental differences in behavior and self-perception were examined in a group of 44 preschool and school-age children referred for evaluation of sexual abuse and 41 comparison children with no history of sexual abuse, matched on age and gender, and from a similar socioeconomic background. Children suspected of having been sexually abused were rated by their parents as having more internalizing and externalizing problems than comparison children. When children rated their self-competence and social acceptance, there were no group differences between children based on their abuse status; however, there was significant within-group variation among the children suspected of having been sexually abused. Preschool children had elevated scores of perceived competence and social acceptance, and school-age children had depressed scores. There were no age differences among the children in the comparison group. The results suggest that among children suspected of abuse, not only does their self-perception vary by their developmental level, but preschool children may respond with elevated perceptions of themselves. Focusing on individual differences in children's response to suspicions of sexual abuse enables us to identify risk and protective factors that contribute to the psychological outcomes of child sexual abuse.