首页 | 本学科首页   官方微博 | 高级检索  
相似文献
 共查询到20条相似文献,搜索用时 38 毫秒
1.
A large body of data suggest that brain cholecystokinin (CCK) systems are involved in the regulation of anxiety, and numerous studies have demonstrated that CCK-4, a CCKB agonist, reliably induces panic attacks in patients with panic disorder. Recently, pentagastrin, a commercially available CCKB agonist, has been reported to have similar anxiogenic properties. To further explore the utility of pentagastrin as a challenge agent and to determine whether its effects are dose-related, a dose-response study was conducted in ten healthy volunteers. Pentagastrin (0.2 microgram/kg, 0.6 microgram/kg and 1.0 microgram/kg) and inactive placebo were infused over one minute on four separate challenge days in a double-blind fashion. Subjects received pentagastrin while participating in a structured social interaction task. Repeated measures of anxiety, blood pressure, pulse, ACTH, and cortisol were taken at baseline and postinfusion. Pentagastrin administration led to increases in anxiety, pulse, ACTH, cortisol and physical symptoms of panic, in a dose-related manner. Participation in the social interaction task led to increases in measures of anxiety as well as increases in pulse and blood pressure. Few differences were found between the 0.2 microgram/kg dose of pentagastrin and placebo, or between the 0.6 microgram/kg and the 1.0 microgram/kg doses of pentagastrin. These findings support the notion that CCK systems are involved in the regulation of anxiety, and suggest that the 0.6 microgram/kg dose may be optimal for increasing symptoms of anxiety while minimizing unpleasant side effects. The powerful anxiogenic effects of the social interaction task underscore the importance of contextual variables in challenge studies.  相似文献   

2.
BACKGROUND: Psychological manipulations (supplied information, safety cues) may influence panic rates during pharmacologic challenge tests in subjects with panic disorder (PD). Psychological panic models assume that fear of stress-related bodily sensations is central to the etiology of PD. METHODS: Prior to infusion of epinephrine, 50 subjects with PD were randomly assigned to one out of four experimental conditions: with or without extensive information and with or without external control, according to a 2 x 2 design. The panic rate was hypothesized to be lower in subgroups possessing extensive information and/or control. Fear of bodily sensations was used as a predictor. RESULTS: Thirty-four out of 50 patients (68%) panicked during the infusion. Subjects who received extensive information were marginally less likely to panic, but manipulation of control did not influence panic rates. Panickers did not differ from nonpanickers in measures of fear of fear. Anxiety sensitivity best predicted baseline anxiety and cognitive symptom scores, but was not associated with other outcome measures in panickers. Only baseline partial pressure of CO2 discriminated between panickers and nonpanickers. CONCLUSIONS: Manipulating external safety cues appears to be of limited value in modulating responses to epinephrine challenge. Together with our finding that fear of anxiety symptoms does not predict panic rates, these data argue against "fear of fear" as a key mechanism in epinephrine-induced panic.  相似文献   

3.
Eighty subjects underwent three trials of cold-pressor pain. The first cold-pressor trial served as a baseline. Next, subjects in a neutral (no expectancy information) condition were taught a distraction strategy (shadowing letters) before one cold-pressor trial and an imagery strategy before the other. Subjects in other conditions received positive expectancy information about one of the strategies and negative expectancy information about the other. Negative information reduced expectancy ratings and decreased the magnitude of reported pain reductions. Both pretested levels of social desirability and degree of absorption in strategy use made contributions to the prediction of pain reduction that were independent of expectancy ratings. Theoretical implications are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   

4.
This study of 397 undergraduate students examined relations between self-reported control, goal orientation, future time perspective, affect, and strategic self-regulation. Five patterns were found in three canonical dimensions. The high end of bipolar Dimension 1 linked high self-regulated strategy use and study effort to high self-efficacy, outcome expectancy, and effort causal attribution; high mastery and performance approach and low work avoidance goal orientations; and positive affect. The low end of Dimension 1 linked low strategy use and effort to low self-efficacy, outcome expectancy, and effort causal attribution; high work avoidance goal orientation; and low affect. The high end of bipolar Dimension 2 linked knowledge-building strategies, but not active self-regulation or study effort, to high self-efficacy, outcome expectancy for learning but not grades, and affect causal attribution; high mastery goal orientation; and positive affect. The low end of Dimension 2 linked surface learning, consisting of active self-regulation and study effort but not personal knowledge building, to high effort causal attribution but low self-efficacy and outcome expectancy. Unipolar Dimension 3 linked learned helplessness to high outcome expectancy and external causal attribution but low self-efficacy; high work avoidance goal orientation; and high negative affect and anxiety. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   

5.
Reports an error in the original article by Janz (Journal of Applied Psychology. Vol 67(4) Aug 1982, 480-485). On page 481 and 484, the numbers of subjects in some places were reported incorrectly. The corrections are provided. (The following abstract of this article originally appeared in record 1982-29612-001.) Investigated the form of the expectancy-performance relationship in a laboratory study of the performance of 132 undergraduates on a simple clerical task. As feedback after each of 8 trials, Ss were told that their performance was better, worse, or borderline. Ss recorded their subjective expectancies before each trial. Over all Ss, feedback condition had no impact on performance; but when 39 Ss whose reported expectancy did not match their assigned feedback were eliminated, a strong expectancy-performance relationship emerged. Ss having intermediate expectancy outperformed those whose expectancy was low or high. Examination of the nonbelievers supported the mediating role of cognitive variables in deciding how hard to work at this task. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   

6.
Panic patients with agoraphobia were compared with normal controls on tasks of face recognition. The subjects were presented with 20 photos, and were required to make a judgement of the persons on the photos; shortly afterwards they were unexpectedly presented with a recognition task. In the first study, one task was to judge whether the persons on the photos were critical or accepting: unlike social phobics (Lundh and Ost, 1996b, Behaviour Research and Therapy, 34, 787-794), panic patients showed no bias for critical vs accepting faces on the recognition task. In a secondary study, the task was to judge whether the persons on the photos were 'safe' or 'unsafe', i.e. whether they could be relied on if the subject would need help in some situation. The results showed a recognition bias for safe vs neutral faces in panic patients. The index of recognition bias for safe faces correlated with avoidance of feared situations when accompanied by others, as measured by the Mobility Inventory. The possibility that memory bias in emotional disorders is a function of basic concern, or functional importance, rather than positive/negative valence is discussed. The results are also discussed in terms of degree of elaboration, exposure duration of the stimuli, and the generality of the findings.  相似文献   

7.
Investigated the form of the expectancy–performance relationship in a laboratory study of the performance of 132 undergraduates on a simple clerical task. As feedback after each of 8 trials, Ss were told that their performance was better, worse, or borderline. Ss recorded their subjective expectancies before each trial. Over all Ss, feedback condition had no impact on performance; but when 39 Ss whose reported expectancy did not match their assigned feedback were eliminated, a strong expectancy–performance relationship emerged. Ss having intermediate expectancy outperformed those whose expectancy was low or high. Examination of the nonbelievers supported the mediating role of cognitive variables in deciding how hard to work at this task. (8 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   

8.
Evaluated the effects of manipulated cognitive expectancy on avoidance behavior in an experimental paradigm that simulated systematic desensitization. 72 female undergraduates with moderate fear of spiders were divided among 4 expectancy conditions ranging from a set to improve to a set that fear would increase. 2 measures of electrodermal activity were continuously recorded while the Ss, who relaxed in a reclining chair, were exposed to a preserved tarantula. Results indicate that both overt avoidance behavior and 2 verbal indexes were differentially affected by expectancy and that no relationship between avoidance behavior and autonomic reactivity was evident. It is concluded that the processes which mediate systematic desensitization can not adequately be explained by the counterconditioning model alone. (34 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   

9.
OBJECTIVE: Patients with panic symptoms are heavy users of the health care system, although many do not seek care specifically for those symptoms. This study documents utilization of various sources of health care of subjects with panic symptoms, including those who met criteria for panic disorder and those with infrequent panic, distinguishing between use specifically for panic symptoms and use for reasons not related to panic. METHODS: This community-based sample, predominantly Mexican American and female, included 97 subjects with panic symptoms and 97 matched control subjects with no panic symptoms. Data were collected on two-month utilization of various sources of health care both within and outside the mainstream health care system, barriers to access to care, and levels of medical insurance coverage. RESULTS: Subjects with panic symptoms had higher utilization rates for the services of psychiatrists and psychologists and for ambulance services than control subjects. Subjects who met criteria for panic disorder and who sought care specifically for panic symptoms generally accounted for the differences between the group with panic symptoms and the control group. The two groups differed little in barriers to access, but the control group reported that their medical insurance covered more types of services. CONCLUSIONS: Compared with control subjects, subjects with panic symptoms reported higher rates of health care utilization despite having less insurance coverage and experiencing similar barriers to access. The higher rate was due to increased utilization of health care by subjects who met criteria for panic disorder and to help seeking specifically for symptoms of panic.  相似文献   

10.
Thirty patients with a diagnosis of panic disorder with agoraphobia and 30 normal controls were compared on explicit memory (cued recall) and implicit memory (word stem completion) for positive, neutral, social threat, and physical threat words. The panic patients showed an explicit memory bias, but no implicit memory bias, for physical threat words. The index of explicit memory bias for physical threat words was found to correlate with anxiety sensitivity and degree of agoraphobic fear and avoidance. The index of baseline bias for threat words on the word completion task, on the other hand, correlated with trait anxiety. Although there were no correlations between explicit and implicit memory bias for physical threat words, explicit memory bias for physical threat words correlated with explicit memory bias indexes for positive words and social threat words. The results are discussed in terms of the functional role of an explicit memory bias for physically threatening events in panic disorder. The negative results on implicit memory bias are discussed in relation to earlier studies, the use of different implicit memory tasks, and the role of baseline bias on implicit memory tasks. Finally, the hypothesis is suggested that explicit and implicit memory bias for emotional information may represent two different styles of information processing, which serve as vulnerability factors for different emotional disorders.  相似文献   

11.
Hemodynamic, cardiac, and hormonal responses to lower-body negative pressure (LBNP) were examined in 24 healthy men to test the hypothesis that responsiveness of reflex control of blood pressure during orthostatic challenge is associated with interactions between strength and aerobic power. Subjects underwent treadmill tests to determine peak oxygen uptake (VO2max) and isokinetic dynamometer tests to determine knee extensor strength. Based on predetermined criteria, subjects were classified into one of four fitness profiles of six subjects each, matched for age, height, and body mass: (a) low strength/average aerobic fitness, (b) low strength/high aerobic fitness, (c) high strength/average aerobic fitness, and (d) high strength/high aerobic fitness. Following 90 min of 0.11 rad (6 degrees) head-down tilt (HDT), each subject underwent graded LBNP to -6.7 kPa or presyncope, with maximal duration 15 min, while hemodynamic, cardiac, and hormonal responses were measured. All groups exhibited typical hemodynamic, hormonal, and fluid shift responses during LBNP, with no intergroup differences between high and low strength characteristics. Subjects with high aerobic power exhibited greater (P < 0.05) stroke volume and lower (P < 0.05) heart rate, vascular peripheral resistance, and mean arterial pressure during rest, HDT, and LBNP. Seven subjects, distributed among the four fitness profiles, became presyncopal. These subjects showed greatest reduction in mean arterial pressure during LBNP, had greater elevations in vasopressin, and lesser increases in heart rate and peripheral resistance. Neither VO2max nor leg strength were associated with fall in arterial pressure or with syncopal episodes. We conclude that interactions between aerobic and strength fitness characteristics do not influence responses to LBNP challenge.  相似文献   

12.
This article presents data on the prevalence and symptomatology of panic attacks and panic disorder (PD) in a large nonclinical sample (n?=?2,375) of college students. Results showed that approximately 12% of the sample had experienced at least one unexpected panic attack and that 2.36% met Diagnostic and Statistical Manual of Mental Disorders-III—Revised (DSM-III—R) criteria for panic disorder. Although there were no sex differences in overall panic attack prevalence, men reported significantly more panic-related worry than women, and women reported a higher panic frequency than men. Compared to subjects who met DSM-III-R criteria for PD, infrequent panickers presented with fewer panic symptoms, fewer panic episodes, less panic-related worry, lower anxiety sensitivity, and less panic-related avoidance. Moreover, compared with PD subjects, the infrequent panickers were much less likely to report fears of dying, going insane, and derealization during a panic attack. The findings provide preliminary support for the role of anxious apprehension as a psychological vulnerability factor in the pathogenesis of panic disorder. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   

13.
Panic disorder (PD) and asthma share many common characteristics and have been found in epidemiological studies to be significantly comorbid. To investigate possible reasons for this overlapping, the authors evaluated 51 patients with asthma, assessing the prevalence of PD and sporadic panic attacks, the temporal relationship between these two disorders, and the familial risk for PD in the families of asthmatics. The results showed significantly higher prevalences of PD, sporadic panic attacks, and social phobia in asthmatics than those reported for the general population. In 9 (90%) of the asthmatics with PD, asthma appeared first. Finally, the morbidity risk for PD in families of asthmatics with PD (13.5%) was significantly higher than in families of asthmatics without evidence of panic (2%). Our results suggest that the high prevalence of PD in asthmatics might be related to a facilitating effect of asthma on the development of PD in subjects with familial predisposition to PD.  相似文献   

14.
Prior to hypnotic induction, subjects selected for high hypnotizability and ability to experience hypnotic amnesia were read one of two expectancy manipulations designed to convince them that deepening of hypnosis either would or would not allow them to breach amnesia. After memorizing a list of six words, subjects heard a hypnotic induction, an amnesia suggestion, a challenge to remember, a trance-deepening procedure, and a second challenge to remember. On the first challenge, subjects in both conditions demonstrated considerable and equivalent degrees of amnesia. Following the trance-deepening procedure, subjects in the amnesia expectancy condition displayed even more amnesia, whereas 80% of the subjects in the memory expectancy condition completely recovered their memory of the word list. These data demonstrate that for most subjects in whom hypnotic amnesia can be elicited, it can be completely breached by manipulating subjects' expectancies. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   

15.
OBJECTIVE: Comorbidity between anxiety and substance use disorders was examined. The hypothesis was tested that social phobics may report greater problem alcohol use (if alcohol is used to manage social anxiety) while problem use of sedative-hypnotics may be greater in people with panic (who may be over-prescribed anxiolytics because they repeatedly seek medical assistance). METHOD: Self-reported lifetime rates of drug and alcohol problems were assessed with the computerised Diagnostic Interview Schedule-Revised. Subjects were 146 consecutive patients treated for panic disorder (with and without agoraphobia) and social phobia at the Clinical Research Unit for Anxiety Disorders. RESULTS: High prevalences of alcohol problems (three times that expected) and problem use of sedative hypnotics (eight times that expected) were found in all diagnoses. Social phobics exhibited comparatively high rates of problem alcohol use, but no diagnostic specific differences in problem sedative-hypnotic use were found. CONCLUSION: Routine screening for drug and alcohol problems is necessary for patients with anxiety disorders.  相似文献   

16.
We tested the hypothesis that a heritable EEG trait, the low voltage alpha (LV), is associated with psychiatric disorders. Modest to moderate evidence for genetic linkage of both panic disorder and the low voltage alpha trait to the same region of chromosome 20q has recently been reported, raising the issue of whether there is a phenotypic correlation between these traits. A total of 124 subjects including 50 unrelated index subjects and 74 relatives were studied. Alpha EEG power was measured and EEG phenotypes were impressionistically classified. Subjects were psychiatrically interviewed using the SADS-L and blind-rated by RDC criteria. Alcoholics were four times more likely to be LV (including so-called borderline low voltage alpha) than were nonalcoholic, nonanxious subjects. Alcoholics with anxiety disorder are 10 times more likely to be LV. However, alcoholics without anxiety disorder were similar to nonalcoholics in alpha power. An anxiety disorder (panic disorder, phobia, or generalized anxiety) was found in 14/17 LV subjects as compared to 34/101 of the rest of the sample (P < 0.01). Support for these observations was found in the unrelated index subjects in whom no traits would be shared by familial clustering. Lower alpha power in anxiety disorders was not state-dependent, as indicated by the Spielberger Anxiety Scale. Familial covariance of alpha power was 0.25 (P < 0.01). These findings indicate there may be a shared factor underlying the transmissible low voltage alpha EEG variant and vulnerability to anxiety disorders with associated alcoholism. This factor is apparently not rare, because LV was found in approximately 10% of unrelated index subjects and 5% of subjects free of alcoholism and anxiety disorders.  相似文献   

17.
This study compared 96 women and 58 men suffering from panic disorder with agoraphobia. Participants completed questionnaires assessing various clinical features associated with panic disorder with agoraphobia (PDA), general adjustment, and drug/alcohol use. Results showed that PDA is a more severe condition in women. Women reported more severe agoraphobic avoidance when facing situations or places alone, more catastrophic thoughts, more body sensations, and higher scores on the Fear Survey Schedule. Also, women more often had a comorbid social phobia or posttraumatic stress disorder. The lower agoraphobic avoidance of men was associated with their alcohol use. However, there were no differences between genders in other dimensions, including depression, situational and trait anxiety, stressful life events, social self-esteem, marital adjustment, and drug use.  相似文献   

18.
We tested the hypothesis that anxiety sensitivity enhances responses to biological challenge by exposing college students who scored either high or low on the Anxiety Sensitivity Index (ASI) to 5 min of voluntary hyperventilation. The ASI is a validated self-report instrument that measures the fear of anxiety symptoms. Following hyperventilation, high-anxiety-sensitivity (HAS) subjects reported more frequent and more intense hyperventilation sensations and a higher level of subjective anxiety than did low-anxiety-sensitivity (LAS) subjects. Analyses of covariance controlling for baseline differences indicated that the magnitude of increase (i.e., reactivity) in hyperventilation symptoms remained greater in the HAS than in the LAS group, whereas the magnitude of increase in anxiety did not. HAS subjects also exhibited a bias for reporting bodily sensations in general. These findings parallel those obtained when panic patients and normal controls are biologically challenged with hyperventilation, lactate infusion, and other anxiogenic agents. Taken together, these results suggest that anxiety sensitivity may also enhance the anxiety responses of panic patients during biological challenge tests. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   

19.
Tested 23 male and 22 female institutionalized retarded children who had previously experienced either a success, failure, or control precondition on a probability learning task designed to assess expectancy of success. Ss were matched for CA, MA, IQ, and length of institutionalization. The following measures were also collected as S variables: Locus-of-Control Scale, Cottage Rating Scales, school rating, and Reading and Arithmetic subscales from the Metropolitan Achievement Test. The preconditions were found to have many of the expected effects on the cognitive strategies employed in the learning task. Ss in the failure condition showed the greatest avoidance of failure (maximizing strategy), while Ss in the success condition tended to show more success striving (lose-shift strategy). Males were found to exhibit more failure-avoiding strategies than females. The overall pattern of results is interpreted as providing support for the hypothesis that a low expectancy of success in retarded children can be modified. (19 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   

20.
An experiment was conducted to examine the notion that depressives' responses would reflect a protective self-presentation style (M. G. Hill et al, 1986), the underlying goal of which would be the avoidance of future performance demands and potential losses in self-esteem. In this study, depressed and nondepressed Ss were asked to perform a relatively simple visual–motor task. Half of the depressed and half of the nondepressed Ss were told that if they were successful at the task, they would be asked to perform a 2nd similar task. The remaining Ss were given no such expectation of future performance. We predicted and found that depressed compared with nondepressed Ss strategically failed at the task when presented with the possibility of future performance and further losses in esteem. Moreover, this strategic failure was associated with some costs; depressed, future performance expectancy Ss experienced more discomfort or negative affect as a result of their performance. The relationship between this depressive self-presentation and self-handicapping strategies is discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   

设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号