The best medicine. Interview by Jim Montague

Laughter can be crucial to patient care, but physician and clown Patch Adams, M.D., sees nothing funny about the greed he finds in the nation's health care system and in current reform plans. Adams has spent almost 25 years infusing practitioners with a sense of humor. This philosophy extends into his work as founder of the not-for-profit Gesundheit Institute, which is trying to build an "ultimate fantasy" hospital on 310 acres in rural West Virginia. So far, he's raised $1.1 million, built one of three main buildings, and broken ground on a second. However, millions of dollars still need to be raised. Adams sees the very notion of his dream hospital as a necessary pie in the face of the traditional health care system. Besides speaking and performing, Adams takes groups of clowns to Russia, where they perform in hospitals, orphanages, prisons and on the street. Adams has co-authored a book about his philosophies, Gesundheit, and sold the rights to a Hollywood studio. He spoke recently with staff editor Jim Montague.     

The politics of nursing. Interview by Ian McMillan

Using the retrograde axonal marker transport it was shown that in dog nucleus accumbens medial and lateral segments receive similar projections. Cortical ones receive projections from mesocortical (prelimbic, infralimbic, orbital, insular and cingular) cortical fields, whereas subcortical receive projections from ventral tegmental field and basal nucleus of amygdala. The differences between projections of nucleus accumbens studied are that apart from the above-mentioned common afferents medial segment receives projections from allocortical (entorhinal, periamygdalar) fields and subicular portion of hippocampal formation while lateral segment receives projections from all dopaminergic portions of substantia nigra.     

The Tom and Tim machine

Translocation of precursor proteins into mitochondria depends on loosely assembled protein complexes in the outer and inner membranes. Recent studies indicate that dynamic interactions of subcomplexes and cooperation with molecular chaperones drive key steps in protein import.