共查询到20条相似文献,搜索用时 15 毫秒
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Meng Shi Karyn Ho Armand Keating Molly S. Shoichet 《Advanced functional materials》2009,19(11):1689-1696
A polymeric nanoparticle comprised of surface furan groups is used to bind, by Diels–Alder (DA) coupling chemistry, both targeting anti‐human epidermal growth factor receptor 2 (anti‐HER2) antibodies and chemotherapeutic doxorubicin (DOX) for targeted, intracellular delivery of DOX. In this new approach for delivery, where both chemotherapeutic and targeting ligand are attached, for the first time, to the surface of the delivery vehicle, the nuclear localization of DOX in HER2‐overexpressing breast cancer SKBR‐3 cells is demonstrated, as determined by confocal laser scanning microscopy. Flow cytometric analysis shows that the conjugated DOX maintains its biological function and induces similar apoptotic progression in SKBR‐3 cells as free DOX. The viable cell counts of SKBR‐3 cancer cells following incubation with different nanoparticle formulations demonstrates that the combined DOX and anti‐HER2 nanoparticle is more efficacious than the nanoparticle formulation with either DOX or anti‐HER2 alone. While free DOX shows similar cytotoxicity against both cancerous SKBR‐3 cells and healthy HMEC‐1 cells, the combined DOX‐anti‐HER2 nanoparticle is significantly more cytotoxic against SKBR‐3 cells than HMEC‐1 cells, suggesting the benefit of nanoparticle‐conjugated DOX for cell type‐specific targeting. The DOX‐conjugated immuno‐nanoparticle represents an entirely new method for localized co‐delivery of chemotherapeutics and antibodies. 相似文献
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Drug Delivery: Polylactide‐block‐Polypeptide‐block‐Polylactide Copolymer Nanoparticles with Tunable Cleavage and Controlled Drug Release (Adv. Funct. Mater. 26/2014) 下载免费PDF全文
Robert Dorresteijn Nils Billecke Mischa Schwendy Sabine Pütz Mischa Bonn Sapun H. Parekh Markus Klapper Klaus Müllen 《Advanced functional materials》2014,24(26):4025-4025
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Sarah J. Leung Xenia M. Kachur Michael C. Bobnick Marek Romanowski 《Advanced functional materials》2011,21(6):1010-1010
Biodegradable, spectrally tunable plasmon resonant nanocapsules are created via the deposition of gold onto the surface of 100 nm diameter thermosensitive liposomes. These nanocapsules exhibit selective release of encapsulated contents upon illumination with light of a wavelength matching their distinct resonance bands. In this study, 760 and 1210 nm laser illumination elicits complete release from gold‐coated liposomes with a corresponding resonance, while causing minimal release from liposomes with an unmatching resonance. Spectrally selective release is accomplished through the use of multiple, low‐intensity laser pulses delivered over a period of minutes, ensuring that illumination affects the gold‐coated liposomes without heating the surrounding media. The use of pulsed illumination to achieve spectral selectivity is validated experimentally and through modeling of the heat equation. The result of this illumination scheme for selective release using multiple wavelengths of light is a biologically safe mechanism for realizing drug delivery, microfluidic, and sensor applications. 相似文献
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Drug Delivery: On‐Chip Fabrication of Paclitaxel‐Loaded Chitosan Nanoparticles for Cancer Therapeutics (Adv. Funct. Mater. 4/2014) 下载免费PDF全文
Fatemeh Sadat Majedi Mohammad Mahdi Hasani‐Sadrabadi Jules John VanDersarl Nassir Mokarram Shahirar Hojjati‐Emami Erfan Dashtimoghadam Shahin Bonakdar Mohammad Ali Shokrgozar Arnaud Bertsch Philippe Renaud 《Advanced functional materials》2014,24(4):418-418
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In recent years, nanomedicine has emerged at the forefront of nanotechnology, generating great expectations in the biomedical field. Researchers are developing novel nanoparticles for both diagnostic applications using imaging technology and treatment purposes through drug delivery technologies. Among all the available nanoparticles, inorganic mesoporous silica nanoparticles are the newcomers to the field, contributing with their unique and superlative properties. A brief overview of the most recent progress in the synthesis of mesoporous silica nanoparticles and their use as drug delivery nanocarriers is provided. The latest trends in this type of nanoparticles and their use in modern medicine are discussed, highlighting the significant impact that this technology might have in the near future. 相似文献
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Cancer Treatment: Biocompatible,Uniform, and Redispersible Mesoporous Silica Nanoparticles for Cancer‐Targeted Drug Delivery In Vivo (Adv. Funct. Mater. 17/2014) 下载免费PDF全文
Quan Zhang Xiaoling Wang Pei‐Zhou Li Kim Truc Nguyen Xiao‐Jun Wang Zhong Luo Huacheng Zhang Nguan Soon Tan Yanli Zhao 《Advanced functional materials》2014,24(17):2413-2413
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Drug Delivery: Gel–Liposome‐Mediated Co‐Delivery of Anticancer Membrane‐Associated Proteins and Small‐Molecule Drugs for Enhanced Therapeutic Efficacy (Adv. Funct. Mater. 16/2014) 下载免费PDF全文
Tianyue Jiang Ran Mo Adriano Bellotti Jianping Zhou Zhen Gu 《Advanced functional materials》2014,24(16):2258-2258
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Hybrid Materials: Theranostic USPIO‐Loaded Microbubbles for Mediating and Monitoring Blood‐Brain Barrier Permeation (Adv. Funct. Mater. 1/2015) 下载免费PDF全文
Twan Lammers Patrick Koczera Stanley Fokong Felix Gremse Josef Ehling Michael Vogt Andrij Pich Gert Storm Marc van Zandvoort Fabian Kiessling 《Advanced functional materials》2015,25(1):2-2
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Drug Co‐Delivery: Biodegradable Photothermal and pH Responsive Calcium Carbonate@Phospholipid@Acetalated Dextran Hybrid Platform for Advancing Biomedical Applications (Adv. Funct. Mater. 34/2016) 下载免费PDF全文
Feng Kong Hongbo Zhang Xu Zhang Dongfei Liu Dong Chen Weixia Zhang Liyuan Zhang Hélder A. Santos Mingtan Hai 《Advanced functional materials》2016,26(34):6138-6138
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Drug Delivery: Virus‐Inspired Mimics Based on Dendritic Lipopeptides for Efficient Tumor‐Specific Infection and Systemic Drug Delivery (Adv. Funct. Mater. 33/2015) 下载免费PDF全文
Zhijun Zhang Xiao Zhang Xianghui Xu Yunkun Li Yachao Li Dan Zhong Yiyan He Zhongwei Gu 《Advanced functional materials》2015,25(33):5241-5241