Reproductive and neurobehavioural toxicity study of chlorpropham in mice

Chlorpropham was given in the diet to provide levels of 0 (control), 500, 1,000, and 2,000mg/kg from 5 weeks of age of the F0 generation to 9 weeks of age of the F1 generation in mice, and selected reproductive and neurobehavioural parameters were measured. There were no adverse effects of chlorpropham on either litter size or litter weight and sex ratio at birth. The average body weight of offspring was significantly reduced in the middle-dose group at postnataldays (PNDs) 0 and 4 in female offspring, and was significantly increased in the middle-dose group at PND 14 in male offspring. In neurobehavioural parameters, surface righting at PND 4 was significantly affected in a dose-related manner, and negative geotaxis at PND 4 was significantly accelerated in a dose-related manner in female offspring. In male offspring, surface righting at PND 7 was significantly depressed in the middle-dose group, and olfactory orientation at PND 14 was significantly affected in the low- and middle-dose groups. The dose levels of chlorpropham in the present study produced few adverse effects in reproductive and neurobehavioural parameters in mice.     

Reproductive and neurobehavioural effects of piperonyl butoxide administered to mice in the diet.

Piperonyl butoxide was given in the diet to mice to provide levels of 0 (control), 0.01, 0.03 and 0.09% from 5 weeks of age of the F(0) generation to 9 weeks of age of the F(1) generation, and selected reproductive and neurobehavioural parameters were measured. There were no adverse effects of piperonyl butoxide on either litter size, litter weight or sex ratio at birth. The average body weight of male offspring was significantly increased in the middle-dose group at post-natal days 4 and 7 during lactation. That of female offspring was significantly increased in the middle-dose group at post-natal days 7 and 14 during lactation. In behavioural developmental parameters, surface righting at post-natal day 7 was significantly delayed in the higher-dose groups in male offspring, and those effects were significantly dose related (p < 0.01). Olfactory orientation at post-natal day 14 was significantly depressed in the higher-dose groups in male offspring, and those effects were significantly dose related (p < 0.01). For movement activity of exploratory behaviour at 9 weeks of age of the F(1) generation, the total distance of males was significantly increased in the higher-dose groups, and those effects showed a dose-related manner (p < 0.01). Average distance and speed were significantly increased in the high-dose group, and those effects showed a dose-related manner (p < 0.01 in each). The dose levels of piperonyl butoxide in the present study produced some adverse effects in reproductive and neurobehavioural parameters in mice.     

杭菊花乙醇提取物对大鼠生殖发育毒性研究

目的研究杭菊花乙醇提取物(CME)经过亲代、宫内、哺乳期和断乳后持续暴露对子代的影响。方法设对照组和CME低、中和高剂量组,CME掺入饲料,剂量分别为0、1、3、9 g/kg BW;参照OECD TG 443开展一代延长试验,每组孕鼠20只及其子鼠每组40只(雌雄各半),子鼠断乳后持续给予CME 13周,测定生长发育、生殖发育、血象、血生化指标,做组织病理学检查。结果 CME高、中剂量组子鼠睁眼时间明显迟于对照组;低剂量组子代雌性大鼠出生后(PND)56～112天体质量明显高于对照组,子代雌性大鼠CME高、低剂量组红细胞计数(RBC)和血红蛋白浓度(HGB)均降低,CME高剂量组谷丙转氨酶(ALT)升高,高、中剂量组谷草转氨酶(AST)、血磷(P)升高,CME各剂量组血糖(GLU)均降低、乳酸脱氢酶(LDH)均升高;子代雄性大鼠CME高、低剂量组血清钾(K~+)降低;子代雌雄大鼠CME高剂量组脾脏/体质量系数均高于对照组;以上均差异有统计学意义(F=2.818～42.75,P0.05)。结论低剂量CME促进子代雌性大鼠体质量生长发育,降低子代雌性大鼠的血糖,影响RBC、HGB和LDH;高、中剂量CME影响子代大鼠发育和子代雌性大鼠的肝功能,高剂量CME影响子代雌雄大鼠脾脏/体质量系数。     

戴瑞羊、小尾寒羊及其杂交后代乳成分比较分析

为培育我国自主知识产权的新品种奶绵羊,本研究对戴瑞羊(DM)、小尾寒羊(STH)、戴寒杂交F1(F1)和戴寒杂交F2(F2)乳中常规成分、脂肪酸、氨基酸、矿物质和维生素进行了比较分析.结果表明,F1乳的脂肪含量最高,其蛋白质、酪蛋白、固形物和非乳脂固形物以及必需氨基酸含量仅次于STH乳,显著高于DM和F2乳(P<0.0...     

Effects of gamma radiation on the progeny of irradiated Ephestia cautella (Walker) (Lepidoptera: Pyralidae) males

One-day-old P₁ males of Ephestia cautella, Baghdad strain, were treated with 0.15, 0.20 and 0.25 kGy of γ radiation and mated in groups (15 pairs) with untreated virgin females. Radiation effects were assayed by determining percentage of egg hatch, mating ability and F₁ sex ratio. Our results showed the greater the initial dose, the greater the reduction in the percent egg hatch, and the greater the male-to-female ratio. Radiation effects on F₁ males were greater than the effect on the P₁ males. Furthermore, the results showed that the effects on F₁ males were greater than the effects on F₁ females. These results were confirmed cytologically by examination of the developing meiotic germ cells of F₁ males which showed that the meiotic nuclei carried multiple translocations. Such chromosomal aberrations explain the sterility observed in the F₁ male generation.     

滇橄榄叶羟基酪醇对CS2致小鼠睾丸组织损伤的保护作用

目的:研究从滇橄榄叶中提取的羟基酪醇（hydroxytyrosol from Phyllanthus emblica Linn leaves,PHT）对二硫化碳（carbon disulfide,CS₂）致小鼠睾丸组织损伤的保护作用。方法:实验小鼠随机分为对照组（蒸馏水）、CS₂染毒组（50 mg/m3）和3个PHT干预组（450、150、50 mg/kg）,4周后计算睾丸脏器系数、检测精子质量、测定睾丸组织匀浆中的超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）活性及丙二醛（MDA）含量并观察睾丸组织病理切片,采用Western blot实验检测睾丸组织中凋亡相关因子蛋白的表达情况。结果:经过干预后,PHT高、中剂量组睾丸脏器系数均高于CS₂染毒组（P<0.01）,且PHT高剂量组与对照组间无统计学差异（P>0.05）;各PHT剂量组精子计数和精子活动率均高于CS₂染毒组（P<0.01）,但低于对照组（P<0.01）;各PHT剂量组精子畸形率低于CS₂染毒组（P<0.01）,且PHT高剂量组与对照组的精子畸形率无统计学差异（P>0.05）;观察睾丸组织病理切片发现,与CS₂染毒组相比,各PHT剂量组的睾丸组织形态均得到了改善,其中PHT高剂量组与对照组的病理切片在镜下未观察到明显差别;氧化应激指标与凋亡相关因子蛋白的表达情况表明,各PHT剂量组睾丸组织中MDA含量均低于CS₂染毒组（P<0.01）,PHT高剂量组与对照组间MDA含量无显著差异（P>0.05）;各PHT剂量组睾丸组织中SOD和GSH-Px活性高于CS₂染毒组（P<0.05）,但低于对照组（P<0.01）;与CS₂染毒组相比,PHT高、中剂量组睾丸组织中Bax和Caspase-3表达降低,Bcl-2表达升高（P<0.01）,且各剂量组与对照组间也存在差异（P<0.05）。结论:CS₂可以引起小鼠睾丸氧化损伤,且PHT可以针对CS₂所致的睾丸组织损伤发挥拮抗作用,其机制可能与PHT的强抗氧化性维持了部分抗氧化酶的活性,缓解了氧化损伤,从而减少了细胞凋亡因子的形成有关。     

乳铁蛋白对幼年大鼠骨健康影响

目的:研究乳铁蛋白(Lactoferrin,LF)对幼年大鼠骨健康的作用。方法:将40 只4 周龄雄性SD大鼠随机分为对照组(0 mg/kg bw/d)、LF低剂量组(100 mg/kg bw/d)、LF中剂量组(500 mg/kg bw/d)和LF高剂量组(1000 mg/kg bw/d),连续喂养30 d后,测定幼年大鼠体重和脏体比变化、股骨骨密度(Bone mineral density,BMD)和骨微观结构变化、血清及股骨骨髓组织中抗酒石酸酸性磷酸酶(Tartrate resistant acid phosphatase,TRACP)、基质金属蛋白酶9(Matrix metalloproteinase 9,MMP-9)、组织蛋白酶K(Cathepsin,CTSK)、核因子κB受体激活因子配体(Receptor activator for nuclear factor-κB ligand,RANKL)和骨保护素(Osteocalcin,OPG)水平。结果:灌胃LF 30 d后,与对照组比较,LF剂量组幼年大鼠体重、脏体比增长趋势相近,差异不显著(P>0.05),LF中、高剂量组骨小梁数量(Trabecular bone number,Tb.N)、骨小梁厚度(Trabecular bone thickness,Tb.Th)、血清及股骨骨髓组织中OPG和OPG/RANKL水平显著增加(P<0.05),骨小梁分离度(Trabecular bone space,Tb.Sp)、TRACP、MMP-9、CTSK和RANKL显著降低(P<0.05)。结论:补充LF能够减少幼年大鼠骨吸收,增加骨形成和骨量,调节骨代谢平衡,促进骨健康。     

钇对子代大鼠神经行为和认知能力的影响

目的研究硝酸钇对子代大鼠神经行为和认知能力的影响。方法将孕鼠随机分为对照和受试物低、中、高4个试验组,20只/组。从孕期第6天(GD 6)至分娩后第21天(PND 21),受试物组每天分别灌胃给予硝酸钇溶液5、15、45 mg/kg BW,对照组灌胃给予蒸馏水。断乳后,继续给予子鼠原剂量受试物直至PND 63天。观察不同剂量硝酸钇对子鼠生长发育、脏器组织和神经行为的影响。结果在PND 21天时,雄鼠低、中、高3个剂量组体重均高于对照组,且差异有统计学意义(P0.05)。但从PND 42天开始至试验结束,雄性高剂量组体重明显低于对照组,导致高剂量组雄鼠总增重和总进食量均低于对照组,且差异有统计学意义(P0.05),但食物利用率无变化。PND 42天时雌鼠低剂量组体重和雄鼠高剂量组脑体比均高于对照组,且差异有统计学意义(P0.05),但不认为有生物学意义。Morris水迷宫试验中仅高剂量组雌鼠第5天的潜伏期高于对照组,且差异有统计学意义(P0.05),其他神经行为试验结果均未见差异。结论在本试验条件下,断乳后持续给予硝酸钇受试物会导致高剂量组雄性子鼠的体重下降,但不会影响脑组织重量,也不会在成年早期对子鼠的痛觉、运动活力和认知能力等神经行为造成影响。     

Efficacy of the insect growth regulators methoprene, fenoxycarb and diflubenzuron against Rhyzopertha dominica (F.) (Coleoptera: Bostrichidae) on maize and paddy rice

The activity of fresh deposits of methoprene, fenoxycarb and diflubenzuron against F₁ progeny of Rhyzopertha dominica on maize and paddy was compared with that on wheat, at two equilibrium relative humidities. There were differences between slopes of log concentration-probit (lc-p) lines for different compounds, and for the same compound on different grains. Judging by values of the IC_99.9, i.e. the concentration which inhibited progeny production by 99.9%, the order of activity against F₁ progeny on different grains was: methoprene, wheat and paddy > maize; fenoxycarb, wheat > paddy > maize; diflubenzuron, wheat and maize > paddy. Equilibrium relative humidity (e.r.h.) had no consistent effect on activity—at 90% e.r.h., the IC₅₀ of fenoxycarb on wheat was reduced and the IC₅₀ of diflubenzuron on maize was increased compared with 70% e.r.h., and other treatments were unaffected.

The efficacy of these compounds on maize and paddy against F₁ and F₂ progeny was evaluated during 48 weeks storage at 30°C, 70% r.h. The resolved S isomer of methoprene was also included. Slopes of lc-p lines were greater against the F₂ than against the F₁, particularly using diflubenzuron on paddy, with corresponding smaller values of the IC_99.9. Equally effective concentrations did not decline systematically over 48 weeks. Minimum effective application rates were judged as the concentrations that prevented living F₂ progeny in at least 2 of 3 replicates. Estimates for 48 weeks protection on maize were: methoprene, 2 mg kg⁻¹; S-methoprene, 1 mg kg⁻¹; fenoxycarb, 10 mg kg⁻¹; and diflubenzuron, 5 mg kg⁻¹. Corresponding estimates on paddy were 0.15 mg kg⁻¹, 0.05 mg kg⁻¹, 5 mg kg⁻¹, and 5 mg kg⁻¹.     

Synergized bioresmethrin as a potential grain protectant

Results of grain protectant trials comparing 4 ppm bioresmethrin + 20 ppm piperonyl butoxide with 12 ppm malathion are presented. The trials utilised commercial welded-steel silos of 5 tonne capacity as commonly used for grain storage on farms and were undertaken during 1967–69 and 1973–74. Treated wheat, in 5-tonne lots, was sampled at monthly intervals and subjected to bioassays of 7, 14 and 28 days duration, F₁ and sometimes F₂ generation counts were also made.

The best overall treatment was 4 ppm bioresmethrin plus 20 ppm piperonyl butoxide. After 12 months, the treated grain controlled Rhyzopertha dominica, 2 susceptible and 1 resistant strain; Sitophilus granarius, 1 resistant strain; S. oryzae, 2 susceptible and 1 resistant strains: Oryzaephilus surinamensis; Plodia interpunctella and Ephestia cautella. A much lower efficiency was observed in the control of adult Tribolium confusum, however, there was complete suppression of the F₁ generation. Poor adult control in the 14-day bioassays contrasted with excellent control in the 28-day bioassay and the F₁ and F₂ bioassays of T. castaneum.

In Australia R. dominica resistant to organo-phosphorus insecticides poses a severe threat to the grain handling industry. Synergised bioresmethrin should be able to restore broad spectrum control, the probable exception being Tribolium species. Bioresmethrin is less toxic to mammals than pyrethrins for which there is an established tolerance of 3 ppm and 20 ppm for piperonyl butoxide on grain.     

Evaluation of resistance development by Tribolium confusum Du Val (Coleoptera: Tenebrionidae) to diatomaceous earth under laboratory selection

Laboratory selection experiments were undertaken in order for the resistance development of Tribolium confusum adults to diatomaceous earth (DE) to be assessed. Adults from an initial laboratory reared population (P) were selected by exposure on hard wheat treated with 800 ppm of DE for 4 days at 25 °C and 65% r.h. The surviving adults and their progeny were maintained on flour and 5% brewer's yeast until the emergence of the next generation of adults. The emerged (F₁) adults were again exposed on treated hard wheat, as described above, and the whole procedure was repeated for 10 consecutive generations. Mortality of the emerged adults was assessed through bioassays that were undertaken in each generation at 25 °C and 65% r.h. In each bioassay, five dose levels of DE (250, 500, 800, 1000 and 1500 ppm) and four exposure intervals (24, 48 h, 7 and 14 days) were tested. Mortality of confused flour beetles generally declined at each dose rate and exposure interval with each generation, and significant differences were observed between the initial population (P) and after five or more (F₅+) generations of selection.     

白芍总苷对高尿酸血症肾损害大鼠肾脏的保护作用

目的:探讨白芍总苷（total glucosides of paeony, TGP）对高尿酸血症肾损害（hyperuricemic nephropathy, HN）大鼠肾脏的保护作用。方法:雄性SD大鼠50只,随机分为5组:正常组、模型组、TGP低、高剂量组（100、300 mg·kg?1·bw?1）、别嘌醇组（27.0 mg·kg?1·bw?1）,每组10只。每天上午7:00和晚上20:00,模型组、TGP低、高剂量组和别嘌醇组分别灌胃腺嘌呤100 mg/kg+氧嗪酸钾1500 mg/kg混悬液制造HN模型,每天中午12:00按剂量灌胃给药TGP和别嘌醇,正常组和模型组灌胃给予等量生理盐水,持续5周。每隔1周检测各组大鼠体重、血清尿酸、肌酐、尿素氮等指标,5周后,检测大鼠双肾重与体重的比值,同时对肾进行病理切片观察。结果:第5周时,与模型组相比,TGP高剂量组能显著降低HN模型的肾重（P<0.01）、肾体比（P<0.01）,降低HN模型血清中的尿酸（P<0.01）、尿素氮（P<0.05）和肌酐（P<0.01）水平,缓解HN模型肾小球系膜细胞增生,缓解肾小管扩张,减少肾小管间质损伤和肾脏炎性细胞浸润。结论:TGP对HN大鼠的肾脏有一定的保护作用。     

低温冷藏对烟草粉螟亲代和子代适合度的影响

为明确低温冷藏对烟草粉螟亲代和子代适合度的影响,根据年龄-龄期两性生命表理论,对5℃冷藏160d后的烟草粉螟5龄幼虫亲代生殖适合度及其子代发育历期、存活率、繁殖率和种群参数进行研究。结果表明,低温冷藏160d后烟草粉螟F₀代的蛹期显著长于对照,雌雄成虫寿命、平均繁殖力和产卵时间均显著低于对照;但在F₁代中,除了低温处理的平均繁殖力（148.29粒）显著高于对照（113.93粒）外,其他参数均无显著差异。研究表明,低温冷藏显著降低烟草粉螟亲代的适合度,对子代的适合度则无显著影响。     

Susceptibility of Rhyzopertha dominica to ionizing radiation

The effects of ionizing radiation doses between 1 and 20 krad on all stages of Rhyzopertha dominica were studied. Adult emergence from treated eggs and larvae was prevented by 4 and 8 krad respectively. Doses up to 20 krad to pupae only slightly reduced the emergence of adults. However there was considerable (up to 30 per cent) mortality of the adults within 8 hours of eclosion. The 20 krad dose caused very high mortality of adults from irradiated pupae and of irradiated adults within 3–5 weeks. Complete sterility, as evidenced by the lack of an F₁ generation, was induced in pupae by a dose of 14 krad and in adults by 11·5 krad.     

基于主成分分析的芹菜品质评价

为完善芹菜品质评价体系,对13个适宜食用时采收的品种的14项品质和生理生化指标进行测定。分析芹菜各指标间的相关性,采用主成分分析法建立芹菜品质的评价模型,对芹菜品种的品质进行综合评价。结果表明,芹菜品种间的品质和理化特性存在一定差异,a*值与叶绿素含量呈极显著负相关(P<0.01);V_C与叶柄硬度呈极显著正相关(P<0.01),与叶绿素和总糖含量、过氧化物酶(peroxidase,POD)和苯丙氨酸解氨酶(phenylalanine ammonia lyase,PAL)活性均呈显著正相关(P<0.05);硬度与总糖、纤维素酶活性呈极显著正相关(P<0.01),总糖与POD活性呈显著正相关(P<0.05),与纤维素酶活性呈极显著正相关(P<0.01)。通过主成分分析法分别提取出叶绿素含量、总糖含量、可食率、PAL活性、硬度、膳食纤维含量和汁液损失率共7项关键指标,建立了基于主成分分析的综合数学模型F=0.388F₁+0.238F₂+0.143F₃+0.134F₄+0.098F₅。据此计算综合得分并排序确定品质较好的品种分别为"山东红芹"、"法国皇后"、"良峰玉芹"、"玻璃脆芹"和"黄心芹(云南)",为芹菜品质评价和利用提供了参考。     

烟草青枯病抗性基因的遗传分析及RAPD标记

选用高感青枯病品种"红花大金元"与高抗青枯病品种"Ti448A"配制杂交组合,采用温室苗期叶片人工注射法接种鉴定两亲本及其杂交后代F₁、F₂、BC₁P₁代的青枯病抗性表现,结果表明抗病亲本材料Ti448A的抗病性由一对显性基因控制。依据混合群体分组分析法(BSA)建立抗青枯病基因池和感青枯病基因池,通过RAPD试验,从近200个随机引物中筛选出一个在两池间具有多态性的引物S503,用双亲、F₁、F₂单株DNA进行RAPD试验证明了该引物扩增出的特异性片段S503-750是一个与抗青枯病基因连锁的RAPD标记,利用JOINMAP (version 1.4)软件计算得此标记与抗青枯病基因间的重组率为5.984%,连锁距离为6.261 cM。      

荜茇宁对小鼠酒精性脂肪肝的预防作用

目的：探讨荜茇成分荜茇宁（piperlonguminine,GBN）对小鼠酒精性脂肪肝肝损伤的预防作用。方法：将成年雄性昆明小鼠随机分为空白对照组、酒精性脂肪肝模型组以及GBN（低、高）剂量组。空白对照组以基础饲料喂养,其余各组以高脂饲料喂养并每天用白酒按0.8 mL/30 g灌胃;GBN低剂量（10 mg/（kg•d））和高剂量组（40 mg/（kg•d））组分别按设计的药物和剂量给予小鼠灌胃,给药体积为0.8 mL/30 g体质量,空白对照组、模型组给予相同体积的水灌胃,连续给药6 周。于实验第6周末,测定各组小鼠体质量、肝脏指数,检测血清丙氨酸氨基转移酶（alanine aminotransferase,ALT）、天冬氨酸氨基转移酶（aspartate aminotransferase,AST）活力、总胆固醇（total cholesterol,TC）和甘油三酯（triglyceride,TG）含量,并做肝脏病理学检查。结果：GBN低、高剂量组肝脏指数分别为（4.42±0.50）%、（4.53±0.44）%,与模型组比较均显著降低;血清ALT与AST活力极显著降低（P＜0.01）;血清TC与TG含量极显著降低（P＜0.01）;同时病理组织学显示GBN能明显改善酒精性脂肪肝小鼠的肝细胞脂肪变性。结论：GBN够有效预防酒精性脂肪肝的发生或发展。     

动物双歧杆菌乳亚种M8胞外多糖的分离纯化和分子特征

动物双歧杆菌是一种高产胞外多糖(exopolysaccharide,EPS)的益生菌,在食品工业中应用广泛.该研究以动物双歧杆菌亚种M8为研究对象,发酵提取EPS,分别选用乙醇分级沉淀(ethanol gradient precipitation,EGP)法和阴离子交换色谱(anion-exchange chromat...     

蓝靛果花色苷对高脂膳食诱导肥胖大鼠脂代谢和抗氧化能力的影响

目的:研究蓝靛果果渣花色苷(Lonicera caerulea residue anthocyanin,LCRA)对高脂膳食诱导肥胖大鼠脂类代谢和抗氧化能力的影响。方法:将大鼠随机分为基础对照,肥胖模型对照和低、中、高剂量花色苷共5组,即4.0、40.0、120mg/kg bw.d的花色苷灌胃,基础对照组和肥胖模型对照组分别灌胃生理盐水(1.2g/kg bw.d);连续28d后,分别测定大鼠体质量、脂肪、肝脏质量,血清总胆固醇(TC)、总甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)含量以及肝脏脂肪酶(LPS)、肝脂酶(HL)、脂蛋白脂肪酶(LPL)、超氧化歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)的活性和脂质过氧化物(MDA)含量。结果:与肥胖模型对照组相比,LCRA能显著降低肥胖模型大鼠血脂水平,使肝脏LPS、HL、LPL、SOD和GSH-Px活性明显增强,MDA的生成量显著减少。结论:LCRA对高脂膳食诱导肥胖大鼠脂代谢有明显调节作用,可有效减少肝脏过氧化损伤,预防动脉硬化的发生。     

玉米肽对免疫性肝损伤小鼠的保护作用

研究了玉米肽(CCP)对卡介苗与脂多糖(BCG+LPS)诱导的小鼠免疫性肝损伤的保护作用.将60只小鼠随机分成正常组、模型组、水飞蓟宾阳性对照组、CCP低、中、高剂量组,第1 d,除正常组外,其余各组均经尾静脉注射BCG致敏;玉米肽组分别灌胃CCP 150、300、600 mb/kg·bw,阳性对照组灌胃水飞蓟宾50 mg/kg·bw,正常组、模型组则给予等量生理盐水,每天灌胃一次.15 d后,除正常组外,其余各组经尾静脉注射LPS攻击,诱导小鼠肝损伤.用试剂盒的方法分别检测各组小鼠血清中谷丙转氨酶(ALT)、谷草转氨酶(AST)活力,肝组织中丙二醛(MDA)、谷胱甘肽(GSH)、NO含量及超氧化物歧化酶(SOD)与谷胱甘肽过氧化物酶(GSH-Px)的活力;并进行肝组织病理学镜检.结果与模型组相比,CCP高剂量组可极显著降低血清中ALT、AST活性(P<0.01),提高肝组织中GSH含量和SOD、GSH-Px活力,并降低肝组织中MDA、NO的含量(P<0.01),其护肝效果与50 mg/kg·bw水飞蓟宾接近;肝组织病理学镜检结果显示接近于正常组.玉米肽对卡介苗与脂多糖(BCG+LPS)诱导的小鼠免疫性肝损伤有良好的保护作用.