Phase-mode LAPS and its application to chemical imaging

The light-addressable potentiometric sensor (LAPS) is a chemical sensor based on the field effect in the electrolyte-insulator-semiconductor (EIS) structure. In the conventional LAPS, the ion concentration in the analyte solution in contact with the sensing surface is determined by measuring the amplitude of the photocurrent induced by illumination. In this study, we developed the phase-mode LAPS, in which the phase of the alternating photocurrent is measured instead of its amplitude. The phase-voltage curve shifted along the voltage axis in response to the variation of the ion concentration in analogy to the shift of the amplitude-voltage curve in the conventional LAPS. The primary advantage of the phase-mode LAPS is that it is much less sensitive to the variation of the light intensity. It is also demonstrated that chemical imaging based on the phase-mode LAPS is free from artifacts related to defects in the semiconductor substrate.     

光寻址电位传感器及其应用

光寻址电位传感器(LAPS)是一种基于半导体光电效应的化学传感器,在稳定性、重复性、灵敏度、准确性和响应速度等方面具有优良的性能。介绍了LAPS的基本原理和测量方法,阐述了LAPS在细胞传感器、图像传感器、金属离子敏感薄膜传感器、气体传感器及生物医学领域中的应用,并对其存在问题和研究方向进行了总结和展望。     

In vitro assessing the risk of drug-induced cardiotoxicity by embryonic stem cell-based biosensor

Drug-induced prolongation of ventricular repolarization with arrhythmia is a major concern in clinic safety pharmacology, and has been a common reason for the withdrawal of several promising drugs from the market. Therefore, novel techniques should be developed to evaluate cardiotoxicity of new drugs in preclinical research. A cardiomyocyte based biosensor was developed using the light addressable potentiometric sensor (LAPS). Mouse embryonic stem cells cultured on the surface of LAPS were induced to differentiate into synchronized spontaneity beating cardiomyocytes. Changes of extracellular potentials and cell shapes with their mechanical beatings could induce modulation of photocurrents in the LAPS system, and finally change the output of the sensor. With the characteristics of light addressability, LAPS can record cell clusters at any desired position. The sensor can be used to record the prolongation of ventricular action potentials with the cardiotoxicity induced by drugs such as amiodarone, levofloxacin, sparfloxacin, and noradrenaline. The quick and on time characteristics of the sensor were promising to establish a high-throughput platform for pharmacological toxicity investigation.     

光寻址电位式传感器在有机磷检测上的应用

通过将乙酰胆碱酯酶用戊二醛交联法固定在光寻址电位式传感器的H+敏Si3N4膜上,即可用于检测有机磷农药。介绍了该传感器的工作原理及制作方法,并且分析探讨了缓冲溶液和乙酰胆碱底液的影响,还给出了在不同抑制时间和不同有机磷浓度下的响应特性。实验表明这是一种简捷灵敏、高效实用的有机磷农药检测新方法。     

基于光电复合传感器的重金属检测算法的研究

基于光寻址电位传感器(Light Addressable Potentiometric Sensor,LAPS)和微电极阵列传感器(Microelectrode Array Sensor,MEA)的复合传感器件,作为无线传感器网络的敏感元件,已应用于水环境痕量重金属的检测中.本文基于该光电复合传感器,分别对LAPS及M...     

Hg2 + 离子传感器的最新研究进展

综述了汞离子传感器的最新研究进展，主要介绍了利用光化学传感器、离子选择电极和生物传感器检测汞离子的状况，重点分析比较了功能材料和传感器特性。在此基础上，介绍了我们的研究情况，通过两个阶段的固相反应合成了汞离子传感器，并且通过激光脉冲沉积(PLD)技术把靶材(汞离子传感器)制备在光寻址电位传感器(LAPS)的表面上，形成薄膜，实现了汞离子传感器的微型化。     

A high-density multi-point LAPS set-up using a VCSEL array and FPGA control

A new LAPS (light-addressable potentiometric sensor) set-up will be introduced, in which the light sources are miniaturised by the utilisation of a VCSEL (vertical-cavity surface-emitting laser) array to increase the measurement spot density. An FPGA (field-programmable gate array) is used to generate modulation signals for individual illumination of each measurement spot of the LAPS. The new set-up can operate a large number of measurement spots simultaneously by reading out the sum photocurrent and separate the signals of the individual measurement spots by an FFT analysis. The frequency, amplitude and offset of the modulation signal can be configured for each measurement spot by software. The new system can be combined with a positioning stage allowing the parallel read out of a single line of measurement spots and a scan perpendicular to that line in a similar manner, like for an optical scanner set-up. First measurements demonstrate the functionality of the new LAPS set-up as a chemical imaging system.     

基于光电复合传感器的重金属原位监测系统嵌入式软件设计

针对水环境重金属监测仪器,设计了一种智能化嵌入式软件。该仪器采用光电复合传感器芯片,包括微阵列电化学传感器和光电位寻址传感器。仪器设计了可靠稳定的通信机制与上位机进行人机交互,仪器具有智能化自检功能,能够及时反馈传感器的故障信息。在检测过程中具有自动量程功能,能够最大发挥硬件优势,同时具有误差补偿和电路异常的检测机制。仪器具有高稳定性、自动化检测的特点,并完成了在野外无人值守的条件下的检测任务。     

结合LAPS及纳米多孔硅的气体传感器研究#

结合光寻址电位传感器及纳米多孔硅技术研制了一种新型的气体传感器.该传感器结合光寻址电位传感器的微机电系统工艺和平面器件特点以及纳米多孔硅的高灵敏度特性,对实现进一步细胞代谢气体的检测提供了一种可能的手段.初步实验结果表明,在室温条件下,该气体传感器对于乙醇气体具有较明显的响应,并具有一定的浓度梯度特性,证明该传感器的设计是可行的.     

基于光电复合传感器的重金属监测系统嵌入式软件设计?

针对水环境重金属监测仪器,设计了一种智能化嵌入式软件。该仪器采用光电复合传感器芯片,包括微阵列电化学传感器和光电位寻址传感器。仪器设计了可靠稳定的通信机制与上位机进行人机交互,仪器具有智能化自检功能,能够及时反馈传感器的故障信息。在检测过程中具有自动量程功能,能够最大发挥硬件优势,同时具有误差补偿和电路异常的检测机制。仪器具有高稳定性、自动化检测的特点,并完成了在野外无人值守条件下的检测任务。     

H~＋敏LAPS及其信号检测系统的研制

Ｈ＋敏光寻址电位传感器采用电解质Ｓｉ３Ｎ４－ＳｉＯ２—Ｓｉ结构，取光响应曲线的拐点电位值作为测量ｐＨ的输出参数．整个信号检测和数据处理过程在微处理器控制下实现．传感器的灵敏度为４８ｍＶ／ｐＨ．     

应用于海洋平台振动检测的无线传感器系统技术研究

海洋平台长期服役在恶劣的海洋环境里,特别是进入中后期服役阶段,其安全问题越来越成为制约海洋平台正常作业的重要因素,对海洋平台结构进行快速、便捷、实时动态检测是进行平台结构安全评估、维修决策、保障海洋平台正常使用的重要前提。文章介绍了一种用于海洋平台快速振动检测的无线传感网络检测系统,提出了系统的总体架构,分析了系统中加速度传感器的选取方法,完成了无线传感节点的原理及架构设计,最后通过在海洋平台结构模型上进行模拟海冰撞击的敲击试验,验证了所设计的无线传感网络检测系统在海洋平台结构振动检测中的应用可行性。     

基于匹配滤波解调的光纤光栅振动传感器研究

采用双悬臂梁结构,研制了基于匹配滤波解调的光纤光栅振动传感器,可通过悬臂梁对匹配光栅静态工作点进行精确调整.该传感器集振动传感和动态波长解调于一体,并具有温度补偿功能.对传感器的工作原理进行了理论分析,通过与压电式加速度传感器进行的比较实验,得到了一致的实验测量结果.     

Light-addressable suspended-gate gas sensor

A light-addressable potentiometric sensing (LAPS) system has been applied to construct an oxygen sensor using a suspended-gate electrode. The sensor principally consists of an MIS structure, i.e., suspended gate/air gap/LaF₃/SiO₂/Si. The use of the suspended gate makes it possible to realize a contactless sensing system, which provides a flexible structure to integrate multiple sensing elements on a single-chip semiconductor surface. The sensor shows a stable response at room temperature to oxygen partial-pressure changes in the range 0.25-1.0 atm. The fabrication conditions of the LaF₂ film are also discussed.     

具有闭环系统的法拉第电流传感器

利用法拉第效应建立了一种偏振结构的电流传感器，它具有闭环反馈系统，从输出端反馈的电流信号驱动偏振调制螺线管产生补偿信号使传感器工作在正交状态，这样就有效地消除了费德尔常数变化给传感器带来的误差．该传感器线性测量范围是：1mA～6．5A。     

基于光寻址电位传感器的水环境重金属无线检测仪器设计

针对水环境重金属检测问题,设计了一种新型的基于光寻址电位传感器(LAPS)的重金属检测仪器。相对于原子荧光光度法等其他方法,该仪器操作简便,无需繁杂的前处理过程,具有自动量程功能以及独立的水路系统。仪器通过ARM开发板与上位机无线通讯,检测过程自动化进行。经验证,仪器可以对水环境酸碱度以及重金属Pb2+浓度进行快速、自动化检测。其中pH的检测范围为5~9,灵敏度为37.321 mV/pH,平均误差为4.4%,满足水环境酸碱度的实测需求。重金属Pb2+的检测范围为10-7~10-1mol/L,灵敏度为26.43 mV/pPb2+,平均重复率为86.7%,并进行了Zn2+,Cu2+及pH对Pb2+检测的干扰测量。     

光纤传感器桥式补偿技术的实用性研究

本文对桥式补偿结构在光纤传感器中的应用进行了深入的研究，其补偿效果的优劣主要取决于补偿结构的稳定性，用这种补偿技术的光纤压力传感器系统计量油罐贮量得到优于０．２％的长期稳定性，把这种结构使用在激光雷达光纤传感器系统中同样取得显著的补偿效果。     

一种适合于水中爆炸压力测量的传感器

为了对炸药在水中爆炸产生的威力进行评估,开展了用于水中爆炸压力测量的传感器及测试系统的研究。以电气石为敏感元件,利用其体积压电效应的特点,研制了一种成本低、测量精度高、操作简便、适合用于水中爆炸压力测量的传感器,并与美国PCB公司生产的传感器同时进行了水中爆炸压力的对比试验。结果表明:研制的MCR I型传感器与美国PCB公司生产的传感器的测量结果基本一致。     

光寻址电位传感器信号的实时采集与数据管理——基于数据库和TeeChart的实时动态采集、显示和管理

光寻址电位传感器(LAPS)是一种基于集成电路制造技术的传感器,在生物化学领域有着广泛的应用前景。使用专用图表控件和数据库技术为LAPS测控系统建立了数据采集与管理系统,实现了LAPS输出信号的实时采集与动态显示,并采用数据库的形式对检测结果进行实时存储和历史查询,有助于进一步推进LAPS系统在应用领域的发展。     

A device for skin moisture and environment humidity detection

Water content detection is important for our daily life. For environmental detection, the relative humidity is an index for comfortable living atmosphere. For skin health, the water content in stratum corneum is a parameter to diagnose the skin condition. This paper mainly describes a moisture sensor for determination of human skin moisture. The skin moisture sensor is based on the conventional humidity sensor structure (interdigital capacitance, IDC), and the moisture sensor is also sensitive to the environmental humidity. Therefore, the effects of the environment, temperature and humidity, are discussed to find the appropriate operation conditions for skin moisture detection. Besides, the application of the moisture sensor for the environment detection is also described. The IDC structure is fabricated by using printed circuit board (PCB) technology which simplifies the bonding technique and reduces the cost.