Reye''s syndrome: relapses and neurological sequelae

Twenty-two children aged 2 months to 11 years were seen at our institution from January 1970 to March 1975 with clinical, laboratory, and/or histological features consistent with the diagnosis of Reye's syndrome. There were three pairs of siblings. Severity of the illness ranged from relatively benign to rapidly fatal forms. Five received live attenuated vaccines within the three weeks prior to admission. Four relapsed 1 to 21 months after the initial episode, and in one there were multiple recurrences. Six developed major neurological sequelae. All patients graded levels IV and V by EEGs on admission subsequently died in contrast to none from grades 1 and 2. Peritoneal dialysis was carried out in the more severely affected patients. The procedure did not influence final outcome as predicted by the first EEG and is thought to be of limited value.     

Co-existence of hepatitis A and adult Reye''s syndrome

The amyloid precursor protein is contained in platelet alpha granules and released with degranulation. Methods are described to control for amyloid precursor protein release from platelets during blood collection and processing. In normal subjects (n = 97; age range, 44-84 years), the average plasma level of amyloid precursor protein was 6.5 +/- 1.8 ng/ml.     

Inhibition of beta-oxidation by 3-mercaptopropionic acid produces features of Reye''s syndrome in perfused rat liver

PURPOSE: To evaluate the effects of lossy image (noninvertible) compression on diagnostic accuracy of thoracic computed tomographic images. MATERIALS AND METHODS: Sixty images from patients with mediastinal adenopathy and pulmonary nodules were compressed to six different levels with tree-structured vector quantization. Three radiologists then used the original and compressed images for diagnosis. Unlike many previous receiver operating characteristic-based studies that used confidence rankings and binary detection tasks, this study examined the sensitivity and predictive value positive scores from nonbinary detection tasks. RESULTS: At the 5% significance level, there was no statistically significant difference in diagnostic accuracy of image assessment at compression rates of up to 9:1. CONCLUSION: The techniques presented for evaluation of image quality do not depend on the specific compression algorithm and provide a useful approach to evaluation of the benefits of any lossy image processing technique.     

落实科学发展观 追求钢铁强国梦

30年前,党的十一届三中全会,做出把党和国家工作中心转移到经济建设上来、实行改革开放的历史性决策,吹响了走自己的路、建设中国特色社会主义的时代号角,中国人民从此踏上了改革开放的伟大历史征程。30年来,以邓小平同志为核心的党的第二代中央领导集体、以江泽民同志为核心的党的第三代中央领导集体和以胡锦涛同志为总书记的党中央,团结带领全党全国各族人民,     

改革开放—铸就钢铁强国的必由之路——纪念中国钢铁工业改革开放30周年

1978年中国共产党十一届三中全会拉开了我国改革开放的大幕，至今我国已经走过了不断探索、不断进步的30年改革开放历程，取得了举世瞩目的伟大成就。钢铁工业作为我国最重要的基础原材料产业之一，与国家改革开放、经济发展与社会进步的步伐息息相连。30年来，钢铁行业在党中央、国务院的正确领导下，在改革开放方针的指引下，在各地方和相关行业的大力支持下，经过几代钢铁人的不懈努力，已把自身打造成为一个管理体制和运行机制基本适应社会主义市场经济环境、产品数量、品种和质量能够基本满足国民经济和有关行业发展的需要、具有一定国际竞争力和技术开发创新能力、在世界钢铁业有举足轻重地位的产业。     

鞍钢改革开放三十年发展历程回顾

鞍钢是我国解放后最早恢复和建设起来的第一个大犁钢铁联合企业。始建于1916年,前身是日伪时期的鞍山制铁所和昭和制钢所。1948年鞍山钢铁公司成立,翌年7月9日在废墟上开工,迅速恢复了生产,并进行了大规模技术改造和基本建设,成为新中国第一个钢铁生产基地,走过了六十年的建设和发展历程。     

Clinical pharmacokinetics of ibuprofen. The first 30 years

Ibuprofen is a chiral nonsteroidal anti-inflammatory drug (NSAID) of the 2 arylpropionic acid (2-APA) class. A common structural feature of 2-APANSAIDs is a sp3-hybridised tetrahedral chiral carbon atom within the propionic acid side chain moiety with the S-(+)-enantiomer possessing most of the beneficial anti-inflammatory activity. Ibuprofen demonstrates marked stereoselectivity in its pharmacokinetics. Substantial unidirectional inversion of the R-(-) to the S-(+) enantiomer occurs and thus, data generated using nonstereospecific assays may not be extrapolated to explain the disposition of the individual enantiomers. The absorption of ibuprofen is rapid and complete when given orally. The area under the plasma concentration-time curve (AUC) of ibuprofen is dose-dependent. Ibuprofen binds extensively, in a concentration-dependent manner, to plasma albumin. At doses greater than 600mg there is an increase in the unbound fraction of the drug, leading to an increased clearance of ibuprofen and a reduced AUC of the total drug. Substantial concentrations of ibuprofen are attained in synovial fluid, which is a proposed site of action for nonsteroidal anti-inflammatory drugs. Ibuprofen is eliminated following biotransformation to glucuronide conjugate metabolites that are excreted in urine, with little of the drug being eliminated unchanged. The excretion of conjugates may be tied to renal function and the accumulation of conjugates occurs in end-stage renal disease. Hepatic disease and cystic fibrosis can alter the disposition kinetics of ibuprofen. Ibuprofen is not excreted in substantial concentrations into breast milk. Significant drug interactions have been demonstrated for aspirin (acetylsalicylic acid), cholestyramine and methotrexate. A relationship between ibuprofen plasma concentrations and analgesic and antipyretic effects has been elucidated.     

改革开放30年中国铝罐料工业从无到有

本文比较全面分析了铝罐料的需求和产能,同时重点从铝罐料的规格到生产技术的发展,从国内从无到有的发展过程进行了有理有利的分析。     

天铁技术装备发展三十年

企业的技术装备是企业有形资产的集中体现。文章介绍了天津铁厂30年来技术装备的建设、发展、维护管理的特点及其与企业生产发展的密切关系。     

30 years later: children attending a counseling service up to 3 years of age

From 1953 through 1955 a total of 2364 individuals between o and 18 years were discharged from the Stockholm Child Guidance Clinics. Among these patients 125 (68 boys, 57 girls) were under the age of 3 years. A follow-up study was conducted 30 years later on this sample using records from psychiatric clinics and data from official registers of problematic behaviours. The majority of the infants when seen at the Child Guidance Clinics were judged to be mentally healthy or to have shown mild environmental reactions. However sixty per cent of these patients were identified in at least one of the registers during the follow-up period. Thus the initial evaluation was not prognostic of the future development. Boys developed mainly social maladjustment, whereas girls more often applied for psychiatric care during the follow-up. Significant prognostic factors in the 1950s were gender and parental psychiatric diagnosis.     

Extraversion and vigilance performance: 30 years of inconsistencies.

Deteriorating efficiency in detecting critical events is a pervasive phenomenon. It has been asserted that the personality dimension of extraversion–introversion (E-I) could serve as a selection device: Introverts would be superior in sustained attention. A meta-analysis revealed better performance of introverts, but the effect size was small because of a high incidence of inconsistencies. In a subset of the studies, the effect size was much larger: Introverts were superior in overall level of correct detections but not in maintaining efficiency over time. Inconsistent findings may partly have been caused by inappropriate use of univariate ANOVA in repeated measures designs. The validity of some "classic" findings in the vigilance literature was questioned. The relationship of E-I to electrodermal speed of habituation was discussed. Finally, here also a trend was noted to move to new problems before solving old ones. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Treatment of Basedow-Graves' hyperthyroidism: retrospective analysis after 30 years

BACKGROUND: It is still debated which is the best treatment for Basedow-Graves' hyperthyroidism (BGH). We reviewed 195 patients treated and followed-up during the past 30 years: 88 treated with propylthiouracil (PTU), 70 with 131I and 37 thyroidectomized. AIM: to analyze the efficacy of each therapy in terms of achieving euthyroidism and the search of possible indexes for success. Surgery attained euthyroidism in 70.2% but has disadvantages; 131I accounted for the highest hypothyroid rate (72.1%) irrespective of the dose administered; PTU alone was successful in only 26.4% but combined with T4, success rose to 62.5% (p < 0.025). Suppression test and/or TRAb measurements after 6 mo PTU therapy were used to decide if therapy continued or was changed to other form of treatment. Using this criteria, 87.5% of pts with positive results achieved longstanding euthyroidism. Pretreatment predictive indexes were goiter size, T4 levels and 24 h/RAI uptake. CONCLUSIONS: As 131I induces hypothyroidism in over 2/3 of pts and surgery besides its cost is not devoid of serious complications, we advocate for the use of PTU as first line therapy; combined treatment (PTU + T4) seems promising. If after 6 mo on PTU, TRAb or Suppression test do not improve, we recommend 131I or surgery.     

Interventions for coronary stenosis--a Canadian experience of 30 revolutionary years

OBJECTIVE: To report 2324 coronary stenosis interventions (Vineberg procedures [VbP], coronary artery bypass graft operations [CABG] and percutaneous transluminal coronary angioplasties [PTCA]), in 1711 patients of a Canadian military hospital between 1965 and 1995 and to report their evolution and interaction in a historical context. DESIGN: Retrospective examination of clinical and angiographic findings in hard records, collected from the beginning for long term follow-up and later embedded in a custom-designed computer database. PATIENTS: Most were male, mean ages 43.2 and 43.3 years for first and second VbPs; 48.9 and 58.2 years for first and repeat CABGs; and 53.4 and 59.9 years for first and repeat PTCAs, respectively; 12% of all patients were 39 years old or younger at the first intervention. INTERVENTIONS: There were 160 VbPs, 1637 CABGs and 527 PTCAs. Of 1711 subjects, 74% had only one procedure, 15% had more than one of the same kind, and 11% had more than one of different kinds. MAIN RESULTS: Perioperative mortality for VbPs was 4.4%; for 'isolated' first CABGs it was 1.4% and 6.6% for reoperations, when other concurrent major cardiac procedures, excepting ventricular aneurysm repair, were excluded. It was 0.4% for PTCAs. Perioperative mortality for all 1761 'isolated' coronary interventions necessitating thoracotomy, during 30 years, was 2.4%. Angiographic follow-up rates were high and some findings are reported, including early postoperative patency rates for 5065 coronary bypass grafts, and long term follow-up data on graft patency and disease. CONCLUSIONS: Each intervention was used to circumvent or relieve coronary stenosis, in the early years when it became available and, later, as was most appropriate for dealing with specific clinical problems. The impact of advances in the evolution of these interventions on therapeutic decision-making is discussed. Finally, tributes are paid to those responsible for making these procedures possible, including a Canadian surgeon whose role was pivotal.     

Frequency of positive skin tests in asthma patients over 30 years

Frequency of positive skin in adults with asthma is poorly understood. 153 persons aged over 30 years were selected out of 575 patients suspected of asthma (26.6%). Positive skin reactions among adults, were confirmed in 64.1% of the examined patients. Positive skin reactions were analysed according to age and sex. Opinion about low frequency of allergy and asthma in elderly should be verified.