共查询到20条相似文献,搜索用时 31 毫秒
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R Taneja C Rochette-Egly JL Plassat L Penna MP Gaub P Chambon 《Canadian Metallurgical Quarterly》1997,16(21):6452-6465
The role of RAR alpha 1 and RAR gamma 2 AF-1 and AF-2 activation functions and of their phosphorylation was investigated during RA-induced primitive and parietal differentiation of F9 cells. We found that: (i) primitive endodermal differentiation requires RAR gamma 2, whereas parietal endodermal differentiation requires both RAR gamma 2 and RAR alpha 1, and in all cases AF-1 and AF-2 must synergize; (ii) primitive endodermal differentiation requires the proline-directed kinase site of RAR gamma 2-AF-1, whereas parietal endodermal differentiation additionally requires that of RAR alpha 1-AF-1; (iii) the cAMP-induced parietal endodermal differentiation also requires the protein kinase A site of RAR alpha-AF-2, but not that of RAR gamma; and (iv) the AF-1-AF-2 synergism and AF-1 phosphorylation site requirements for RA-responsive gene induction are promoter context-dependent. Thus, AF-1 and AF-2 of distinct RARs exert specific cellular and molecular functions in a cell-autonomous system mimicking physiological situations, and their phosphorylation by kinases belonging to two main signalling pathways is required to enable RARs to transduce the RA signal during F9 cell differentiation. 相似文献
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Determination of the crystal structure of the human TBP-associated factor (hTAF(II))28/hTAF(II)18 heterodimer shows that these TAF(II)s form a novel histone-like pair in the TFIID complex. The histone folds in hTAF(II)28 and hTAF(II)18 were not predicted from their primary sequence, indicating that these TAF(II)s define a novel family of atypical histone fold sequences. The TAF(II)18 and TAF(II)28 histone fold motifs are also present in the N- and C-terminal regions of the SPT3 proteins, suggesting that the histone fold in SPT3 may be reconstituted by intramolecular rather than classical intermolecular interactions. The existence of additional histone-like pairs in both the TFIID and SAGA complexes shows that the histone fold is a more commonly used motif for mediating TAF-TAF interactions than previously believed. 相似文献
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Functional analysis of a transactivation domain in the thyroid hormone beta receptor 总被引:1,自引:0,他引:1
Y Tone TN Collingwood M Adams VK Chatterjee 《Canadian Metallurgical Quarterly》1994,269(49):31157-31161
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JJ Michaille B Kanzler S Blanchet JM Garnier D Dhouailly 《Canadian Metallurgical Quarterly》1995,39(4):587-596
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CA Berrevoets P Doesburg K Steketee J Trapman AO Brinkmann 《Canadian Metallurgical Quarterly》1998,12(8):1172-1183
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