Behavior modification through covert semantic desensitization.

Matched 12 male and 18 female snake-phobic undergraduates on degrees of behavioral avoidance and subjective fear. Ss were randomly assigned to (a) an experimental group who received a semantic counterconditioning of meaning treatment; or (b) a control group who were pseudodesensitized on a buffer task. Results show that snake-phobic Ss initially rated the word "snake" on the semantic differential scale as significantly negative in evaluative meaning. Ss in the experimental group showed significant alteration in their semantic differential rating of the word snake, significant decrement in their fear of snakes, and significant behavioral approach toward a live gopher snake. Semantic counterconditioning of meaning is interpreted to provide the basis for some desensitization procedures. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

External validity of laboratory fear assessment: Implications from two case studies.

Exposed 1 snake-phobic woman and 1 spider-phobic woman to a live snake or spider after they received systematic desensitization. In one assessment condition the 2 Ss were asked to approach and handle a caged snake or spider as in the traditional behavioral approach test, whereas in the other condition the Ss were exposed to the uncaged phobic stimuli. Both Ss manifested substantially greater physiological and cognitive distress while looking at the uncaged stimuli from a distance of 30 ft than when actually touching the caged snake or spider. Although both Ss were able to touch the caged snake or spider, they still reported being unable to engage in behaviors that were previously inhibited because of their phobia. Both Ss emphasized the importance of feeling in control when the phobic stimulus was caged but feeling out of control when the phobic stimulus was uncaged. Implications for the external validity of the behavioral approach test are discussed. (20 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Maternal presence and rearing condition affect responses to live predator in kangaroo rats (Dipodomys heermanni arenae).

Experiment 1 compared the responses of wild-caught adult and captive-born adult and juvenile kangaroo rats (Dipodomys heermanni arenae) to a live snake. Wild-caught adult rats were less active and monitored the snake more than during a control condition; captive-born juvenile rats did not behave differently during snake and control tests. Snake-naive adult rats behaved more like the wild-caught adult rats, but not on all measures. In Experiment 2, pups were tested at 25 and 50 days of age in 4 conditions: no-snake control, alone with the snake, with a sibling and the snake, and with the mother and the snake. Pups did not behave differently during control and snake tests, but during tests with the mother, pups faced the snake less and followed the mother. Younger pups were more often near the mother than a sibling and followed the mother more when the snake was present. Development of defensive behavior may depend on both predator experience and maternal influence. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Strategies within hypnosis for reducing phobic behavior.

Compared 3 methods for reducing fear of snakes using approach behavior and self-report anxiety measures of 36 adult female snake phobics. The methods, all involving hypnosis, were: (a) relaxation while recalling fearful snake-related events, (b) fear arousal during similar recall, and (c) posthypnotic suggestion about the disappearance of the snake phobia. All methods led to a significant decrease in fear as measured by overt behavior and self-report instruments, while notreatment controls showed little change. Because fear arousal within treatment had no advantage over methods, some doubt it cast on abreaction as essential to therapy of fears. Hypnotizability was positively related to degree of final approach behavior, and S's self-report of depth of hypnosis was positively related to degree of improvement. No S had ever experienced a harmful contact with snakes; the role of cognitive elaborations in the development of persistent fears is noted. (36 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Individual differences in the responses of na?ve rhesus monkeys to snakes.

The authors demonstrated individual differences in inhibited behavior and withdrawal responses of laboratory-born rhesus monkeys when initially exposed to a snake. Most monkeys displayed a small significant increase in their behavioral inhibition in the presence of a snake. A few monkeys had marked responses, and some actively withdrew. Although the responses of the most extreme laboratory-born monkeys were comparable to feral-born monkeys, the responses of the laboratory-born monkeys rapidly habituated. The individual differences in the responses of naive monkeys likely reflect a continuum from orienting to wariness to fear. A neurobiological model is presented that addresses potential mechanisms underlying these individual differences, their relation to fear, and how they may predispose to phobia development. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Relationships among measures of fear and anxiety for snake phobics.

Examined the relationships between various measures of fear for snake phobic Ss. 107 female undergraduates reporting high degrees of fear for snakes were given the Fear Survey Schedule, the Bendig Emotionality Scale, the MA scale, the Lang Snake Questionnaire, the Endler Stimulus Situation-Response Inventory of Anxiousness, Nawas' Behavioral Avoidance Test, and the Walk Fear Thermometer. 25 Ss who were unable to touch the snake also completed Welsh's A scale. 2 factors were extracted which accounted for 61% of the total variance: (a) generalized and pervasive anxiety, and (b) specific fears. A correlation matrix of results is presented. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Fear-relevant illusory correlations: What types of associations promote judgmental bias?

A. J. Tomarken, S. Mineka, and M. Cook (see record 1990-11527-001) found that high-fear individuals markedly overestimated the covariation between fear-relevant stimuli and aversive outcomes. The authors assessed what features of stimulus–outcome associations promote illusory correlations. In Experiment 1, participants with high snake fear exhibited significant covariation bias for slides of snakes and shocks, but not for slides of damaged electric outlets (DEOs) and shocks. In Experiment 2, individuals with high and low snake fear rated DEOs and shocks as belonging together better than snakes and shocks. However, the shapes of high-fear individuals' affective response profiles to snakes and shocks were more similar than their profile shapes involving other pairings. In addition, their affective responses to snakes and snake–shock profile similarity predicted snake–shock belongingness ratings. These results suggest the importance of emotional responses and emotional profile similarity in mediating illusory correlations involving fear-relevant stimuli. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Correction of complete transposition of great vessels by the Mustard technic (26 cases operated)

Laser Raman spectra of neurotoxins of Pelamis platurus (yellow-bellied sea snake) and Laticauda semifasciata (broad-banded blue sea snake) were investigated. The amide I band appeared at 1672 cm-1 for both toxins, which presents an indication of anti-parallel beta structure. Since this agrees well with the result from the CD-ORD studies of snake neurotoxin, it was concluded that snake neurotoxins mainly consist of beta structure. The amide III band appeared at 1245 cm-1 for P. platurus toxin and 1248 cm-1 for L. semifasciata toxin. The four disulfide bonds present in the toxin have a very similar geometry. After vigorous heat treatment, the backbone configuration of the toxin molecule basically remained the same although it was partially denatured. The major peak at 512 cm-1 was not altered by the heat treatment but a new shoulder appeared at 546 cm-1. This suggests that a new type of S-S stretching vibration (trans-gauche-trans) was produced as a result of heat treatment. However, the majority of the S-S vibrations remained in the gauche-gauche-gauche orientation. A substantial change in the interactions between a tyrosine aromatic ring and neighboring residues was apparently the alteration caused by the heat treatment.     

Roles of the vomeronasal and olfactory systems in courtship behavior of male garter snakes.

Studied whether male garter snakes required intact vomeronasal or olfactory systems to detect the pheromone that triggers the chin-pressing behavior of courtship. Male garter snakes with testosterone propionate pellets implanted sc were tested for courtship displays with estradiol-benzoate-treated females. Three groups of 10 males were formed from snakes exhibiting strong courtship responses. Bilateral olfactory nerve cuts were attempted on 1 group, vomeronasal nerve cuts on a 2nd, and control surgeries on a 3rd. All snakes in the olfactory nerve cut and control groups courted after surgery, and 3 snakes in each group copulated. More than half of the snakes in the olfactory nerve cut group had complete nerve cuts. Nine of the 10 snakes in the vomeronasal nerve cut group exhibited no courtship responses after surgery. The 1 snake in this group that courted was the only snake in which intact vomeronasal nerve fascicles were observed. Data indicate that male garter snakes without functional olfactory systems do court and mate normally, but that male garter snakes without functional vomeronasal systems exhibit no courtship responses. (38 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The role of radiation therapy and chemotherapy in the treatment of Merkel cell carcinoma

BACKGROUND: Merkel cell carcinoma is a rare and highly aggressive skin tumor. The purpose of this study was to determine the role of radiation therapy and chemotherapy in the treatment of patients with Merkel cell carcinoma. METHODS: A retrospective analysis of 27 patients treated at Rabin Medical Center in Israel is presented, focusing on the treatment details. Data for 40 patients (the authors' 27 patients and an additional 13 patients from the Israeli Cancer Registry), were analyzed for prognostic factors using univariate and multivariate analyses. RESULTS: Univariate analyses revealed regional lymph node involvement and the coexistence of a second primary tumor as unfavorable prognostic factors. On multivariate analysis, only lymph node involvement showed borderline statistical significance. Radiation therapy was highly effective when given as consolidation after surgery or chemotherapy. In 11 patients irradiated effectively, only 1 (9%) in-field recurrence occurred. Radiation therapy yielded responses in 15 of 15 measurable sites (5 complete responses and 10 partial responses). Chemotherapy produced responses in 18 of 26 patients (69%), mostly complete (41%). However, in the absence of radiation therapy, the responses were short lived. CONCLUSIONS: These data support the use of combined treatment with chemotherapy followed by radiation therapy for patients with advanced locoregional Merkel cell carcinoma. In patients with metastatic disease, chemotherapy as well as radiotherapy can provide effective palliation. Further large scale investigations are warranted to confirm this approach.     

Exotic snakebite: envenomation by an African puff adder (Bitis arietans)

We report an envenomation by the African puff adder (Bitis arietans), an exotic snake in the United States. The patient developed swelling and ecchymoses in the affected extremity, and cutaneous necrosis of the envenomated fingertip. There was no significant coagulopathy. He received 20 vials of specific antivenin (Schlangengift-Immunserum Behring Zentralafrika, Behringwerke, Marburg, Germany) and debridement of devitalized finger tissue. The only permanent sequelae were cutaneous scarring and permanent loss of the fingernail on the envenomated finger. Exotic snakebite is a rare presenting problem in emergency departments. The initial approach to a patient envenomated by an exotic venomous snake is discussed. Use of antivenin and supportive care are emphasized.     

Psychodynamic changes through systematic desensitization.

Attempted to integrate psychoanalytic theory and the data from behavior therapy, specifically systematic desensitization. It was found that snake phobics could be significantly discriminated from a group of normals on a measure of castration anxiety. Following systematic desensitization of the fear of harmless snakes, (a) 10 treated snake phobics were significantly lower on manifest anxiety than 10 nontreated snake phobics, but not as low as 10 normals; (b) treated snake phobics were significantly lower than nontreated snake phobics on a TAT measure of castration anxiety, but not as low as normals; and (c) treated snake phobics were not significantly lower than nontreated snake phobics on a Rorschach measure of castration anxiety, and both were significantly higher than normals. (20 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Response bias and Murdock's D scale.

Murdock's D scale predicts a U shaped curve of % correct identification as a function of the position of the stimulus. An inadequacy in the D scale was brought to light in an absolute judgment study by this author. Ss displayed a powerful response bias, avoiding end responses, when judging line lengths. A simple correction for such a response frequency imbalance is suggested, and with this correction the line-length data support the D scale approach to the quantification of distinctiveness. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Systematic desensitization versus implosive therapy.

Compared systematic desensitization (SDT) and implosive therapies (IT) for their effectiveness and efficiency in reducing snake phobic behavior in 36 otherwise normal adults. SDT and IT Ss differed significantly from control Ss in posttreatment avoidance of a snake and in change of reported discomfort. SDT and IT, however, did not differ in effectiveness. Results of a 6-mo follow-up show that IT was more efficient in that treatment was completed in 45% of the time required for SDT. Results were qualified by the finding that SDT had a consistent and continuing effect across Ss and across time whereas IT effect was more variable. Occurrence of unusual disturbance of Ss during SDT and of IT Ss between sessions are discussed. (23 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A nonsurgical treatment approach for patients with lumbar spinal stenosis

The purpose of this case report is to describe a physical therapy approach to the evaluation, treatment, and outcome assessment of two patients diagnosed with lumbar spinal stenosis. Evaluation consisted of assessment of neurological status, spinal range of motion, and lower-extremity muscle force production and flexibility; administration of the Modified Oswestry Low Back Pain Questionnaire and the Roland-Morris Disability Questionnaire; assessment of pain using a visual analog scale; and performance of a two-stage treadmill test. The treatment program was designed to treat the impairments, and harness-supported treadmill ambulation (unloading) was used to address the limitation in ambulation identified by the treadmill test. Outcome assessment included measuring changes in the status of the impairments and assessing responses to the disability questionnaires and performance of the two-stage treadmill test. Improvements were noted on all outcome measures for both patients after 6 weeks of physical therapy and at the 4-week follow-up examination. Larger case series and randomized trials with long-term follow-ups are recommended.     

Comment on: A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the the Danish Head and Neck Cancer Study (DAHNCA) Protocol 5-85

Colonic adenocarcinoma was diagnosed by surgical biopsy in a domestically raised 3-yr-old male corn snake (Elaphe guttata guttata). The snake presented with a history of constipation. Several masses were palpated in the distal coelomic cavity. On proctoscopy, a nodular firm white mass encircled the distal colon proximal to the cloaca. The histologic diagnosis was transmural mucinous colonic adenocarcinoma with scirrhous reaction. Resection of the affected region alleviated intestinal obstruction for at least 4 mo, after which the snake was lost to follow-up.     

Pineal multiunit activity in conscious quail: effects of light, blinding, ganglionectomy

The study assessed the extent to which heart-rate responsivity in the presence of a snake is correlated with behavioral avoidance of a snake. College students described, by a commonly used method, as either snake-avoidant or nonavoidant were exposed to a snake and to a neutral stimulus while their heart rates were monitored. Those Ss who were not behaviorally avoidant responded to the snake and to the neutral stimulus in essentially the same way. Those who were behaviorally avoidant showed less heart-rate responsivity to the neutral stimulus than to the snake. However, this difference was marginal and of insufficient magnitude to argue that snake-avoidant volunteer Ss are meaningful surrogates for clinically phobic patients. The results indict the value of dozens of previous experiments.     

Practical applications of snake venom toxins in haemostasis

Snake venom toxins have an established role in the coagulation laboratory for the assay of haemostatic parameters and a potential role for therapeutic treatment of thrombotic disorders. In the laboratory, snake venom thrombin-like enzymes (SVTLEs) are used for the assay of fibrinogen and detection of fibrinogen breakdown products and dysfibrinogenaemias. Importantly, because SVTLEs are not inhibited by heparin, they can be used for assaying antithrombin III and other parameters in samples which contain heparin. Prothrombin activators occur in many snake venoms and these have become established in the assay of prothrombin, in the study of dysprothrombinaemias and in the preparation of meizothrombin and non enzymic forms of prothrombin. Russell's viper (Daboia russelli) venom contains a number of useful compounds including toxins which can be used to assay blood clotting factors V, VII, X, platelet factor 3 and lupus anticoagulants (LA). More recently, activators from the taipan, Australian brown snake and saw-scaled viper have been used to assay LA. Proteins C and S can be measured by means of protac, a fast acting inhibitor from Southern copperhead snake venom and von Willebrand factor can be studied with botrocetin from Bothrops jararaca venom. The disintegrins, a large family of Arg-Gly-Asp (RGD)-containing proteins found in snake venoms, show great potential for the study of platelet glycoprotein receptors, notably, GPIIb/IIIa and Ib, and in the treatment of arterial thrombotic disease. Established SVTLEs used in clinical practice include ancrod and defibrase although success with these agents has been limited. A further group of enzymes under consideration as thrombolytic agents are the fibrinogenases.