Images and realities of alcohol

The paper discusses the relationship between the images of alcohol and society, on one hand, and the reality of drinking and drinking problems on the other hand, from the point of view of policy-relevant research. Images of alcohol influence policy but they also depend on the social and cultural environment of policy-making. The epidemiological total consumption theory of alcohol-related problems is used as an example. The theory is embedded in the modern welfare state's ideals and its policy relevance presupposes that these ideals--universalism, consequentialism and public planning--are respected. If the approach today receives less attention by policy-makers than its empirical validity merits, it may be due to an erosion of these ideals, not of the epidemiological model itself. Images of alcohol influence behaviour and drinking problems but they also articulate the social context in which the images are constructed. This paper demonstrates the point, applying Lévi-Straussian cultural theory to an analysis of a recent beer advertisement addressed to young people. The advertisement not only reflects the images associated with youthful drinking but also the ambiguous status of youth as non-adults in contemporary society. The author stresses that for social and cultural research alcohol is a two-way window, to look at society through alcohol and to look at alcohol through society. Both directions are necessary for policy-relevant research.     

Oral administration of polymer-grafted starch microparticles activates gut-associated lymphocytes and primes mice for a subsequent systemic antigen challenge

The mucosal and systemic humoral immune systems can function essentially independent of each other, responding to mucosal and parenteral antigens, respectively. Nevertheless, antigen administered by one route can modify responsiveness to subsequent immunization by an alternate route. Here we demonstrated, in mice, in addition to stimulating rapid and robust sera antibody responses, intragastric (i.g.) immunization with human serum albumin (HSA)-containing starch microparticles (MP) grafted with 3-(triethoxysilyl)-propyl-terminated polydimethylsiloxane (TS-PDMS) primed for enhanced specific sera IgG following a parenteral antigen boost. After as little as one i.g. immunization with microentrapped, but not with soluble, HSA antigen-specific proliferation and antibody secretion were detected in Peyer's patches (PP); this activity peaked after three i.g. MP immunizations. We observed a progressive dissemination of antigen-specific lymphocyte reactivity from PP to splenic tissue following oral MP immunization. Similarly, we observed a shift in HSA-specific antibody-secreting cells from PP and mesenteric lymph nodes to splenic tissue following i.g. MP immunization. We also demonstrated that oral immunization with microentrapped, but not with soluble HSA, resulted in enhanced numbers of spontaneous Th2-cytokine secreting lymphocytes which disseminated from mucosal to systemic lymphoid compartments. This observation coincided with our findings that HSA-specific sera IgG1 responses in animals given HSA in MP were significantly higher than those detected in the sera of mice given soluble HSA i.g., both before and after parenteral antigen challenge. These findings suggest that orally-administered TS-PDMS-grafted MP, by stimulating elements of the mucosal immune system, are a valuable addition to mucosal and systemic vaccine delivery systems.     

On the critical behaviour of simple epidemics

We show how ideas and models which were originally introduced to gain an understanding of critical phenomena can be used to interpret the dynamics of epidemics of communicable disease in real populations. Specifically, we present an analysis of the dynamics of disease outbreaks for three common communicable infections from a small isolated island population. The strongly fluctuating nature of the temporal incidence of disease is captured by the model, and comparisons between exponents calculated from the data and from simulations are made. A forest-fire model with sparks is used to classify the observed scaling dynamics of the epidemics and provides a unified picture of the epidemiology which conventional epidemiological analysis is unable to reproduce. This study suggests that power-law scaling can emerge in natural systems when they are driven on widely separated time-scales, in accordance with recent analytic renormalization group calculations.     

Age-associated decrease in response of rat aquaporin-2 gene expression to dehydration

In biological movement systems, the level of muscular-articular links is responsible for assembling highly reliable, stable, and reproducible coordination patterns involving very many joints and muscles. Research shows that the important perceptual capabilities of this level arise from the bulk sensitivity of muscles and tendons, so-called effortful or dynamic touch, to the quantities of rotational dynamics that remain invariant (such as the inertia tensor) over variations in rotational forces and motions. The power laws characterizing this sensitivity point to underlying fractal (self-similar) processes. Other research shows that the hallmark ability of this level to produce repetitive interlimb coordinations can be addressed through a dynamics of coordination in which equations express the time-evolution of collective neuromuscular states. This research also suggests that the assembled rhythms exploit the unique blend of stability and variability characteristic of low-dimensional chaotic motion on strange attractors. In overview, research into the capabilities of the level of muscular-articular links highlights the importance of applying classical and modern (nonlinear) dynamics to understanding the assembly and perceptual control of biological movements.     

An endogenous calcium oscillator may control early embryonic division

Transient elevations in the concentration of free cytosolic calcium ion ([Ca2+]i) promote cell phase transitions in early embryonic division and persist even if these transitions are blocked. These observations suggest that a [Ca2+]i oscillator is an essential timing element of the early embryonic "master clock." We explore this possibility by coupling a [Ca2+]i oscillator model to an early embryonic cell cycle model based on the protein interactions that govern the activity of the M-phase-promoting factor (MPF). We hypothesize three dynamical states of the MPF system and choose parameter sets to represent each. We then investigate how [Ca2+]i dynamics may control early embryonic division in both sea urchin and Xenopus embryos. To investigate both systems, distinct [Ca2+]i profiles matching those observed in sea urchin embryos (in which [Ca2+]i exhibits sharp transients) and Xenopus embryos (in which [Ca2+]i is elevated and oscillates sinusoidally) are imposed on each of the hypothesized dynamical states of MPF. In the first hypothesis, [Ca2+]i oscillations entrain the autonomous MPF oscillator. In the second and third hypotheses, where the MPF system rests in excitatory and bistable states, respectively, [Ca2+]i oscillations drive MPF activation cycles. Simulation results show that hypotheses two and three, in which a [Ca2+]i oscillator is a fundamental timing element of the master clock, best account for key experimental observations and the questions that they raise. Finally, we propose experiments to elucidate further [Ca2+]i regulation and the fundamental components of the early embryonic master clock.     

International psychological research that matters for policy and practice.

After a brief history of the Committee on International Relations of the American Psychological Association, 3 points are made about international psychological research that matters. First, it matters when the definition of the research problem area and the findings can potentially be reflected in policy change, in the practice of educators or psychologists, or in the mindsets of a new generation of researchers. Person-centered analysis of adolescents’ social and political attitudes has this potential and can complement variable-centered analysis. A cluster analysis of the IEA Civic Education Study’s data in 5 Western European and 5 Eastern European countries illustrates this. The following 5 clusters of adolescents were identified: those supportive of social justice but not participative, those active in conventional politics and the community, those indifferent, those disaffected, and a problematic cluster of alienated adolescents. Second, research that matters is situated in a cultural context. It is proposed that publications using data from any single country be required to include information about the cultural context in which the research was conducted. Finally, it matters that attention be given to the dynamics of the collaborative international research process, not only to research results. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Stereotypic muscle-torque patterns are systematically adopted during acquisition of a multi-articular kicking task

Motor-control mechanisms used to learn multi-joint (kinematically indeterminate) movements, which involve the control of intersegmental dynamics, are poorly understood, because the few kinetic studies which examined them studied only a few trials performed early and late in learning. Therefore, we examined changes in movement kinematics and kinetics accompanying multi-joint movement acquisition to address the following questions: Once subjects can produce accurate movements, do motor patterns (i.e. net muscle torques) change with further learning? Are motor patterns learned using a systematic strategy? Following learning, are the same motor patterns consistently used for movement production? Subjects performed 16 blocks of 16 trials of a discrete weighted (mass = 1.674 kg) kicking movement, involving hip, knee, and ankle motion. They attempted to perform 400 ms spatially accurate movements. Kinematics were recorded for the hip, knee, ankle, and toe of the kicking leg, and inverse dynamics were used to obtain net-muscle-torque profiles. Subjects did not adopt the motor patterns initially used to produce accurate movements. With further learning, net muscle torques became less variable both within and between blocks; inter-joint dependency of muscle torques increased, as evidenced by decreased variability in the pair of muscle torques which directly affect a segment's motion (i.e. hip-knee and knee ankle muscle torques); and inter-joint relationships of muscle torques became more phase-locked, with hip and knee torques being produced simultaneously, as were knee and ankle torques. As there was a progression across blocks until the preferred motor patterns were adopted, the learned stereotypic motor patterns were systematically selected.     

What's the latest? Cultural age deadlines for family transitions

Several questions about the degree to which cultural schedules exist for the timing of life transitions, as well as the nature of these schedules, remain unexplored. In this article, we examine age timetables for central family transitions. Do individuals perceive age deadlines for these transitions, and by what ages do they think that men or women should have experienced them? How much consensus exists about these deadlines? Why are they considered important, and what consequences are perceived for men or women who miss them? A key theoretical question with which we are concerned is whether contemporary thinking about these deadlines can be considered "normative." A random sample of 319 adults from the Chicago metropolitan area were interviewed about eleven separate life-course transitions, six of which were from the family sphere. By and large, the majority of respondents perceived deadlines for most of the family transitions discussed. While the deadlines cited were quite variable in range, they were also concentrated within a narrow band of ages. The dimensions underlying individuals' thinking about deadlines were centered primarily on the development of self and personality, or were linked to concerns about the sequencing of roles and experiences over lifetime. However, late timing was generally thought to be acceptable, accompanied by little social tension, and without consequences for the individual's life or the lives of other persons to whom one is intimately connected. While a rough, "normal biography" of family life existed in the minds of our respondents, the deadlines attached to that biography were flexible guidelines for the course of family life, not rigid, normative principles. These findings are discussed in light of recent debates about life-course theory and research.     

Biocultural orchestration of developmental plasticity across levels: The interplay of biology and culture in shaping the mind and behavior across the life span.

The author reviews reemerging coconstructive conceptions of development and recent empirical findings of developmental plasticity at different levels spanning several fields of developmental and life sciences. A cross-level dynamic biocultural coconstructive framework is endorsed to understand cognitive and behavioral development across the life span. This framework integrates main conceptions of earlier views into a unifying frame, viewing the dynamics of life span development as occurring simultaneously within different time scales (i.e., moment-to-moment microgenesis, life span ontogeny, and human phylogeny) and encompassing multiple levels (i.e., neurobiological, cognitive, behavioral, and sociocultural). Viewed through this metatheoretical framework, new insights of potential interfaces for reciprocal cultural and experiential influences to be integrated with behavioral genetics and cognitive neuroscience research can be more easily prescribed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Matching treatment to alcoholism subtypes.

In the field of alcoholism treatment, as in mental health treatment more generally, no one treatment model is equally effective for all patients and problem types. Literature in both alcohol treatment and in psychotherapy research suggests some relationships in common between treatment efficacy and patient coping style, drinking patterns, and family dynamics. This literature suggests that "internalizing" alcoholics, whose drinking tends to be steady and to be functionally interwoven with family dynamics, will benefit more from family systems oriented treatments than from symptom- or individually focused treatments. Conversely, "externalizing" alcoholics may derive more benefit from symptom-focused cognitive and behavioral treatments than from family systems treatment. An ongoing research project designed to test these hypotheses and the development of treatment manuals that may increase differential treatment efficacy is described. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Interventions into the problem of wife assault: Therapeutic, policy and research implications.

Reviews psychological contributions to the study of the social problem of wife assault in the following areas: assessment of police response to family crisis calls, training of police for family crisis intervention, evaluation of training and policy change, treatment of wife assaulters, and causes of wife assault and its effects on the victim. Causes of wife abuse are discussed in relation to cultural influences, community systems such as occupational or friendship groups, family dynamics, and personality. A "traumatic bonding" process that may occur in cases of wife abuse is described. It is concluded that research on wife abuse constitutes a problem-focused approach that incorporates the study of basic processes such as the cognitive interpretation of affective states, applied issues such as treatment strategies for assaultive males, and policy issues such as the delivery of services. (French abstract) (102 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effect of the character of the (Ni, Pd) cluster/graphene interatomic bonds on the thermosize effects and structural-isomeric transitions

The thermal evolution of nanoclusters is studied by molecular dynamics simulation to analyze the nucleation and kinetics of the kinetic processes that determine the basic factors of the onset of premelting and the loss of thermal stability of a two-dimensional system of transition-metal (Pd, Ni) nanoclusters located on a graphene substrate. A comprehensive analysis reveals the effect of the initial structural characteristics of nanoclusters, the heating conditions, and the kinetic factors during thermally activated diffusion on the nanostructuring in the thermal evolution of the nanoclusters. This evolution includes the following stages: isomerization, quasi-melting, and the decomposition of a given regular structure; it is classified as an order-disorder transition and as an analog of phase transitions in macroscopic systems on the nanoscale.     

Psychologists as change agents in chronic pain management practice: Cultural competence in the health care system.

Psychologists bring great value to health care systems, but our ethnocentrism regarding the medical community often limits our effectiveness as agents of change. Based on experience in developing pain management services within the Department of Veterans Affairs health care system, we discuss cultural issues as central to effective systems change and provide specific recommendations for psychologists aspiring to change organized health care systems, such as the Department of Veterans Affairs. Consideration is given to the misfit of the biomedical model to chronic pain, “physics envy” affecting the authority accorded psychology, and societal stigmatization of psychopathology. A process-based definition of cultural competence is recommended as improving on psychology's intrinsic group-based notion of culture in engaging the medical community. The systems thinking literature is sampled in summarizing practical recommendations that include identifying features of local medical culture and power dynamics between psychology and medicine that can be modified by engaging stakeholders in an interpersonally effective manner. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Exercise and physical health: cancer and immune function

Over the last decade, there has been accumulating epidemiological data suggesting that exercise may decrease the risk of cancer, particularly colon cancer. However, exercise appears unrelated to rectal cancer risk. With regard to other cancers, because physical activity can alter levels of reproductive hormones, investigators have hypothesized that active individuals should experience decreased incidence of breast or prostate cancer. The better conducted studies suggest that exercise may reduce the risk of developing breast cancer. However, the epidemiological data on prostate cancer have been inconsistent. Meanwhile, data on other site-specific cancers have been sparse. An exciting and emerging body of research has suggested that exercise, at least in moderate amounts, can enhance the human immune system. Theoretically, then, this provides a further biological basis for expecting an inverse relationship between physical activity and cancer risk. However, the changes seen in immune function tend to be transient in nature; thus, the physiological significance with respect to cancer development is uncertain. Preliminary data also suggest that exercise may be beneficial for cancer patients by improving the quality of life and enhancing immune function. Although promising, this needs more careful research. Again, it is unclear whether the enhanced immune function is of any clinical significance in retarding the spread of cancer that has already developed. Finally, with regard to URTIs, moderate exercise appears to decrease the risk of this infection, although high-endurance exercise may increase the risk. This finding parallels the changes seen in the immune system in response to exercise and comes as no surprise, as the immune system also regulates susceptibility to infections.     

Child and mother play in three U.S. cultural groups: Comparisons and associations.

Child and mother play (n = 113 20-month-olds) among South American Latino immigrants, Japanese immigrants, and European Americans in the United States was investigated. Culturally universal patterns of play dominated the findings. For example, no cultural differences in the prevalence of exploratory or symbolic play were found for either children or their mothers. Regardless of their culture, boys engaged in significantly more exploratory and less symbolic play than did girls when they played by themselves. Few relations were found between child play in the two play sessions. Across cultural groups, children’s exploratory play was significantly positively related to both maternal demonstrations and solicitations of exploratory play. The results identify which realms of child growth, parenting, and family function call for special attention and cultural sensitivity, as well as which do not, in the dynamics of immigrant families. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Narratology, Cultural Psychology, and Counseling Research.

Narratological research is defined in relation to narrative theory and a cultural psychology perspective. Narrative concepts and methodology are explained, including the configural mode of understanding and principles of narrative analysis. Examples of application in psychological and counseling research are presented, with a discussion of issues of validity and voice. Suggestions are made on how narrative studies are to be evaluated. It is concluded that narratological research, with its focus on meanings and the storied nature of human life, can be especially useful in discovery research on identity development and the experience of counseling and life transitions. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Coparenting around siblings' differential treatment in Mexican-origin families.

In this study we examined patterns of mothers' and fathers' differential affection and discipline toward 2 adolescent offspring in 243 Mexican-origin families. Grounding our work in a family systems perspective, we used interparental patterns of differential treatment as an index of the coparental alliance and tested their associations with parents' reports of familism values, traditional gender role attitudes, and cultural orientations. We also sought to replicate prior research on European American samples linking interparental patterns of differential treatment to marital qualities (coparenting satisfaction, love, and conflict) and adolescent depressive symptoms and risky behaviors. Three interparental patterns emerged: families in which both mothers and fathers treated their 2 offspring equally, incongruent families in which 1 parent treated both offspring equally while the other parent favored 1 offspring, and congruent families in which both parents favored the same offspring. Most parents reported equal treatment, but others fell into the incongruent affection (30%), incongruent discipline (45%), and congruent discipline (16%) groups. Mixed model analyses of variances revealed that in families in which mothers and fathers both treated their offspring equally, parents reported higher familism values, more traditional gender role attitudes, and relatively stronger orientations to Mexican than Anglo culture. Consistent with previous research, interparental incongruence was associated with less positive marital qualities and more adolescent adjustment problems. Discussion focuses on the role of culture in shaping coparenting and the processes through which these coparenting dynamics are linked to marital and youth adjustment. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Symmetry breaking dynamics of human multilimb coordination.

The dynamics of pattern formation and change are studied in a complex multicomponent system, specifically the arms and legs of human Ss. Among the novel features observed are differential stability of coordinative modes produced by limbs moving in the same vs different directions (Exp 1); transitions between coordinative modes preceded by a slow drift in relative phase (Exps 1 and 2); bifurcations or phase transitions from one 4-limb pattern to another (Exp 2); and spontaneous emergence of non-1:1-frequency- and phase-locked patterns, in addition to periods of relative coordination (Exp 3). All observed relative phasing patterns and their dynamics (stability, loss of stability, intermittency) are shown to arise from the same underlying nonlinear dynamical structure, an important feature of which is broken symmetry. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Spatial electrical patterns in simulated neuronal dendrites

Steady state longitudinal distributions of (a) the density of channels conducting an inward transmembrane current of cations, (b) the submembrane concentrations of these cations, and (c) the resting membrane potential, were investigated in a phenomenological model of a cylinder-shaped dendritic process of the neuron. It was found that spatially non-uniform patterns of these distributions occur only if one of the following conditions held (i) an increase in the intracellular concentration of cations conducting an inward passive transmembrane current amplified the active efflux of those cations by the pump and attenuated their passive influx through the voltage dependent channels, with amplification of the efflux lower than attenuation of the influx; (ii) molecules of mobile channels bore a negative electrophoretic charge exposed to the intracellular space and were subject to lateral electrodiffusion in the membrane; (iii) the cations induced a further release of cations from intracellular stores. Numerical simulation studies of the membrane with Na and K channels and Na/K pumps with conditions (i) and (ii) have demonstrated the possibility of the creation of inhomogeneous patterns in the neurites. These inhomogeneous patterns are dissipative structures (DSs), and they can be spatially periodic.     

Dynamics of human postural transitions.

In the present study, the authors examined transitions between postural coordination modes involved in human stance. The analysis was motivated by dynamical theories of pattern formation, in which coordination modes and transitions between modes are emergent, self-organized properties of the dynamics of animal-environment systems. In 2 experiments, standing participants tracked a moving target with the head. Results are consistent with the hypothesis that changes in body coordination follow typical nonequilibrium, phase transitions, exhibiting multistability, bifurcation, critical fluctuations, hysteresis, and critical slowing down. The findings suggest that posture may be organized in terms of dynamical principles and favor the existence of general and common principles governing pattern formation and flexibility in complex systems. (PsycINFO Database Record (c) 2010 APA, all rights reserved)