Novel Gas-assisted Three-liquid-phase Extraction System for Simultaneous Separation and Concentration of Anthraquinones in Herbal Extract

abstract Gas-assisted three-liquid-phase extraction (GATE), which has the advantages of both three-liquid-phase extrac-tion and solvent sublation, is a novel separation technique for separation and con...     

Partition Behavior of Penicillin in Three-liquid-phase Extraction System

Partition behavior of penicillins G and V was studied in a novel three-liquid-phase extraction system, which is composed of butyl acetate (BA), polyethylene glycol (PEG), ammonia sulfate [(NH4)2SO4] and water (H2O). The main components in the top, middle and bottom phases are butyl acetate, polyethylene glycol aqueous solution and ammonia sulfate aqueous solution, respectively. Some parameters such as partition coefficients Di/j and mass fractions Ei of penicillins G and V were determined at the room temperature, respectively. Experimental efforts have been made to investigate the partition behavior of penicillin in the three-liquid-phase extraction system, including initial concentrations of phase-forming components [PEG and (NH4)2SO4], PEG molecular weight, pH, initial concentration of penicillin. The results indicated that penicillins G and V have the similar partition behavior. They preferentially distribute into the middle phase with the increase of initial concentration of phase-forming components and into the top phase with the decrease of pH, while partition coefficient Dm/b is hardly affected by pH value. The variation of PEG molecular weight has little effect on mass fractions of penicillin. The increase of initial concentration of penicillins G and V could lead to the increase of Dt/b, Dm/b and the decrease of Dt/m, while their mass fractions in all phases were almost independent on their initial concentrations.     

药桑色素的提取方法及分离研究

采用正交实验对药桑色素用不同溶剂、在不同时间、不同温度、不同配比下的提取工艺进行了探索,并用AB-8型大孔吸附树脂对其进行分离纯化。结果表明:用0.1%的HCl-C2H5OH溶液,按1∶5的配比在40℃提取1h为最佳提取条件。纯化后的色素为紫红色粉末,色价提高近7倍。初步分析表明药桑色素主要为花青素类色素。     

姜辣素提取与分离纯化工艺的研究进展

介绍了姜辣素的化学组成和性质,重点阐述了姜辣素的提取、分离纯化和测定的方法,并探讨了姜辣素研究中存在的问题。     

溶剂萃取法净化湿法磷酸的研究

研究了在用磷酸三丁酯作为主要萃取剂时萃取塔的结构参数和操作参数对萃取效率的影响，比较了洗涤条件对杂质离子的脱除效果，以及不同条件下反萃效果的差异。实验结果表明：萃取效率不会随着振动频率的增大而增大，当萃取酯中有夹带酸时振动频率越小萃取率就越大，萃取塔筛板间距为5．5cm时萃取效果最好；铵盐和钠盐的脱除硫酸根离子能力大致相同，加大它们的浓度或缩小洗涤相比有利于脱除硫酸根离子，反萃取操作容易。     

醋酸甲酯-甲醇-水的复合盐萃取分离研究

针对醋酸甲酯-甲醇-水体系分离难,生产能耗高的现状,采用复合盐萃取技术对该体系进行分离.气相色谱测试结果表明,盐类可降低该体系的互溶度.采用MgCl2、CH3COOK和水组成的复合盐萃取剂CEA在常温下可显著地增大体系的非均相区,醋酸甲酯在有机相中的极限质量分数由87%提高到98%.当CEA的密度从1050 kg·m-3提高到1280 kg·m-3时,有机相中醋酸甲酯的质量分数从77%增加到90%以上,分配系数从2增加到13.增加萃取比、萃取级数有利于提高分离效果,在25℃采用密度为1220 kg·m-3的CEA,萃取比为1:1,三级逆流萃取后,有机相中醋酸甲酯的质量分数由65.41%增加到98.01 %,其分配系数由萃取前的1提高到37,甲醇的质量分数降低到0.06%.复合盐萃取作用机理主要是盐对甲醇分子的络合作用及盐与水分子的氢键作用.采用该技术对聚乙烯醇生产中的醇解废液醋酸甲酯提纯工艺进行改进,得到的醋酸甲酯质量分数可达98%以上,与传统分离工艺相比节能约35%.     

替考拉宁在不同液液萃取体系中分配系数的测定

Teicoplanin is one of the macrocyclic glycopeptide antibiotics, which is active against Gram-positive bacteria, and has attracted a lot of attention in the field of chiral separation recently. In this work, the partition coefficients and extraction ratio of teicoplanin in three different solvent systems were studied: conventional extraction, reactive extraction and reverse micelle extraction. With conventional solvent extraction, n-butanol demonstrated high partition coefficient for teicoplanin, but low extraction ratio because of its high solubility in water. Reactive extraction of teicoplanin showed the highest partition coefficient with almost 100% recovery in organic phase when tri-n-octylmethyl ammonium chloride (TOMAC) was used as extractant and pH value was above 5.0. A reverse micelle system, consisted of isooctane 10 mmol-L^-1 TOMAC -t-1% n-octanol, also offered high separation factor for teicoplanin. The results are beneficial for the design of teicoplanin separation and purification process.     

Determination of Teicoplanin A2's Partition Coefficient in Different Liquid-Liquid Extraction Systems

Teicoplanin is one of the macrocyclic glycopeptide antibiotics, which is active against Gram-positive bacteria, and has attracted a lot of attention in the field of chiral separation recently. In this work, the partition coefficients and extraction ratio of teicoplanin in three different solvent systems were studied: conventional extraction, reactive extraction and reverse micelle extraction. With conventional solvent extraction, n-butanol demonstrated high partition coefficient for teicoplanin, but low extraction ratio because of its high solubility in water. Reactive extraction of teicoplanin showed the highest partition coefficient with almost 100% recovery in organic phase when tri-n-octylmethyl ammonium chloride (TOMAC) was used as extractant and pH value was above 5.0. A reverse micelle system, consisted of isooctane 10mmol-L-1 TOMAC 1% n-octanol, also offered high separation factor for teicoplanin. The results are beneficial for the design of teicoplanin separation and purification process.     

气体搅拌萃取过氧化氢实验研究

在内径为50 mm的筛板塔内,研究了空气-水-蒽醌工作液三相体系萃取过氧化氢过程.萃取温度为40℃,空气和分散相的表观流速分别为(1.31～3.22)×10-3m·s-1和(1.27～1.70)×10-3 m·s-1,分散相和连续相的表观流速之比为50:1.结果表明,在普通液-液萃取过氧化氢过程中引入气体作搅拌,可减小分散相的液滴直径,增大相际接触面积,明显提高萃取效率,降低萃余相中过氧化氢的含量.传质单元高度随气体表观流速的增加而降低,传质系数随气体表观流速的增加而增大.     

蛋白质分离纯化方法研究进展

蛋白质的分离纯化方法是生命科学领域关注的热点之一.根据蛋白质的酸碱性质、分子大小与形状、溶解性质及其与配体亲和性等,对其分离纯化方法进行了综述.     

杜仲活性成分的提取及分离纯化方法研究进展

总结了近年来杜仲活性成分的提取和分离纯化方法,对每种方法的优缺点和适用范围进行了小结;以开发杜仲活性成分为目的,提出了提取和分离纯化杜仲活性成分的几点建议。     

Separation of Gallium and Aluminum from HCl Solution by Microemulsion

Gallium was separated from aluminum in hydrochloric acid medium by a steady microemulsion. In the cetyltrimethylammonium bromide (CTAB)/n-pentanol/n-heptane/HCl/tributyl phosphate (TBP) system, TBP was introduced as the modifier to avoid emulsification of the microemulsion. The extraction efficiency on gallium was also improved by adding TBP. The factors that influenced the separation efficiency were explored. The results of the experiments showed that the gallium and aluminum were effectively separated within a very short time, and the extraction efficiencies of gallium and aluminum were 92% and 5%, respectively. The maximum back-extraction efficiency of gallium was 92% in HCl solution (4 M).     

双水相萃取技术在药物分离和提取中的应用

系统地介绍了双水相萃取技术在基因工程药物、抗生素以及动、植物药物分离和提取中的应用研究,并着重提出了应用该技术开发我国传统中草药的重要意义。     

天然香料的提取分离技术

文章综述了目前传统的天然香料的提取分离技术，如水蒸气蒸馏法、浸提法、压榨法、吸收法、结晶法；新兴的提取分离技术，如分子蒸馏、超临界CO2苹取、微波辅助苹取、加速溶剂苹取、超声提取、色谱法、膜分离、毛细管电泳法和旋转带精馏，以及这些方法的特点与应用前景。     

糠醛和水逆流萃取分离的研究

选择三氯乙烯为糠醛和水萃取分离的溶剂,采用逆流萃取法进行模拟计算,并进行萃取试验,为进一步逆流萃取中试试验提供可行性依据。     

植物农药提取及纯化新技术研究

综述了新型分离技术如超临界流体萃取、微波辅助提取、超声技术提取和液膜萃取技术提取特点以及它们在植物农药提取分离中的应用研究进展,简要叙述了其发展前景。     

天然有机物的提取与分离

简要叙述了天然有机物提取与分离方法,如超临界流体萃取技术,超声波提取技术,微波提取技术,酶提取和仿生提取技术,固相萃取和固相微萃取技术技术.对高数逆流色谱技术、大孔树脂吸附法技术进行了详细的描述.     

Experimental Investigation and Thermodynamic Modeling of Glycerin/Methanol/Organic Solvent Systems

Glycerin is an important by‐product in biodiesel production. To increase its quality to be suitable for use it in other operations, e.g., the pharmaceutical industry, it needs to be purified. Therefore, the purification of glycerin by liquid‐liquid extraction of methanol using different solvents was investigated. It was shown that, in terms of separation, petroleum ether was more effective than toluene and toluene was more effective than n‐butanol. In addition to the experimental investigations, the NRTL and UNIQUAC thermodynamic models were used to predict the compositions of ternary mixtures of glycerin + methanol + organic solvent in glycerin‐rich and organic solvent‐rich phases. The results showed the high accuracy of the presented models and their consistency with the measured data.     

煤焦油蒸馏与萃取分离技术比较研究

分别对煤焦油蒸馏分离技术和萃取分离技术进行了介绍,并对两种分离工艺进行了比较研究,指出蒸馏分离技术能耗较高、设备投资大及破坏原始组分等不足之处;萃取分离技术弥补了以上缺陷并具有很强的可操作性和稳定性,但同时萃取分离技术仍然停留在实验室阶段,需要进一步开发推广应用。     

微乳液在萃取分离中的应用研究

微乳液作为分离介质具有分离速度快、效率高、选择性好等优点,可应用于湿法冶金、环境保护、生物工程、化工、医药等领域。本文综述了微乳液萃取分离金属离子、有机化合物及生化物质的研究进展。